In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership t...

Autores: Hooli, Shubhada; King, Carina; McCollum, Eric D.; Colbourn, Tim; Lufesi, Norman; Mwansambo, Charles; Gregory, Christopher J.; Thamthitiwat, Somsak; Cutland, Clare; Madhi, Shabir Ahmed; Nunes, Marta C.; Gessner, Bradford D.; Hazir, Tabish; Mathew, Joseph L.; Addo Yobo, Emmanuel; Chisaka, Noel; Hassan, Mumtaz; Hibberd, Patricia L.; Jeena, Prakash; Lozano, Juan M.; MacLeod, William B.; Patel, Archana; Thea, Donald M.; Nguyen, Ngoc Tuong Vy; Zaman, Syed M.A.; Ruvinsky, Raul O.; Lucero, Marilla; Turner, Claudia; Asghar, Rai; Banajeh, Salem; Iqbal, Imran; Maulen Radovan, Irene; Mino Leon, Greta; Saha, Samir K.; Santosham, Mathuram; Singhi, Sunit; Singhi, Sunit; Awasthi, Shally; Bavdekar, Ashish; Chou, Monidarin; Nymadawa, Pagbajabyn; Pape, Jean William; Paranhos Baccala, Glaucia; Picot, Valentina Sanchez; Rakoto Andrianarivelo, Mala; Rouzier, Vanessa; Russomando, Graciela; Sylla, Mariam; Vanhems, Philippe; Wang, Jianwei; Basnet, Sudha; Strand, Tor A.; Neuman, Mark I.; Arroyo, Luis Martinez; Echavarría, Marcela Silvia; Bhatnagar, Shinjini; Wadhwa, Nitya; Lodha, Rakesh; Aneja, Satinder; Gentile, Angela; Chadha, Mandeep; Hirve, Siddhivinayak; O'Grady, Kerry Ann F.; Clara, Alexey W.; Rees, Chris A.; Campbell, Harry; Nair, Harish; Falconer, Jennifer; Williams, Linda J.; Horne, Margaret; Qazi, Shamim A.; Nisar, Yasir Bin
Año de publicación: 2023
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratificationand chest-indrawing pneumonia in-hospital mortality risk factors.Methods: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendationsdataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identifymortality risk factors.Results: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumoniacase fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%,95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawingpneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94,95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32).Conclusion: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalizedwith chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutri-tion were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry shouldbe integrated in pneumonia hospital care for children under 5 years.
Fil: Hooli, Shubhada. Baylor University; Estados Unidos
Fil: King, Carina. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: McCollum, Eric D.. Johns Hopkins University School of Medicine; Estados Unidos
Fil: Colbourn, Tim. University College London; Estados Unidos
Fil: Lufesi, Norman. No especifíca;
Fil: Mwansambo, Charles. No especifíca;
Fil: Gregory, Christopher J.. No especifíca;
Fil: Thamthitiwat, Somsak. No especifíca;
Fil: Cutland, Clare. No especifíca;
Fil: Madhi, Shabir Ahmed. No especifíca;
Fil: Nunes, Marta C.. No especifíca;
Fil: Gessner, Bradford D.. No especifíca;
Fil: Hazir, Tabish. No especifíca;
Fil: Mathew, Joseph L.. No especifíca;
Fil: Addo Yobo, Emmanuel. Kwame Nkrumah University of Science & Technology; Ghana
Fil: Chisaka, Noel. No especifíca;
Fil: Hassan, Mumtaz. No especifíca;
Fil: Hibberd, Patricia L.. No especifíca;
Fil: Jeena, Prakash. University of KwaZulu-Natal; Sudáfrica
Fil: Lozano, Juan M.. University of Florida; Estados Unidos
Fil: MacLeod, William B.. University of the Witwatersrand; Sudáfrica
Fil: Patel, Archana. No especifíca;
Fil: Thea, Donald M.. No especifíca;
Fil: Nguyen, Ngoc Tuong Vy. No especifíca;
Fil: Zaman, Syed M.A.. No especifíca;
Fil: Ruvinsky, Raul O.. No especifíca;
Fil: Lucero, Marilla. No especifíca;
Fil: Turner, Claudia. No especifíca;
Fil: Asghar, Rai. No especifíca;
Fil: Banajeh, Salem. No especifíca;
Fil: Iqbal, Imran. No especifíca;
Fil: Maulen Radovan, Irene. No especifíca;
Fil: Mino Leon, Greta. No especifíca;
Fil: Saha, Samir K.. No especifíca;
Fil: Santosham, Mathuram. No especifíca;
Fil: Singhi, Sunit. No especifíca;
Fil: Singhi, Sunit. No especifíca;
Fil: Awasthi, Shally. No especifíca;
Fil: Bavdekar, Ashish. No especifíca;
Fil: Chou, Monidarin. No especifíca;
Fil: Nymadawa, Pagbajabyn. Mongolian Academy of Sciences; Mongolia
Fil: Pape, Jean William. No especifíca;
Fil: Paranhos Baccala, Glaucia. No especifíca;
Fil: Picot, Valentina Sanchez. No especifíca;
Fil: Rakoto Andrianarivelo, Mala. Université d'Antananarivo; Madagascar
Fil: Rouzier, Vanessa. Weill Cornell Medicine; Estados Unidos
Fil: Russomando, Graciela. Universidad Nacional de Asunción; Paraguay
Fil: Sylla, Mariam. Centre Hospitalier Universitaire Gabriel Touré; Malí
Fil: Vanhems, Philippe. No especifíca;
Fil: Wang, Jianwei. Chinese Academy of Sciences; República de China
Fil: Basnet, Sudha. No especifíca;
Fil: Strand, Tor A.. Innlandet Hospital Trust; Noruega
Fil: Neuman, Mark I.. Harvard Medical School; Estados Unidos
Fil: Arroyo, Luis Martinez. No especifíca;
Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Bhatnagar, Shinjini. No especifíca;
Fil: Wadhwa, Nitya. No especifíca;
Fil: Lodha, Rakesh. No especifíca;
Fil: Aneja, Satinder. No especifíca;
Fil: Gentile, Angela. No especifíca;
Fil: Chadha, Mandeep. No especifíca;
Fil: Hirve, Siddhivinayak. No especifíca;
Fil: O'Grady, Kerry Ann F.. No especifíca;
Fil: Clara, Alexey W.. No especifíca;
Fil: Rees, Chris A.. No especifíca;
Fil: Campbell, Harry. No especifíca;
Fil: Nair, Harish. No especifíca;
Fil: Falconer, Jennifer. No especifíca;
Fil: Williams, Linda J.. No especifíca;
Fil: Horne, Margaret. No especifíca;
Fil: Qazi, Shamim A.. No especifíca;
Fil: Nisar, Yasir Bin. No especifíca;
Materia: PNEUMONIA
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/283742

Acceder

id	CONICETDig_02bc1b1f18ed32a046267135c9782de8
oai_identifier_str	oai:ri.conicet.gov.ar:11336/283742
network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) datasetHooli, ShubhadaKing, CarinaMcCollum, Eric D.Colbourn, TimLufesi, NormanMwansambo, CharlesGregory, Christopher J.Thamthitiwat, SomsakCutland, ClareMadhi, Shabir AhmedNunes, Marta C.Gessner, Bradford D.Hazir, TabishMathew, Joseph L.Addo Yobo, EmmanuelChisaka, NoelHassan, MumtazHibberd, Patricia L.Jeena, PrakashLozano, Juan M.MacLeod, William B.Patel, ArchanaThea, Donald M.Nguyen, Ngoc Tuong VyZaman, Syed M.A.Ruvinsky, Raul O.Lucero, MarillaTurner, ClaudiaAsghar, RaiBanajeh, SalemIqbal, ImranMaulen Radovan, IreneMino Leon, GretaSaha, Samir K.Santosham, MathuramSinghi, SunitSinghi, SunitAwasthi, ShallyBavdekar, AshishChou, MonidarinNymadawa, PagbajabynPape, Jean WilliamParanhos Baccala, GlauciaPicot, Valentina SanchezRakoto Andrianarivelo, MalaRouzier, VanessaRussomando, GracielaSylla, MariamVanhems, PhilippeWang, JianweiBasnet, SudhaStrand, Tor A.Neuman, Mark I.Arroyo, Luis MartinezEchavarría, Marcela SilviaBhatnagar, ShinjiniWadhwa, NityaLodha, RakeshAneja, SatinderGentile, AngelaChadha, MandeepHirve, SiddhivinayakO'Grady, Kerry Ann F.Clara, Alexey W.Rees, Chris A.Campbell, HarryNair, HarishFalconer, JenniferWilliams, Linda J.Horne, MargaretQazi, Shamim A.Nisar, Yasir BinPNEUMONIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratificationand chest-indrawing pneumonia in-hospital mortality risk factors.Methods: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendationsdataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identifymortality risk factors.Results: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumoniacase fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%,95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawingpneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94,95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32).Conclusion: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalizedwith chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutri-tion were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry shouldbe integrated in pneumonia hospital care for children under 5 years.Fil: Hooli, Shubhada. Baylor University; Estados UnidosFil: King, Carina. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: McCollum, Eric D.. Johns Hopkins University School of Medicine; Estados UnidosFil: Colbourn, Tim. University College London; Estados UnidosFil: Lufesi, Norman. No especifíca;Fil: Mwansambo, Charles. No especifíca;Fil: Gregory, Christopher J.. No especifíca;Fil: Thamthitiwat, Somsak. No especifíca;Fil: Cutland, Clare. No especifíca;Fil: Madhi, Shabir Ahmed. No especifíca;Fil: Nunes, Marta C.. No especifíca;Fil: Gessner, Bradford D.. No especifíca;Fil: Hazir, Tabish. No especifíca;Fil: Mathew, Joseph L.. No especifíca;Fil: Addo Yobo, Emmanuel. Kwame Nkrumah University of Science & Technology; GhanaFil: Chisaka, Noel. No especifíca;Fil: Hassan, Mumtaz. No especifíca;Fil: Hibberd, Patricia L.. No especifíca;Fil: Jeena, Prakash. University of KwaZulu-Natal; SudáfricaFil: Lozano, Juan M.. University of Florida; Estados UnidosFil: MacLeod, William B.. University of the Witwatersrand; SudáfricaFil: Patel, Archana. No especifíca;Fil: Thea, Donald M.. No especifíca;Fil: Nguyen, Ngoc Tuong Vy. No especifíca;Fil: Zaman, Syed M.A.. No especifíca;Fil: Ruvinsky, Raul O.. No especifíca;Fil: Lucero, Marilla. No especifíca;Fil: Turner, Claudia. No especifíca;Fil: Asghar, Rai. No especifíca;Fil: Banajeh, Salem. No especifíca;Fil: Iqbal, Imran. No especifíca;Fil: Maulen Radovan, Irene. No especifíca;Fil: Mino Leon, Greta. No especifíca;Fil: Saha, Samir K.. No especifíca;Fil: Santosham, Mathuram. No especifíca;Fil: Singhi, Sunit. No especifíca;Fil: Singhi, Sunit. No especifíca;Fil: Awasthi, Shally. No especifíca;Fil: Bavdekar, Ashish. No especifíca;Fil: Chou, Monidarin. No especifíca;Fil: Nymadawa, Pagbajabyn. Mongolian Academy of Sciences; MongoliaFil: Pape, Jean William. No especifíca;Fil: Paranhos Baccala, Glaucia. No especifíca;Fil: Picot, Valentina Sanchez. No especifíca;Fil: Rakoto Andrianarivelo, Mala. Université d'Antananarivo; MadagascarFil: Rouzier, Vanessa. Weill Cornell Medicine; Estados UnidosFil: Russomando, Graciela. Universidad Nacional de Asunción; ParaguayFil: Sylla, Mariam. Centre Hospitalier Universitaire Gabriel Touré; MalíFil: Vanhems, Philippe. No especifíca;Fil: Wang, Jianwei. Chinese Academy of Sciences; República de ChinaFil: Basnet, Sudha. No especifíca;Fil: Strand, Tor A.. Innlandet Hospital Trust; NoruegaFil: Neuman, Mark I.. Harvard Medical School; Estados UnidosFil: Arroyo, Luis Martinez. No especifíca;Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Bhatnagar, Shinjini. No especifíca;Fil: Wadhwa, Nitya. No especifíca;Fil: Lodha, Rakesh. No especifíca;Fil: Aneja, Satinder. No especifíca;Fil: Gentile, Angela. No especifíca;Fil: Chadha, Mandeep. No especifíca;Fil: Hirve, Siddhivinayak. No especifíca;Fil: O'Grady, Kerry Ann F.. No especifíca;Fil: Clara, Alexey W.. No especifíca;Fil: Rees, Chris A.. No especifíca;Fil: Campbell, Harry. No especifíca;Fil: Nair, Harish. No especifíca;Fil: Falconer, Jennifer. No especifíca;Fil: Williams, Linda J.. No especifíca;Fil: Horne, Margaret. No especifíca;Fil: Qazi, Shamim A.. No especifíca;Fil: Nisar, Yasir Bin. No especifíca;Elsevier2023-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/283742Hooli, Shubhada; King, Carina; McCollum, Eric D.; Colbourn, Tim; Lufesi, Norman; et al.; In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset; Elsevier; International Journal of Infectious Diseases; 129; 2-2023; 240-2501878-35111201-9712CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(23)00050-4info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2023.02.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:35:11Zoai:ri.conicet.gov.ar:11336/283742instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:35:11.746CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
title	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
spellingShingle	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset Hooli, Shubhada PNEUMONIA
title_short	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
title_full	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
title_fullStr	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
title_full_unstemmed	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
title_sort	In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset
dc.creator.none.fl_str_mv	Hooli, Shubhada King, Carina McCollum, Eric D. Colbourn, Tim Lufesi, Norman Mwansambo, Charles Gregory, Christopher J. Thamthitiwat, Somsak Cutland, Clare Madhi, Shabir Ahmed Nunes, Marta C. Gessner, Bradford D. Hazir, Tabish Mathew, Joseph L. Addo Yobo, Emmanuel Chisaka, Noel Hassan, Mumtaz Hibberd, Patricia L. Jeena, Prakash Lozano, Juan M. MacLeod, William B. Patel, Archana Thea, Donald M. Nguyen, Ngoc Tuong Vy Zaman, Syed M.A. Ruvinsky, Raul O. Lucero, Marilla Turner, Claudia Asghar, Rai Banajeh, Salem Iqbal, Imran Maulen Radovan, Irene Mino Leon, Greta Saha, Samir K. Santosham, Mathuram Singhi, Sunit Singhi, Sunit Awasthi, Shally Bavdekar, Ashish Chou, Monidarin Nymadawa, Pagbajabyn Pape, Jean William Paranhos Baccala, Glaucia Picot, Valentina Sanchez Rakoto Andrianarivelo, Mala Rouzier, Vanessa Russomando, Graciela Sylla, Mariam Vanhems, Philippe Wang, Jianwei Basnet, Sudha Strand, Tor A. Neuman, Mark I. Arroyo, Luis Martinez Echavarría, Marcela Silvia Bhatnagar, Shinjini Wadhwa, Nitya Lodha, Rakesh Aneja, Satinder Gentile, Angela Chadha, Mandeep Hirve, Siddhivinayak O'Grady, Kerry Ann F. Clara, Alexey W. Rees, Chris A. Campbell, Harry Nair, Harish Falconer, Jennifer Williams, Linda J. Horne, Margaret Qazi, Shamim A. Nisar, Yasir Bin
author	Hooli, Shubhada
author_facet	Hooli, Shubhada King, Carina McCollum, Eric D. Colbourn, Tim Lufesi, Norman Mwansambo, Charles Gregory, Christopher J. Thamthitiwat, Somsak Cutland, Clare Madhi, Shabir Ahmed Nunes, Marta C. Gessner, Bradford D. Hazir, Tabish Mathew, Joseph L. Addo Yobo, Emmanuel Chisaka, Noel Hassan, Mumtaz Hibberd, Patricia L. Jeena, Prakash Lozano, Juan M. MacLeod, William B. Patel, Archana Thea, Donald M. Nguyen, Ngoc Tuong Vy Zaman, Syed M.A. Ruvinsky, Raul O. Lucero, Marilla Turner, Claudia Asghar, Rai Banajeh, Salem Iqbal, Imran Maulen Radovan, Irene Mino Leon, Greta Saha, Samir K. Santosham, Mathuram Singhi, Sunit Awasthi, Shally Bavdekar, Ashish Chou, Monidarin Nymadawa, Pagbajabyn Pape, Jean William Paranhos Baccala, Glaucia Picot, Valentina Sanchez Rakoto Andrianarivelo, Mala Rouzier, Vanessa Russomando, Graciela Sylla, Mariam Vanhems, Philippe Wang, Jianwei Basnet, Sudha Strand, Tor A. Neuman, Mark I. Arroyo, Luis Martinez Echavarría, Marcela Silvia Bhatnagar, Shinjini Wadhwa, Nitya Lodha, Rakesh Aneja, Satinder Gentile, Angela Chadha, Mandeep Hirve, Siddhivinayak O'Grady, Kerry Ann F. Clara, Alexey W. Rees, Chris A. Campbell, Harry Nair, Harish Falconer, Jennifer Williams, Linda J. Horne, Margaret Qazi, Shamim A. Nisar, Yasir Bin
author_role	author
author2	King, Carina McCollum, Eric D. Colbourn, Tim Lufesi, Norman Mwansambo, Charles Gregory, Christopher J. Thamthitiwat, Somsak Cutland, Clare Madhi, Shabir Ahmed Nunes, Marta C. Gessner, Bradford D. Hazir, Tabish Mathew, Joseph L. Addo Yobo, Emmanuel Chisaka, Noel Hassan, Mumtaz Hibberd, Patricia L. Jeena, Prakash Lozano, Juan M. MacLeod, William B. Patel, Archana Thea, Donald M. Nguyen, Ngoc Tuong Vy Zaman, Syed M.A. Ruvinsky, Raul O. Lucero, Marilla Turner, Claudia Asghar, Rai Banajeh, Salem Iqbal, Imran Maulen Radovan, Irene Mino Leon, Greta Saha, Samir K. Santosham, Mathuram Singhi, Sunit Awasthi, Shally Bavdekar, Ashish Chou, Monidarin Nymadawa, Pagbajabyn Pape, Jean William Paranhos Baccala, Glaucia Picot, Valentina Sanchez Rakoto Andrianarivelo, Mala Rouzier, Vanessa Russomando, Graciela Sylla, Mariam Vanhems, Philippe Wang, Jianwei Basnet, Sudha Strand, Tor A. Neuman, Mark I. Arroyo, Luis Martinez Echavarría, Marcela Silvia Bhatnagar, Shinjini Wadhwa, Nitya Lodha, Rakesh Aneja, Satinder Gentile, Angela Chadha, Mandeep Hirve, Siddhivinayak O'Grady, Kerry Ann F. Clara, Alexey W. Rees, Chris A. Campbell, Harry Nair, Harish Falconer, Jennifer Williams, Linda J. Horne, Margaret Qazi, Shamim A. Nisar, Yasir Bin
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	PNEUMONIA
topic	PNEUMONIA
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratificationand chest-indrawing pneumonia in-hospital mortality risk factors.Methods: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendationsdataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identifymortality risk factors.Results: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumoniacase fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%,95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawingpneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94,95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32).Conclusion: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalizedwith chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutri-tion were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry shouldbe integrated in pneumonia hospital care for children under 5 years. Fil: Hooli, Shubhada. Baylor University; Estados Unidos Fil: King, Carina. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: McCollum, Eric D.. Johns Hopkins University School of Medicine; Estados Unidos Fil: Colbourn, Tim. University College London; Estados Unidos Fil: Lufesi, Norman. No especifíca; Fil: Mwansambo, Charles. No especifíca; Fil: Gregory, Christopher J.. No especifíca; Fil: Thamthitiwat, Somsak. No especifíca; Fil: Cutland, Clare. No especifíca; Fil: Madhi, Shabir Ahmed. No especifíca; Fil: Nunes, Marta C.. No especifíca; Fil: Gessner, Bradford D.. No especifíca; Fil: Hazir, Tabish. No especifíca; Fil: Mathew, Joseph L.. No especifíca; Fil: Addo Yobo, Emmanuel. Kwame Nkrumah University of Science & Technology; Ghana Fil: Chisaka, Noel. No especifíca; Fil: Hassan, Mumtaz. No especifíca; Fil: Hibberd, Patricia L.. No especifíca; Fil: Jeena, Prakash. University of KwaZulu-Natal; Sudáfrica Fil: Lozano, Juan M.. University of Florida; Estados Unidos Fil: MacLeod, William B.. University of the Witwatersrand; Sudáfrica Fil: Patel, Archana. No especifíca; Fil: Thea, Donald M.. No especifíca; Fil: Nguyen, Ngoc Tuong Vy. No especifíca; Fil: Zaman, Syed M.A.. No especifíca; Fil: Ruvinsky, Raul O.. No especifíca; Fil: Lucero, Marilla. No especifíca; Fil: Turner, Claudia. No especifíca; Fil: Asghar, Rai. No especifíca; Fil: Banajeh, Salem. No especifíca; Fil: Iqbal, Imran. No especifíca; Fil: Maulen Radovan, Irene. No especifíca; Fil: Mino Leon, Greta. No especifíca; Fil: Saha, Samir K.. No especifíca; Fil: Santosham, Mathuram. No especifíca; Fil: Singhi, Sunit. No especifíca; Fil: Singhi, Sunit. No especifíca; Fil: Awasthi, Shally. No especifíca; Fil: Bavdekar, Ashish. No especifíca; Fil: Chou, Monidarin. No especifíca; Fil: Nymadawa, Pagbajabyn. Mongolian Academy of Sciences; Mongolia Fil: Pape, Jean William. No especifíca; Fil: Paranhos Baccala, Glaucia. No especifíca; Fil: Picot, Valentina Sanchez. No especifíca; Fil: Rakoto Andrianarivelo, Mala. Université d'Antananarivo; Madagascar Fil: Rouzier, Vanessa. Weill Cornell Medicine; Estados Unidos Fil: Russomando, Graciela. Universidad Nacional de Asunción; Paraguay Fil: Sylla, Mariam. Centre Hospitalier Universitaire Gabriel Touré; Malí Fil: Vanhems, Philippe. No especifíca; Fil: Wang, Jianwei. Chinese Academy of Sciences; República de China Fil: Basnet, Sudha. No especifíca; Fil: Strand, Tor A.. Innlandet Hospital Trust; Noruega Fil: Neuman, Mark I.. Harvard Medical School; Estados Unidos Fil: Arroyo, Luis Martinez. No especifíca; Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: Bhatnagar, Shinjini. No especifíca; Fil: Wadhwa, Nitya. No especifíca; Fil: Lodha, Rakesh. No especifíca; Fil: Aneja, Satinder. No especifíca; Fil: Gentile, Angela. No especifíca; Fil: Chadha, Mandeep. No especifíca; Fil: Hirve, Siddhivinayak. No especifíca; Fil: O'Grady, Kerry Ann F.. No especifíca; Fil: Clara, Alexey W.. No especifíca; Fil: Rees, Chris A.. No especifíca; Fil: Campbell, Harry. No especifíca; Fil: Nair, Harish. No especifíca; Fil: Falconer, Jennifer. No especifíca; Fil: Williams, Linda J.. No especifíca; Fil: Horne, Margaret. No especifíca; Fil: Qazi, Shamim A.. No especifíca; Fil: Nisar, Yasir Bin. No especifíca;
description	Objectives: We determined the pulse oximetry benefit in pediatric pneumonia mortality risk stratificationand chest-indrawing pneumonia in-hospital mortality risk factors.Methods: We report the characteristics and in-hospital pneumonia-related mortality of children aged 2-59 months who were included in the Pneumonia Research Partnership to Assess WHO Recommendationsdataset. We developed multivariable logistic regression models of chest-indrawing pneumonia to identifymortality risk factors.Results: Among 285,839 children, 164,244 (57.5%) from hospital-based studies were included. Pneumoniacase fatality risk (CFR) without pulse oximetry measurement was higher than with measurement (5.8%,95% confidence interval [CI] 5.6-5.9% vs 2.1%, 95% CI 1.9-2.4%). One in five children with chest-indrawingpneumonia was hypoxemic (19.7%, 95% CI 19.0-20.4%), and the hypoxemic CFR was 10.3% (95% CI 9.1-11.5%). Other mortality risk factors were younger age (either 2-5 months [adjusted odds ratio (aOR) 9.94,95% CI 6.67-14.84] or 6-11 months [aOR 2.67, 95% CI 1.71-4.16]), moderate malnutrition (aOR 2.41, 95% CI1.87-3.09), and female sex (aOR 1.82, 95% CI 1.43-2.32).Conclusion: Children with a pulse oximetry measurement had a lower CFR. Many children hospitalizedwith chest-indrawing pneumonia were hypoxemic and one in 10 died. Young age and moderate malnutri-tion were risk factors for in-hospital chest-indrawing pneumonia-related mortality. Pulse oximetry shouldbe integrated in pneumonia hospital care for children under 5 years.
publishDate	2023
dc.date.none.fl_str_mv	2023-02
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/283742 Hooli, Shubhada; King, Carina; McCollum, Eric D.; Colbourn, Tim; Lufesi, Norman; et al.; In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset; Elsevier; International Journal of Infectious Diseases; 129; 2-2023; 240-250 1878-3511 1201-9712 CONICET Digital CONICET
url	http://hdl.handle.net/11336/283742
identifier_str_mv	Hooli, Shubhada; King, Carina; McCollum, Eric D.; Colbourn, Tim; Lufesi, Norman; et al.; In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) dataset; Elsevier; International Journal of Infectious Diseases; 129; 2-2023; 240-250 1878-3511 1201-9712 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(23)00050-4 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2023.02.005
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_	1874774240270483456
score	13.265058

In-hospital mortality risk stratification in children aged under 5 years with pneumonia with or without pulse oximetry: A secondary analysis of the Pneumonia REsearch Partnership t...

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