The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity

Autores
Ingaramo, Paola Inés; Zenclussen, Maria Laura
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Exposure to poly- and perfluoroalkyl substances (PFASs) has been a cause for concern for decades due to evidence linking exposure to these substances with adverse health effects. Its widespread use in industrial and consumer products combined with their persistence in the environment poses a toxicological and regulatory challenge. Due to its ubiquity, resistance to degradation, and accumulation in biological systems, humans are exposed to a mixture of multiple PFASs, which complicates the analysis of exposure effects. As PFASs pose a risk to human health, it is crucial to study their impact during vulnerable periods, such as pregnancy. In this regard, understanding the impact of PFASs on the placenta is essential, as they can affect both pregnancy and the well-being of the developing fetus. This article reviews the current evidence linking PFAS exposure with altered placental function, focusing on the affected molecular pathways. Furthermore, we examine current methodologies for analyzing the effects of exposure to complex mixtures and explore how these approaches could be employed to evaluate the potential impact of such mixtures on placental function in the context of real-life exposure to these chemicals.
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
Fil: Zenclussen, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
Materia
PFAS
PLACENTA
OXIDATIVE STRESS
NAMs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/286643
Acceder
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spelling The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of ToxicityIngaramo, Paola InésZenclussen, Maria LauraPFASPLACENTAOXIDATIVE STRESSNAMshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Exposure to poly- and perfluoroalkyl substances (PFASs) has been a cause for concern for decades due to evidence linking exposure to these substances with adverse health effects. Its widespread use in industrial and consumer products combined with their persistence in the environment poses a toxicological and regulatory challenge. Due to its ubiquity, resistance to degradation, and accumulation in biological systems, humans are exposed to a mixture of multiple PFASs, which complicates the analysis of exposure effects. As PFASs pose a risk to human health, it is crucial to study their impact during vulnerable periods, such as pregnancy. In this regard, understanding the impact of PFASs on the placenta is essential, as they can affect both pregnancy and the well-being of the developing fetus. This article reviews the current evidence linking PFAS exposure with altered placental function, focusing on the affected molecular pathways. Furthermore, we examine current methodologies for analyzing the effects of exposure to complex mixtures and explore how these approaches could be employed to evaluate the potential impact of such mixtures on placental function in the context of real-life exposure to these chemicals.Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Fisiología Humana; ArgentinaFil: Zenclussen, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; ArgentinaMolecular Diversity Preservation International2026-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/286643Ingaramo, Paola Inés; Zenclussen, Maria Laura; The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 27; 4; 2-2026; 1-171422-0067CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/27/4/2036info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms27042036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:30:33Zoai:ri.conicet.gov.ar:11336/286643instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:30:33.9CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
title The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
spellingShingle The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
Ingaramo, Paola Inés
PFAS
PLACENTA
OXIDATIVE STRESS
NAMs
title_short The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
title_full The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
title_fullStr The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
title_full_unstemmed The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
title_sort The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity
dc.creator.none.fl_str_mv Ingaramo, Paola Inés
Zenclussen, Maria Laura
author Ingaramo, Paola Inés
author_facet Ingaramo, Paola Inés
Zenclussen, Maria Laura
author_role author
author2 Zenclussen, Maria Laura
author2_role author
dc.subject.none.fl_str_mv PFAS
PLACENTA
OXIDATIVE STRESS
NAMs
topic PFAS
PLACENTA
OXIDATIVE STRESS
NAMs
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Exposure to poly- and perfluoroalkyl substances (PFASs) has been a cause for concern for decades due to evidence linking exposure to these substances with adverse health effects. Its widespread use in industrial and consumer products combined with their persistence in the environment poses a toxicological and regulatory challenge. Due to its ubiquity, resistance to degradation, and accumulation in biological systems, humans are exposed to a mixture of multiple PFASs, which complicates the analysis of exposure effects. As PFASs pose a risk to human health, it is crucial to study their impact during vulnerable periods, such as pregnancy. In this regard, understanding the impact of PFASs on the placenta is essential, as they can affect both pregnancy and the well-being of the developing fetus. This article reviews the current evidence linking PFAS exposure with altered placental function, focusing on the affected molecular pathways. Furthermore, we examine current methodologies for analyzing the effects of exposure to complex mixtures and explore how these approaches could be employed to evaluate the potential impact of such mixtures on placental function in the context of real-life exposure to these chemicals.
Fil: Ingaramo, Paola Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Fisiología Humana; Argentina
Fil: Zenclussen, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina
description Exposure to poly- and perfluoroalkyl substances (PFASs) has been a cause for concern for decades due to evidence linking exposure to these substances with adverse health effects. Its widespread use in industrial and consumer products combined with their persistence in the environment poses a toxicological and regulatory challenge. Due to its ubiquity, resistance to degradation, and accumulation in biological systems, humans are exposed to a mixture of multiple PFASs, which complicates the analysis of exposure effects. As PFASs pose a risk to human health, it is crucial to study their impact during vulnerable periods, such as pregnancy. In this regard, understanding the impact of PFASs on the placenta is essential, as they can affect both pregnancy and the well-being of the developing fetus. This article reviews the current evidence linking PFAS exposure with altered placental function, focusing on the affected molecular pathways. Furthermore, we examine current methodologies for analyzing the effects of exposure to complex mixtures and explore how these approaches could be employed to evaluate the potential impact of such mixtures on placental function in the context of real-life exposure to these chemicals.
publishDate 2026
dc.date.none.fl_str_mv 2026-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/286643
Ingaramo, Paola Inés; Zenclussen, Maria Laura; The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 27; 4; 2-2026; 1-17
1422-0067
CONICET Digital
CONICET
url http://hdl.handle.net/11336/286643
identifier_str_mv Ingaramo, Paola Inés; Zenclussen, Maria Laura; The Placenta as a Target Organ for Poly- and Perfluoroalkyl Substances (PFASs): Molecular Mechanisms of Toxicity; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 27; 4; 2-2026; 1-17
1422-0067
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/27/4/2036
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms27042036
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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