NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans

Autores
Espino, Magdalena Belén; Solari, Victor Manuel; Fernández, María de Los Ángeles; Boiteux, Joana Jaqueline; Gomez, Maria Roxana Anabel; Silva, María Fernanda
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Candida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract and vagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern over the emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. In the present work, novel bioextracts from folk medicinal plants were directly used as active ingredient in a topical formulation for dermal candidiasis. With the aim to replace hazardous traditional reagents, a natural solvent composed by lactic acid: glucose: water (LGH) was used as vehicle for bioactive compound extraction. Furthermore, phenolic and alkaloid composition were determined by HPLC and their individual antifungal effect was evaluated. LGH extracts of Larrea spices demonstrate a significant antimicrobial activity against C. albicans being higher than their individual bioactive constituents. Notably, the mixture of Larrea cuneifolia and L divaricata extracts in topical formulations reveal a synergistic antifungal effect highlighting their potential for candidiasis treatment.
Fil: Espino, Magdalena Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Solari, Victor Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández, María de Los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Boiteux, Joana Jaqueline. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Gomez, Maria Roxana Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Silva, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Materia
ALKALOIDS
CANDIDA ALBICANS
MEDICINAL PLANTS
NADES
PHARMACEUTICAL FORMULATIONS
PHENOLIC COMPOUNDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/104378
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/104378
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling NADES-mediated folk plant extracts as novel antifungal agents against Candida albicansEspino, Magdalena BelénSolari, Victor ManuelFernández, María de Los ÁngelesBoiteux, Joana JaquelineGomez, Maria Roxana AnabelSilva, María FernandaALKALOIDSCANDIDA ALBICANSMEDICINAL PLANTSNADESPHARMACEUTICAL FORMULATIONSPHENOLIC COMPOUNDShttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Candida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract and vagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern over the emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. In the present work, novel bioextracts from folk medicinal plants were directly used as active ingredient in a topical formulation for dermal candidiasis. With the aim to replace hazardous traditional reagents, a natural solvent composed by lactic acid: glucose: water (LGH) was used as vehicle for bioactive compound extraction. Furthermore, phenolic and alkaloid composition were determined by HPLC and their individual antifungal effect was evaluated. LGH extracts of Larrea spices demonstrate a significant antimicrobial activity against C. albicans being higher than their individual bioactive constituents. Notably, the mixture of Larrea cuneifolia and L divaricata extracts in topical formulations reveal a synergistic antifungal effect highlighting their potential for candidiasis treatment.Fil: Espino, Magdalena Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Solari, Victor Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernández, María de Los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Boiteux, Joana Jaqueline. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaFil: Gomez, Maria Roxana Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Silva, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; ArgentinaElsevier Science2019-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/104378Espino, Magdalena Belén; Solari, Victor Manuel; Fernández, María de Los Ángeles; Boiteux, Joana Jaqueline; Gomez, Maria Roxana Anabel; et al.; NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 167; 4-2019; 15-200731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2019.01.026info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0731708518322957info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:12:00Zoai:ri.conicet.gov.ar:11336/104378instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:12:00.367CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
title NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
spellingShingle NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
Espino, Magdalena Belén
ALKALOIDS
CANDIDA ALBICANS
MEDICINAL PLANTS
NADES
PHARMACEUTICAL FORMULATIONS
PHENOLIC COMPOUNDS
title_short NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
title_full NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
title_fullStr NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
title_full_unstemmed NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
title_sort NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans
dc.creator.none.fl_str_mv Espino, Magdalena Belén
Solari, Victor Manuel
Fernández, María de Los Ángeles
Boiteux, Joana Jaqueline
Gomez, Maria Roxana Anabel
Silva, María Fernanda
author Espino, Magdalena Belén
author_facet Espino, Magdalena Belén
Solari, Victor Manuel
Fernández, María de Los Ángeles
Boiteux, Joana Jaqueline
Gomez, Maria Roxana Anabel
Silva, María Fernanda
author_role author
author2 Solari, Victor Manuel
Fernández, María de Los Ángeles
Boiteux, Joana Jaqueline
Gomez, Maria Roxana Anabel
Silva, María Fernanda
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ALKALOIDS
CANDIDA ALBICANS
MEDICINAL PLANTS
NADES
PHARMACEUTICAL FORMULATIONS
PHENOLIC COMPOUNDS
topic ALKALOIDS
CANDIDA ALBICANS
MEDICINAL PLANTS
NADES
PHARMACEUTICAL FORMULATIONS
PHENOLIC COMPOUNDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Candida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract and vagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern over the emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. In the present work, novel bioextracts from folk medicinal plants were directly used as active ingredient in a topical formulation for dermal candidiasis. With the aim to replace hazardous traditional reagents, a natural solvent composed by lactic acid: glucose: water (LGH) was used as vehicle for bioactive compound extraction. Furthermore, phenolic and alkaloid composition were determined by HPLC and their individual antifungal effect was evaluated. LGH extracts of Larrea spices demonstrate a significant antimicrobial activity against C. albicans being higher than their individual bioactive constituents. Notably, the mixture of Larrea cuneifolia and L divaricata extracts in topical formulations reveal a synergistic antifungal effect highlighting their potential for candidiasis treatment.
Fil: Espino, Magdalena Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Solari, Victor Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández, María de Los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Boiteux, Joana Jaqueline. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
Fil: Gomez, Maria Roxana Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Silva, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
description Candida albicans is an opportunistic pathogenic yeast commonly found in mouth, gastrointestinal tract and vagina. Under certain conditions, it causes skin, mucosal and systemic infections. With growing concern over the emergence of resistant strains to conventional antifungals, the development of novel antifungal agents for the management of this pathogen is an urgent need. In the present work, novel bioextracts from folk medicinal plants were directly used as active ingredient in a topical formulation for dermal candidiasis. With the aim to replace hazardous traditional reagents, a natural solvent composed by lactic acid: glucose: water (LGH) was used as vehicle for bioactive compound extraction. Furthermore, phenolic and alkaloid composition were determined by HPLC and their individual antifungal effect was evaluated. LGH extracts of Larrea spices demonstrate a significant antimicrobial activity against C. albicans being higher than their individual bioactive constituents. Notably, the mixture of Larrea cuneifolia and L divaricata extracts in topical formulations reveal a synergistic antifungal effect highlighting their potential for candidiasis treatment.
publishDate 2019
dc.date.none.fl_str_mv 2019-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/104378
Espino, Magdalena Belén; Solari, Victor Manuel; Fernández, María de Los Ángeles; Boiteux, Joana Jaqueline; Gomez, Maria Roxana Anabel; et al.; NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 167; 4-2019; 15-20
0731-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/104378
identifier_str_mv Espino, Magdalena Belén; Solari, Victor Manuel; Fernández, María de Los Ángeles; Boiteux, Joana Jaqueline; Gomez, Maria Roxana Anabel; et al.; NADES-mediated folk plant extracts as novel antifungal agents against Candida albicans; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 167; 4-2019; 15-20
0731-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jpba.2019.01.026
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0731708518322957
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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