Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds

Autores
Fernández Peña, Laura; Larguier, Emilie; d’Aligny, Solange; Toledo-Sánchez, Alejandro; Porawski González, Paula; Lucia, Alejandro; Amara, Chaïma; Ortega, Francisco; Rubio, Ramón G.; Guzmán, Eduardo
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The encapsulation of hydrophobic bioactive molecules, such as essential oil compounds (EOCs), in aqueous nanodispersions is critical for enhancing their solubility, stability, and applicability across diverse industries. This study examines the formulation of oleic acid nanodroplets stabilized by a biobased alkylpolyglucoside (APG), without the need for auxiliary cosurfactants. In this system, oleic acid simultaneously provides the oil core and contributes to interfacial charging, enabling the nanodroplets to act as efficient carriers for thymol and carvacrol. In contrast to conventional formulations requiring cosurfactants, this work presents a simplified and greener approach. A pseudoternary phase diagram defined the regions of stable dispersion formation, confirming the feasibility of a one-surfactant-only system. Dynamic light scattering confirmed a monomodal size distribution (10–15 nm), whereas fluorescence spectroscopy revealed up to three distinct chemical environments for the EOCs within the droplets. Crucially, the system’s stability is governed by the pH-dependent dissociation of oleic acid at the interface, as elucidated by conductivity and pH measurements. The results demonstrate that increasing EOC concentration leads to droplet growth, which may destabilize dispersions, highlighting the need for compositional optimization. This APG/oleic acid platform provides a scalable, eco-friendly alternative for delivering poorly soluble bioactives, aligning with the principles of sustainable chemistry and reducing the environmental footprint of essential oil formulations.
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Larguier, Emilie. Universidad Complutense de Madrid; España
Fil: d’Aligny, Solange. Universidad Complutense de Madrid; España
Fil: Toledo-Sánchez, Alejandro. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Porawski González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Amara, Chaïma. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Ortega, Francisco. Universidad Complutense de Madrid; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Materia
ESSENTIAL OIL
SURFACTANTS
INSECTS
PEST
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/290126
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/290126
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil CompoundsFernández Peña, LauraLarguier, Emilied’Aligny, SolangeToledo-Sánchez, AlejandroPorawski González, PaulaLucia, AlejandroAmara, ChaïmaOrtega, FranciscoRubio, Ramón G.Guzmán, EduardoESSENTIAL OILSURFACTANTSINSECTSPESThttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The encapsulation of hydrophobic bioactive molecules, such as essential oil compounds (EOCs), in aqueous nanodispersions is critical for enhancing their solubility, stability, and applicability across diverse industries. This study examines the formulation of oleic acid nanodroplets stabilized by a biobased alkylpolyglucoside (APG), without the need for auxiliary cosurfactants. In this system, oleic acid simultaneously provides the oil core and contributes to interfacial charging, enabling the nanodroplets to act as efficient carriers for thymol and carvacrol. In contrast to conventional formulations requiring cosurfactants, this work presents a simplified and greener approach. A pseudoternary phase diagram defined the regions of stable dispersion formation, confirming the feasibility of a one-surfactant-only system. Dynamic light scattering confirmed a monomodal size distribution (10–15 nm), whereas fluorescence spectroscopy revealed up to three distinct chemical environments for the EOCs within the droplets. Crucially, the system’s stability is governed by the pH-dependent dissociation of oleic acid at the interface, as elucidated by conductivity and pH measurements. The results demonstrate that increasing EOC concentration leads to droplet growth, which may destabilize dispersions, highlighting the need for compositional optimization. This APG/oleic acid platform provides a scalable, eco-friendly alternative for delivering poorly soluble bioactives, aligning with the principles of sustainable chemistry and reducing the environmental footprint of essential oil formulations.Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Larguier, Emilie. Universidad Complutense de Madrid; EspañaFil: d’Aligny, Solange. Universidad Complutense de Madrid; EspañaFil: Toledo-Sánchez, Alejandro. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Porawski González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Amara, Chaïma. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Ortega, Francisco. Universidad Complutense de Madrid; EspañaFil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaAmerican Chemical Society2026-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/290126Fernández Peña, Laura; Larguier, Emilie; d’Aligny, Solange; Toledo-Sánchez, Alejandro; Porawski González, Paula; et al.; Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds; American Chemical Society; ACS Sustainable Chemistry & Engineering; 3-2026; 1-142168-04852168-0485CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acssuschemeng.5c13845info:eu-repo/semantics/altIdentifier/doi/10.1021/acssuschemeng.5c13845info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:44:17Zoai:ri.conicet.gov.ar:11336/290126instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:44:18.05CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
title Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
spellingShingle Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
Fernández Peña, Laura
ESSENTIAL OIL
SURFACTANTS
INSECTS
PEST
title_short Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
title_full Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
title_fullStr Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
title_full_unstemmed Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
title_sort Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds
dc.creator.none.fl_str_mv Fernández Peña, Laura
Larguier, Emilie
d’Aligny, Solange
Toledo-Sánchez, Alejandro
Porawski González, Paula
Lucia, Alejandro
Amara, Chaïma
Ortega, Francisco
Rubio, Ramón G.
Guzmán, Eduardo
author Fernández Peña, Laura
author_facet Fernández Peña, Laura
Larguier, Emilie
d’Aligny, Solange
Toledo-Sánchez, Alejandro
Porawski González, Paula
Lucia, Alejandro
Amara, Chaïma
Ortega, Francisco
Rubio, Ramón G.
Guzmán, Eduardo
author_role author
author2 Larguier, Emilie
d’Aligny, Solange
Toledo-Sánchez, Alejandro
Porawski González, Paula
Lucia, Alejandro
Amara, Chaïma
Ortega, Francisco
Rubio, Ramón G.
Guzmán, Eduardo
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ESSENTIAL OIL
SURFACTANTS
INSECTS
PEST
topic ESSENTIAL OIL
SURFACTANTS
INSECTS
PEST
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The encapsulation of hydrophobic bioactive molecules, such as essential oil compounds (EOCs), in aqueous nanodispersions is critical for enhancing their solubility, stability, and applicability across diverse industries. This study examines the formulation of oleic acid nanodroplets stabilized by a biobased alkylpolyglucoside (APG), without the need for auxiliary cosurfactants. In this system, oleic acid simultaneously provides the oil core and contributes to interfacial charging, enabling the nanodroplets to act as efficient carriers for thymol and carvacrol. In contrast to conventional formulations requiring cosurfactants, this work presents a simplified and greener approach. A pseudoternary phase diagram defined the regions of stable dispersion formation, confirming the feasibility of a one-surfactant-only system. Dynamic light scattering confirmed a monomodal size distribution (10–15 nm), whereas fluorescence spectroscopy revealed up to three distinct chemical environments for the EOCs within the droplets. Crucially, the system’s stability is governed by the pH-dependent dissociation of oleic acid at the interface, as elucidated by conductivity and pH measurements. The results demonstrate that increasing EOC concentration leads to droplet growth, which may destabilize dispersions, highlighting the need for compositional optimization. This APG/oleic acid platform provides a scalable, eco-friendly alternative for delivering poorly soluble bioactives, aligning with the principles of sustainable chemistry and reducing the environmental footprint of essential oil formulations.
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Larguier, Emilie. Universidad Complutense de Madrid; España
Fil: d’Aligny, Solange. Universidad Complutense de Madrid; España
Fil: Toledo-Sánchez, Alejandro. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Porawski González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Amara, Chaïma. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Ortega, Francisco. Universidad Complutense de Madrid; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
description The encapsulation of hydrophobic bioactive molecules, such as essential oil compounds (EOCs), in aqueous nanodispersions is critical for enhancing their solubility, stability, and applicability across diverse industries. This study examines the formulation of oleic acid nanodroplets stabilized by a biobased alkylpolyglucoside (APG), without the need for auxiliary cosurfactants. In this system, oleic acid simultaneously provides the oil core and contributes to interfacial charging, enabling the nanodroplets to act as efficient carriers for thymol and carvacrol. In contrast to conventional formulations requiring cosurfactants, this work presents a simplified and greener approach. A pseudoternary phase diagram defined the regions of stable dispersion formation, confirming the feasibility of a one-surfactant-only system. Dynamic light scattering confirmed a monomodal size distribution (10–15 nm), whereas fluorescence spectroscopy revealed up to three distinct chemical environments for the EOCs within the droplets. Crucially, the system’s stability is governed by the pH-dependent dissociation of oleic acid at the interface, as elucidated by conductivity and pH measurements. The results demonstrate that increasing EOC concentration leads to droplet growth, which may destabilize dispersions, highlighting the need for compositional optimization. This APG/oleic acid platform provides a scalable, eco-friendly alternative for delivering poorly soluble bioactives, aligning with the principles of sustainable chemistry and reducing the environmental footprint of essential oil formulations.
publishDate 2026
dc.date.none.fl_str_mv 2026-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/290126
Fernández Peña, Laura; Larguier, Emilie; d’Aligny, Solange; Toledo-Sánchez, Alejandro; Porawski González, Paula; et al.; Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds; American Chemical Society; ACS Sustainable Chemistry & Engineering; 3-2026; 1-14
2168-0485
2168-0485
CONICET Digital
CONICET
url http://hdl.handle.net/11336/290126
identifier_str_mv Fernández Peña, Laura; Larguier, Emilie; d’Aligny, Solange; Toledo-Sánchez, Alejandro; Porawski González, Paula; et al.; Alkylpolyglucoside-Stabilized Oleic Acid Nanodroplets as a Sustainable Platform for the Aqueous Dispersion of Essential Oil Compounds; American Chemical Society; ACS Sustainable Chemistry & Engineering; 3-2026; 1-14
2168-0485
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acssuschemeng.5c13845
info:eu-repo/semantics/altIdentifier/doi/10.1021/acssuschemeng.5c13845
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24418

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