Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina

Autores
Cantón, Candela; Bosco, Antonio; Maurelli, María Paula; Vitiello, Paula; Ceballos, Laura; Dominguez, Maria Paula; Moriones, Lucila; Torres, Juan Manuel; Alvarez, Luis Ignacio; Lanusse, Carlos Edmundo; Rinaldi, Laura
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Beef cattle farming plays a crucial role in the agricultural economies of both Argentina and Italy. Although both countries have grazing systems of meat production, the heterogeneity of these systems leads to different parasitological scenarios regarding epidemiology and anthelmintic resistance. In this context, considering ivermectin (IVM) is the most widely used anthelmintic for treating gastrointestinal nematodes in cattle, the current study evaluated the efficacy and the pharmacokinetic profile after the subcutaneous (SC) administration of ivermectin (IVM) given both to young calves and adult cows in ten commercial cattle farms from Italy (A to E) and Argentina (F to J). While in Italy adult cows and young calves were included in the study, in Argentina only calves aged 8-14 months old were selected to perform the efficacy trial. On each farm fifteen (15) calves/ cows naturally infected with gastrointestinal nematodes were treated with IVM (0.2 mg/kg). The efficacy was determined at 14 days after treatment by the FECRT. Six (6) adult cows and eight (8) young calves treated with IVM were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. Drug concentrations were measured by HPLC. Similar IVM PK trends were obtained for both adult and young cattle. The IVM systemic exposure (expressed as AUC) obtained for adult cows (380±158 ng.d/mL) was similar to that observed in young calves group (313±85.5 ng.d/mL). No statistical differences between both categories were observed for the most representative PK parameters (P>0.05). Surprisingly, while in Argentina IVM resistance was present in all the farms (90% CI = 0%-95%), in Italy a susceptible nematode population was presented in three farms (90% CI = 96%-100%) and a low level of IVM resistance in the rest of the farms (90% CI = 92%-98%). Cooperia spp. and Haemonchus spp. were the main genera resistant to IVM. In conclusion, IVM can be effectively used in both young cattle and adult cows. While its efficacy remains notably high in Italy, its use should always be preceded by a diagnostic assessment of the nematode population’s resistance status.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Bosco, Antonio. Università degli Studi di Napoli Federico II; Italia
Fil: Maurelli, María Paula. Università degli Studi di Napoli Federico II; Italia
Fil: Vitiello, Paula. Università degli Studi di Napoli Federico II; Italia
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Torres, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Rinaldi, Laura. Università degli Studi di Napoli Federico II; Italia
30th Conference of the World Association for the Advancements of Veterinary Parasitology
Curitiba
Brasil
World Association for the Advancements of Veterinary Parasitology
Materia
Ivermectin
Pharmaco-parasitological
Beef cattle
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/285919

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network_name_str CONICET Digital (CONICET)
spelling Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and ArgentinaCantón, CandelaBosco, AntonioMaurelli, María PaulaVitiello, PaulaCeballos, LauraDominguez, Maria PaulaMoriones, LucilaTorres, Juan ManuelAlvarez, Luis IgnacioLanusse, Carlos EdmundoRinaldi, LauraIvermectinPharmaco-parasitologicalBeef cattlehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Beef cattle farming plays a crucial role in the agricultural economies of both Argentina and Italy. Although both countries have grazing systems of meat production, the heterogeneity of these systems leads to different parasitological scenarios regarding epidemiology and anthelmintic resistance. In this context, considering ivermectin (IVM) is the most widely used anthelmintic for treating gastrointestinal nematodes in cattle, the current study evaluated the efficacy and the pharmacokinetic profile after the subcutaneous (SC) administration of ivermectin (IVM) given both to young calves and adult cows in ten commercial cattle farms from Italy (A to E) and Argentina (F to J). While in Italy adult cows and young calves were included in the study, in Argentina only calves aged 8-14 months old were selected to perform the efficacy trial. On each farm fifteen (15) calves/ cows naturally infected with gastrointestinal nematodes were treated with IVM (0.2 mg/kg). The efficacy was determined at 14 days after treatment by the FECRT. Six (6) adult cows and eight (8) young calves treated with IVM were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. Drug concentrations were measured by HPLC. Similar IVM PK trends were obtained for both adult and young cattle. The IVM systemic exposure (expressed as AUC) obtained for adult cows (380±158 ng.d/mL) was similar to that observed in young calves group (313±85.5 ng.d/mL). No statistical differences between both categories were observed for the most representative PK parameters (P>0.05). Surprisingly, while in Argentina IVM resistance was present in all the farms (90% CI = 0%-95%), in Italy a susceptible nematode population was presented in three farms (90% CI = 96%-100%) and a low level of IVM resistance in the rest of the farms (90% CI = 92%-98%). Cooperia spp. and Haemonchus spp. were the main genera resistant to IVM. In conclusion, IVM can be effectively used in both young cattle and adult cows. While its efficacy remains notably high in Italy, its use should always be preceded by a diagnostic assessment of the nematode population’s resistance status.Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Bosco, Antonio. Università degli Studi di Napoli Federico II; ItaliaFil: Maurelli, María Paula. Università degli Studi di Napoli Federico II; ItaliaFil: Vitiello, Paula. Università degli Studi di Napoli Federico II; ItaliaFil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Torres, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Rinaldi, Laura. Università degli Studi di Napoli Federico II; Italia30th Conference of the World Association for the Advancements of Veterinary ParasitologyCuritibaBrasilWorld Association for the Advancements of Veterinary ParasitologyWorld Association for the Advancements of Veterinary Parasitology2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/285919Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina; 30th Conference of the World Association for the Advancements of Veterinary Parasitology; Curitiba; Brasil; 2025; 270-271CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.waavp.org/resources/conferences.htmlInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:32:26Zoai:ri.conicet.gov.ar:11336/285919instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:32:26.416CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
title Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
spellingShingle Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
Cantón, Candela
Ivermectin
Pharmaco-parasitological
Beef cattle
title_short Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
title_full Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
title_fullStr Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
title_full_unstemmed Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
title_sort Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina
dc.creator.none.fl_str_mv Cantón, Candela
Bosco, Antonio
Maurelli, María Paula
Vitiello, Paula
Ceballos, Laura
Dominguez, Maria Paula
Moriones, Lucila
Torres, Juan Manuel
Alvarez, Luis Ignacio
Lanusse, Carlos Edmundo
Rinaldi, Laura
author Cantón, Candela
author_facet Cantón, Candela
Bosco, Antonio
Maurelli, María Paula
Vitiello, Paula
Ceballos, Laura
Dominguez, Maria Paula
Moriones, Lucila
Torres, Juan Manuel
Alvarez, Luis Ignacio
Lanusse, Carlos Edmundo
Rinaldi, Laura
author_role author
author2 Bosco, Antonio
Maurelli, María Paula
Vitiello, Paula
Ceballos, Laura
Dominguez, Maria Paula
Moriones, Lucila
Torres, Juan Manuel
Alvarez, Luis Ignacio
Lanusse, Carlos Edmundo
Rinaldi, Laura
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ivermectin
Pharmaco-parasitological
Beef cattle
topic Ivermectin
Pharmaco-parasitological
Beef cattle
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Beef cattle farming plays a crucial role in the agricultural economies of both Argentina and Italy. Although both countries have grazing systems of meat production, the heterogeneity of these systems leads to different parasitological scenarios regarding epidemiology and anthelmintic resistance. In this context, considering ivermectin (IVM) is the most widely used anthelmintic for treating gastrointestinal nematodes in cattle, the current study evaluated the efficacy and the pharmacokinetic profile after the subcutaneous (SC) administration of ivermectin (IVM) given both to young calves and adult cows in ten commercial cattle farms from Italy (A to E) and Argentina (F to J). While in Italy adult cows and young calves were included in the study, in Argentina only calves aged 8-14 months old were selected to perform the efficacy trial. On each farm fifteen (15) calves/ cows naturally infected with gastrointestinal nematodes were treated with IVM (0.2 mg/kg). The efficacy was determined at 14 days after treatment by the FECRT. Six (6) adult cows and eight (8) young calves treated with IVM were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. Drug concentrations were measured by HPLC. Similar IVM PK trends were obtained for both adult and young cattle. The IVM systemic exposure (expressed as AUC) obtained for adult cows (380±158 ng.d/mL) was similar to that observed in young calves group (313±85.5 ng.d/mL). No statistical differences between both categories were observed for the most representative PK parameters (P>0.05). Surprisingly, while in Argentina IVM resistance was present in all the farms (90% CI = 0%-95%), in Italy a susceptible nematode population was presented in three farms (90% CI = 96%-100%) and a low level of IVM resistance in the rest of the farms (90% CI = 92%-98%). Cooperia spp. and Haemonchus spp. were the main genera resistant to IVM. In conclusion, IVM can be effectively used in both young cattle and adult cows. While its efficacy remains notably high in Italy, its use should always be preceded by a diagnostic assessment of the nematode population’s resistance status.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Bosco, Antonio. Università degli Studi di Napoli Federico II; Italia
Fil: Maurelli, María Paula. Università degli Studi di Napoli Federico II; Italia
Fil: Vitiello, Paula. Università degli Studi di Napoli Federico II; Italia
Fil: Ceballos, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moriones, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Torres, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Rinaldi, Laura. Università degli Studi di Napoli Federico II; Italia
30th Conference of the World Association for the Advancements of Veterinary Parasitology
Curitiba
Brasil
World Association for the Advancements of Veterinary Parasitology
description Beef cattle farming plays a crucial role in the agricultural economies of both Argentina and Italy. Although both countries have grazing systems of meat production, the heterogeneity of these systems leads to different parasitological scenarios regarding epidemiology and anthelmintic resistance. In this context, considering ivermectin (IVM) is the most widely used anthelmintic for treating gastrointestinal nematodes in cattle, the current study evaluated the efficacy and the pharmacokinetic profile after the subcutaneous (SC) administration of ivermectin (IVM) given both to young calves and adult cows in ten commercial cattle farms from Italy (A to E) and Argentina (F to J). While in Italy adult cows and young calves were included in the study, in Argentina only calves aged 8-14 months old were selected to perform the efficacy trial. On each farm fifteen (15) calves/ cows naturally infected with gastrointestinal nematodes were treated with IVM (0.2 mg/kg). The efficacy was determined at 14 days after treatment by the FECRT. Six (6) adult cows and eight (8) young calves treated with IVM were randomly selected to perform the PK study with blood samples being taken from these animals at regular intervals. Drug concentrations were measured by HPLC. Similar IVM PK trends were obtained for both adult and young cattle. The IVM systemic exposure (expressed as AUC) obtained for adult cows (380±158 ng.d/mL) was similar to that observed in young calves group (313±85.5 ng.d/mL). No statistical differences between both categories were observed for the most representative PK parameters (P>0.05). Surprisingly, while in Argentina IVM resistance was present in all the farms (90% CI = 0%-95%), in Italy a susceptible nematode population was presented in three farms (90% CI = 96%-100%) and a low level of IVM resistance in the rest of the farms (90% CI = 92%-98%). Cooperia spp. and Haemonchus spp. were the main genera resistant to IVM. In conclusion, IVM can be effectively used in both young cattle and adult cows. While its efficacy remains notably high in Italy, its use should always be preceded by a diagnostic assessment of the nematode population’s resistance status.
publishDate 2025
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Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina; 30th Conference of the World Association for the Advancements of Veterinary Parasitology; Curitiba; Brasil; 2025; 270-271
CONICET Digital
CONICET
url http://hdl.handle.net/11336/285919
identifier_str_mv Ivermectin pharmaco-parasitological evaluation on different beef cattle anthelmintic resistance scenarios in Italy and Argentina; 30th Conference of the World Association for the Advancements of Veterinary Parasitology; Curitiba; Brasil; 2025; 270-271
CONICET Digital
CONICET
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