Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes

Autores
Horas, Jorge Alberto; Olguín, Osvaldo Roberto; Rizzotto, Marcos Gregorio
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose: To compare the results obtained for tumour control probability (TCP) in protracted treatments, we used two models which apply Poisson statistics for clonogenic cell distribution and a non-Poissonian model, emphasising the conditions for the validity of Poissonian models. Previously published results on two cell lines growing as megacolonies in vitro irradiated with conventional and accelerated dose fractionation schemes were used. Materials and methods: The expressions of TCP for three models are described and conclusions are drawn on the applicability of each model, and their usefulness for different fractionations. Results: The fits to experimental data are shown and the parameter values for both Poissonian and non-Poissonian models are given. We also determined if differences exist in repopulation rate and other related parameters, for different protocols of treatment. Conclusions: Both the Poissonian models, when they satisfied the required conditions, and the non-Poissonian model, gave acceptable fits. We observed no significant differences in repopulation for different irradiation protocols.
Fil: Horas, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; Argentina
Fil: Olguín, Osvaldo Roberto. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; Argentina
Fil: Rizzotto, Marcos Gregorio. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; Argentina
Materia
TUMOUR CONTROL PROBABILITY
CLONOGENIC CELLS DISTRIBUTION
POISSONIAN AND NON POISSONIAN TCP MODELS
PROTRACTED TREATMENTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/284443
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemesHoras, Jorge AlbertoOlguín, Osvaldo RobertoRizzotto, Marcos GregorioTUMOUR CONTROL PROBABILITYCLONOGENIC CELLS DISTRIBUTIONPOISSONIAN AND NON POISSONIAN TCP MODELSPROTRACTED TREATMENTShttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Purpose: To compare the results obtained for tumour control probability (TCP) in protracted treatments, we used two models which apply Poisson statistics for clonogenic cell distribution and a non-Poissonian model, emphasising the conditions for the validity of Poissonian models. Previously published results on two cell lines growing as megacolonies in vitro irradiated with conventional and accelerated dose fractionation schemes were used. Materials and methods: The expressions of TCP for three models are described and conclusions are drawn on the applicability of each model, and their usefulness for different fractionations. Results: The fits to experimental data are shown and the parameter values for both Poissonian and non-Poissonian models are given. We also determined if differences exist in repopulation rate and other related parameters, for different protocols of treatment. Conclusions: Both the Poissonian models, when they satisfied the required conditions, and the non-Poissonian model, gave acceptable fits. We observed no significant differences in repopulation for different irradiation protocols.Fil: Horas, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; ArgentinaFil: Olguín, Osvaldo Roberto. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; ArgentinaFil: Rizzotto, Marcos Gregorio. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; ArgentinaTaylor & Francis Ltd2010-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/284443Horas, Jorge Alberto; Olguín, Osvaldo Roberto; Rizzotto, Marcos Gregorio; Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes; Taylor & Francis Ltd; International Journal Of Radiation Biology; 86; 8; 8-2010; 711-7170955-3002CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/09553001003734618info:eu-repo/semantics/altIdentifier/doi/10.3109/09553001003734618info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:30:41Zoai:ri.conicet.gov.ar:11336/284443instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:30:41.771CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
title Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
spellingShingle Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
Horas, Jorge Alberto
TUMOUR CONTROL PROBABILITY
CLONOGENIC CELLS DISTRIBUTION
POISSONIAN AND NON POISSONIAN TCP MODELS
PROTRACTED TREATMENTS
title_short Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
title_full Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
title_fullStr Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
title_full_unstemmed Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
title_sort Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
dc.creator.none.fl_str_mv Horas, Jorge Alberto
Olguín, Osvaldo Roberto
Rizzotto, Marcos Gregorio
author Horas, Jorge Alberto
author_facet Horas, Jorge Alberto
Olguín, Osvaldo Roberto
Rizzotto, Marcos Gregorio
author_role author
author2 Olguín, Osvaldo Roberto
Rizzotto, Marcos Gregorio
author2_role author
author
dc.subject.none.fl_str_mv TUMOUR CONTROL PROBABILITY
CLONOGENIC CELLS DISTRIBUTION
POISSONIAN AND NON POISSONIAN TCP MODELS
PROTRACTED TREATMENTS
topic TUMOUR CONTROL PROBABILITY
CLONOGENIC CELLS DISTRIBUTION
POISSONIAN AND NON POISSONIAN TCP MODELS
PROTRACTED TREATMENTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Purpose: To compare the results obtained for tumour control probability (TCP) in protracted treatments, we used two models which apply Poisson statistics for clonogenic cell distribution and a non-Poissonian model, emphasising the conditions for the validity of Poissonian models. Previously published results on two cell lines growing as megacolonies in vitro irradiated with conventional and accelerated dose fractionation schemes were used. Materials and methods: The expressions of TCP for three models are described and conclusions are drawn on the applicability of each model, and their usefulness for different fractionations. Results: The fits to experimental data are shown and the parameter values for both Poissonian and non-Poissonian models are given. We also determined if differences exist in repopulation rate and other related parameters, for different protocols of treatment. Conclusions: Both the Poissonian models, when they satisfied the required conditions, and the non-Poissonian model, gave acceptable fits. We observed no significant differences in repopulation for different irradiation protocols.
Fil: Horas, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi". Universidad Nacional de San Luis. Facultad de Ciencias Físico, Matemáticas y Naturales. Instituto de Matemática Aplicada de San Luis "Prof. Ezio Marchi"; Argentina. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; Argentina
Fil: Olguín, Osvaldo Roberto. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; Argentina
Fil: Rizzotto, Marcos Gregorio. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Departamento de Física; Argentina
description Purpose: To compare the results obtained for tumour control probability (TCP) in protracted treatments, we used two models which apply Poisson statistics for clonogenic cell distribution and a non-Poissonian model, emphasising the conditions for the validity of Poissonian models. Previously published results on two cell lines growing as megacolonies in vitro irradiated with conventional and accelerated dose fractionation schemes were used. Materials and methods: The expressions of TCP for three models are described and conclusions are drawn on the applicability of each model, and their usefulness for different fractionations. Results: The fits to experimental data are shown and the parameter values for both Poissonian and non-Poissonian models are given. We also determined if differences exist in repopulation rate and other related parameters, for different protocols of treatment. Conclusions: Both the Poissonian models, when they satisfied the required conditions, and the non-Poissonian model, gave acceptable fits. We observed no significant differences in repopulation for different irradiation protocols.
publishDate 2010
dc.date.none.fl_str_mv 2010-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/284443
Horas, Jorge Alberto; Olguín, Osvaldo Roberto; Rizzotto, Marcos Gregorio; Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes; Taylor & Francis Ltd; International Journal Of Radiation Biology; 86; 8; 8-2010; 711-717
0955-3002
CONICET Digital
CONICET
url http://hdl.handle.net/11336/284443
identifier_str_mv Horas, Jorge Alberto; Olguín, Osvaldo Roberto; Rizzotto, Marcos Gregorio; Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes; Taylor & Francis Ltd; International Journal Of Radiation Biology; 86; 8; 8-2010; 711-717
0955-3002
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/09553001003734618
info:eu-repo/semantics/altIdentifier/doi/10.3109/09553001003734618
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24418

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