Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review

Autores
Ceballos Morales, Alejandra; Villalobos Lermanda, Celeste; González Burboa, Alexis; Ciapponi, Agustín; Bardach, Ariel Esteban
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progestins have shown to be highly effective, adequately safe contraceptives and a realalternative in the cases with contraindications to estrogen use. This review assesses theeffectiveness of treatments for managing uterine bleeding due to the use of progestin-onlycontraceptives. A systematic review of databases such as Embase, LILACS, CINAHL, andPubMed, with a result of 701 studies published in English between 2005 and 2022, was carried out. 21 randomized clinical trials were analyzed. There were effective non-hormonalalternatives for managing progestin-related bleeding. While several treatments showpromise, results must be replicated by studies with longer follow-up periods. Differencescame from the five new studies and their good methodological quality—specifically, blinding and assessment of population losses. Benefits were the stop of uterine bleeding and a shortened duration of these episodes, with studies generally reporting satisfaction amongtheir patients. There were few adverse effects seen, with the most common being headachesand nausea, which should be addressed by future studies. These results are expected to beof use for health professionals and midwives working on contraceptive management.
Fil: Ceballos Morales, Alejandra. Universidad de Concepción; Chile
Fil: Villalobos Lermanda, Celeste. Universidad de Concepción; Chile
Fil: González Burboa, Alexis. Universidad de Concepción; Chile
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
CONTRACEPTION PROGESTIN AGENTS
UTERINE BLEEDING
TREATMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291234
Acceder
id CONICETDig_3087dffdd43a56f8ecbe2553c7a174d8
oai_identifier_str oai:ri.conicet.gov.ar:11336/291234
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic ReviewCeballos Morales, AlejandraVillalobos Lermanda, CelesteGonzález Burboa, AlexisCiapponi, AgustínBardach, Ariel EstebanCONTRACEPTION PROGESTIN AGENTSUTERINE BLEEDINGTREATMENThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Progestins have shown to be highly effective, adequately safe contraceptives and a realalternative in the cases with contraindications to estrogen use. This review assesses theeffectiveness of treatments for managing uterine bleeding due to the use of progestin-onlycontraceptives. A systematic review of databases such as Embase, LILACS, CINAHL, andPubMed, with a result of 701 studies published in English between 2005 and 2022, was carried out. 21 randomized clinical trials were analyzed. There were effective non-hormonalalternatives for managing progestin-related bleeding. While several treatments showpromise, results must be replicated by studies with longer follow-up periods. Differencescame from the five new studies and their good methodological quality—specifically, blinding and assessment of population losses. Benefits were the stop of uterine bleeding and a shortened duration of these episodes, with studies generally reporting satisfaction amongtheir patients. There were few adverse effects seen, with the most common being headachesand nausea, which should be addressed by future studies. These results are expected to beof use for health professionals and midwives working on contraceptive management.Fil: Ceballos Morales, Alejandra. Universidad de Concepción; ChileFil: Villalobos Lermanda, Celeste. Universidad de Concepción; ChileFil: González Burboa, Alexis. Universidad de Concepción; ChileFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaMDPI2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291234Ceballos Morales, Alejandra; Villalobos Lermanda, Celeste; González Burboa, Alexis; Ciapponi, Agustín; Bardach, Ariel Esteban; Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review; MDPI; Sexes; 6; 3; 8-2025; 1-322411-5118CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2411-5118/6/3/45info:eu-repo/semantics/altIdentifier/doi/10.3390/sexes6030045info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:52:14Zoai:ri.conicet.gov.ar:11336/291234instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:52:14.577CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
title Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
spellingShingle Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
Ceballos Morales, Alejandra
CONTRACEPTION PROGESTIN AGENTS
UTERINE BLEEDING
TREATMENT
title_short Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
title_full Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
title_fullStr Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
title_full_unstemmed Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
title_sort Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review
dc.creator.none.fl_str_mv Ceballos Morales, Alejandra
Villalobos Lermanda, Celeste
González Burboa, Alexis
Ciapponi, Agustín
Bardach, Ariel Esteban
author Ceballos Morales, Alejandra
author_facet Ceballos Morales, Alejandra
Villalobos Lermanda, Celeste
González Burboa, Alexis
Ciapponi, Agustín
Bardach, Ariel Esteban
author_role author
author2 Villalobos Lermanda, Celeste
González Burboa, Alexis
Ciapponi, Agustín
Bardach, Ariel Esteban
author2_role author
author
author
author
dc.subject.none.fl_str_mv CONTRACEPTION PROGESTIN AGENTS
UTERINE BLEEDING
TREATMENT
topic CONTRACEPTION PROGESTIN AGENTS
UTERINE BLEEDING
TREATMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progestins have shown to be highly effective, adequately safe contraceptives and a realalternative in the cases with contraindications to estrogen use. This review assesses theeffectiveness of treatments for managing uterine bleeding due to the use of progestin-onlycontraceptives. A systematic review of databases such as Embase, LILACS, CINAHL, andPubMed, with a result of 701 studies published in English between 2005 and 2022, was carried out. 21 randomized clinical trials were analyzed. There were effective non-hormonalalternatives for managing progestin-related bleeding. While several treatments showpromise, results must be replicated by studies with longer follow-up periods. Differencescame from the five new studies and their good methodological quality—specifically, blinding and assessment of population losses. Benefits were the stop of uterine bleeding and a shortened duration of these episodes, with studies generally reporting satisfaction amongtheir patients. There were few adverse effects seen, with the most common being headachesand nausea, which should be addressed by future studies. These results are expected to beof use for health professionals and midwives working on contraceptive management.
Fil: Ceballos Morales, Alejandra. Universidad de Concepción; Chile
Fil: Villalobos Lermanda, Celeste. Universidad de Concepción; Chile
Fil: González Burboa, Alexis. Universidad de Concepción; Chile
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description Progestins have shown to be highly effective, adequately safe contraceptives and a realalternative in the cases with contraindications to estrogen use. This review assesses theeffectiveness of treatments for managing uterine bleeding due to the use of progestin-onlycontraceptives. A systematic review of databases such as Embase, LILACS, CINAHL, andPubMed, with a result of 701 studies published in English between 2005 and 2022, was carried out. 21 randomized clinical trials were analyzed. There were effective non-hormonalalternatives for managing progestin-related bleeding. While several treatments showpromise, results must be replicated by studies with longer follow-up periods. Differencescame from the five new studies and their good methodological quality—specifically, blinding and assessment of population losses. Benefits were the stop of uterine bleeding and a shortened duration of these episodes, with studies generally reporting satisfaction amongtheir patients. There were few adverse effects seen, with the most common being headachesand nausea, which should be addressed by future studies. These results are expected to beof use for health professionals and midwives working on contraceptive management.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291234
Ceballos Morales, Alejandra; Villalobos Lermanda, Celeste; González Burboa, Alexis; Ciapponi, Agustín; Bardach, Ariel Esteban; Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review; MDPI; Sexes; 6; 3; 8-2025; 1-32
2411-5118
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291234
identifier_str_mv Ceballos Morales, Alejandra; Villalobos Lermanda, Celeste; González Burboa, Alexis; Ciapponi, Agustín; Bardach, Ariel Esteban; Treatment of Irregular Uterine Bleeding Caused by Progestin-Only Contraceptives: A Systematic Review; MDPI; Sexes; 6; 3; 8-2025; 1-32
2411-5118
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2411-5118/6/3/45
info:eu-repo/semantics/altIdentifier/doi/10.3390/sexes6030045
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874774807507107840
score 13.265058

Publicaciones similares