Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications

Autores
Marcos Valdez, Marina Monserrat; Sperandeo, Norma Rebeca; Bueno, Maria Soledad; Garnero, Claudia
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pharmaceutical cocrystals are a well-established class of solid-state forms that can modulatethe solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredientswithout altering their molecular identity. Although traditional oral formulations havedemonstrated translational potential, recent research has emphasized the importance ofintegrating cocrystals into emerging drug-delivery technologies. This review systematicallyanalyzes recent advances in conventional and innovative cocrystal-based platforms,critically evaluating their therapeutic relevance. A comprehensive literature search wasconducted, focusing on publications from the last decade, with emphasis on studies from2020 to 2025, including peer-reviewed articles, patents, and regulatory documents. Evidencewas organized into traditional oral, inhalable, intranasal, and transdermal formulations,followed by emerging platforms such as 3D printing, nano-cocrystals, andmicroneedles. Case studies and preclinical/clinical data were critically assessed to identifystrengths, limitations, and future directions. Advancements in formulation science andnovel delivery technologies are allowing pharmaceutical cocrystals to transition from laboratoryinnovations to clinical applications. Despite challenges in scalability, stability, andregulatory clarity, the application of cocrystals into emerging platforms highlights theirpotential as transformative tools in next-generation therapeutics.
Fil: Marcos Valdez, Marina Monserrat. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Sperandeo, Norma Rebeca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Bueno, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
CRYSTAL ENGINEERING
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
COCRYSTALS
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/287855
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/287855
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic ApplicationsMarcos Valdez, Marina MonserratSperandeo, Norma RebecaBueno, Maria SoledadGarnero, ClaudiaCRYSTAL ENGINEERINGADVANCED FORMULATIONSEMERGING DRUG-DELIVERY TECHNOLOGIESCLINICAL TRANSLATIONCOCRYSTALSADVANCED FORMULATIONSEMERGING DRUG-DELIVERY TECHNOLOGIESCLINICAL TRANSLATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Pharmaceutical cocrystals are a well-established class of solid-state forms that can modulatethe solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredientswithout altering their molecular identity. Although traditional oral formulations havedemonstrated translational potential, recent research has emphasized the importance ofintegrating cocrystals into emerging drug-delivery technologies. This review systematicallyanalyzes recent advances in conventional and innovative cocrystal-based platforms,critically evaluating their therapeutic relevance. A comprehensive literature search wasconducted, focusing on publications from the last decade, with emphasis on studies from2020 to 2025, including peer-reviewed articles, patents, and regulatory documents. Evidencewas organized into traditional oral, inhalable, intranasal, and transdermal formulations,followed by emerging platforms such as 3D printing, nano-cocrystals, andmicroneedles. Case studies and preclinical/clinical data were critically assessed to identifystrengths, limitations, and future directions. Advancements in formulation science andnovel delivery technologies are allowing pharmaceutical cocrystals to transition from laboratoryinnovations to clinical applications. Despite challenges in scalability, stability, andregulatory clarity, the application of cocrystals into emerging platforms highlights theirpotential as transformative tools in next-generation therapeutics.Fil: Marcos Valdez, Marina Monserrat. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Sperandeo, Norma Rebeca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Bueno, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaMDPI2026-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/287855Marcos Valdez, Marina Monserrat; Sperandeo, Norma Rebeca; Bueno, Maria Soledad; Garnero, Claudia; Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications; MDPI; Pharmaceutics; 18; 1; 1-2026; 128-1551999-4923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/18/1/128info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics18010128info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:38:06Zoai:ri.conicet.gov.ar:11336/287855instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:38:06.327CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
title Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
spellingShingle Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
Marcos Valdez, Marina Monserrat
CRYSTAL ENGINEERING
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
COCRYSTALS
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
title_short Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
title_full Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
title_fullStr Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
title_full_unstemmed Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
title_sort Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications
dc.creator.none.fl_str_mv Marcos Valdez, Marina Monserrat
Sperandeo, Norma Rebeca
Bueno, Maria Soledad
Garnero, Claudia
author Marcos Valdez, Marina Monserrat
author_facet Marcos Valdez, Marina Monserrat
Sperandeo, Norma Rebeca
Bueno, Maria Soledad
Garnero, Claudia
author_role author
author2 Sperandeo, Norma Rebeca
Bueno, Maria Soledad
Garnero, Claudia
author2_role author
author
author
dc.subject.none.fl_str_mv CRYSTAL ENGINEERING
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
COCRYSTALS
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
topic CRYSTAL ENGINEERING
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
COCRYSTALS
ADVANCED FORMULATIONS
EMERGING DRUG-DELIVERY TECHNOLOGIES
CLINICAL TRANSLATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pharmaceutical cocrystals are a well-established class of solid-state forms that can modulatethe solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredientswithout altering their molecular identity. Although traditional oral formulations havedemonstrated translational potential, recent research has emphasized the importance ofintegrating cocrystals into emerging drug-delivery technologies. This review systematicallyanalyzes recent advances in conventional and innovative cocrystal-based platforms,critically evaluating their therapeutic relevance. A comprehensive literature search wasconducted, focusing on publications from the last decade, with emphasis on studies from2020 to 2025, including peer-reviewed articles, patents, and regulatory documents. Evidencewas organized into traditional oral, inhalable, intranasal, and transdermal formulations,followed by emerging platforms such as 3D printing, nano-cocrystals, andmicroneedles. Case studies and preclinical/clinical data were critically assessed to identifystrengths, limitations, and future directions. Advancements in formulation science andnovel delivery technologies are allowing pharmaceutical cocrystals to transition from laboratoryinnovations to clinical applications. Despite challenges in scalability, stability, andregulatory clarity, the application of cocrystals into emerging platforms highlights theirpotential as transformative tools in next-generation therapeutics.
Fil: Marcos Valdez, Marina Monserrat. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Sperandeo, Norma Rebeca. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Bueno, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Pharmaceutical cocrystals are a well-established class of solid-state forms that can modulatethe solubility, dissolution, stability, and bioavailability of active pharmaceutical ingredientswithout altering their molecular identity. Although traditional oral formulations havedemonstrated translational potential, recent research has emphasized the importance ofintegrating cocrystals into emerging drug-delivery technologies. This review systematicallyanalyzes recent advances in conventional and innovative cocrystal-based platforms,critically evaluating their therapeutic relevance. A comprehensive literature search wasconducted, focusing on publications from the last decade, with emphasis on studies from2020 to 2025, including peer-reviewed articles, patents, and regulatory documents. Evidencewas organized into traditional oral, inhalable, intranasal, and transdermal formulations,followed by emerging platforms such as 3D printing, nano-cocrystals, andmicroneedles. Case studies and preclinical/clinical data were critically assessed to identifystrengths, limitations, and future directions. Advancements in formulation science andnovel delivery technologies are allowing pharmaceutical cocrystals to transition from laboratoryinnovations to clinical applications. Despite challenges in scalability, stability, andregulatory clarity, the application of cocrystals into emerging platforms highlights theirpotential as transformative tools in next-generation therapeutics.
publishDate 2026
dc.date.none.fl_str_mv 2026-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/287855
Marcos Valdez, Marina Monserrat; Sperandeo, Norma Rebeca; Bueno, Maria Soledad; Garnero, Claudia; Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications; MDPI; Pharmaceutics; 18; 1; 1-2026; 128-155
1999-4923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/287855
identifier_str_mv Marcos Valdez, Marina Monserrat; Sperandeo, Norma Rebeca; Bueno, Maria Soledad; Garnero, Claudia; Pharmaceutical Cocrystals in Drug-Delivery Technologies: Advances from Rational Design to Therapeutic Applications; MDPI; Pharmaceutics; 18; 1; 1-2026; 128-155
1999-4923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4923/18/1/128
info:eu-repo/semantics/altIdentifier/doi/10.3390/pharmaceutics18010128
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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