Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk

Autores
Paola Antonella, Avaca Gagliardi; Gomez, Germán Ernesto; Fernandez, Liliana Patricia; Talio, María Carolina
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Breastfeeding is essential for the healthy development and growth of infants, fostering astrong bond between mother and child. Exposure to nicotine through maternal smokingrepresents a significant risk to the health of both. This study proposes the quantificationand monitoring of nicotine by molecular fluorescence in breast milk samples frommothers who smoke and who are passive smokers at different stages of lactation. A metalorganicnetwork (MOF) was synthesized and characterized by UV-Vis spectroscopy andmolecular luminescence. The enhancement effect of the luminescence signal at em = 611nm could be correlated with nicotine concentration into the 38.5 – 8.95×103 ng L-1concentration range. Experimental variables that influence Nicotine quantification werestudied and deeply optimized. The study was conducted on samples from 10 mothers,subdivided into three groups: smokers, passive smokers and negative controls. In orderto minimize the contamination risk, manual extraction was used as collection method.The nicotine concentrations found show a close relationship with the addiction degreeand the variety of tobacco consumed. The proposed methodology constitutes a cost effectivealternative to the standard techniques used to determine nicotine and representsa valuable contribution in the area of maternal health.
Fil: Paola Antonella, Avaca Gagliardi. Universidad Nacional de San Luis; Argentina
Fil: Gomez, Germán Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Talio, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
MOF
SENSOR
NICOTINE
MILK SAMPLE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/289514
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milkPaola Antonella, Avaca GagliardiGomez, Germán ErnestoFernandez, Liliana PatriciaTalio, María CarolinaMOFSENSORNICOTINEMILK SAMPLEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Breastfeeding is essential for the healthy development and growth of infants, fostering astrong bond between mother and child. Exposure to nicotine through maternal smokingrepresents a significant risk to the health of both. This study proposes the quantificationand monitoring of nicotine by molecular fluorescence in breast milk samples frommothers who smoke and who are passive smokers at different stages of lactation. A metalorganicnetwork (MOF) was synthesized and characterized by UV-Vis spectroscopy andmolecular luminescence. The enhancement effect of the luminescence signal at em = 611nm could be correlated with nicotine concentration into the 38.5 – 8.95×103 ng L-1concentration range. Experimental variables that influence Nicotine quantification werestudied and deeply optimized. The study was conducted on samples from 10 mothers,subdivided into three groups: smokers, passive smokers and negative controls. In orderto minimize the contamination risk, manual extraction was used as collection method.The nicotine concentrations found show a close relationship with the addiction degreeand the variety of tobacco consumed. The proposed methodology constitutes a cost effectivealternative to the standard techniques used to determine nicotine and representsa valuable contribution in the area of maternal health.Fil: Paola Antonella, Avaca Gagliardi. Universidad Nacional de San Luis; ArgentinaFil: Gomez, Germán Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Talio, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaRoyal Society of Chemistry2025-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/289514Paola Antonella, Avaca Gagliardi; Gomez, Germán Ernesto; Fernandez, Liliana Patricia; Talio, María Carolina; Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk; Royal Society of Chemistry; Analytical Methods; 18; 2; 12-2025; 361-3711759-96601759-9679CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2025/AY/D5AY01777Ginfo:eu-repo/semantics/altIdentifier/doi/10.1039/D5AY01777Ginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:35:31Zoai:ri.conicet.gov.ar:11336/289514instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:35:31.487CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
title Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
spellingShingle Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
Paola Antonella, Avaca Gagliardi
MOF
SENSOR
NICOTINE
MILK SAMPLE
title_short Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
title_full Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
title_fullStr Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
title_full_unstemmed Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
title_sort Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk
dc.creator.none.fl_str_mv Paola Antonella, Avaca Gagliardi
Gomez, Germán Ernesto
Fernandez, Liliana Patricia
Talio, María Carolina
author Paola Antonella, Avaca Gagliardi
author_facet Paola Antonella, Avaca Gagliardi
Gomez, Germán Ernesto
Fernandez, Liliana Patricia
Talio, María Carolina
author_role author
author2 Gomez, Germán Ernesto
Fernandez, Liliana Patricia
Talio, María Carolina
author2_role author
author
author
dc.subject.none.fl_str_mv MOF
SENSOR
NICOTINE
MILK SAMPLE
topic MOF
SENSOR
NICOTINE
MILK SAMPLE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Breastfeeding is essential for the healthy development and growth of infants, fostering astrong bond between mother and child. Exposure to nicotine through maternal smokingrepresents a significant risk to the health of both. This study proposes the quantificationand monitoring of nicotine by molecular fluorescence in breast milk samples frommothers who smoke and who are passive smokers at different stages of lactation. A metalorganicnetwork (MOF) was synthesized and characterized by UV-Vis spectroscopy andmolecular luminescence. The enhancement effect of the luminescence signal at em = 611nm could be correlated with nicotine concentration into the 38.5 – 8.95×103 ng L-1concentration range. Experimental variables that influence Nicotine quantification werestudied and deeply optimized. The study was conducted on samples from 10 mothers,subdivided into three groups: smokers, passive smokers and negative controls. In orderto minimize the contamination risk, manual extraction was used as collection method.The nicotine concentrations found show a close relationship with the addiction degreeand the variety of tobacco consumed. The proposed methodology constitutes a cost effectivealternative to the standard techniques used to determine nicotine and representsa valuable contribution in the area of maternal health.
Fil: Paola Antonella, Avaca Gagliardi. Universidad Nacional de San Luis; Argentina
Fil: Gomez, Germán Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Talio, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description Breastfeeding is essential for the healthy development and growth of infants, fostering astrong bond between mother and child. Exposure to nicotine through maternal smokingrepresents a significant risk to the health of both. This study proposes the quantificationand monitoring of nicotine by molecular fluorescence in breast milk samples frommothers who smoke and who are passive smokers at different stages of lactation. A metalorganicnetwork (MOF) was synthesized and characterized by UV-Vis spectroscopy andmolecular luminescence. The enhancement effect of the luminescence signal at em = 611nm could be correlated with nicotine concentration into the 38.5 – 8.95×103 ng L-1concentration range. Experimental variables that influence Nicotine quantification werestudied and deeply optimized. The study was conducted on samples from 10 mothers,subdivided into three groups: smokers, passive smokers and negative controls. In orderto minimize the contamination risk, manual extraction was used as collection method.The nicotine concentrations found show a close relationship with the addiction degreeand the variety of tobacco consumed. The proposed methodology constitutes a cost effectivealternative to the standard techniques used to determine nicotine and representsa valuable contribution in the area of maternal health.
publishDate 2025
dc.date.none.fl_str_mv 2025-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/289514
Paola Antonella, Avaca Gagliardi; Gomez, Germán Ernesto; Fernandez, Liliana Patricia; Talio, María Carolina; Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk; Royal Society of Chemistry; Analytical Methods; 18; 2; 12-2025; 361-371
1759-9660
1759-9679
CONICET Digital
CONICET
url http://hdl.handle.net/11336/289514
identifier_str_mv Paola Antonella, Avaca Gagliardi; Gomez, Germán Ernesto; Fernandez, Liliana Patricia; Talio, María Carolina; Luminescent metal–organic framework (MOF) sensors for sensitive determination of nicotine in breast milk; Royal Society of Chemistry; Analytical Methods; 18; 2; 12-2025; 361-371
1759-9660
1759-9679
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2025/AY/D5AY01777G
info:eu-repo/semantics/altIdentifier/doi/10.1039/D5AY01777G
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874774253530775552
score 13.265058

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