Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma

Autores
Pascual, Lourdes Inés; Real Varela, Sebastián Martín; Sosa Lochedino, Arianna Lourdes; Campo Verde Arbocco, Fiorella; Hapon, María Belén; Gamarra Luques, Carlos Diego
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Melanoma is one of the deathliest cancers worldwide and its incidence is reachingepidemic proportions. It is characterized by intrinsic chemo-resistance, low response ratesto treatment and high metastatic potential. Because of this, new therapeutic options arepermanently required. Tessaria absinthioides (Hook. & Arn.) DC. is a traditional medicinalplant, with antioxidant, selective cytotoxicity and anti-colorectal cancer evidence-basedproperties. This study aims to demonstrate the antitumoral and antimetastatic effectsof T. absinthioides decoction (DETa), correlating in vitro and in vivo activities in a murinemelanoma model. DETa was assayed on B16F0 murine non-metastatic cells to determinecytotoxicity and clonogenicity; while, in the B16F10 metastatic siblings, adhesion, woundhealing migration and Boyden chamber invasion were studied. The ex vivo intestinalsacmodel was used to quantify DETa bioavailability. Meanwhile, in C57BL6/wt mice,DETa was orally administered to evaluate its antitumoral and antimetastatic activities.DETa induced cytotoxicity in a dose- and time-dependent manner, affecting the longtermclonogenic survival, as well as the processes of adhesion and migration. Then, theintestinal absorption of DETa phenolics was proven, while the systemic anti-tumoral andanti-metastatic activities of DETa were confirmed. Results demonstrated that DETa hasantimelanoma activity promoting this botanical compound as a relevant agent for cancerresearch and treatment.
Fil: Pascual, Lourdes Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Real Varela, Sebastián Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Sosa Lochedino, Arianna Lourdes. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; Argentina
Fil: Campo Verde Arbocco, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
Materia
BOTANICAL COMPOUNDS
ASTERACEAE
CYTOTOXICITY
ANTITUMORAL
ANTIMETASTATIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
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oai:ri.conicet.gov.ar:11336/291035
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network_name_str CONICET Digital (CONICET)
spelling Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanomaPascual, Lourdes InésReal Varela, Sebastián MartínSosa Lochedino, Arianna LourdesCampo Verde Arbocco, FiorellaHapon, María BelénGamarra Luques, Carlos DiegoBOTANICAL COMPOUNDSASTERACEAECYTOTOXICITYANTITUMORALANTIMETASTATIChttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Melanoma is one of the deathliest cancers worldwide and its incidence is reachingepidemic proportions. It is characterized by intrinsic chemo-resistance, low response ratesto treatment and high metastatic potential. Because of this, new therapeutic options arepermanently required. Tessaria absinthioides (Hook. & Arn.) DC. is a traditional medicinalplant, with antioxidant, selective cytotoxicity and anti-colorectal cancer evidence-basedproperties. This study aims to demonstrate the antitumoral and antimetastatic effectsof T. absinthioides decoction (DETa), correlating in vitro and in vivo activities in a murinemelanoma model. DETa was assayed on B16F0 murine non-metastatic cells to determinecytotoxicity and clonogenicity; while, in the B16F10 metastatic siblings, adhesion, woundhealing migration and Boyden chamber invasion were studied. The ex vivo intestinalsacmodel was used to quantify DETa bioavailability. Meanwhile, in C57BL6/wt mice,DETa was orally administered to evaluate its antitumoral and antimetastatic activities.DETa induced cytotoxicity in a dose- and time-dependent manner, affecting the longtermclonogenic survival, as well as the processes of adhesion and migration. Then, theintestinal absorption of DETa phenolics was proven, while the systemic anti-tumoral andanti-metastatic activities of DETa were confirmed. Results demonstrated that DETa hasantimelanoma activity promoting this botanical compound as a relevant agent for cancerresearch and treatment.Fil: Pascual, Lourdes Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Real Varela, Sebastián Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; ArgentinaFil: Sosa Lochedino, Arianna Lourdes. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; ArgentinaFil: Campo Verde Arbocco, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; ArgentinaMultidisciplinary Digital Publishing Institute2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291035Pascual, Lourdes Inés; Real Varela, Sebastián Martín; Sosa Lochedino, Arianna Lourdes; Campo Verde Arbocco, Fiorella; Hapon, María Belén; et al.; Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma; Multidisciplinary Digital Publishing Institute; Plants; 14; 9; 5-2025; 1-182223-7747CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2223-7747/14/9/1379info:eu-repo/semantics/altIdentifier/doi/10.3390/plants14091379info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:10:28Zoai:ri.conicet.gov.ar:11336/291035instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:10:28.348CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
title Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
spellingShingle Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
Pascual, Lourdes Inés
BOTANICAL COMPOUNDS
ASTERACEAE
CYTOTOXICITY
ANTITUMORAL
ANTIMETASTATIC
title_short Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
title_full Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
title_fullStr Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
title_full_unstemmed Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
title_sort Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma
dc.creator.none.fl_str_mv Pascual, Lourdes Inés
Real Varela, Sebastián Martín
Sosa Lochedino, Arianna Lourdes
Campo Verde Arbocco, Fiorella
Hapon, María Belén
Gamarra Luques, Carlos Diego
author Pascual, Lourdes Inés
author_facet Pascual, Lourdes Inés
Real Varela, Sebastián Martín
Sosa Lochedino, Arianna Lourdes
Campo Verde Arbocco, Fiorella
Hapon, María Belén
Gamarra Luques, Carlos Diego
author_role author
author2 Real Varela, Sebastián Martín
Sosa Lochedino, Arianna Lourdes
Campo Verde Arbocco, Fiorella
Hapon, María Belén
Gamarra Luques, Carlos Diego
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BOTANICAL COMPOUNDS
ASTERACEAE
CYTOTOXICITY
ANTITUMORAL
ANTIMETASTATIC
topic BOTANICAL COMPOUNDS
ASTERACEAE
CYTOTOXICITY
ANTITUMORAL
ANTIMETASTATIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Melanoma is one of the deathliest cancers worldwide and its incidence is reachingepidemic proportions. It is characterized by intrinsic chemo-resistance, low response ratesto treatment and high metastatic potential. Because of this, new therapeutic options arepermanently required. Tessaria absinthioides (Hook. & Arn.) DC. is a traditional medicinalplant, with antioxidant, selective cytotoxicity and anti-colorectal cancer evidence-basedproperties. This study aims to demonstrate the antitumoral and antimetastatic effectsof T. absinthioides decoction (DETa), correlating in vitro and in vivo activities in a murinemelanoma model. DETa was assayed on B16F0 murine non-metastatic cells to determinecytotoxicity and clonogenicity; while, in the B16F10 metastatic siblings, adhesion, woundhealing migration and Boyden chamber invasion were studied. The ex vivo intestinalsacmodel was used to quantify DETa bioavailability. Meanwhile, in C57BL6/wt mice,DETa was orally administered to evaluate its antitumoral and antimetastatic activities.DETa induced cytotoxicity in a dose- and time-dependent manner, affecting the longtermclonogenic survival, as well as the processes of adhesion and migration. Then, theintestinal absorption of DETa phenolics was proven, while the systemic anti-tumoral andanti-metastatic activities of DETa were confirmed. Results demonstrated that DETa hasantimelanoma activity promoting this botanical compound as a relevant agent for cancerresearch and treatment.
Fil: Pascual, Lourdes Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Real Varela, Sebastián Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina
Fil: Sosa Lochedino, Arianna Lourdes. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; Argentina
Fil: Campo Verde Arbocco, Fiorella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Hapon, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Gamarra Luques, Carlos Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Fisiología; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
description Melanoma is one of the deathliest cancers worldwide and its incidence is reachingepidemic proportions. It is characterized by intrinsic chemo-resistance, low response ratesto treatment and high metastatic potential. Because of this, new therapeutic options arepermanently required. Tessaria absinthioides (Hook. & Arn.) DC. is a traditional medicinalplant, with antioxidant, selective cytotoxicity and anti-colorectal cancer evidence-basedproperties. This study aims to demonstrate the antitumoral and antimetastatic effectsof T. absinthioides decoction (DETa), correlating in vitro and in vivo activities in a murinemelanoma model. DETa was assayed on B16F0 murine non-metastatic cells to determinecytotoxicity and clonogenicity; while, in the B16F10 metastatic siblings, adhesion, woundhealing migration and Boyden chamber invasion were studied. The ex vivo intestinalsacmodel was used to quantify DETa bioavailability. Meanwhile, in C57BL6/wt mice,DETa was orally administered to evaluate its antitumoral and antimetastatic activities.DETa induced cytotoxicity in a dose- and time-dependent manner, affecting the longtermclonogenic survival, as well as the processes of adhesion and migration. Then, theintestinal absorption of DETa phenolics was proven, while the systemic anti-tumoral andanti-metastatic activities of DETa were confirmed. Results demonstrated that DETa hasantimelanoma activity promoting this botanical compound as a relevant agent for cancerresearch and treatment.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291035
Pascual, Lourdes Inés; Real Varela, Sebastián Martín; Sosa Lochedino, Arianna Lourdes; Campo Verde Arbocco, Fiorella; Hapon, María Belén; et al.; Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma; Multidisciplinary Digital Publishing Institute; Plants; 14; 9; 5-2025; 1-18
2223-7747
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291035
identifier_str_mv Pascual, Lourdes Inés; Real Varela, Sebastián Martín; Sosa Lochedino, Arianna Lourdes; Campo Verde Arbocco, Fiorella; Hapon, María Belén; et al.; Tessaria absinthioides (Hook. & Arn.) DC. Determines inhibition of tumor growth and metastasis in vitro and in vivo in murine melanoma; Multidisciplinary Digital Publishing Institute; Plants; 14; 9; 5-2025; 1-18
2223-7747
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3390/plants14091379
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
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dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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