Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment

Autores
Guiñez, María Evangelina; Martínez Pérez Cejuela, Héctor; Mandelli Roubineau, Alejandro Luis; Herrero Martínez, José M.; Cerutti, Estela Soledad
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Heterocyclic aromatic amines (HAAs) are organic pollutants originating from several emission sources and pose significant health risks. There is a gap in information regarding their concentration levels in environmental samples. This study presents a novel methodology for the extraction and preconcentration of HAAs in waters. The proposed methodology employs a μSPE strategy followed by ultra-high-performance liquid chromatography coupled to mass spectrometry determination. This methodology demonstrated a satisfactory alignment with the principles of green chemistry. The concentrations of HAAs detected ranged from non-detectable levels to 0.15 μg/L in irrigation water samples collected from rural areas, and up to 0.49 μg/L in urban areas. Additionally, drinking and bottled water samples exhibited concentrations ranging from 0.24 to 1.60 μg/L. Significantly lower concentrations of HAAs were observed in mineral water samples. Finally, an analysis of the incremental lifetime cancer risk associated with ingesting HAAs-contaminated water was conducted.
Fil: Guiñez, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Martínez Pérez Cejuela, Héctor. Universidad de Valencia; España
Fil: Mandelli Roubineau, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Herrero Martínez, José M.. Universidad de Valencia; España
Fil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
aqueous samples
organic pollutants
polymeric sorbent
cancer risk
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/264990
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/264990
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessmentGuiñez, María EvangelinaMartínez Pérez Cejuela, HéctorMandelli Roubineau, Alejandro LuisHerrero Martínez, José M.Cerutti, Estela Soledadaqueous samplesorganic pollutantspolymeric sorbentcancer riskhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Heterocyclic aromatic amines (HAAs) are organic pollutants originating from several emission sources and pose significant health risks. There is a gap in information regarding their concentration levels in environmental samples. This study presents a novel methodology for the extraction and preconcentration of HAAs in waters. The proposed methodology employs a μSPE strategy followed by ultra-high-performance liquid chromatography coupled to mass spectrometry determination. This methodology demonstrated a satisfactory alignment with the principles of green chemistry. The concentrations of HAAs detected ranged from non-detectable levels to 0.15 μg/L in irrigation water samples collected from rural areas, and up to 0.49 μg/L in urban areas. Additionally, drinking and bottled water samples exhibited concentrations ranging from 0.24 to 1.60 μg/L. Significantly lower concentrations of HAAs were observed in mineral water samples. Finally, an analysis of the incremental lifetime cancer risk associated with ingesting HAAs-contaminated water was conducted.Fil: Guiñez, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Martínez Pérez Cejuela, Héctor. Universidad de Valencia; EspañaFil: Mandelli Roubineau, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Herrero Martínez, José M.. Universidad de Valencia; EspañaFil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaPergamon-Elsevier Science Ltd2025-05info:eu-repo/date/embargoEnd/2025-11-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/264990Guiñez, María Evangelina; Martínez Pérez Cejuela, Héctor; Mandelli Roubineau, Alejandro Luis; Herrero Martínez, José M.; Cerutti, Estela Soledad; Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment; Pergamon-Elsevier Science Ltd; Food and Chemical Toxicology; 202; 5-2025; 1-350278-6915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0278691525003266info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2025.115558info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:10:40Zoai:ri.conicet.gov.ar:11336/264990instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:10:40.732CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
title Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
spellingShingle Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
Guiñez, María Evangelina
aqueous samples
organic pollutants
polymeric sorbent
cancer risk
title_short Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
title_full Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
title_fullStr Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
title_full_unstemmed Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
title_sort Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment
dc.creator.none.fl_str_mv Guiñez, María Evangelina
Martínez Pérez Cejuela, Héctor
Mandelli Roubineau, Alejandro Luis
Herrero Martínez, José M.
Cerutti, Estela Soledad
author Guiñez, María Evangelina
author_facet Guiñez, María Evangelina
Martínez Pérez Cejuela, Héctor
Mandelli Roubineau, Alejandro Luis
Herrero Martínez, José M.
Cerutti, Estela Soledad
author_role author
author2 Martínez Pérez Cejuela, Héctor
Mandelli Roubineau, Alejandro Luis
Herrero Martínez, José M.
Cerutti, Estela Soledad
author2_role author
author
author
author
dc.subject.none.fl_str_mv aqueous samples
organic pollutants
polymeric sorbent
cancer risk
topic aqueous samples
organic pollutants
polymeric sorbent
cancer risk
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Heterocyclic aromatic amines (HAAs) are organic pollutants originating from several emission sources and pose significant health risks. There is a gap in information regarding their concentration levels in environmental samples. This study presents a novel methodology for the extraction and preconcentration of HAAs in waters. The proposed methodology employs a μSPE strategy followed by ultra-high-performance liquid chromatography coupled to mass spectrometry determination. This methodology demonstrated a satisfactory alignment with the principles of green chemistry. The concentrations of HAAs detected ranged from non-detectable levels to 0.15 μg/L in irrigation water samples collected from rural areas, and up to 0.49 μg/L in urban areas. Additionally, drinking and bottled water samples exhibited concentrations ranging from 0.24 to 1.60 μg/L. Significantly lower concentrations of HAAs were observed in mineral water samples. Finally, an analysis of the incremental lifetime cancer risk associated with ingesting HAAs-contaminated water was conducted.
Fil: Guiñez, María Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Martínez Pérez Cejuela, Héctor. Universidad de Valencia; España
Fil: Mandelli Roubineau, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Herrero Martínez, José M.. Universidad de Valencia; España
Fil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description Heterocyclic aromatic amines (HAAs) are organic pollutants originating from several emission sources and pose significant health risks. There is a gap in information regarding their concentration levels in environmental samples. This study presents a novel methodology for the extraction and preconcentration of HAAs in waters. The proposed methodology employs a μSPE strategy followed by ultra-high-performance liquid chromatography coupled to mass spectrometry determination. This methodology demonstrated a satisfactory alignment with the principles of green chemistry. The concentrations of HAAs detected ranged from non-detectable levels to 0.15 μg/L in irrigation water samples collected from rural areas, and up to 0.49 μg/L in urban areas. Additionally, drinking and bottled water samples exhibited concentrations ranging from 0.24 to 1.60 μg/L. Significantly lower concentrations of HAAs were observed in mineral water samples. Finally, an analysis of the incremental lifetime cancer risk associated with ingesting HAAs-contaminated water was conducted.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
info:eu-repo/date/embargoEnd/2025-11-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/264990
Guiñez, María Evangelina; Martínez Pérez Cejuela, Héctor; Mandelli Roubineau, Alejandro Luis; Herrero Martínez, José M.; Cerutti, Estela Soledad; Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment; Pergamon-Elsevier Science Ltd; Food and Chemical Toxicology; 202; 5-2025; 1-35
0278-6915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/264990
identifier_str_mv Guiñez, María Evangelina; Martínez Pérez Cejuela, Héctor; Mandelli Roubineau, Alejandro Luis; Herrero Martínez, José M.; Cerutti, Estela Soledad; Quantitative evaluation of food-relevant heterocyclic aromatic amines in water samples for agricultural and human use. Selective extraction and cancer risk assessment; Pergamon-Elsevier Science Ltd; Food and Chemical Toxicology; 202; 5-2025; 1-35
0278-6915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0278691525003266
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fct.2025.115558
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874775252397981696
score 13.24418

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