Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline

Autores
Villa Perez, Cristian; Cadavid Vargas, Juan Fernando; Di Virgilio, Ana Laura; Echeverría, Gustavo Alberto; Camí, Gerardo Enrique; Soria, Delia Beatriz
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Three ternary complexes of sulfaquinoxaline (SQO-4-amino-N-2-quinoxalinylbenzenesulfonamide) or sulfamethazine (SMT-4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzenesulfonamide) with Cu(ii) or Ni(ii) and 2,2′-biquinoline (BQ) as an auxiliary ligand have been studied. Their structures have been determined by single-crystal X-ray crystallography as Ni(SQO)2(BQ)·2H2O (I), Cu(SQO)(BQ)Cl·CH3OH (II) and Cu(SMT)(BQ)Cl (III). Compounds I and II crystallize in the triclinic space group P1 while complex III crystallizes in the monoclinic P21/c space group. The crystal lattice of all complexes is stabilized by the presence of diverse intermolecular interactions as verified by Hirshfeld surface analysis. Besides, electronic spectroscopies have also been used to characterize the compounds. The thermal behavior of the complexes was investigated by thermogravimetric and differential thermal analyses. Furthermore, the cytotoxic effect of the compounds has been tested against A549 (lung cancer) and MG-63 (human osteosarcoma) cell lines using the MTT methodology.
Fil: Villa Perez, Cristian. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Cadavid Vargas, Juan Fernando. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Di Virgilio, Ana Laura. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Camí, Gerardo Enrique. Universidad Nacional de Rosario; Argentina
Fil: Soria, Delia Beatriz. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Materia
Sulfaquinoxaline
Sulfamethazine
X-ray structure
Hirshfeld surface calculations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93255
Acceder
id CONICETDig_49703e8f2bc7d9576dfc464afb168344
oai_identifier_str oai:ri.conicet.gov.ar:11336/93255
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinolineVilla Perez, CristianCadavid Vargas, Juan FernandoDi Virgilio, Ana LauraEcheverría, Gustavo AlbertoCamí, Gerardo EnriqueSoria, Delia BeatrizSulfaquinoxalineSulfamethazineX-ray structureHirshfeld surface calculationshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Three ternary complexes of sulfaquinoxaline (SQO-4-amino-N-2-quinoxalinylbenzenesulfonamide) or sulfamethazine (SMT-4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzenesulfonamide) with Cu(ii) or Ni(ii) and 2,2′-biquinoline (BQ) as an auxiliary ligand have been studied. Their structures have been determined by single-crystal X-ray crystallography as Ni(SQO)2(BQ)·2H2O (I), Cu(SQO)(BQ)Cl·CH3OH (II) and Cu(SMT)(BQ)Cl (III). Compounds I and II crystallize in the triclinic space group P1 while complex III crystallizes in the monoclinic P21/c space group. The crystal lattice of all complexes is stabilized by the presence of diverse intermolecular interactions as verified by Hirshfeld surface analysis. Besides, electronic spectroscopies have also been used to characterize the compounds. The thermal behavior of the complexes was investigated by thermogravimetric and differential thermal analyses. Furthermore, the cytotoxic effect of the compounds has been tested against A549 (lung cancer) and MG-63 (human osteosarcoma) cell lines using the MTT methodology.Fil: Villa Perez, Cristian. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; ArgentinaFil: Cadavid Vargas, Juan Fernando. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; ArgentinaFil: Di Virgilio, Ana Laura. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; ArgentinaFil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; ArgentinaFil: Camí, Gerardo Enrique. Universidad Nacional de Rosario; ArgentinaFil: Soria, Delia Beatriz. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; ArgentinaRoyal Society of Chemistry2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93255Villa Perez, Cristian; Cadavid Vargas, Juan Fernando; Di Virgilio, Ana Laura; Echeverría, Gustavo Alberto; Camí, Gerardo Enrique; et al.; Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline; Royal Society of Chemistry; New Journal of Chemistry; 42; 2; 12-2017; 891-9011144-0546CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C7NJ03624Hinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C7NJ03624Hinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:39:47Zoai:ri.conicet.gov.ar:11336/93255instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:39:47.996CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
title Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
spellingShingle Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
Villa Perez, Cristian
Sulfaquinoxaline
Sulfamethazine
X-ray structure
Hirshfeld surface calculations
title_short Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
title_full Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
title_fullStr Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
title_full_unstemmed Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
title_sort Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline
dc.creator.none.fl_str_mv Villa Perez, Cristian
Cadavid Vargas, Juan Fernando
Di Virgilio, Ana Laura
Echeverría, Gustavo Alberto
Camí, Gerardo Enrique
Soria, Delia Beatriz
author Villa Perez, Cristian
author_facet Villa Perez, Cristian
Cadavid Vargas, Juan Fernando
Di Virgilio, Ana Laura
Echeverría, Gustavo Alberto
Camí, Gerardo Enrique
Soria, Delia Beatriz
author_role author
author2 Cadavid Vargas, Juan Fernando
Di Virgilio, Ana Laura
Echeverría, Gustavo Alberto
Camí, Gerardo Enrique
Soria, Delia Beatriz
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Sulfaquinoxaline
Sulfamethazine
X-ray structure
Hirshfeld surface calculations
topic Sulfaquinoxaline
Sulfamethazine
X-ray structure
Hirshfeld surface calculations
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Three ternary complexes of sulfaquinoxaline (SQO-4-amino-N-2-quinoxalinylbenzenesulfonamide) or sulfamethazine (SMT-4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzenesulfonamide) with Cu(ii) or Ni(ii) and 2,2′-biquinoline (BQ) as an auxiliary ligand have been studied. Their structures have been determined by single-crystal X-ray crystallography as Ni(SQO)2(BQ)·2H2O (I), Cu(SQO)(BQ)Cl·CH3OH (II) and Cu(SMT)(BQ)Cl (III). Compounds I and II crystallize in the triclinic space group P1 while complex III crystallizes in the monoclinic P21/c space group. The crystal lattice of all complexes is stabilized by the presence of diverse intermolecular interactions as verified by Hirshfeld surface analysis. Besides, electronic spectroscopies have also been used to characterize the compounds. The thermal behavior of the complexes was investigated by thermogravimetric and differential thermal analyses. Furthermore, the cytotoxic effect of the compounds has been tested against A549 (lung cancer) and MG-63 (human osteosarcoma) cell lines using the MTT methodology.
Fil: Villa Perez, Cristian. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Cadavid Vargas, Juan Fernando. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Di Virgilio, Ana Laura. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Echeverría, Gustavo Alberto. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
Fil: Camí, Gerardo Enrique. Universidad Nacional de Rosario; Argentina
Fil: Soria, Delia Beatriz. Facultad de Ciencias Exactas, Universidad Nacional de la Plata; Argentina
description Three ternary complexes of sulfaquinoxaline (SQO-4-amino-N-2-quinoxalinylbenzenesulfonamide) or sulfamethazine (SMT-4-amino-N-(4,6-dimethylpyrimidin-2-yl)-benzenesulfonamide) with Cu(ii) or Ni(ii) and 2,2′-biquinoline (BQ) as an auxiliary ligand have been studied. Their structures have been determined by single-crystal X-ray crystallography as Ni(SQO)2(BQ)·2H2O (I), Cu(SQO)(BQ)Cl·CH3OH (II) and Cu(SMT)(BQ)Cl (III). Compounds I and II crystallize in the triclinic space group P1 while complex III crystallizes in the monoclinic P21/c space group. The crystal lattice of all complexes is stabilized by the presence of diverse intermolecular interactions as verified by Hirshfeld surface analysis. Besides, electronic spectroscopies have also been used to characterize the compounds. The thermal behavior of the complexes was investigated by thermogravimetric and differential thermal analyses. Furthermore, the cytotoxic effect of the compounds has been tested against A549 (lung cancer) and MG-63 (human osteosarcoma) cell lines using the MTT methodology.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93255
Villa Perez, Cristian; Cadavid Vargas, Juan Fernando; Di Virgilio, Ana Laura; Echeverría, Gustavo Alberto; Camí, Gerardo Enrique; et al.; Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline; Royal Society of Chemistry; New Journal of Chemistry; 42; 2; 12-2017; 891-901
1144-0546
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93255
identifier_str_mv Villa Perez, Cristian; Cadavid Vargas, Juan Fernando; Di Virgilio, Ana Laura; Echeverría, Gustavo Alberto; Camí, Gerardo Enrique; et al.; Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline; Royal Society of Chemistry; New Journal of Chemistry; 42; 2; 12-2017; 891-901
1144-0546
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C7NJ03624H
info:eu-repo/semantics/altIdentifier/doi/10.1039/C7NJ03624H
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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