Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring

Autores
Bartos, Mariana; Gallegos, Cristina Eugenia; Baier, Carlos Javier; Dominguez, Sergio Ariel; Lencinas, Ileana Beatriz; García, Betina Noemi; Delbés, Andrés J.; Gumilar, Fernanda Andrea
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Drinking water is the main route of fluoride (F) exposure. In the Chaco-Pampean region, rural and peri-urban aquifers often have elevated F, posing health risks. F crosses the placenta and is present in maternal milk; developmental exposure has been linked to neurobehavioral alterations in rat offspring, though mechanisms remain unclear.We evaluated behavior and blood biochemical parameters in 45-day-old female offspring exposed to 10 mg/L F during gestation and lactation. Sociability was assessed using the Three-Chamber Social Test and Reciprocal Social Interaction, and obsessive-compulsive–like behavior with the Marble Burying Test. Serum levels of glucose, urea, creatinine, total cholesterol, triglycerides, and the activity of alkaline phosphatase, lactate dehydrogenase, creatine kinase, and the transaminases GOT and GPT were determined using enzymatic and UV-kinetic methods.F exposure induced significant metabolic alterations, including increased glucose and cholesterol and reduced enzymatic biomarkers. Trends toward decreased sociability and increased obsessive-compulsive–like behavior were observed but were not statistically significant.These results highlight the relevance of metabolic disruptions in developmental F toxicity and the need for further research on neurobehavioral effects. Raising awareness of F toxicity during pre- and postnatal development is essential for promoting safe drinking water, particularly during pregnancy and lactation.
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Dominguez, Sergio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Lencinas, Ileana Beatriz. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: García, Betina Noemi. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Delbés, Andrés J.. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
XL SAN Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigaciones en Neurociencias
Materia
FLUORIDE
DEVELOPMENTAL EXPOSURE
RAT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/288253
Acceder
id CONICETDig_4f9c0adc3e4224265f52a0668a9c71f1
oai_identifier_str oai:ri.conicet.gov.ar:11336/288253
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspringBartos, MarianaGallegos, Cristina EugeniaBaier, Carlos JavierDominguez, Sergio ArielLencinas, Ileana BeatrizGarcía, Betina NoemiDelbés, Andrés J.Gumilar, Fernanda AndreaFLUORIDEDEVELOPMENTAL EXPOSURERAThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Drinking water is the main route of fluoride (F) exposure. In the Chaco-Pampean region, rural and peri-urban aquifers often have elevated F, posing health risks. F crosses the placenta and is present in maternal milk; developmental exposure has been linked to neurobehavioral alterations in rat offspring, though mechanisms remain unclear.We evaluated behavior and blood biochemical parameters in 45-day-old female offspring exposed to 10 mg/L F during gestation and lactation. Sociability was assessed using the Three-Chamber Social Test and Reciprocal Social Interaction, and obsessive-compulsive–like behavior with the Marble Burying Test. Serum levels of glucose, urea, creatinine, total cholesterol, triglycerides, and the activity of alkaline phosphatase, lactate dehydrogenase, creatine kinase, and the transaminases GOT and GPT were determined using enzymatic and UV-kinetic methods.F exposure induced significant metabolic alterations, including increased glucose and cholesterol and reduced enzymatic biomarkers. Trends toward decreased sociability and increased obsessive-compulsive–like behavior were observed but were not statistically significant.These results highlight the relevance of metabolic disruptions in developmental F toxicity and the need for further research on neurobehavioral effects. Raising awareness of F toxicity during pre- and postnatal development is essential for promoting safe drinking water, particularly during pregnancy and lactation.Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Dominguez, Sergio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Lencinas, Ileana Beatriz. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: García, Betina Noemi. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Delbés, Andrés J.. Universidad Nacional del Sur. Departamento de Química; ArgentinaFil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaXL SAN MeetingBuenos AiresArgentinaSociedad Argentina de Investigaciones en NeurocienciasSociedad Argentina de Investigaciones en NeurocienciasAmigo Durán, Macarena2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/288253Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring; XL SAN Meeting; Buenos Aires; Argentina; 2025; 97-97CONICET DigitalCONICETenghttps://csan2025.saneurociencias.org.ar/info:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/info:eu-repo/semantics/altIdentifier/url/https://csan2025.saneurociencias.org.ar/wp-content/uploads/2025/10/SAN2025-Poster-EBOOK-.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:35:37Zoai:ri.conicet.gov.ar:11336/288253instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:35:37.7CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
title Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
spellingShingle Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
Bartos, Mariana
FLUORIDE
DEVELOPMENTAL EXPOSURE
RAT
title_short Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
title_full Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
title_fullStr Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
title_full_unstemmed Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
title_sort Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring
dc.creator.none.fl_str_mv Bartos, Mariana
Gallegos, Cristina Eugenia
Baier, Carlos Javier
Dominguez, Sergio Ariel
Lencinas, Ileana Beatriz
García, Betina Noemi
Delbés, Andrés J.
Gumilar, Fernanda Andrea
author Bartos, Mariana
author_facet Bartos, Mariana
Gallegos, Cristina Eugenia
Baier, Carlos Javier
Dominguez, Sergio Ariel
Lencinas, Ileana Beatriz
García, Betina Noemi
Delbés, Andrés J.
Gumilar, Fernanda Andrea
author_role author
author2 Gallegos, Cristina Eugenia
Baier, Carlos Javier
Dominguez, Sergio Ariel
Lencinas, Ileana Beatriz
García, Betina Noemi
Delbés, Andrés J.
Gumilar, Fernanda Andrea
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Amigo Durán, Macarena
dc.subject.none.fl_str_mv FLUORIDE
DEVELOPMENTAL EXPOSURE
RAT
topic FLUORIDE
DEVELOPMENTAL EXPOSURE
RAT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Drinking water is the main route of fluoride (F) exposure. In the Chaco-Pampean region, rural and peri-urban aquifers often have elevated F, posing health risks. F crosses the placenta and is present in maternal milk; developmental exposure has been linked to neurobehavioral alterations in rat offspring, though mechanisms remain unclear.We evaluated behavior and blood biochemical parameters in 45-day-old female offspring exposed to 10 mg/L F during gestation and lactation. Sociability was assessed using the Three-Chamber Social Test and Reciprocal Social Interaction, and obsessive-compulsive–like behavior with the Marble Burying Test. Serum levels of glucose, urea, creatinine, total cholesterol, triglycerides, and the activity of alkaline phosphatase, lactate dehydrogenase, creatine kinase, and the transaminases GOT and GPT were determined using enzymatic and UV-kinetic methods.F exposure induced significant metabolic alterations, including increased glucose and cholesterol and reduced enzymatic biomarkers. Trends toward decreased sociability and increased obsessive-compulsive–like behavior were observed but were not statistically significant.These results highlight the relevance of metabolic disruptions in developmental F toxicity and the need for further research on neurobehavioral effects. Raising awareness of F toxicity during pre- and postnatal development is essential for promoting safe drinking water, particularly during pregnancy and lactation.
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Baier, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Dominguez, Sergio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Lencinas, Ileana Beatriz. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: García, Betina Noemi. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Delbés, Andrés J.. Universidad Nacional del Sur. Departamento de Química; Argentina
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
XL SAN Meeting
Buenos Aires
Argentina
Sociedad Argentina de Investigaciones en Neurociencias
description Drinking water is the main route of fluoride (F) exposure. In the Chaco-Pampean region, rural and peri-urban aquifers often have elevated F, posing health risks. F crosses the placenta and is present in maternal milk; developmental exposure has been linked to neurobehavioral alterations in rat offspring, though mechanisms remain unclear.We evaluated behavior and blood biochemical parameters in 45-day-old female offspring exposed to 10 mg/L F during gestation and lactation. Sociability was assessed using the Three-Chamber Social Test and Reciprocal Social Interaction, and obsessive-compulsive–like behavior with the Marble Burying Test. Serum levels of glucose, urea, creatinine, total cholesterol, triglycerides, and the activity of alkaline phosphatase, lactate dehydrogenase, creatine kinase, and the transaminases GOT and GPT were determined using enzymatic and UV-kinetic methods.F exposure induced significant metabolic alterations, including increased glucose and cholesterol and reduced enzymatic biomarkers. Trends toward decreased sociability and increased obsessive-compulsive–like behavior were observed but were not statistically significant.These results highlight the relevance of metabolic disruptions in developmental F toxicity and the need for further research on neurobehavioral effects. Raising awareness of F toxicity during pre- and postnatal development is essential for promoting safe drinking water, particularly during pregnancy and lactation.
publishDate 2025
dc.date.none.fl_str_mv 2025
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dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/288253
Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring; XL SAN Meeting; Buenos Aires; Argentina; 2025; 97-97
CONICET Digital
CONICET
url http://hdl.handle.net/11336/288253
identifier_str_mv Developmental Fluoride exposure: assessment of sociability, obsessive-compulsive behavior, and blood biochemistry in female rat offspring; XL SAN Meeting; Buenos Aires; Argentina; 2025; 97-97
CONICET Digital
CONICET
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language eng
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dc.publisher.none.fl_str_mv Sociedad Argentina de Investigaciones en Neurociencias
publisher.none.fl_str_mv Sociedad Argentina de Investigaciones en Neurociencias
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