Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances

Autores
Binda, Leonardo David; Cachile, Mario Andres; D'angelo, María Verónica; Martínez Ceron, María Camila
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Conventional drug delivery systems often lead to fluctuating plasma concentrations (“Peak and Trough” phenomenon), causing toxicity or inefficacy. Microfluidics has emerged as a revolutionary tool to overcome, among other applications, the limitations of conventional bulk encapsulation methods, such as polydispersity and poor reproducibility. Methods: A systematic review of the literature published between 2020 and 2025 was conducted to evaluate the application of microfluidics in the synthesis of advanced nanomedicines. The review focused on Lipid Nanoparticles (LNPs), Polymeric Nanoparticles (PNPs), and Hydrogel Microspheres. Results: Microfluidics enables the production of monodisperse particles with precise control over geometry and drug loading stoichiometry. Key therapeutic applications include oncology (passive and active targeting), gene therapy (mRNA vaccines), and regenerative medicine (diabetic wound healing). Conclusions: While microfluidics offers superior quality control compared to bulk methods, industrial scalability remains the primary challenge, currently addressed through parallelization and continuous flow strategies.
Fil: Binda, Leonardo David. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cachile, Mario Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina
Fil: D'angelo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina
Fil: Martínez Ceron, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina
Materia
microfluidics
drug delivery
nanoparticles
liposomes
hydrogels
scalability
encapsulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291792
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent AdvancesBinda, Leonardo DavidCachile, Mario AndresD'angelo, María VerónicaMartínez Ceron, María Camilamicrofluidicsdrug deliverynanoparticlesliposomeshydrogelsscalabilityencapsulationhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Background: Conventional drug delivery systems often lead to fluctuating plasma concentrations (“Peak and Trough” phenomenon), causing toxicity or inefficacy. Microfluidics has emerged as a revolutionary tool to overcome, among other applications, the limitations of conventional bulk encapsulation methods, such as polydispersity and poor reproducibility. Methods: A systematic review of the literature published between 2020 and 2025 was conducted to evaluate the application of microfluidics in the synthesis of advanced nanomedicines. The review focused on Lipid Nanoparticles (LNPs), Polymeric Nanoparticles (PNPs), and Hydrogel Microspheres. Results: Microfluidics enables the production of monodisperse particles with precise control over geometry and drug loading stoichiometry. Key therapeutic applications include oncology (passive and active targeting), gene therapy (mRNA vaccines), and regenerative medicine (diabetic wound healing). Conclusions: While microfluidics offers superior quality control compared to bulk methods, industrial scalability remains the primary challenge, currently addressed through parallelization and continuous flow strategies.Fil: Binda, Leonardo David. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cachile, Mario Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: D'angelo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; ArgentinaFil: Martínez Ceron, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; ArgentinaMDPI2026-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291792Binda, Leonardo David; Cachile, Mario Andres; D'angelo, María Verónica; Martínez Ceron, María Camila; Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances; MDPI; Journal of Pharmaceutical and BioTech Industry; 3; 13; 6-2026; 2-262813-9380CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2813-9380/3/2/13info:eu-repo/semantics/altIdentifier/doi/10.3390/jpbi3020013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:37:29Zoai:ri.conicet.gov.ar:11336/291792instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:37:29.584CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
title Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
spellingShingle Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
Binda, Leonardo David
microfluidics
drug delivery
nanoparticles
liposomes
hydrogels
scalability
encapsulation
title_short Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
title_full Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
title_fullStr Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
title_full_unstemmed Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
title_sort Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances
dc.creator.none.fl_str_mv Binda, Leonardo David
Cachile, Mario Andres
D'angelo, María Verónica
Martínez Ceron, María Camila
author Binda, Leonardo David
author_facet Binda, Leonardo David
Cachile, Mario Andres
D'angelo, María Verónica
Martínez Ceron, María Camila
author_role author
author2 Cachile, Mario Andres
D'angelo, María Verónica
Martínez Ceron, María Camila
author2_role author
author
author
dc.subject.none.fl_str_mv microfluidics
drug delivery
nanoparticles
liposomes
hydrogels
scalability
encapsulation
topic microfluidics
drug delivery
nanoparticles
liposomes
hydrogels
scalability
encapsulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Background: Conventional drug delivery systems often lead to fluctuating plasma concentrations (“Peak and Trough” phenomenon), causing toxicity or inefficacy. Microfluidics has emerged as a revolutionary tool to overcome, among other applications, the limitations of conventional bulk encapsulation methods, such as polydispersity and poor reproducibility. Methods: A systematic review of the literature published between 2020 and 2025 was conducted to evaluate the application of microfluidics in the synthesis of advanced nanomedicines. The review focused on Lipid Nanoparticles (LNPs), Polymeric Nanoparticles (PNPs), and Hydrogel Microspheres. Results: Microfluidics enables the production of monodisperse particles with precise control over geometry and drug loading stoichiometry. Key therapeutic applications include oncology (passive and active targeting), gene therapy (mRNA vaccines), and regenerative medicine (diabetic wound healing). Conclusions: While microfluidics offers superior quality control compared to bulk methods, industrial scalability remains the primary challenge, currently addressed through parallelization and continuous flow strategies.
Fil: Binda, Leonardo David. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Cachile, Mario Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina
Fil: D'angelo, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Grupo de Medios Porosos; Argentina
Fil: Martínez Ceron, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Ingeniería Biomédica; Argentina
description Background: Conventional drug delivery systems often lead to fluctuating plasma concentrations (“Peak and Trough” phenomenon), causing toxicity or inefficacy. Microfluidics has emerged as a revolutionary tool to overcome, among other applications, the limitations of conventional bulk encapsulation methods, such as polydispersity and poor reproducibility. Methods: A systematic review of the literature published between 2020 and 2025 was conducted to evaluate the application of microfluidics in the synthesis of advanced nanomedicines. The review focused on Lipid Nanoparticles (LNPs), Polymeric Nanoparticles (PNPs), and Hydrogel Microspheres. Results: Microfluidics enables the production of monodisperse particles with precise control over geometry and drug loading stoichiometry. Key therapeutic applications include oncology (passive and active targeting), gene therapy (mRNA vaccines), and regenerative medicine (diabetic wound healing). Conclusions: While microfluidics offers superior quality control compared to bulk methods, industrial scalability remains the primary challenge, currently addressed through parallelization and continuous flow strategies.
publishDate 2026
dc.date.none.fl_str_mv 2026-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291792
Binda, Leonardo David; Cachile, Mario Andres; D'angelo, María Verónica; Martínez Ceron, María Camila; Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances; MDPI; Journal of Pharmaceutical and BioTech Industry; 3; 13; 6-2026; 2-26
2813-9380
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291792
identifier_str_mv Binda, Leonardo David; Cachile, Mario Andres; D'angelo, María Verónica; Martínez Ceron, María Camila; Microfluidics for Drug Encapsulation and Controlled Release: A Systematic Review of Recent Advances; MDPI; Journal of Pharmaceutical and BioTech Industry; 3; 13; 6-2026; 2-26
2813-9380
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2813-9380/3/2/13
info:eu-repo/semantics/altIdentifier/doi/10.3390/jpbi3020013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24418

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