HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality

Autores
Olivera, Carolina; Paira, Daniela Andrea; Olmedo, Andres; Olmedo, Jose J.; Tissera, Andrea Daniela; Molina, Rosa Isabel; Ferreyra, Fernando Nicolás; Martinez, María Sol; Chocobar Torres, Yair Aron; Cuffini, Cecilia Gabriela; Motrich, Ruben Dario; Rivero, Virginia Elena
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide, which has been suggested to induce male urogenital inflammation and affect fertility. However, reported evidence is scarce and inconclusive. Moreover, the putative effects of coinfections remain largely unexplored. This study aimed to analyze HPV male urogenital infection, both as a single infection and in conjunction with other common uropathogens, along with its impact on inflammatory biomarkers in semen, oxidative stress and sperm quality.Methods: The prevalence of HPV urogenital infection and its coinfection with several other uropathogens was analyzed in a cohort of 205 men attending a urology clinic. Furthermore, levels of sperm leukocyte subsets and inflammatory cytokines, semen analysis, sperm apoptosis and necrosis, and sperm ROS production were assessed.Results: A considerable prevalence (19%) of HPV male urogenital infection was found. Interestingly, HPV was detected coinfecting with at least one other uropathogen in most cases (74.4%). Notably, the most frequently detected coinfection was C. trachomatis (CT, 52% of cases). Remarkably, patients solely infected with HPV showed no significant alterations in conventional sperm quality parameters as well as reduced concentrations of IL-6 and leukocytes in semen. However, patients coinfected with HPV and CT showed significantly impaired sperm concentration and motility and increased levels of IL-6 in semen.Conclusion: These results indicate that HPV infection alone does not associate with semen inflammation or major changes in sperm quality. However, co-infection with CT is associated with both semen inflammation and reduced sperm quality. This indicates that, besides being prevalent, concurrent HPV and CT infections in semen may represent a unique clinical entity with particular characteristics.
Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Paira, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Olmedo, Andres. Universidad Nacional de Córdoba; Argentina
Fil: Olmedo, Jose J.. Centro de Inmunología Clínica de Córdoba; Argentina. Fundación Urológica Córdoba para la Docencia e Investigación Médica; Argentina
Fil: Tissera, Andrea Daniela. Centro de Inmunología Clínica de Córdoba; Argentina. Laboratorio de Andrologia y Reproduccion; Argentina
Fil: Molina, Rosa Isabel. Centro de Inmunología Clínica de Córdoba; Argentina. Laboratorio de Andrologia y Reproduccion; Argentina
Fil: Ferreyra, Fernando Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Martinez, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Chocobar Torres, Yair Aron. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Cuffini, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Rivero, Virginia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Materia
HPV
Chlamydia trachomatis
Infection
Semen
Inflammation
Fertility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/289647
Acceder
id CONICETDig_60739f6a7e1bcabb48b731cdcf514714
oai_identifier_str oai:ri.conicet.gov.ar:11336/289647
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm qualityOlivera, CarolinaPaira, Daniela AndreaOlmedo, AndresOlmedo, Jose J.Tissera, Andrea DanielaMolina, Rosa IsabelFerreyra, Fernando NicolásMartinez, María SolChocobar Torres, Yair AronCuffini, Cecilia GabrielaMotrich, Ruben DarioRivero, Virginia ElenaHPVChlamydia trachomatisInfectionSemenInflammationFertilityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Introduction: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide, which has been suggested to induce male urogenital inflammation and affect fertility. However, reported evidence is scarce and inconclusive. Moreover, the putative effects of coinfections remain largely unexplored. This study aimed to analyze HPV male urogenital infection, both as a single infection and in conjunction with other common uropathogens, along with its impact on inflammatory biomarkers in semen, oxidative stress and sperm quality.Methods: The prevalence of HPV urogenital infection and its coinfection with several other uropathogens was analyzed in a cohort of 205 men attending a urology clinic. Furthermore, levels of sperm leukocyte subsets and inflammatory cytokines, semen analysis, sperm apoptosis and necrosis, and sperm ROS production were assessed.Results: A considerable prevalence (19%) of HPV male urogenital infection was found. Interestingly, HPV was detected coinfecting with at least one other uropathogen in most cases (74.4%). Notably, the most frequently detected coinfection was C. trachomatis (CT, 52% of cases). Remarkably, patients solely infected with HPV showed no significant alterations in conventional sperm quality parameters as well as reduced concentrations of IL-6 and leukocytes in semen. However, patients coinfected with HPV and CT showed significantly impaired sperm concentration and motility and increased levels of IL-6 in semen.Conclusion: These results indicate that HPV infection alone does not associate with semen inflammation or major changes in sperm quality. However, co-infection with CT is associated with both semen inflammation and reduced sperm quality. This indicates that, besides being prevalent, concurrent HPV and CT infections in semen may represent a unique clinical entity with particular characteristics.Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFil: Paira, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFil: Olmedo, Andres. Universidad Nacional de Córdoba; ArgentinaFil: Olmedo, Jose J.. Centro de Inmunología Clínica de Córdoba; Argentina. Fundación Urológica Córdoba para la Docencia e Investigación Médica; ArgentinaFil: Tissera, Andrea Daniela. Centro de Inmunología Clínica de Córdoba; Argentina. Laboratorio de Andrologia y Reproduccion; ArgentinaFil: Molina, Rosa Isabel. Centro de Inmunología Clínica de Córdoba; Argentina. Laboratorio de Andrologia y Reproduccion; ArgentinaFil: Ferreyra, Fernando Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFil: Martinez, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFil: Chocobar Torres, Yair Aron. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFil: Cuffini, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFil: Rivero, Virginia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; ArgentinaFrontiers Media2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/289647Olivera, Carolina; Paira, Daniela Andrea; Olmedo, Andres; Olmedo, Jose J.; Tissera, Andrea Daniela; et al.; HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 15; 3-2025; 1-132235-2988CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fcimb.2025.1539871/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2025.1539871info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:38:59Zoai:ri.conicet.gov.ar:11336/289647instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:38:59.677CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
title HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
spellingShingle HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
Olivera, Carolina
HPV
Chlamydia trachomatis
Infection
Semen
Inflammation
Fertility
title_short HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
title_full HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
title_fullStr HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
title_full_unstemmed HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
title_sort HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality
dc.creator.none.fl_str_mv Olivera, Carolina
Paira, Daniela Andrea
Olmedo, Andres
Olmedo, Jose J.
Tissera, Andrea Daniela
Molina, Rosa Isabel
Ferreyra, Fernando Nicolás
Martinez, María Sol
Chocobar Torres, Yair Aron
Cuffini, Cecilia Gabriela
Motrich, Ruben Dario
Rivero, Virginia Elena
author Olivera, Carolina
author_facet Olivera, Carolina
Paira, Daniela Andrea
Olmedo, Andres
Olmedo, Jose J.
Tissera, Andrea Daniela
Molina, Rosa Isabel
Ferreyra, Fernando Nicolás
Martinez, María Sol
Chocobar Torres, Yair Aron
Cuffini, Cecilia Gabriela
Motrich, Ruben Dario
Rivero, Virginia Elena
author_role author
author2 Paira, Daniela Andrea
Olmedo, Andres
Olmedo, Jose J.
Tissera, Andrea Daniela
Molina, Rosa Isabel
Ferreyra, Fernando Nicolás
Martinez, María Sol
Chocobar Torres, Yair Aron
Cuffini, Cecilia Gabriela
Motrich, Ruben Dario
Rivero, Virginia Elena
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HPV
Chlamydia trachomatis
Infection
Semen
Inflammation
Fertility
topic HPV
Chlamydia trachomatis
Infection
Semen
Inflammation
Fertility
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide, which has been suggested to induce male urogenital inflammation and affect fertility. However, reported evidence is scarce and inconclusive. Moreover, the putative effects of coinfections remain largely unexplored. This study aimed to analyze HPV male urogenital infection, both as a single infection and in conjunction with other common uropathogens, along with its impact on inflammatory biomarkers in semen, oxidative stress and sperm quality.Methods: The prevalence of HPV urogenital infection and its coinfection with several other uropathogens was analyzed in a cohort of 205 men attending a urology clinic. Furthermore, levels of sperm leukocyte subsets and inflammatory cytokines, semen analysis, sperm apoptosis and necrosis, and sperm ROS production were assessed.Results: A considerable prevalence (19%) of HPV male urogenital infection was found. Interestingly, HPV was detected coinfecting with at least one other uropathogen in most cases (74.4%). Notably, the most frequently detected coinfection was C. trachomatis (CT, 52% of cases). Remarkably, patients solely infected with HPV showed no significant alterations in conventional sperm quality parameters as well as reduced concentrations of IL-6 and leukocytes in semen. However, patients coinfected with HPV and CT showed significantly impaired sperm concentration and motility and increased levels of IL-6 in semen.Conclusion: These results indicate that HPV infection alone does not associate with semen inflammation or major changes in sperm quality. However, co-infection with CT is associated with both semen inflammation and reduced sperm quality. This indicates that, besides being prevalent, concurrent HPV and CT infections in semen may represent a unique clinical entity with particular characteristics.
Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Paira, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Olmedo, Andres. Universidad Nacional de Córdoba; Argentina
Fil: Olmedo, Jose J.. Centro de Inmunología Clínica de Córdoba; Argentina. Fundación Urológica Córdoba para la Docencia e Investigación Médica; Argentina
Fil: Tissera, Andrea Daniela. Centro de Inmunología Clínica de Córdoba; Argentina. Laboratorio de Andrologia y Reproduccion; Argentina
Fil: Molina, Rosa Isabel. Centro de Inmunología Clínica de Córdoba; Argentina. Laboratorio de Andrologia y Reproduccion; Argentina
Fil: Ferreyra, Fernando Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Martinez, María Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Chocobar Torres, Yair Aron. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Cuffini, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina
Fil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
Fil: Rivero, Virginia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina. Centro de Inmunología Clínica de Córdoba; Argentina
description Introduction: Human papillomavirus (HPV) is the most common sexually transmitted viral infection worldwide, which has been suggested to induce male urogenital inflammation and affect fertility. However, reported evidence is scarce and inconclusive. Moreover, the putative effects of coinfections remain largely unexplored. This study aimed to analyze HPV male urogenital infection, both as a single infection and in conjunction with other common uropathogens, along with its impact on inflammatory biomarkers in semen, oxidative stress and sperm quality.Methods: The prevalence of HPV urogenital infection and its coinfection with several other uropathogens was analyzed in a cohort of 205 men attending a urology clinic. Furthermore, levels of sperm leukocyte subsets and inflammatory cytokines, semen analysis, sperm apoptosis and necrosis, and sperm ROS production were assessed.Results: A considerable prevalence (19%) of HPV male urogenital infection was found. Interestingly, HPV was detected coinfecting with at least one other uropathogen in most cases (74.4%). Notably, the most frequently detected coinfection was C. trachomatis (CT, 52% of cases). Remarkably, patients solely infected with HPV showed no significant alterations in conventional sperm quality parameters as well as reduced concentrations of IL-6 and leukocytes in semen. However, patients coinfected with HPV and CT showed significantly impaired sperm concentration and motility and increased levels of IL-6 in semen.Conclusion: These results indicate that HPV infection alone does not associate with semen inflammation or major changes in sperm quality. However, co-infection with CT is associated with both semen inflammation and reduced sperm quality. This indicates that, besides being prevalent, concurrent HPV and CT infections in semen may represent a unique clinical entity with particular characteristics.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/289647
Olivera, Carolina; Paira, Daniela Andrea; Olmedo, Andres; Olmedo, Jose J.; Tissera, Andrea Daniela; et al.; HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 15; 3-2025; 1-13
2235-2988
CONICET Digital
CONICET
url http://hdl.handle.net/11336/289647
identifier_str_mv Olivera, Carolina; Paira, Daniela Andrea; Olmedo, Andres; Olmedo, Jose J.; Tissera, Andrea Daniela; et al.; HPV and co-infections: impacts on semen inflammation, oxidative stress, and sperm quality; Frontiers Media; Frontiers in Cellular and Infection Microbiology; 15; 3-2025; 1-13
2235-2988
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fcimb.2025.1539871
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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