3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy

Autores
Rivero Berti, Ignacio; Horue, Manuel; Boztepe, Tugce; Katz, Sergio Fabian; Islan, German Abel; Karp, Federico
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chronic and acute wounds are important health system problems due to re-hospitalization rates and treatment engagement. Antibiotic-controlled release systems can be a relevant solution for generating long-term therapies without patient intervention. The present work investigated pH-sensitive biopolymeric systems obtained by extrusion-based 3D printing. Alginate and carboxymethyl chitosan were used as matrix polymers for ink production, while octenidine was the vehiculized antibiotic. Different polymer proportions were explored to evaluate the release mechanism in response to different pH environments. Physicochemical characterization was performed using infrared spectrometry (FTIR) and thermogravimetric analysis (TGA). Detailed photography was used to determine 3D-printing fidelity. SEM images were used for the morphological characterization. Swelling and octenidine release profiles were evaluated in different non-chelating buffers. After the print´s crosslinking bath, the obtained encapsulation efficiency was 100%. The printing fidelity was in the order of 0.9 - 1.8. Swelling studies showed that some formulations lost weight, whereas others increased by 400%. After 7 days, the drug released was 20 - 85%, depending on the polymer composition and buffer/pH environment. All the prints presented antimicrobial capacity against Staphylococcus aureus. The present work demonstrates the potential of biopolymeric 3D-printed systems as advanced wound dressings, combining pH-responsive antibiotic release and antimicrobial activity with the adaptive design capabilities of 3D printing, offering a versatile platform for personalized wound-healing therapies.
Fil: Rivero Berti, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Horue, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Boztepe, Tugce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Katz, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Karp, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Materia
3D-PRINTER BIOPOLYMER MATRICES
VEHICULIZATION
CONTROLLED RELEASE
OCTEDINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291662
Acceder
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network_name_str CONICET Digital (CONICET)
spelling 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapyRivero Berti, IgnacioHorue, ManuelBoztepe, TugceKatz, Sergio FabianIslan, German AbelKarp, Federico3D-PRINTER BIOPOLYMER MATRICESVEHICULIZATIONCONTROLLED RELEASEOCTEDINEhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Chronic and acute wounds are important health system problems due to re-hospitalization rates and treatment engagement. Antibiotic-controlled release systems can be a relevant solution for generating long-term therapies without patient intervention. The present work investigated pH-sensitive biopolymeric systems obtained by extrusion-based 3D printing. Alginate and carboxymethyl chitosan were used as matrix polymers for ink production, while octenidine was the vehiculized antibiotic. Different polymer proportions were explored to evaluate the release mechanism in response to different pH environments. Physicochemical characterization was performed using infrared spectrometry (FTIR) and thermogravimetric analysis (TGA). Detailed photography was used to determine 3D-printing fidelity. SEM images were used for the morphological characterization. Swelling and octenidine release profiles were evaluated in different non-chelating buffers. After the print´s crosslinking bath, the obtained encapsulation efficiency was 100%. The printing fidelity was in the order of 0.9 - 1.8. Swelling studies showed that some formulations lost weight, whereas others increased by 400%. After 7 days, the drug released was 20 - 85%, depending on the polymer composition and buffer/pH environment. All the prints presented antimicrobial capacity against Staphylococcus aureus. The present work demonstrates the potential of biopolymeric 3D-printed systems as advanced wound dressings, combining pH-responsive antibiotic release and antimicrobial activity with the adaptive design capabilities of 3D printing, offering a versatile platform for personalized wound-healing therapies.Fil: Rivero Berti, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Horue, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Boztepe, Tugce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Katz, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Karp, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaEditions Sante2025-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291662Rivero Berti, Ignacio; Horue, Manuel; Boztepe, Tugce; Katz, Sergio Fabian; Islan, German Abel; et al.; 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy; Editions Sante; Journal of Drug Delivery Science and Technology; 114; 107558; 12-2025; 1-131773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2025.107558info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S177322472500961Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:53:37Zoai:ri.conicet.gov.ar:11336/291662instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:53:37.496CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
title 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
spellingShingle 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
Rivero Berti, Ignacio
3D-PRINTER BIOPOLYMER MATRICES
VEHICULIZATION
CONTROLLED RELEASE
OCTEDINE
title_short 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
title_full 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
title_fullStr 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
title_full_unstemmed 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
title_sort 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy
dc.creator.none.fl_str_mv Rivero Berti, Ignacio
Horue, Manuel
Boztepe, Tugce
Katz, Sergio Fabian
Islan, German Abel
Karp, Federico
author Rivero Berti, Ignacio
author_facet Rivero Berti, Ignacio
Horue, Manuel
Boztepe, Tugce
Katz, Sergio Fabian
Islan, German Abel
Karp, Federico
author_role author
author2 Horue, Manuel
Boztepe, Tugce
Katz, Sergio Fabian
Islan, German Abel
Karp, Federico
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv 3D-PRINTER BIOPOLYMER MATRICES
VEHICULIZATION
CONTROLLED RELEASE
OCTEDINE
topic 3D-PRINTER BIOPOLYMER MATRICES
VEHICULIZATION
CONTROLLED RELEASE
OCTEDINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chronic and acute wounds are important health system problems due to re-hospitalization rates and treatment engagement. Antibiotic-controlled release systems can be a relevant solution for generating long-term therapies without patient intervention. The present work investigated pH-sensitive biopolymeric systems obtained by extrusion-based 3D printing. Alginate and carboxymethyl chitosan were used as matrix polymers for ink production, while octenidine was the vehiculized antibiotic. Different polymer proportions were explored to evaluate the release mechanism in response to different pH environments. Physicochemical characterization was performed using infrared spectrometry (FTIR) and thermogravimetric analysis (TGA). Detailed photography was used to determine 3D-printing fidelity. SEM images were used for the morphological characterization. Swelling and octenidine release profiles were evaluated in different non-chelating buffers. After the print´s crosslinking bath, the obtained encapsulation efficiency was 100%. The printing fidelity was in the order of 0.9 - 1.8. Swelling studies showed that some formulations lost weight, whereas others increased by 400%. After 7 days, the drug released was 20 - 85%, depending on the polymer composition and buffer/pH environment. All the prints presented antimicrobial capacity against Staphylococcus aureus. The present work demonstrates the potential of biopolymeric 3D-printed systems as advanced wound dressings, combining pH-responsive antibiotic release and antimicrobial activity with the adaptive design capabilities of 3D printing, offering a versatile platform for personalized wound-healing therapies.
Fil: Rivero Berti, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Horue, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Boztepe, Tugce. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Katz, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Karp, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
description Chronic and acute wounds are important health system problems due to re-hospitalization rates and treatment engagement. Antibiotic-controlled release systems can be a relevant solution for generating long-term therapies without patient intervention. The present work investigated pH-sensitive biopolymeric systems obtained by extrusion-based 3D printing. Alginate and carboxymethyl chitosan were used as matrix polymers for ink production, while octenidine was the vehiculized antibiotic. Different polymer proportions were explored to evaluate the release mechanism in response to different pH environments. Physicochemical characterization was performed using infrared spectrometry (FTIR) and thermogravimetric analysis (TGA). Detailed photography was used to determine 3D-printing fidelity. SEM images were used for the morphological characterization. Swelling and octenidine release profiles were evaluated in different non-chelating buffers. After the print´s crosslinking bath, the obtained encapsulation efficiency was 100%. The printing fidelity was in the order of 0.9 - 1.8. Swelling studies showed that some formulations lost weight, whereas others increased by 400%. After 7 days, the drug released was 20 - 85%, depending on the polymer composition and buffer/pH environment. All the prints presented antimicrobial capacity against Staphylococcus aureus. The present work demonstrates the potential of biopolymeric 3D-printed systems as advanced wound dressings, combining pH-responsive antibiotic release and antimicrobial activity with the adaptive design capabilities of 3D printing, offering a versatile platform for personalized wound-healing therapies.
publishDate 2025
dc.date.none.fl_str_mv 2025-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291662
Rivero Berti, Ignacio; Horue, Manuel; Boztepe, Tugce; Katz, Sergio Fabian; Islan, German Abel; et al.; 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy; Editions Sante; Journal of Drug Delivery Science and Technology; 114; 107558; 12-2025; 1-13
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291662
identifier_str_mv Rivero Berti, Ignacio; Horue, Manuel; Boztepe, Tugce; Katz, Sergio Fabian; Islan, German Abel; et al.; 3D-printed biopolymer matrices for the vehiculization and controlled release of octenidine in wound antibiotic therapy; Editions Sante; Journal of Drug Delivery Science and Technology; 114; 107558; 12-2025; 1-13
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2025.107558
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S177322472500961X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Editions Sante
publisher.none.fl_str_mv Editions Sante
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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