Lung ultrasound as a predictor of mortality of patients with Covid-19

Autores
Sosa, Fernando A.; Matarrese, Agustín; Saavedra, Santiago; Osatnik, Javier; Roberti, Javier Eugenio; Tort Oribe, Barbara; Ivulich, Daniel; Durán, Ana Laura; Caputo, Celeste; Benay, Cristian Gabriel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To evaluate the performance of lung ultrasound to determine short-term outcomes of patients with COVID-19 admitted to the intensive care unit. Methods: This is a Prospective, observational study. Between July and November 2020, 59 patients were included and underwent at least two LUS assessments using LUS score (range 0-42) on day of admission, day 5th, and 10th of admission. Results: Age was 66.5±15 years, APACHE II was 8.3±3.9, 12 (20%) patients had malignancy, 46 (78%) patients had a non‑invasive ventilation/high-flow nasal cannula and 38 (64%) patients required mechanical ventilation. The median stay in ICU was 12 days (IQR 8.5-20.5 days). ICU or hospital mortality was 54%. On admission, the LUS score was 20.8±6.1; on day 5th and day 10th of admission, scores were 27.6±5.5 and 29.4±5.3, respectively (P=0.007). As clinical condition deteriorated the LUS score increased, with a positive correlation of 0.52, P <0.001. Patients with worse LUS on day 5th versus better score had a mortality of 76% versus 33% (OR 6.29, 95%CI 2.01-19.65, p. 0.003); a similar difference was observed on day 10. LUS score of 5th day of admission had an area under the curve of 0.80, best cut-point of 27, sensitivity and specificity of 0.75 and 0.78 respectively. Conclusion: These findings position LUS as a simple and reproducible method to predict the course of COVID-19 patients.
Fil: Sosa, Fernando A.. Hospital Alemán; Argentina
Fil: Matarrese, Agustín. Hospital Aleman; Argentina
Fil: Saavedra, Santiago. Hospital Aleman; Argentina
Fil: Osatnik, Javier. Hospital Alemán; Argentina
Fil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Tort Oribe, Barbara. Hospital Alemán; Argentina
Fil: Ivulich, Daniel. Hospital Aleman; Argentina
Fil: Durán, Ana Laura. Hospital Alemán; Argentina
Fil: Caputo, Celeste. Hospital Aleman; Argentina
Fil: Benay, Cristian Gabriel. Hospital Alemán; Argentina
Materia
COVID-19
LUND DISEASES
ULTRASONOGRAPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145826
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145826
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lung ultrasound as a predictor of mortality of patients with Covid-19Sosa, Fernando A.Matarrese, AgustínSaavedra, SantiagoOsatnik, JavierRoberti, Javier EugenioTort Oribe, BarbaraIvulich, DanielDurán, Ana LauraCaputo, CelesteBenay, Cristian GabrielCOVID-19LUND DISEASESULTRASONOGRAPHYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To evaluate the performance of lung ultrasound to determine short-term outcomes of patients with COVID-19 admitted to the intensive care unit. Methods: This is a Prospective, observational study. Between July and November 2020, 59 patients were included and underwent at least two LUS assessments using LUS score (range 0-42) on day of admission, day 5th, and 10th of admission. Results: Age was 66.5±15 years, APACHE II was 8.3±3.9, 12 (20%) patients had malignancy, 46 (78%) patients had a non‑invasive ventilation/high-flow nasal cannula and 38 (64%) patients required mechanical ventilation. The median stay in ICU was 12 days (IQR 8.5-20.5 days). ICU or hospital mortality was 54%. On admission, the LUS score was 20.8±6.1; on day 5th and day 10th of admission, scores were 27.6±5.5 and 29.4±5.3, respectively (P=0.007). As clinical condition deteriorated the LUS score increased, with a positive correlation of 0.52, P <0.001. Patients with worse LUS on day 5th versus better score had a mortality of 76% versus 33% (OR 6.29, 95%CI 2.01-19.65, p. 0.003); a similar difference was observed on day 10. LUS score of 5th day of admission had an area under the curve of 0.80, best cut-point of 27, sensitivity and specificity of 0.75 and 0.78 respectively. Conclusion: These findings position LUS as a simple and reproducible method to predict the course of COVID-19 patients.Fil: Sosa, Fernando A.. Hospital Alemán; ArgentinaFil: Matarrese, Agustín. Hospital Aleman; ArgentinaFil: Saavedra, Santiago. Hospital Aleman; ArgentinaFil: Osatnik, Javier. Hospital Alemán; ArgentinaFil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Tort Oribe, Barbara. Hospital Alemán; ArgentinaFil: Ivulich, Daniel. Hospital Aleman; ArgentinaFil: Durán, Ana Laura. Hospital Alemán; ArgentinaFil: Caputo, Celeste. Hospital Aleman; ArgentinaFil: Benay, Cristian Gabriel. Hospital Alemán; ArgentinaSociedade Brasileira de Pneumologia e Tisiologia2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145826Sosa, Fernando A.; Matarrese, Agustín; Saavedra, Santiago; Osatnik, Javier; Roberti, Javier Eugenio; et al.; Lung ultrasound as a predictor of mortality of patients with Covid-19; Sociedade Brasileira de Pneumologia e Tisiologia; Jornal Brasileiro de Pneumologia; 47; 4; 7-2021; 1-71806-3756CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.36416/1806-3756/E20210092info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:37:35Zoai:ri.conicet.gov.ar:11336/145826instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:37:35.73CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lung ultrasound as a predictor of mortality of patients with Covid-19
title Lung ultrasound as a predictor of mortality of patients with Covid-19
spellingShingle Lung ultrasound as a predictor of mortality of patients with Covid-19
Sosa, Fernando A.
COVID-19
LUND DISEASES
ULTRASONOGRAPHY
title_short Lung ultrasound as a predictor of mortality of patients with Covid-19
title_full Lung ultrasound as a predictor of mortality of patients with Covid-19
title_fullStr Lung ultrasound as a predictor of mortality of patients with Covid-19
title_full_unstemmed Lung ultrasound as a predictor of mortality of patients with Covid-19
title_sort Lung ultrasound as a predictor of mortality of patients with Covid-19
dc.creator.none.fl_str_mv Sosa, Fernando A.
Matarrese, Agustín
Saavedra, Santiago
Osatnik, Javier
Roberti, Javier Eugenio
Tort Oribe, Barbara
Ivulich, Daniel
Durán, Ana Laura
Caputo, Celeste
Benay, Cristian Gabriel
author Sosa, Fernando A.
author_facet Sosa, Fernando A.
Matarrese, Agustín
Saavedra, Santiago
Osatnik, Javier
Roberti, Javier Eugenio
Tort Oribe, Barbara
Ivulich, Daniel
Durán, Ana Laura
Caputo, Celeste
Benay, Cristian Gabriel
author_role author
author2 Matarrese, Agustín
Saavedra, Santiago
Osatnik, Javier
Roberti, Javier Eugenio
Tort Oribe, Barbara
Ivulich, Daniel
Durán, Ana Laura
Caputo, Celeste
Benay, Cristian Gabriel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
LUND DISEASES
ULTRASONOGRAPHY
topic COVID-19
LUND DISEASES
ULTRASONOGRAPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To evaluate the performance of lung ultrasound to determine short-term outcomes of patients with COVID-19 admitted to the intensive care unit. Methods: This is a Prospective, observational study. Between July and November 2020, 59 patients were included and underwent at least two LUS assessments using LUS score (range 0-42) on day of admission, day 5th, and 10th of admission. Results: Age was 66.5±15 years, APACHE II was 8.3±3.9, 12 (20%) patients had malignancy, 46 (78%) patients had a non‑invasive ventilation/high-flow nasal cannula and 38 (64%) patients required mechanical ventilation. The median stay in ICU was 12 days (IQR 8.5-20.5 days). ICU or hospital mortality was 54%. On admission, the LUS score was 20.8±6.1; on day 5th and day 10th of admission, scores were 27.6±5.5 and 29.4±5.3, respectively (P=0.007). As clinical condition deteriorated the LUS score increased, with a positive correlation of 0.52, P <0.001. Patients with worse LUS on day 5th versus better score had a mortality of 76% versus 33% (OR 6.29, 95%CI 2.01-19.65, p. 0.003); a similar difference was observed on day 10. LUS score of 5th day of admission had an area under the curve of 0.80, best cut-point of 27, sensitivity and specificity of 0.75 and 0.78 respectively. Conclusion: These findings position LUS as a simple and reproducible method to predict the course of COVID-19 patients.
Fil: Sosa, Fernando A.. Hospital Alemán; Argentina
Fil: Matarrese, Agustín. Hospital Aleman; Argentina
Fil: Saavedra, Santiago. Hospital Aleman; Argentina
Fil: Osatnik, Javier. Hospital Alemán; Argentina
Fil: Roberti, Javier Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Tort Oribe, Barbara. Hospital Alemán; Argentina
Fil: Ivulich, Daniel. Hospital Aleman; Argentina
Fil: Durán, Ana Laura. Hospital Alemán; Argentina
Fil: Caputo, Celeste. Hospital Aleman; Argentina
Fil: Benay, Cristian Gabriel. Hospital Alemán; Argentina
description Objective: To evaluate the performance of lung ultrasound to determine short-term outcomes of patients with COVID-19 admitted to the intensive care unit. Methods: This is a Prospective, observational study. Between July and November 2020, 59 patients were included and underwent at least two LUS assessments using LUS score (range 0-42) on day of admission, day 5th, and 10th of admission. Results: Age was 66.5±15 years, APACHE II was 8.3±3.9, 12 (20%) patients had malignancy, 46 (78%) patients had a non‑invasive ventilation/high-flow nasal cannula and 38 (64%) patients required mechanical ventilation. The median stay in ICU was 12 days (IQR 8.5-20.5 days). ICU or hospital mortality was 54%. On admission, the LUS score was 20.8±6.1; on day 5th and day 10th of admission, scores were 27.6±5.5 and 29.4±5.3, respectively (P=0.007). As clinical condition deteriorated the LUS score increased, with a positive correlation of 0.52, P <0.001. Patients with worse LUS on day 5th versus better score had a mortality of 76% versus 33% (OR 6.29, 95%CI 2.01-19.65, p. 0.003); a similar difference was observed on day 10. LUS score of 5th day of admission had an area under the curve of 0.80, best cut-point of 27, sensitivity and specificity of 0.75 and 0.78 respectively. Conclusion: These findings position LUS as a simple and reproducible method to predict the course of COVID-19 patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145826
Sosa, Fernando A.; Matarrese, Agustín; Saavedra, Santiago; Osatnik, Javier; Roberti, Javier Eugenio; et al.; Lung ultrasound as a predictor of mortality of patients with Covid-19; Sociedade Brasileira de Pneumologia e Tisiologia; Jornal Brasileiro de Pneumologia; 47; 4; 7-2021; 1-7
1806-3756
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145826
identifier_str_mv Sosa, Fernando A.; Matarrese, Agustín; Saavedra, Santiago; Osatnik, Javier; Roberti, Javier Eugenio; et al.; Lung ultrasound as a predictor of mortality of patients with Covid-19; Sociedade Brasileira de Pneumologia e Tisiologia; Jornal Brasileiro de Pneumologia; 47; 4; 7-2021; 1-7
1806-3756
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.36416/1806-3756/E20210092
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
publisher.none.fl_str_mv Sociedade Brasileira de Pneumologia e Tisiologia
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.365483

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