Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair

Autores
Carbone Schellman, Javier; Fontecilla Escobar, Javiera Valentina; Sales Salinas, Nicolás; Chaparro Pico William F.; Molina Berrios, Alfredo; Ruete, María Celeste; González, Pablo A.; Machuca, Mayra A.; Opazo, María Cecilia; Ezquer, Marcelo E.; Duarte, Luisa F.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although significant progress has been made in medicine and antimicrobial research, viral infections continue to pose a critical global health challenge, particularly when they involve the central nervous system (CNS). Despite advances in vaccines, antiviral agents, and small molecule therapeutics, current strategies remain insufficient to address the complex consequences of many CNS infections fully. Notably, many viruses are neurotropic and can invade the CNS, triggering infectious neuroinflammation that often lead to chronic neurological disorders and lasting morbidity. Current therapeutic approaches are largely ineffective in preventing or reversing this long-term neurological damage, underscoring the urgent need for innovative prophylactic and therapeutic interventions. Mesenchymal stem cells (MSCs) have emerged as a promising strategy to counteract chronic neuroinflammation and promote tissue repair following viral CNS infections. This review provides a comprehensive overview of CNS viral infection and neuroinflammation, including epidemiology and pathophysiology, and critically examines the limitations of existing treatments, particularly their inability to mitigate persistent neurological sequelae. Furthermore, we summarize recent preclinical and clinical studies investigating the use of MSCs in the context of CNS viral infections, highlighting their immunomodulatory and neuroprotective mechanisms, and discuss the challenges and future directions for MSC-based therapies in clinical settings.
Fil: Carbone Schellman, Javier. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Millennium Institute on Immunology and Immunotherapy; Chile
Fil: Fontecilla Escobar, Javiera Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
Fil: Sales Salinas, Nicolás. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
Fil: Chaparro Pico William F.. Universidad Industrial Santander; Colombia
Fil: Molina Berrios, Alfredo. Universidad de Chile; Chile
Fil: Ruete, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: González, Pablo A.. Universidad de Chile; Chile
Fil: Machuca, Mayra A.. Universidad Industrial Santander; Colombia
Fil: Opazo, María Cecilia. Universidad de Las Américas; Chile
Fil: Ezquer, Marcelo E.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
Fil: Duarte, Luisa F.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Millennium Institute on Immunology and Immunotherapy; Chile
Materia
Extracellular vesicle
Mesenchymal stem cells
Neuroinflammation
Neurological and neurodegenerative diseases
Persistent infections
Central nervous system
Secretome
Virus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291890
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/291890
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repairCarbone Schellman, JavierFontecilla Escobar, Javiera ValentinaSales Salinas, NicolásChaparro Pico William F.Molina Berrios, AlfredoRuete, María CelesteGonzález, Pablo A.Machuca, Mayra A.Opazo, María CeciliaEzquer, Marcelo E.Duarte, Luisa F.Extracellular vesicleMesenchymal stem cellsNeuroinflammationNeurological and neurodegenerative diseasesPersistent infectionsCentral nervous systemSecretomeVirushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Although significant progress has been made in medicine and antimicrobial research, viral infections continue to pose a critical global health challenge, particularly when they involve the central nervous system (CNS). Despite advances in vaccines, antiviral agents, and small molecule therapeutics, current strategies remain insufficient to address the complex consequences of many CNS infections fully. Notably, many viruses are neurotropic and can invade the CNS, triggering infectious neuroinflammation that often lead to chronic neurological disorders and lasting morbidity. Current therapeutic approaches are largely ineffective in preventing or reversing this long-term neurological damage, underscoring the urgent need for innovative prophylactic and therapeutic interventions. Mesenchymal stem cells (MSCs) have emerged as a promising strategy to counteract chronic neuroinflammation and promote tissue repair following viral CNS infections. This review provides a comprehensive overview of CNS viral infection and neuroinflammation, including epidemiology and pathophysiology, and critically examines the limitations of existing treatments, particularly their inability to mitigate persistent neurological sequelae. Furthermore, we summarize recent preclinical and clinical studies investigating the use of MSCs in the context of CNS viral infections, highlighting their immunomodulatory and neuroprotective mechanisms, and discuss the challenges and future directions for MSC-based therapies in clinical settings.Fil: Carbone Schellman, Javier. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Millennium Institute on Immunology and Immunotherapy; ChileFil: Fontecilla Escobar, Javiera Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; ChileFil: Sales Salinas, Nicolás. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; ChileFil: Chaparro Pico William F.. Universidad Industrial Santander; ColombiaFil: Molina Berrios, Alfredo. Universidad de Chile; ChileFil: Ruete, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: González, Pablo A.. Universidad de Chile; ChileFil: Machuca, Mayra A.. Universidad Industrial Santander; ColombiaFil: Opazo, María Cecilia. Universidad de Las Américas; ChileFil: Ezquer, Marcelo E.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; ChileFil: Duarte, Luisa F.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Millennium Institute on Immunology and Immunotherapy; ChileFrontiers Media2025-10-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291890Carbone Schellman, Javier; Fontecilla Escobar, Javiera Valentina; Sales Salinas, Nicolás; Chaparro Pico William F.; Molina Berrios, Alfredo; et al.; Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair; Frontiers Media; Frontiers in Immunology; 16; 29-10-2025; 1-261664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1677433/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2025.1677433info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:34:04Zoai:ri.conicet.gov.ar:11336/291890instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:34:05.276CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
title Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
spellingShingle Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
Carbone Schellman, Javier
Extracellular vesicle
Mesenchymal stem cells
Neuroinflammation
Neurological and neurodegenerative diseases
Persistent infections
Central nervous system
Secretome
Virus
title_short Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
title_full Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
title_fullStr Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
title_full_unstemmed Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
title_sort Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair
dc.creator.none.fl_str_mv Carbone Schellman, Javier
Fontecilla Escobar, Javiera Valentina
Sales Salinas, Nicolás
Chaparro Pico William F.
Molina Berrios, Alfredo
Ruete, María Celeste
González, Pablo A.
Machuca, Mayra A.
Opazo, María Cecilia
Ezquer, Marcelo E.
Duarte, Luisa F.
author Carbone Schellman, Javier
author_facet Carbone Schellman, Javier
Fontecilla Escobar, Javiera Valentina
Sales Salinas, Nicolás
Chaparro Pico William F.
Molina Berrios, Alfredo
Ruete, María Celeste
González, Pablo A.
Machuca, Mayra A.
Opazo, María Cecilia
Ezquer, Marcelo E.
Duarte, Luisa F.
author_role author
author2 Fontecilla Escobar, Javiera Valentina
Sales Salinas, Nicolás
Chaparro Pico William F.
Molina Berrios, Alfredo
Ruete, María Celeste
González, Pablo A.
Machuca, Mayra A.
Opazo, María Cecilia
Ezquer, Marcelo E.
Duarte, Luisa F.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Extracellular vesicle
Mesenchymal stem cells
Neuroinflammation
Neurological and neurodegenerative diseases
Persistent infections
Central nervous system
Secretome
Virus
topic Extracellular vesicle
Mesenchymal stem cells
Neuroinflammation
Neurological and neurodegenerative diseases
Persistent infections
Central nervous system
Secretome
Virus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although significant progress has been made in medicine and antimicrobial research, viral infections continue to pose a critical global health challenge, particularly when they involve the central nervous system (CNS). Despite advances in vaccines, antiviral agents, and small molecule therapeutics, current strategies remain insufficient to address the complex consequences of many CNS infections fully. Notably, many viruses are neurotropic and can invade the CNS, triggering infectious neuroinflammation that often lead to chronic neurological disorders and lasting morbidity. Current therapeutic approaches are largely ineffective in preventing or reversing this long-term neurological damage, underscoring the urgent need for innovative prophylactic and therapeutic interventions. Mesenchymal stem cells (MSCs) have emerged as a promising strategy to counteract chronic neuroinflammation and promote tissue repair following viral CNS infections. This review provides a comprehensive overview of CNS viral infection and neuroinflammation, including epidemiology and pathophysiology, and critically examines the limitations of existing treatments, particularly their inability to mitigate persistent neurological sequelae. Furthermore, we summarize recent preclinical and clinical studies investigating the use of MSCs in the context of CNS viral infections, highlighting their immunomodulatory and neuroprotective mechanisms, and discuss the challenges and future directions for MSC-based therapies in clinical settings.
Fil: Carbone Schellman, Javier. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Millennium Institute on Immunology and Immunotherapy; Chile
Fil: Fontecilla Escobar, Javiera Valentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
Fil: Sales Salinas, Nicolás. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
Fil: Chaparro Pico William F.. Universidad Industrial Santander; Colombia
Fil: Molina Berrios, Alfredo. Universidad de Chile; Chile
Fil: Ruete, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: González, Pablo A.. Universidad de Chile; Chile
Fil: Machuca, Mayra A.. Universidad Industrial Santander; Colombia
Fil: Opazo, María Cecilia. Universidad de Las Américas; Chile
Fil: Ezquer, Marcelo E.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile
Fil: Duarte, Luisa F.. Universidad del Desarrollo. Facultad de Medicina Clínica Alemana; Chile. Millennium Institute on Immunology and Immunotherapy; Chile
description Although significant progress has been made in medicine and antimicrobial research, viral infections continue to pose a critical global health challenge, particularly when they involve the central nervous system (CNS). Despite advances in vaccines, antiviral agents, and small molecule therapeutics, current strategies remain insufficient to address the complex consequences of many CNS infections fully. Notably, many viruses are neurotropic and can invade the CNS, triggering infectious neuroinflammation that often lead to chronic neurological disorders and lasting morbidity. Current therapeutic approaches are largely ineffective in preventing or reversing this long-term neurological damage, underscoring the urgent need for innovative prophylactic and therapeutic interventions. Mesenchymal stem cells (MSCs) have emerged as a promising strategy to counteract chronic neuroinflammation and promote tissue repair following viral CNS infections. This review provides a comprehensive overview of CNS viral infection and neuroinflammation, including epidemiology and pathophysiology, and critically examines the limitations of existing treatments, particularly their inability to mitigate persistent neurological sequelae. Furthermore, we summarize recent preclinical and clinical studies investigating the use of MSCs in the context of CNS viral infections, highlighting their immunomodulatory and neuroprotective mechanisms, and discuss the challenges and future directions for MSC-based therapies in clinical settings.
publishDate 2025
dc.date.none.fl_str_mv 2025-10-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291890
Carbone Schellman, Javier; Fontecilla Escobar, Javiera Valentina; Sales Salinas, Nicolás; Chaparro Pico William F.; Molina Berrios, Alfredo; et al.; Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair; Frontiers Media; Frontiers in Immunology; 16; 29-10-2025; 1-26
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291890
identifier_str_mv Carbone Schellman, Javier; Fontecilla Escobar, Javiera Valentina; Sales Salinas, Nicolás; Chaparro Pico William F.; Molina Berrios, Alfredo; et al.; Therapeutic challenges in central nervous system viral infections: advancing mesenchymal stem cell-based strategies for treating neuroinflammation and promoting tissue repair; Frontiers Media; Frontiers in Immunology; 16; 29-10-2025; 1-26
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1677433/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2025.1677433
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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