Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease

Autores
Bonaccorso Marinelli, María Paula; González, Natalia Belén; Cabrera Kreiker, Ricardo Jorge; Valdez, Susana Ruth
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several experimental models have been developed to fulfill the clinical, morphological, and neurochemical criteria, mimic the neuropathological lesion, and allow defining therapeutic strategies for Parkinson’s Disease. The unilateral injection of 6-OHDA in the leftcorpus striatum produces a progressive degeneration of the nigrostriatal system on the injured side, allowing internal comparison with the intact contralateral side. This condition is called hemiparkinsonism. Motor impairments generated in the unilateral administration model can be assessed by tests that examine, among other signs, akinesia, body axis deviation, drug-induced asymmetric rotational behavior, and spontaneous motor behaviors. Some evidence has suggested that female sex hormones may influence the onset and severity of the symptoms, suggesting a possible protective influence of estradiol on disease predisposition. The present work’s objective is to evaluate the potential effects of 17β-estradiol on motor dysfunction in a 6-OHDA-induced rat model of Parkinson’s disease. Treatment with 17β-estradiol produced some interesting effects on activity and functionality in motor performance. If degeneration is not severe, this treatment could be a neuroprotective agent. In conclusion, the neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease. These investigations contribute to the recognition of the potential impact of steroid sex hormones on nervous system injuries.
Fil: Bonaccorso Marinelli, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: González, Natalia Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Valdez, Susana Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
PARKINSON´S DISEASE
17-BETA-ESTRADIOL
6-OHDA
MOTOR ACTIVITY
BEHAVIOUR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291068
Acceder
id CONICETDig_6919f179ee16f90f8045a34893a97658
oai_identifier_str oai:ri.conicet.gov.ar:11336/291068
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s diseaseBonaccorso Marinelli, María PaulaGonzález, Natalia BelénCabrera Kreiker, Ricardo JorgeValdez, Susana RuthPARKINSON´S DISEASE17-BETA-ESTRADIOL6-OHDAMOTOR ACTIVITYBEHAVIOURhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Several experimental models have been developed to fulfill the clinical, morphological, and neurochemical criteria, mimic the neuropathological lesion, and allow defining therapeutic strategies for Parkinson’s Disease. The unilateral injection of 6-OHDA in the leftcorpus striatum produces a progressive degeneration of the nigrostriatal system on the injured side, allowing internal comparison with the intact contralateral side. This condition is called hemiparkinsonism. Motor impairments generated in the unilateral administration model can be assessed by tests that examine, among other signs, akinesia, body axis deviation, drug-induced asymmetric rotational behavior, and spontaneous motor behaviors. Some evidence has suggested that female sex hormones may influence the onset and severity of the symptoms, suggesting a possible protective influence of estradiol on disease predisposition. The present work’s objective is to evaluate the potential effects of 17β-estradiol on motor dysfunction in a 6-OHDA-induced rat model of Parkinson’s disease. Treatment with 17β-estradiol produced some interesting effects on activity and functionality in motor performance. If degeneration is not severe, this treatment could be a neuroprotective agent. In conclusion, the neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease. These investigations contribute to the recognition of the potential impact of steroid sex hormones on nervous system injuries.Fil: Bonaccorso Marinelli, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: González, Natalia Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Valdez, Susana Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaBiomedgrid2025-05-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291068Bonaccorso Marinelli, María Paula; González, Natalia Belén; Cabrera Kreiker, Ricardo Jorge; Valdez, Susana Ruth; Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease; Biomedgrid; American Journal of Biomedical Science and Research; 27; 1; 21-5-2025; 152-1602642-1747CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://biomedgrid.com/pdf/AJBSR.MS.ID.003522.pdf.info:eu-repo/semantics/altIdentifier/doi/10.34297/AJBSR.2025.27.003522info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:51:49Zoai:ri.conicet.gov.ar:11336/291068instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:51:49.416CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
title Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
spellingShingle Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
Bonaccorso Marinelli, María Paula
PARKINSON´S DISEASE
17-BETA-ESTRADIOL
6-OHDA
MOTOR ACTIVITY
BEHAVIOUR
title_short Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
title_full Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
title_fullStr Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
title_full_unstemmed Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
title_sort Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease
dc.creator.none.fl_str_mv Bonaccorso Marinelli, María Paula
González, Natalia Belén
Cabrera Kreiker, Ricardo Jorge
Valdez, Susana Ruth
author Bonaccorso Marinelli, María Paula
author_facet Bonaccorso Marinelli, María Paula
González, Natalia Belén
Cabrera Kreiker, Ricardo Jorge
Valdez, Susana Ruth
author_role author
author2 González, Natalia Belén
Cabrera Kreiker, Ricardo Jorge
Valdez, Susana Ruth
author2_role author
author
author
dc.subject.none.fl_str_mv PARKINSON´S DISEASE
17-BETA-ESTRADIOL
6-OHDA
MOTOR ACTIVITY
BEHAVIOUR
topic PARKINSON´S DISEASE
17-BETA-ESTRADIOL
6-OHDA
MOTOR ACTIVITY
BEHAVIOUR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Several experimental models have been developed to fulfill the clinical, morphological, and neurochemical criteria, mimic the neuropathological lesion, and allow defining therapeutic strategies for Parkinson’s Disease. The unilateral injection of 6-OHDA in the leftcorpus striatum produces a progressive degeneration of the nigrostriatal system on the injured side, allowing internal comparison with the intact contralateral side. This condition is called hemiparkinsonism. Motor impairments generated in the unilateral administration model can be assessed by tests that examine, among other signs, akinesia, body axis deviation, drug-induced asymmetric rotational behavior, and spontaneous motor behaviors. Some evidence has suggested that female sex hormones may influence the onset and severity of the symptoms, suggesting a possible protective influence of estradiol on disease predisposition. The present work’s objective is to evaluate the potential effects of 17β-estradiol on motor dysfunction in a 6-OHDA-induced rat model of Parkinson’s disease. Treatment with 17β-estradiol produced some interesting effects on activity and functionality in motor performance. If degeneration is not severe, this treatment could be a neuroprotective agent. In conclusion, the neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease. These investigations contribute to the recognition of the potential impact of steroid sex hormones on nervous system injuries.
Fil: Bonaccorso Marinelli, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: González, Natalia Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Valdez, Susana Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Several experimental models have been developed to fulfill the clinical, morphological, and neurochemical criteria, mimic the neuropathological lesion, and allow defining therapeutic strategies for Parkinson’s Disease. The unilateral injection of 6-OHDA in the leftcorpus striatum produces a progressive degeneration of the nigrostriatal system on the injured side, allowing internal comparison with the intact contralateral side. This condition is called hemiparkinsonism. Motor impairments generated in the unilateral administration model can be assessed by tests that examine, among other signs, akinesia, body axis deviation, drug-induced asymmetric rotational behavior, and spontaneous motor behaviors. Some evidence has suggested that female sex hormones may influence the onset and severity of the symptoms, suggesting a possible protective influence of estradiol on disease predisposition. The present work’s objective is to evaluate the potential effects of 17β-estradiol on motor dysfunction in a 6-OHDA-induced rat model of Parkinson’s disease. Treatment with 17β-estradiol produced some interesting effects on activity and functionality in motor performance. If degeneration is not severe, this treatment could be a neuroprotective agent. In conclusion, the neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease. These investigations contribute to the recognition of the potential impact of steroid sex hormones on nervous system injuries.
publishDate 2025
dc.date.none.fl_str_mv 2025-05-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291068
Bonaccorso Marinelli, María Paula; González, Natalia Belén; Cabrera Kreiker, Ricardo Jorge; Valdez, Susana Ruth; Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease; Biomedgrid; American Journal of Biomedical Science and Research; 27; 1; 21-5-2025; 152-160
2642-1747
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291068
identifier_str_mv Bonaccorso Marinelli, María Paula; González, Natalia Belén; Cabrera Kreiker, Ricardo Jorge; Valdez, Susana Ruth; Neurosteroid 17β-estradiol reduces motor dysfunctions in a 6-OHDA-induced rat model of Parkinson’s disease; Biomedgrid; American Journal of Biomedical Science and Research; 27; 1; 21-5-2025; 152-160
2642-1747
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://biomedgrid.com/pdf/AJBSR.MS.ID.003522.pdf.
info:eu-repo/semantics/altIdentifier/doi/10.34297/AJBSR.2025.27.003522
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Biomedgrid
publisher.none.fl_str_mv Biomedgrid
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874774797822459904
score 13.265058

Publicaciones similares