COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment a...

Autores
Espinola, Natalia; Loudet, Cecilia Ines; Luxardo, Rosario; Moreno, Carolina; Kyaw, Moe H.; Spinardi, Julia; Mendoza, Carlos Fernando; Carballo, Carolina M.; Dantas, Ana Carolina; Ábalos, María Gabriela; Ballivian Cuellar, Jamile Rusbania; Navarro, Emiliano; Bardach, Ariel Esteban
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The COVID-19 pandemic imposed a substantial burden on healthcare systems worldwide, yet reliable data on COVID-19 morbidity, mortality, and healthcare costs in Latin America remain limited. This study explored the disease and economic burden of COVID-19 in Argentina, Brazil, Chile, Colombia, Mexico, and Peru during the pre-vaccination period. Using national databases and a systematic review of the literature, we analyzed data on adults aged 18 and older, reporting cases, death rates, years of life lost, excess mortality, and direct medical costs. Before vaccination programs began, the average COVID-19 incidence rate was 6741 per 100,000 adults. Of these, 91% were mild cases, 7% moderate/severe, and 2% critical. Among 2,201,816 hospitalizations, 27.8% required intensive care, and 17.5% required mechanical ventilation. Excess mortality ranged from 76 to 557 per 100,000, and years of life lost spanned 241,089 to 3,312,346. Direct medical costs ranged from USD 258 million to USD 10,437 million, representing 2-5% of national health expenditures. The findings highlight significant variability across countries and provide crucial insights to help policymakers to make informed decisions and allocate resources effectively to improve national strategies around surveillance, preventive and treatment strategies to control the spread of COVID-19 disease in the future.
Fil: Espinola, Natalia. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Loudet, Cecilia Ines. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Luxardo, Rosario. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Moreno, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Kyaw, Moe H.. Pfizer Inc.; Estados Unidos
Fil: Spinardi, Julia. Pfizer Inc.; Brasil
Fil: Mendoza, Carlos Fernando. Pfizer Inc.; México
Fil: Carballo, Carolina M.. Pfizer Inc.; Argentina
Fil: Dantas, Ana Carolina. Pfizer Inc.; Argentina
Fil: Ábalos, María Gabriela. Pfizer Inc.; México
Fil: Ballivian Cuellar, Jamile Rusbania. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Navarro, Emiliano. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
COVID-19
Latin American
adults
disease burden
economic burden
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291211
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/291211
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature ReviewEspinola, NataliaLoudet, Cecilia InesLuxardo, RosarioMoreno, CarolinaKyaw, Moe H.Spinardi, JuliaMendoza, Carlos FernandoCarballo, Carolina M.Dantas, Ana CarolinaÁbalos, María GabrielaBallivian Cuellar, Jamile RusbaniaNavarro, EmilianoBardach, Ariel EstebanCOVID-19Latin Americanadultsdisease burdeneconomic burdenhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The COVID-19 pandemic imposed a substantial burden on healthcare systems worldwide, yet reliable data on COVID-19 morbidity, mortality, and healthcare costs in Latin America remain limited. This study explored the disease and economic burden of COVID-19 in Argentina, Brazil, Chile, Colombia, Mexico, and Peru during the pre-vaccination period. Using national databases and a systematic review of the literature, we analyzed data on adults aged 18 and older, reporting cases, death rates, years of life lost, excess mortality, and direct medical costs. Before vaccination programs began, the average COVID-19 incidence rate was 6741 per 100,000 adults. Of these, 91% were mild cases, 7% moderate/severe, and 2% critical. Among 2,201,816 hospitalizations, 27.8% required intensive care, and 17.5% required mechanical ventilation. Excess mortality ranged from 76 to 557 per 100,000, and years of life lost spanned 241,089 to 3,312,346. Direct medical costs ranged from USD 258 million to USD 10,437 million, representing 2-5% of national health expenditures. The findings highlight significant variability across countries and provide crucial insights to help policymakers to make informed decisions and allocate resources effectively to improve national strategies around surveillance, preventive and treatment strategies to control the spread of COVID-19 disease in the future.Fil: Espinola, Natalia. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Loudet, Cecilia Ines. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Luxardo, Rosario. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Moreno, Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Kyaw, Moe H.. Pfizer Inc.; Estados UnidosFil: Spinardi, Julia. Pfizer Inc.; BrasilFil: Mendoza, Carlos Fernando. Pfizer Inc.; MéxicoFil: Carballo, Carolina M.. Pfizer Inc.; ArgentinaFil: Dantas, Ana Carolina. Pfizer Inc.; ArgentinaFil: Ábalos, María Gabriela. Pfizer Inc.; MéxicoFil: Ballivian Cuellar, Jamile Rusbania. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Navarro, Emiliano. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaMolecular Diversity Preservation International2025-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291211Espinola, Natalia; Loudet, Cecilia Ines; Luxardo, Rosario; Moreno, Carolina; Kyaw, Moe H.; et al.; COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review; Molecular Diversity Preservation International; International Journal of Environmental Research and Public Health; 22; 5; 4-2025; 1-201660-4601CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1660-4601/22/5/669info:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph22050669info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:34:57Zoai:ri.conicet.gov.ar:11336/291211instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:34:57.641CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
title COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
spellingShingle COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
Espinola, Natalia
COVID-19
Latin American
adults
disease burden
economic burden
title_short COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
title_full COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
title_fullStr COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
title_full_unstemmed COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
title_sort COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review
dc.creator.none.fl_str_mv Espinola, Natalia
Loudet, Cecilia Ines
Luxardo, Rosario
Moreno, Carolina
Kyaw, Moe H.
Spinardi, Julia
Mendoza, Carlos Fernando
Carballo, Carolina M.
Dantas, Ana Carolina
Ábalos, María Gabriela
Ballivian Cuellar, Jamile Rusbania
Navarro, Emiliano
Bardach, Ariel Esteban
author Espinola, Natalia
author_facet Espinola, Natalia
Loudet, Cecilia Ines
Luxardo, Rosario
Moreno, Carolina
Kyaw, Moe H.
Spinardi, Julia
Mendoza, Carlos Fernando
Carballo, Carolina M.
Dantas, Ana Carolina
Ábalos, María Gabriela
Ballivian Cuellar, Jamile Rusbania
Navarro, Emiliano
Bardach, Ariel Esteban
author_role author
author2 Loudet, Cecilia Ines
Luxardo, Rosario
Moreno, Carolina
Kyaw, Moe H.
Spinardi, Julia
Mendoza, Carlos Fernando
Carballo, Carolina M.
Dantas, Ana Carolina
Ábalos, María Gabriela
Ballivian Cuellar, Jamile Rusbania
Navarro, Emiliano
Bardach, Ariel Esteban
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
Latin American
adults
disease burden
economic burden
topic COVID-19
Latin American
adults
disease burden
economic burden
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The COVID-19 pandemic imposed a substantial burden on healthcare systems worldwide, yet reliable data on COVID-19 morbidity, mortality, and healthcare costs in Latin America remain limited. This study explored the disease and economic burden of COVID-19 in Argentina, Brazil, Chile, Colombia, Mexico, and Peru during the pre-vaccination period. Using national databases and a systematic review of the literature, we analyzed data on adults aged 18 and older, reporting cases, death rates, years of life lost, excess mortality, and direct medical costs. Before vaccination programs began, the average COVID-19 incidence rate was 6741 per 100,000 adults. Of these, 91% were mild cases, 7% moderate/severe, and 2% critical. Among 2,201,816 hospitalizations, 27.8% required intensive care, and 17.5% required mechanical ventilation. Excess mortality ranged from 76 to 557 per 100,000, and years of life lost spanned 241,089 to 3,312,346. Direct medical costs ranged from USD 258 million to USD 10,437 million, representing 2-5% of national health expenditures. The findings highlight significant variability across countries and provide crucial insights to help policymakers to make informed decisions and allocate resources effectively to improve national strategies around surveillance, preventive and treatment strategies to control the spread of COVID-19 disease in the future.
Fil: Espinola, Natalia. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Loudet, Cecilia Ines. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Luxardo, Rosario. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Moreno, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Kyaw, Moe H.. Pfizer Inc.; Estados Unidos
Fil: Spinardi, Julia. Pfizer Inc.; Brasil
Fil: Mendoza, Carlos Fernando. Pfizer Inc.; México
Fil: Carballo, Carolina M.. Pfizer Inc.; Argentina
Fil: Dantas, Ana Carolina. Pfizer Inc.; Argentina
Fil: Ábalos, María Gabriela. Pfizer Inc.; México
Fil: Ballivian Cuellar, Jamile Rusbania. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Navarro, Emiliano. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description The COVID-19 pandemic imposed a substantial burden on healthcare systems worldwide, yet reliable data on COVID-19 morbidity, mortality, and healthcare costs in Latin America remain limited. This study explored the disease and economic burden of COVID-19 in Argentina, Brazil, Chile, Colombia, Mexico, and Peru during the pre-vaccination period. Using national databases and a systematic review of the literature, we analyzed data on adults aged 18 and older, reporting cases, death rates, years of life lost, excess mortality, and direct medical costs. Before vaccination programs began, the average COVID-19 incidence rate was 6741 per 100,000 adults. Of these, 91% were mild cases, 7% moderate/severe, and 2% critical. Among 2,201,816 hospitalizations, 27.8% required intensive care, and 17.5% required mechanical ventilation. Excess mortality ranged from 76 to 557 per 100,000, and years of life lost spanned 241,089 to 3,312,346. Direct medical costs ranged from USD 258 million to USD 10,437 million, representing 2-5% of national health expenditures. The findings highlight significant variability across countries and provide crucial insights to help policymakers to make informed decisions and allocate resources effectively to improve national strategies around surveillance, preventive and treatment strategies to control the spread of COVID-19 disease in the future.
publishDate 2025
dc.date.none.fl_str_mv 2025-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291211
Espinola, Natalia; Loudet, Cecilia Ines; Luxardo, Rosario; Moreno, Carolina; Kyaw, Moe H.; et al.; COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review; Molecular Diversity Preservation International; International Journal of Environmental Research and Public Health; 22; 5; 4-2025; 1-20
1660-4601
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291211
identifier_str_mv Espinola, Natalia; Loudet, Cecilia Ines; Luxardo, Rosario; Moreno, Carolina; Kyaw, Moe H.; et al.; COVID-19 Disease and Economic Burden to Healthcare Systems in Adults in Six Latin American Countries Before Nationwide Vaccination Program: Ministry of Health Database Assessment and Literature Review; Molecular Diversity Preservation International; International Journal of Environmental Research and Public Health; 22; 5; 4-2025; 1-20
1660-4601
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1660-4601/22/5/669
info:eu-repo/semantics/altIdentifier/doi/10.3390/ijerph22050669
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24418

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