Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities

Autores
Barrera, Florencia Soledad; Ramirez, Dario; Gomez Mejiba, Sandra Esther
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Obesity has emerged as a significant global health challenge characterized by excessive fat accumulation and a complex interplay of systemic inflammation and metabolic dysregulation. This condition not only impacts overall health but also affects various organ systems, including the lungs. Recent research highlights how obesity influences lung health through mechanisms involving mechanics and chronic low-grade inflammation, which can alter pulmonary structure and function. Despite increasing evidence that inflammation in adipose tissue plays a crucial role in systemic metabolic disturbances, our understanding of its relationship with pulmonary neutrophilic inflammation remains limited. There is a need to explore how adipose tissue inflammation interacts with pulmonary physiology, particularly in the context of obesity-associated metabolic risk. By investigating the mechanisms underlying pulmonary neutrophilic inflammation, we can identify potential therapeutic targets to mitigate pulmonary dysfunction, as well as obesity-associated metabolic risk. This review emphasizes the importance of adipose tissue-derived inflammatory mediators in pulmonary neutrophilic inflammation in obesity-associated metabolic comorbidities.
Fil: Barrera, Florencia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia
OBESITY
PULMONARY NEUTROPHILIC INFLAMMATION
NEUTROPHIL
METABOLIC RISK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291725
Acceder
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spelling Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated ComorbiditiesBarrera, Florencia SoledadRamirez, DarioGomez Mejiba, Sandra EstherOBESITYPULMONARY NEUTROPHILIC INFLAMMATIONNEUTROPHILMETABOLIC RISKhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Obesity has emerged as a significant global health challenge characterized by excessive fat accumulation and a complex interplay of systemic inflammation and metabolic dysregulation. This condition not only impacts overall health but also affects various organ systems, including the lungs. Recent research highlights how obesity influences lung health through mechanisms involving mechanics and chronic low-grade inflammation, which can alter pulmonary structure and function. Despite increasing evidence that inflammation in adipose tissue plays a crucial role in systemic metabolic disturbances, our understanding of its relationship with pulmonary neutrophilic inflammation remains limited. There is a need to explore how adipose tissue inflammation interacts with pulmonary physiology, particularly in the context of obesity-associated metabolic risk. By investigating the mechanisms underlying pulmonary neutrophilic inflammation, we can identify potential therapeutic targets to mitigate pulmonary dysfunction, as well as obesity-associated metabolic risk. This review emphasizes the importance of adipose tissue-derived inflammatory mediators in pulmonary neutrophilic inflammation in obesity-associated metabolic comorbidities.Fil: Barrera, Florencia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaMultidisciplinary Digital Publishing Institute2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291725Barrera, Florencia Soledad; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities; Multidisciplinary Digital Publishing Institute; Preprints.org; 5-2025; 1-182310-287XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.preprints.org/manuscript/202505.1916/v1info:eu-repo/semantics/altIdentifier/doi/10.20944/preprints202505.1916.v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:10:40Zoai:ri.conicet.gov.ar:11336/291725instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:10:40.433CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
title Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
spellingShingle Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
Barrera, Florencia Soledad
OBESITY
PULMONARY NEUTROPHILIC INFLAMMATION
NEUTROPHIL
METABOLIC RISK
title_short Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
title_full Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
title_fullStr Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
title_full_unstemmed Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
title_sort Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities
dc.creator.none.fl_str_mv Barrera, Florencia Soledad
Ramirez, Dario
Gomez Mejiba, Sandra Esther
author Barrera, Florencia Soledad
author_facet Barrera, Florencia Soledad
Ramirez, Dario
Gomez Mejiba, Sandra Esther
author_role author
author2 Ramirez, Dario
Gomez Mejiba, Sandra Esther
author2_role author
author
dc.subject.none.fl_str_mv OBESITY
PULMONARY NEUTROPHILIC INFLAMMATION
NEUTROPHIL
METABOLIC RISK
topic OBESITY
PULMONARY NEUTROPHILIC INFLAMMATION
NEUTROPHIL
METABOLIC RISK
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Obesity has emerged as a significant global health challenge characterized by excessive fat accumulation and a complex interplay of systemic inflammation and metabolic dysregulation. This condition not only impacts overall health but also affects various organ systems, including the lungs. Recent research highlights how obesity influences lung health through mechanisms involving mechanics and chronic low-grade inflammation, which can alter pulmonary structure and function. Despite increasing evidence that inflammation in adipose tissue plays a crucial role in systemic metabolic disturbances, our understanding of its relationship with pulmonary neutrophilic inflammation remains limited. There is a need to explore how adipose tissue inflammation interacts with pulmonary physiology, particularly in the context of obesity-associated metabolic risk. By investigating the mechanisms underlying pulmonary neutrophilic inflammation, we can identify potential therapeutic targets to mitigate pulmonary dysfunction, as well as obesity-associated metabolic risk. This review emphasizes the importance of adipose tissue-derived inflammatory mediators in pulmonary neutrophilic inflammation in obesity-associated metabolic comorbidities.
Fil: Barrera, Florencia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description Obesity has emerged as a significant global health challenge characterized by excessive fat accumulation and a complex interplay of systemic inflammation and metabolic dysregulation. This condition not only impacts overall health but also affects various organ systems, including the lungs. Recent research highlights how obesity influences lung health through mechanisms involving mechanics and chronic low-grade inflammation, which can alter pulmonary structure and function. Despite increasing evidence that inflammation in adipose tissue plays a crucial role in systemic metabolic disturbances, our understanding of its relationship with pulmonary neutrophilic inflammation remains limited. There is a need to explore how adipose tissue inflammation interacts with pulmonary physiology, particularly in the context of obesity-associated metabolic risk. By investigating the mechanisms underlying pulmonary neutrophilic inflammation, we can identify potential therapeutic targets to mitigate pulmonary dysfunction, as well as obesity-associated metabolic risk. This review emphasizes the importance of adipose tissue-derived inflammatory mediators in pulmonary neutrophilic inflammation in obesity-associated metabolic comorbidities.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291725
Barrera, Florencia Soledad; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities; Multidisciplinary Digital Publishing Institute; Preprints.org; 5-2025; 1-18
2310-287X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291725
identifier_str_mv Barrera, Florencia Soledad; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities; Multidisciplinary Digital Publishing Institute; Preprints.org; 5-2025; 1-18
2310-287X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.preprints.org/manuscript/202505.1916/v1
info:eu-repo/semantics/altIdentifier/doi/10.20944/preprints202505.1916.v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24418

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