Taming wild replicons: evolution and domestication of large extrachromosomal replicons

Autores
Jasmin, Ostermayer; Noa, Guzzi; Jakub, Czarnecki; Soler Bistue, Alfonso J. C.; Didier, Mazel; Marie-Eve, Val
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as megaplasmids, secondary chromosomes, or chromids. Multipartite genomes, which include large ERs, are present in approximately 10% of sequenced bacterial species and are thought to have evolved as adaptive solutions to diverse ecological niches. Understanding how these replicons become essential genome components is critical for characterizing bacterial adaptability and genome plasticity. Large ERs become established within the host genome through evolutionary processes that shape their genetic content, promote the acquisition of core functions, and synchronize their replication and segregation with the bacterial cell cycle. In this review, we examine the origin, classification, and functional roles of large ERs. We highlight shared maintenance principles, such as dosage-dependent gene organization, replication control via methylation or checkpoint mechanisms, and dedicated partitioning systems or shared segregation machinery. Examples from Vibrio cholerae and Agrobacterium tumefaciens illustrate these mechanisms, and a conceptual model for ER domestication is proposed.
Fil: Jasmin, Ostermayer. Institut Pasteur de Paris.; Francia
Fil: Noa, Guzzi. Institut Pasteur de Paris.; Francia
Fil: Jakub, Czarnecki. Institut Pasteur de Paris.; Francia
Fil: Soler Bistue, Alfonso J. C.. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Didier, Mazel. Institut Pasteur de Paris.; Francia
Fil: Marie-Eve, Val. Institut Pasteur de Paris.; Francia
Materia
Genomas
Cromosomas secundarios
plásmidos
replicacion del ADN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/289274
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/289274
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Taming wild replicons: evolution and domestication of large extrachromosomal repliconsJasmin, OstermayerNoa, GuzziJakub, CzarneckiSoler Bistue, Alfonso J. C.Didier, MazelMarie-Eve, ValGenomasCromosomas secundariosplásmidosreplicacion del ADNhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as megaplasmids, secondary chromosomes, or chromids. Multipartite genomes, which include large ERs, are present in approximately 10% of sequenced bacterial species and are thought to have evolved as adaptive solutions to diverse ecological niches. Understanding how these replicons become essential genome components is critical for characterizing bacterial adaptability and genome plasticity. Large ERs become established within the host genome through evolutionary processes that shape their genetic content, promote the acquisition of core functions, and synchronize their replication and segregation with the bacterial cell cycle. In this review, we examine the origin, classification, and functional roles of large ERs. We highlight shared maintenance principles, such as dosage-dependent gene organization, replication control via methylation or checkpoint mechanisms, and dedicated partitioning systems or shared segregation machinery. Examples from Vibrio cholerae and Agrobacterium tumefaciens illustrate these mechanisms, and a conceptual model for ER domestication is proposed.Fil: Jasmin, Ostermayer. Institut Pasteur de Paris.; FranciaFil: Noa, Guzzi. Institut Pasteur de Paris.; FranciaFil: Jakub, Czarnecki. Institut Pasteur de Paris.; FranciaFil: Soler Bistue, Alfonso J. C.. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Didier, Mazel. Institut Pasteur de Paris.; FranciaFil: Marie-Eve, Val. Institut Pasteur de Paris.; FranciaCurrent Biology2025-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/289274Jasmin, Ostermayer; Noa, Guzzi; Jakub, Czarnecki; Soler Bistue, Alfonso J. C.; Didier, Mazel; et al.; Taming wild replicons: evolution and domestication of large extrachromosomal replicons; Current Biology; Current Opinion In Microbiology; 88; 12-2025; 1-101369-5274CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1369527425000797info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mib.2025.102657info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:40:13Zoai:ri.conicet.gov.ar:11336/289274instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:40:14.614CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Taming wild replicons: evolution and domestication of large extrachromosomal replicons
title Taming wild replicons: evolution and domestication of large extrachromosomal replicons
spellingShingle Taming wild replicons: evolution and domestication of large extrachromosomal replicons
Jasmin, Ostermayer
Genomas
Cromosomas secundarios
plásmidos
replicacion del ADN
title_short Taming wild replicons: evolution and domestication of large extrachromosomal replicons
title_full Taming wild replicons: evolution and domestication of large extrachromosomal replicons
title_fullStr Taming wild replicons: evolution and domestication of large extrachromosomal replicons
title_full_unstemmed Taming wild replicons: evolution and domestication of large extrachromosomal replicons
title_sort Taming wild replicons: evolution and domestication of large extrachromosomal replicons
dc.creator.none.fl_str_mv Jasmin, Ostermayer
Noa, Guzzi
Jakub, Czarnecki
Soler Bistue, Alfonso J. C.
Didier, Mazel
Marie-Eve, Val
author Jasmin, Ostermayer
author_facet Jasmin, Ostermayer
Noa, Guzzi
Jakub, Czarnecki
Soler Bistue, Alfonso J. C.
Didier, Mazel
Marie-Eve, Val
author_role author
author2 Noa, Guzzi
Jakub, Czarnecki
Soler Bistue, Alfonso J. C.
Didier, Mazel
Marie-Eve, Val
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Genomas
Cromosomas secundarios
plásmidos
replicacion del ADN
topic Genomas
Cromosomas secundarios
plásmidos
replicacion del ADN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as megaplasmids, secondary chromosomes, or chromids. Multipartite genomes, which include large ERs, are present in approximately 10% of sequenced bacterial species and are thought to have evolved as adaptive solutions to diverse ecological niches. Understanding how these replicons become essential genome components is critical for characterizing bacterial adaptability and genome plasticity. Large ERs become established within the host genome through evolutionary processes that shape their genetic content, promote the acquisition of core functions, and synchronize their replication and segregation with the bacterial cell cycle. In this review, we examine the origin, classification, and functional roles of large ERs. We highlight shared maintenance principles, such as dosage-dependent gene organization, replication control via methylation or checkpoint mechanisms, and dedicated partitioning systems or shared segregation machinery. Examples from Vibrio cholerae and Agrobacterium tumefaciens illustrate these mechanisms, and a conceptual model for ER domestication is proposed.
Fil: Jasmin, Ostermayer. Institut Pasteur de Paris.; Francia
Fil: Noa, Guzzi. Institut Pasteur de Paris.; Francia
Fil: Jakub, Czarnecki. Institut Pasteur de Paris.; Francia
Fil: Soler Bistue, Alfonso J. C.. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Didier, Mazel. Institut Pasteur de Paris.; Francia
Fil: Marie-Eve, Val. Institut Pasteur de Paris.; Francia
description Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as megaplasmids, secondary chromosomes, or chromids. Multipartite genomes, which include large ERs, are present in approximately 10% of sequenced bacterial species and are thought to have evolved as adaptive solutions to diverse ecological niches. Understanding how these replicons become essential genome components is critical for characterizing bacterial adaptability and genome plasticity. Large ERs become established within the host genome through evolutionary processes that shape their genetic content, promote the acquisition of core functions, and synchronize their replication and segregation with the bacterial cell cycle. In this review, we examine the origin, classification, and functional roles of large ERs. We highlight shared maintenance principles, such as dosage-dependent gene organization, replication control via methylation or checkpoint mechanisms, and dedicated partitioning systems or shared segregation machinery. Examples from Vibrio cholerae and Agrobacterium tumefaciens illustrate these mechanisms, and a conceptual model for ER domestication is proposed.
publishDate 2025
dc.date.none.fl_str_mv 2025-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/289274
Jasmin, Ostermayer; Noa, Guzzi; Jakub, Czarnecki; Soler Bistue, Alfonso J. C.; Didier, Mazel; et al.; Taming wild replicons: evolution and domestication of large extrachromosomal replicons; Current Biology; Current Opinion In Microbiology; 88; 12-2025; 1-10
1369-5274
CONICET Digital
CONICET
url http://hdl.handle.net/11336/289274
identifier_str_mv Jasmin, Ostermayer; Noa, Guzzi; Jakub, Czarnecki; Soler Bistue, Alfonso J. C.; Didier, Mazel; et al.; Taming wild replicons: evolution and domestication of large extrachromosomal replicons; Current Biology; Current Opinion In Microbiology; 88; 12-2025; 1-10
1369-5274
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1369527425000797
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mib.2025.102657
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Current Biology
publisher.none.fl_str_mv Current Biology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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