Health-related quality-of-life associated with Chagas disease in Argentina and Spain

Autores
Ramponi, Francesco; Sartor, Paula Andrea; Pinazo, María Jesús; Salvá, Liliana; Santos de Oliveira, Matheus; Guzman, Carlos A.; Malchiodi, Emilio Luis; Sicuri, Elisa
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: Evidence on health-related quality of life (HRQoL) in Chagas disease is essential for under- standing its burden and informing interventions. However, studies on HRQoL variation during disease progression and treatment are limited. This study provides new estimates of perceived HRQoL levels among individuals with T.cruzi infection, patients with Chagas disease, and at-risk populations, using a preference-based measure relevant for economic evaluations. Methods: HRQoL data were collected from 1383 individuals in Argentina and 157 in Spain using the EQ- 5D-3L questionnaire. We estimated utility scores and examined clinical subgroups, adjusting for sociode- mographic factors. Overall HRQoL determinants were analyzed with truncated inflated beta regression models; domain-specific determinants with seemingly unrelated ordered probit models. Results: Chagas disease significantly reduces HRQoL, with lower scores among older individuals and women. Chronic cardiac disease and symptoms were key determinants. Higher HRQoL was linked to be- ing male, more educated, and asymptomatic. Urban residents, particularly in San Juan, Argentina, reported lower HRQoL. In Spain, HRQoL declined by 0.01 per month during treatment, likely due to side effects. Conclusion: This first large EQ-5D-3L study on Chagas disease in endemic and non-endemic settings enables QALY estimation and can inform economic evaluations to guide healthcare priorities.
Fil: Ramponi, Francesco. Harvard Medical School; Estados Unidos
Fil: Sartor, Paula Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Pinazo, María Jesús. Instituto de Salud Carlos III; España
Fil: Salvá, Liliana. No especifíca;
Fil: Santos de Oliveira, Matheus. No especifíca;
Fil: Guzman, Carlos A.. No especifíca;
Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Sicuri, Elisa. Universidad de Barcelona; España
Materia
Chagas Disease
Health-related quality of life
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/287370
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/287370
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Health-related quality-of-life associated with Chagas disease in Argentina and SpainRamponi, FrancescoSartor, Paula AndreaPinazo, María JesúsSalvá, LilianaSantos de Oliveira, MatheusGuzman, Carlos A.Malchiodi, Emilio LuisSicuri, ElisaChagas DiseaseHealth-related quality of lifehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objectives: Evidence on health-related quality of life (HRQoL) in Chagas disease is essential for under- standing its burden and informing interventions. However, studies on HRQoL variation during disease progression and treatment are limited. This study provides new estimates of perceived HRQoL levels among individuals with T.cruzi infection, patients with Chagas disease, and at-risk populations, using a preference-based measure relevant for economic evaluations. Methods: HRQoL data were collected from 1383 individuals in Argentina and 157 in Spain using the EQ- 5D-3L questionnaire. We estimated utility scores and examined clinical subgroups, adjusting for sociode- mographic factors. Overall HRQoL determinants were analyzed with truncated inflated beta regression models; domain-specific determinants with seemingly unrelated ordered probit models. Results: Chagas disease significantly reduces HRQoL, with lower scores among older individuals and women. Chronic cardiac disease and symptoms were key determinants. Higher HRQoL was linked to be- ing male, more educated, and asymptomatic. Urban residents, particularly in San Juan, Argentina, reported lower HRQoL. In Spain, HRQoL declined by 0.01 per month during treatment, likely due to side effects. Conclusion: This first large EQ-5D-3L study on Chagas disease in endemic and non-endemic settings enables QALY estimation and can inform economic evaluations to guide healthcare priorities.Fil: Ramponi, Francesco. Harvard Medical School; Estados UnidosFil: Sartor, Paula Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Pinazo, María Jesús. Instituto de Salud Carlos III; EspañaFil: Salvá, Liliana. No especifíca;Fil: Santos de Oliveira, Matheus. No especifíca;Fil: Guzman, Carlos A.. No especifíca;Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Sicuri, Elisa. Universidad de Barcelona; EspañaElsevier2026-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/287370Ramponi, Francesco; Sartor, Paula Andrea; Pinazo, María Jesús; Salvá, Liliana; Santos de Oliveira, Matheus; et al.; Health-related quality-of-life associated with Chagas disease in Argentina and Spain; Elsevier; International Journal of Infectious Diseases; 164; 3-2026; 1-81201-9712CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1201971225005806info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2025.108363info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:38:34Zoai:ri.conicet.gov.ar:11336/287370instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:38:36.047CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Health-related quality-of-life associated with Chagas disease in Argentina and Spain
title Health-related quality-of-life associated with Chagas disease in Argentina and Spain
spellingShingle Health-related quality-of-life associated with Chagas disease in Argentina and Spain
Ramponi, Francesco
Chagas Disease
Health-related quality of life
title_short Health-related quality-of-life associated with Chagas disease in Argentina and Spain
title_full Health-related quality-of-life associated with Chagas disease in Argentina and Spain
title_fullStr Health-related quality-of-life associated with Chagas disease in Argentina and Spain
title_full_unstemmed Health-related quality-of-life associated with Chagas disease in Argentina and Spain
title_sort Health-related quality-of-life associated with Chagas disease in Argentina and Spain
dc.creator.none.fl_str_mv Ramponi, Francesco
Sartor, Paula Andrea
Pinazo, María Jesús
Salvá, Liliana
Santos de Oliveira, Matheus
Guzman, Carlos A.
Malchiodi, Emilio Luis
Sicuri, Elisa
author Ramponi, Francesco
author_facet Ramponi, Francesco
Sartor, Paula Andrea
Pinazo, María Jesús
Salvá, Liliana
Santos de Oliveira, Matheus
Guzman, Carlos A.
Malchiodi, Emilio Luis
Sicuri, Elisa
author_role author
author2 Sartor, Paula Andrea
Pinazo, María Jesús
Salvá, Liliana
Santos de Oliveira, Matheus
Guzman, Carlos A.
Malchiodi, Emilio Luis
Sicuri, Elisa
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas Disease
Health-related quality of life
topic Chagas Disease
Health-related quality of life
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: Evidence on health-related quality of life (HRQoL) in Chagas disease is essential for under- standing its burden and informing interventions. However, studies on HRQoL variation during disease progression and treatment are limited. This study provides new estimates of perceived HRQoL levels among individuals with T.cruzi infection, patients with Chagas disease, and at-risk populations, using a preference-based measure relevant for economic evaluations. Methods: HRQoL data were collected from 1383 individuals in Argentina and 157 in Spain using the EQ- 5D-3L questionnaire. We estimated utility scores and examined clinical subgroups, adjusting for sociode- mographic factors. Overall HRQoL determinants were analyzed with truncated inflated beta regression models; domain-specific determinants with seemingly unrelated ordered probit models. Results: Chagas disease significantly reduces HRQoL, with lower scores among older individuals and women. Chronic cardiac disease and symptoms were key determinants. Higher HRQoL was linked to be- ing male, more educated, and asymptomatic. Urban residents, particularly in San Juan, Argentina, reported lower HRQoL. In Spain, HRQoL declined by 0.01 per month during treatment, likely due to side effects. Conclusion: This first large EQ-5D-3L study on Chagas disease in endemic and non-endemic settings enables QALY estimation and can inform economic evaluations to guide healthcare priorities.
Fil: Ramponi, Francesco. Harvard Medical School; Estados Unidos
Fil: Sartor, Paula Andrea. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas y Naturales y Agrimensura; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Pinazo, María Jesús. Instituto de Salud Carlos III; España
Fil: Salvá, Liliana. No especifíca;
Fil: Santos de Oliveira, Matheus. No especifíca;
Fil: Guzman, Carlos A.. No especifíca;
Fil: Malchiodi, Emilio Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Sicuri, Elisa. Universidad de Barcelona; España
description Objectives: Evidence on health-related quality of life (HRQoL) in Chagas disease is essential for under- standing its burden and informing interventions. However, studies on HRQoL variation during disease progression and treatment are limited. This study provides new estimates of perceived HRQoL levels among individuals with T.cruzi infection, patients with Chagas disease, and at-risk populations, using a preference-based measure relevant for economic evaluations. Methods: HRQoL data were collected from 1383 individuals in Argentina and 157 in Spain using the EQ- 5D-3L questionnaire. We estimated utility scores and examined clinical subgroups, adjusting for sociode- mographic factors. Overall HRQoL determinants were analyzed with truncated inflated beta regression models; domain-specific determinants with seemingly unrelated ordered probit models. Results: Chagas disease significantly reduces HRQoL, with lower scores among older individuals and women. Chronic cardiac disease and symptoms were key determinants. Higher HRQoL was linked to be- ing male, more educated, and asymptomatic. Urban residents, particularly in San Juan, Argentina, reported lower HRQoL. In Spain, HRQoL declined by 0.01 per month during treatment, likely due to side effects. Conclusion: This first large EQ-5D-3L study on Chagas disease in endemic and non-endemic settings enables QALY estimation and can inform economic evaluations to guide healthcare priorities.
publishDate 2026
dc.date.none.fl_str_mv 2026-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/287370
Ramponi, Francesco; Sartor, Paula Andrea; Pinazo, María Jesús; Salvá, Liliana; Santos de Oliveira, Matheus; et al.; Health-related quality-of-life associated with Chagas disease in Argentina and Spain; Elsevier; International Journal of Infectious Diseases; 164; 3-2026; 1-8
1201-9712
CONICET Digital
CONICET
url http://hdl.handle.net/11336/287370
identifier_str_mv Ramponi, Francesco; Sartor, Paula Andrea; Pinazo, María Jesús; Salvá, Liliana; Santos de Oliveira, Matheus; et al.; Health-related quality-of-life associated with Chagas disease in Argentina and Spain; Elsevier; International Journal of Infectious Diseases; 164; 3-2026; 1-8
1201-9712
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1201971225005806
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2025.108363
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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