Mathematical modeling of drug delivery from cylindrical implantable devices

Autores
Ibarra, Juan Carlos Daniel; Helbling, Ignacio Marcelo; Luna, Julio Alberto
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A mechanistic mathematical model applicable to the controlled dispersed-drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volumen of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release fromcylindrical devices is established. This criterion is based on establishing amaximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release.
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
Cylindrical Geometry
Partial Differential Equation
Controlled Release
Implant
Finite External Medium
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/22357
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/22357
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mathematical modeling of drug delivery from cylindrical implantable devicesIbarra, Juan Carlos DanielHelbling, Ignacio MarceloLuna, Julio AlbertoCylindrical GeometryPartial Differential EquationControlled ReleaseImplantFinite External Mediumhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1A mechanistic mathematical model applicable to the controlled dispersed-drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volumen of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release fromcylindrical devices is established. This criterion is based on establishing amaximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release.Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaWiley2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/22357Ibarra, Juan Carlos Daniel; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Mathematical modeling of drug delivery from cylindrical implantable devices; Wiley; Mathematical Methods In The Applied Sciences; 37; 17; 1-2014; 2677-26880170-4214CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/mma.3007info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mma.3007/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:39:38Zoai:ri.conicet.gov.ar:11336/22357instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:39:39.099CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mathematical modeling of drug delivery from cylindrical implantable devices
title Mathematical modeling of drug delivery from cylindrical implantable devices
spellingShingle Mathematical modeling of drug delivery from cylindrical implantable devices
Ibarra, Juan Carlos Daniel
Cylindrical Geometry
Partial Differential Equation
Controlled Release
Implant
Finite External Medium
title_short Mathematical modeling of drug delivery from cylindrical implantable devices
title_full Mathematical modeling of drug delivery from cylindrical implantable devices
title_fullStr Mathematical modeling of drug delivery from cylindrical implantable devices
title_full_unstemmed Mathematical modeling of drug delivery from cylindrical implantable devices
title_sort Mathematical modeling of drug delivery from cylindrical implantable devices
dc.creator.none.fl_str_mv Ibarra, Juan Carlos Daniel
Helbling, Ignacio Marcelo
Luna, Julio Alberto
author Ibarra, Juan Carlos Daniel
author_facet Ibarra, Juan Carlos Daniel
Helbling, Ignacio Marcelo
Luna, Julio Alberto
author_role author
author2 Helbling, Ignacio Marcelo
Luna, Julio Alberto
author2_role author
author
dc.subject.none.fl_str_mv Cylindrical Geometry
Partial Differential Equation
Controlled Release
Implant
Finite External Medium
topic Cylindrical Geometry
Partial Differential Equation
Controlled Release
Implant
Finite External Medium
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A mechanistic mathematical model applicable to the controlled dispersed-drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volumen of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release fromcylindrical devices is established. This criterion is based on establishing amaximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release.
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description A mechanistic mathematical model applicable to the controlled dispersed-drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volumen of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release fromcylindrical devices is established. This criterion is based on establishing amaximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/22357
Ibarra, Juan Carlos Daniel; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Mathematical modeling of drug delivery from cylindrical implantable devices; Wiley; Mathematical Methods In The Applied Sciences; 37; 17; 1-2014; 2677-2688
0170-4214
CONICET Digital
CONICET
url http://hdl.handle.net/11336/22357
identifier_str_mv Ibarra, Juan Carlos Daniel; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Mathematical modeling of drug delivery from cylindrical implantable devices; Wiley; Mathematical Methods In The Applied Sciences; 37; 17; 1-2014; 2677-2688
0170-4214
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/mma.3007
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mma.3007/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.334379

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