Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines

Autores
Bardach, Ariel Esteban; Brizuela, Martin; Berrueta, Mabel; Ciapponi, Agustín; Sambade, Juan M.; Ballivian, Jamile; Ortega, Vanesa; Castellana, Noelia; Comandé, Daniel; Parker, Edward P. K.; Kampmann, Beate; Stegelmann, Katharina; Xiong, Xu; Stergachis, Andy; Munoz, Flor M.; Buekens, Pierre; Mazzoni, Agustina
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chikungunya virus (CHIKV), transmitted through Aedes mosquitoes, is a significant global health concern. Various vaccine platforms have been explored to combat CHIKV, including formalin inactivation, live-attenuated strains, virus-like particles (VLPs), viral vectors, and mRNA technologies. This umbrella review synthesizes evidence on the safety profiles of vaccine platforms used in Chikungunya vaccines that have been applied in other vaccines, focusing on adverse events of special interest (AESI) in pregnant persons, children, and adolescents. A comprehensive overview of systematic reviews (SRs) was conducted. Results: Seven systematic reviews were included and complemented with primary studies. Vaccines like influenza, human papillomavirus (HPV), and COVID-19, which share platforms with Chikungunya vaccines, showed no significant increase in AESI. Moderate-to high-quality SRs supported favorable safety profiles. Vaccines sharing platforms with Chikungunya vaccines generally exhibit acceptable safety profiles in pregnant persons, children, and adolescents.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Brizuela, Martin. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Sambade, Juan M.. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ballivian, Jamile. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ortega, Vanesa. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Castellana, Noelia. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Parker, Edward P. K.. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Kampmann, Beate. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Stegelmann, Katharina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Xiong, Xu. University of Tulane; Estados Unidos
Fil: Stergachis, Andy. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Munoz, Flor M.. Baylor College of Medicine; Estados Unidos
Fil: Buekens, Pierre. University of Washington; Estados Unidos
Fil: Mazzoni, Agustina. Baylor College Of Medicine (baylor College Of Medicine);
Materia
CHIKUNGUNYA VACCINE
CHIKUNGUNYA VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291233
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/291233
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccinesBardach, Ariel EstebanBrizuela, MartinBerrueta, MabelCiapponi, AgustínSambade, Juan M.Ballivian, JamileOrtega, VanesaCastellana, NoeliaComandé, DanielParker, Edward P. K.Kampmann, BeateStegelmann, KatharinaXiong, XuStergachis, AndyMunoz, Flor M.Buekens, PierreMazzoni, AgustinaCHIKUNGUNYA VACCINECHIKUNGUNYA VIRUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chikungunya virus (CHIKV), transmitted through Aedes mosquitoes, is a significant global health concern. Various vaccine platforms have been explored to combat CHIKV, including formalin inactivation, live-attenuated strains, virus-like particles (VLPs), viral vectors, and mRNA technologies. This umbrella review synthesizes evidence on the safety profiles of vaccine platforms used in Chikungunya vaccines that have been applied in other vaccines, focusing on adverse events of special interest (AESI) in pregnant persons, children, and adolescents. A comprehensive overview of systematic reviews (SRs) was conducted. Results: Seven systematic reviews were included and complemented with primary studies. Vaccines like influenza, human papillomavirus (HPV), and COVID-19, which share platforms with Chikungunya vaccines, showed no significant increase in AESI. Moderate-to high-quality SRs supported favorable safety profiles. Vaccines sharing platforms with Chikungunya vaccines generally exhibit acceptable safety profiles in pregnant persons, children, and adolescents.Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Brizuela, Martin. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Sambade, Juan M.. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ballivian, Jamile. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ortega, Vanesa. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Castellana, Noelia. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Parker, Edward P. K.. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Kampmann, Beate. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Stegelmann, Katharina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Xiong, Xu. University of Tulane; Estados UnidosFil: Stergachis, Andy. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Munoz, Flor M.. Baylor College of Medicine; Estados UnidosFil: Buekens, Pierre. University of Washington; Estados UnidosFil: Mazzoni, Agustina. Baylor College Of Medicine (baylor College Of Medicine);Oxford University Press2025-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291233Bardach, Ariel Esteban; Brizuela, Martin; Berrueta, Mabel; Ciapponi, Agustín; Sambade, Juan M.; et al.; Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines; Oxford University Press; Human Vaccines & Immunotherapeutics; 21; 1; 2-2025; 1-132164-5515CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/21645515.2025.2463191info:eu-repo/semantics/altIdentifier/doi/10.1080/21645515.2025.2463191info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:10:03Zoai:ri.conicet.gov.ar:11336/291233instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:10:04.174CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
title Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
spellingShingle Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
Bardach, Ariel Esteban
CHIKUNGUNYA VACCINE
CHIKUNGUNYA VIRUS
title_short Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
title_full Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
title_fullStr Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
title_full_unstemmed Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
title_sort Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines
dc.creator.none.fl_str_mv Bardach, Ariel Esteban
Brizuela, Martin
Berrueta, Mabel
Ciapponi, Agustín
Sambade, Juan M.
Ballivian, Jamile
Ortega, Vanesa
Castellana, Noelia
Comandé, Daniel
Parker, Edward P. K.
Kampmann, Beate
Stegelmann, Katharina
Xiong, Xu
Stergachis, Andy
Munoz, Flor M.
Buekens, Pierre
Mazzoni, Agustina
author Bardach, Ariel Esteban
author_facet Bardach, Ariel Esteban
Brizuela, Martin
Berrueta, Mabel
Ciapponi, Agustín
Sambade, Juan M.
Ballivian, Jamile
Ortega, Vanesa
Castellana, Noelia
Comandé, Daniel
Parker, Edward P. K.
Kampmann, Beate
Stegelmann, Katharina
Xiong, Xu
Stergachis, Andy
Munoz, Flor M.
Buekens, Pierre
Mazzoni, Agustina
author_role author
author2 Brizuela, Martin
Berrueta, Mabel
Ciapponi, Agustín
Sambade, Juan M.
Ballivian, Jamile
Ortega, Vanesa
Castellana, Noelia
Comandé, Daniel
Parker, Edward P. K.
Kampmann, Beate
Stegelmann, Katharina
Xiong, Xu
Stergachis, Andy
Munoz, Flor M.
Buekens, Pierre
Mazzoni, Agustina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHIKUNGUNYA VACCINE
CHIKUNGUNYA VIRUS
topic CHIKUNGUNYA VACCINE
CHIKUNGUNYA VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chikungunya virus (CHIKV), transmitted through Aedes mosquitoes, is a significant global health concern. Various vaccine platforms have been explored to combat CHIKV, including formalin inactivation, live-attenuated strains, virus-like particles (VLPs), viral vectors, and mRNA technologies. This umbrella review synthesizes evidence on the safety profiles of vaccine platforms used in Chikungunya vaccines that have been applied in other vaccines, focusing on adverse events of special interest (AESI) in pregnant persons, children, and adolescents. A comprehensive overview of systematic reviews (SRs) was conducted. Results: Seven systematic reviews were included and complemented with primary studies. Vaccines like influenza, human papillomavirus (HPV), and COVID-19, which share platforms with Chikungunya vaccines, showed no significant increase in AESI. Moderate-to high-quality SRs supported favorable safety profiles. Vaccines sharing platforms with Chikungunya vaccines generally exhibit acceptable safety profiles in pregnant persons, children, and adolescents.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Brizuela, Martin. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Berrueta, Mabel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Sambade, Juan M.. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ballivian, Jamile. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ortega, Vanesa. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Castellana, Noelia. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Comandé, Daniel. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Parker, Edward P. K.. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Kampmann, Beate. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Stegelmann, Katharina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Xiong, Xu. University of Tulane; Estados Unidos
Fil: Stergachis, Andy. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Munoz, Flor M.. Baylor College of Medicine; Estados Unidos
Fil: Buekens, Pierre. University of Washington; Estados Unidos
Fil: Mazzoni, Agustina. Baylor College Of Medicine (baylor College Of Medicine);
description Chikungunya virus (CHIKV), transmitted through Aedes mosquitoes, is a significant global health concern. Various vaccine platforms have been explored to combat CHIKV, including formalin inactivation, live-attenuated strains, virus-like particles (VLPs), viral vectors, and mRNA technologies. This umbrella review synthesizes evidence on the safety profiles of vaccine platforms used in Chikungunya vaccines that have been applied in other vaccines, focusing on adverse events of special interest (AESI) in pregnant persons, children, and adolescents. A comprehensive overview of systematic reviews (SRs) was conducted. Results: Seven systematic reviews were included and complemented with primary studies. Vaccines like influenza, human papillomavirus (HPV), and COVID-19, which share platforms with Chikungunya vaccines, showed no significant increase in AESI. Moderate-to high-quality SRs supported favorable safety profiles. Vaccines sharing platforms with Chikungunya vaccines generally exhibit acceptable safety profiles in pregnant persons, children, and adolescents.
publishDate 2025
dc.date.none.fl_str_mv 2025-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291233
Bardach, Ariel Esteban; Brizuela, Martin; Berrueta, Mabel; Ciapponi, Agustín; Sambade, Juan M.; et al.; Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines; Oxford University Press; Human Vaccines & Immunotherapeutics; 21; 1; 2-2025; 1-13
2164-5515
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291233
identifier_str_mv Bardach, Ariel Esteban; Brizuela, Martin; Berrueta, Mabel; Ciapponi, Agustín; Sambade, Juan M.; et al.; Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines; Oxford University Press; Human Vaccines & Immunotherapeutics; 21; 1; 2-2025; 1-13
2164-5515
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/21645515.2025.2463191
info:eu-repo/semantics/altIdentifier/doi/10.1080/21645515.2025.2463191
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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