Recent advances in the use of gelatin as a biomaterial for tissue engineering

Autores
Maeso, Lidia; Antezana, Pablo Edmundo; Municoy, Sofia; Zarate, Jon; Lertxundi, Unax; Mishra, Yogendra Kumar; Dolatshahi-Pirouz, Alireza; Desimone, Martín Federico; Orive, Gorka
Año de publicación
2026
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The continuous advancement of tissue engineering demands the development of novel biomaterials and strategies to create functional and translational tissue constructs. Despite the emergence of new materials, gelatin remains one of the most practical and versatile, widely used biomaterials, combining biocompatibility, tunable properties, and ease of processing, while its biodegradability and derivation from circular economy resources further position it as a sustainable option. This review unfolds the recent trends in gelatin uses across three key areas. First, advances in functionalization, including chemical modifications that enhance mechanical properties and enable smart, self-healing systems, as well as hybridization with natural, synthetic, or inorganic components to expand multifunctionality. Second, innovations in fabrication techniques, from lyophilization and electrospinning to 3D and 4D bioprinting, which allow precise architectural control and patient-specific scaffold design. Third, emerging applications in tissue engineering, demonstrating the latest achievements of gelatin-based hydrogels, nanoparticles, and composites for skin, soft tissue, bone, cartilage, and ocular regeneration, including drug delivery and stimulus-responsive platforms. As predicted in previous reports on gelatin use, this versatile biomaterial continues to be one of the most widely applied and highly valued materials for tissue engineering purposes.
Fil: Maeso, Lidia. Universidad del País Vasco; España
Fil: Antezana, Pablo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Zarate, Jon. Universidad del País Vasco; España
Fil: Lertxundi, Unax. Universidad del País Vasco; España
Fil: Mishra, Yogendra Kumar. Technical University of Denmark; Dinamarca
Fil: Dolatshahi-Pirouz, Alireza. Technical University of Denmark; Dinamarca
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Orive, Gorka. Universidad del País Vasco; España
Materia
GELATIN
BIOMATERIAL
TISSUE ENGINEERING
HYDROGEL
REGENERATIVE MEDICINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/290123
Acceder
id CONICETDig_c68f6324fc7285ba0ae5d44b9889c6b0
oai_identifier_str oai:ri.conicet.gov.ar:11336/290123
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Recent advances in the use of gelatin as a biomaterial for tissue engineeringMaeso, LidiaAntezana, Pablo EdmundoMunicoy, SofiaZarate, JonLertxundi, UnaxMishra, Yogendra KumarDolatshahi-Pirouz, AlirezaDesimone, Martín FedericoOrive, GorkaGELATINBIOMATERIALTISSUE ENGINEERINGHYDROGELREGENERATIVE MEDICINEhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The continuous advancement of tissue engineering demands the development of novel biomaterials and strategies to create functional and translational tissue constructs. Despite the emergence of new materials, gelatin remains one of the most practical and versatile, widely used biomaterials, combining biocompatibility, tunable properties, and ease of processing, while its biodegradability and derivation from circular economy resources further position it as a sustainable option. This review unfolds the recent trends in gelatin uses across three key areas. First, advances in functionalization, including chemical modifications that enhance mechanical properties and enable smart, self-healing systems, as well as hybridization with natural, synthetic, or inorganic components to expand multifunctionality. Second, innovations in fabrication techniques, from lyophilization and electrospinning to 3D and 4D bioprinting, which allow precise architectural control and patient-specific scaffold design. Third, emerging applications in tissue engineering, demonstrating the latest achievements of gelatin-based hydrogels, nanoparticles, and composites for skin, soft tissue, bone, cartilage, and ocular regeneration, including drug delivery and stimulus-responsive platforms. As predicted in previous reports on gelatin use, this versatile biomaterial continues to be one of the most widely applied and highly valued materials for tissue engineering purposes.Fil: Maeso, Lidia. Universidad del País Vasco; EspañaFil: Antezana, Pablo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Zarate, Jon. Universidad del País Vasco; EspañaFil: Lertxundi, Unax. Universidad del País Vasco; EspañaFil: Mishra, Yogendra Kumar. Technical University of Denmark; DinamarcaFil: Dolatshahi-Pirouz, Alireza. Technical University of Denmark; DinamarcaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Orive, Gorka. Universidad del País Vasco; EspañaElsevier Science2026-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/290123Maeso, Lidia; Antezana, Pablo Edmundo; Municoy, Sofia; Zarate, Jon; Lertxundi, Unax; et al.; Recent advances in the use of gelatin as a biomaterial for tissue engineering; Elsevier Science; International Journal Of Pharmaceutics; 696; 3-2026; 1-440378-5173CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0378517326002760info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijpharm.2026.126828info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:53:05Zoai:ri.conicet.gov.ar:11336/290123instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:53:05.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Recent advances in the use of gelatin as a biomaterial for tissue engineering
title Recent advances in the use of gelatin as a biomaterial for tissue engineering
spellingShingle Recent advances in the use of gelatin as a biomaterial for tissue engineering
Maeso, Lidia
GELATIN
BIOMATERIAL
TISSUE ENGINEERING
HYDROGEL
REGENERATIVE MEDICINE
title_short Recent advances in the use of gelatin as a biomaterial for tissue engineering
title_full Recent advances in the use of gelatin as a biomaterial for tissue engineering
title_fullStr Recent advances in the use of gelatin as a biomaterial for tissue engineering
title_full_unstemmed Recent advances in the use of gelatin as a biomaterial for tissue engineering
title_sort Recent advances in the use of gelatin as a biomaterial for tissue engineering
dc.creator.none.fl_str_mv Maeso, Lidia
Antezana, Pablo Edmundo
Municoy, Sofia
Zarate, Jon
Lertxundi, Unax
Mishra, Yogendra Kumar
Dolatshahi-Pirouz, Alireza
Desimone, Martín Federico
Orive, Gorka
author Maeso, Lidia
author_facet Maeso, Lidia
Antezana, Pablo Edmundo
Municoy, Sofia
Zarate, Jon
Lertxundi, Unax
Mishra, Yogendra Kumar
Dolatshahi-Pirouz, Alireza
Desimone, Martín Federico
Orive, Gorka
author_role author
author2 Antezana, Pablo Edmundo
Municoy, Sofia
Zarate, Jon
Lertxundi, Unax
Mishra, Yogendra Kumar
Dolatshahi-Pirouz, Alireza
Desimone, Martín Federico
Orive, Gorka
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GELATIN
BIOMATERIAL
TISSUE ENGINEERING
HYDROGEL
REGENERATIVE MEDICINE
topic GELATIN
BIOMATERIAL
TISSUE ENGINEERING
HYDROGEL
REGENERATIVE MEDICINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The continuous advancement of tissue engineering demands the development of novel biomaterials and strategies to create functional and translational tissue constructs. Despite the emergence of new materials, gelatin remains one of the most practical and versatile, widely used biomaterials, combining biocompatibility, tunable properties, and ease of processing, while its biodegradability and derivation from circular economy resources further position it as a sustainable option. This review unfolds the recent trends in gelatin uses across three key areas. First, advances in functionalization, including chemical modifications that enhance mechanical properties and enable smart, self-healing systems, as well as hybridization with natural, synthetic, or inorganic components to expand multifunctionality. Second, innovations in fabrication techniques, from lyophilization and electrospinning to 3D and 4D bioprinting, which allow precise architectural control and patient-specific scaffold design. Third, emerging applications in tissue engineering, demonstrating the latest achievements of gelatin-based hydrogels, nanoparticles, and composites for skin, soft tissue, bone, cartilage, and ocular regeneration, including drug delivery and stimulus-responsive platforms. As predicted in previous reports on gelatin use, this versatile biomaterial continues to be one of the most widely applied and highly valued materials for tissue engineering purposes.
Fil: Maeso, Lidia. Universidad del País Vasco; España
Fil: Antezana, Pablo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Municoy, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Zarate, Jon. Universidad del País Vasco; España
Fil: Lertxundi, Unax. Universidad del País Vasco; España
Fil: Mishra, Yogendra Kumar. Technical University of Denmark; Dinamarca
Fil: Dolatshahi-Pirouz, Alireza. Technical University of Denmark; Dinamarca
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Orive, Gorka. Universidad del País Vasco; España
description The continuous advancement of tissue engineering demands the development of novel biomaterials and strategies to create functional and translational tissue constructs. Despite the emergence of new materials, gelatin remains one of the most practical and versatile, widely used biomaterials, combining biocompatibility, tunable properties, and ease of processing, while its biodegradability and derivation from circular economy resources further position it as a sustainable option. This review unfolds the recent trends in gelatin uses across three key areas. First, advances in functionalization, including chemical modifications that enhance mechanical properties and enable smart, self-healing systems, as well as hybridization with natural, synthetic, or inorganic components to expand multifunctionality. Second, innovations in fabrication techniques, from lyophilization and electrospinning to 3D and 4D bioprinting, which allow precise architectural control and patient-specific scaffold design. Third, emerging applications in tissue engineering, demonstrating the latest achievements of gelatin-based hydrogels, nanoparticles, and composites for skin, soft tissue, bone, cartilage, and ocular regeneration, including drug delivery and stimulus-responsive platforms. As predicted in previous reports on gelatin use, this versatile biomaterial continues to be one of the most widely applied and highly valued materials for tissue engineering purposes.
publishDate 2026
dc.date.none.fl_str_mv 2026-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/290123
Maeso, Lidia; Antezana, Pablo Edmundo; Municoy, Sofia; Zarate, Jon; Lertxundi, Unax; et al.; Recent advances in the use of gelatin as a biomaterial for tissue engineering; Elsevier Science; International Journal Of Pharmaceutics; 696; 3-2026; 1-44
0378-5173
CONICET Digital
CONICET
url http://hdl.handle.net/11336/290123
identifier_str_mv Maeso, Lidia; Antezana, Pablo Edmundo; Municoy, Sofia; Zarate, Jon; Lertxundi, Unax; et al.; Recent advances in the use of gelatin as a biomaterial for tissue engineering; Elsevier Science; International Journal Of Pharmaceutics; 696; 3-2026; 1-44
0378-5173
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0378517326002760
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijpharm.2026.126828
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874774826979164160
score 13.265058

Publicaciones similares