Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise

Autores
Bouzat, Cecilia Beatriz
Año de publicación
2025
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Pentameric ligand-gated ion channels (pLGICs) are essential for translating neurotransmitter recognition into electrical signals in both vertebrates and invertebrates, contributing to fundamental processes such as movement, memory, cognition, and synaptic plasticity. These receptors are expressed not only in the nervous system but also in various non-neuronal cells, and are implicated in a wide spectrum of disorders, making them key pharmacological targets for clinically relevant drugs. In vertebrates, the pLGIC family includes cation-selective channels—nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors—as well as anion-selective channels such as glycine and GABAA_A receptors, whereas in invertebrates the repertoire is even more diverse. Remarkably, the free-living nematode Caenorhabditis elegans—a model for both human diseases and anthelmintic drug discovery—possesses one of the largest and most varied pLGIC families, making it an ideal system for investigating their function and therapeutic potential. Using a combination of experimental approaches, including high-resolution patch-clamp recordings primarily focused on nicotinic and serotonin receptors, we characterized their kinetic and functional properties and identified novel modulatory compounds, providing valuable insights into their potential as therapeutic targets. Extending this framework to C. elegans, we bridged molecular and organismal levels to uncover functional features of nematode pLGICs— some conserved and relevant to human diseases, others uniquely nematode-specific and emerging as anthelmintic targets. These findings highlight new molecular targets and lead compounds for the development of novel therapies. Our work offers insights into receptor function under both physiological and pathological conditions, paving the way for innovative therapeutic applications.
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XLVI Congreso Anual de la Sociedad de Farmacología de Chile
Valdivia
Chile
Sociedad de Farmacología de Chile
Materia
LIGAND-GATED ION CHANNEL
NICOTINIC RECEPTOR
PATCH CLAMP
MODULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/289769
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promiseBouzat, Cecilia BeatrizLIGAND-GATED ION CHANNELNICOTINIC RECEPTORPATCH CLAMPMODULATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Pentameric ligand-gated ion channels (pLGICs) are essential for translating neurotransmitter recognition into electrical signals in both vertebrates and invertebrates, contributing to fundamental processes such as movement, memory, cognition, and synaptic plasticity. These receptors are expressed not only in the nervous system but also in various non-neuronal cells, and are implicated in a wide spectrum of disorders, making them key pharmacological targets for clinically relevant drugs. In vertebrates, the pLGIC family includes cation-selective channels—nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors—as well as anion-selective channels such as glycine and GABAA_A receptors, whereas in invertebrates the repertoire is even more diverse. Remarkably, the free-living nematode Caenorhabditis elegans—a model for both human diseases and anthelmintic drug discovery—possesses one of the largest and most varied pLGIC families, making it an ideal system for investigating their function and therapeutic potential. Using a combination of experimental approaches, including high-resolution patch-clamp recordings primarily focused on nicotinic and serotonin receptors, we characterized their kinetic and functional properties and identified novel modulatory compounds, providing valuable insights into their potential as therapeutic targets. Extending this framework to C. elegans, we bridged molecular and organismal levels to uncover functional features of nematode pLGICs— some conserved and relevant to human diseases, others uniquely nematode-specific and emerging as anthelmintic targets. These findings highlight new molecular targets and lead compounds for the development of novel therapies. Our work offers insights into receptor function under both physiological and pathological conditions, paving the way for innovative therapeutic applications.Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaXLVI Congreso Anual de la Sociedad de Farmacología de ChileValdiviaChileSociedad de Farmacología de ChileSociedad de Farmacología de Chile2025info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/289769Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise; XLVI Congreso Anual de la Sociedad de Farmacología de Chile; Valdivia; Chile; 2025; 7-7CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://temasdesalud.cl/evento/xlvi-congreso-anual-de-la-sociedad-de-farmacologia-de-chile-2-al-5-de-diciembre-de-2025/info:eu-repo/semantics/altIdentifier/url/https://www.sofarchi.cl/wp-content/uploads/Revista-Farmacologia-Vol1_2025.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:49:10Zoai:ri.conicet.gov.ar:11336/289769instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:49:10.566CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
title Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
spellingShingle Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
Bouzat, Cecilia Beatriz
LIGAND-GATED ION CHANNEL
NICOTINIC RECEPTOR
PATCH CLAMP
MODULATION
title_short Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
title_full Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
title_fullStr Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
title_full_unstemmed Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
title_sort Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise
dc.creator.none.fl_str_mv Bouzat, Cecilia Beatriz
author Bouzat, Cecilia Beatriz
author_facet Bouzat, Cecilia Beatriz
author_role author
dc.subject.none.fl_str_mv LIGAND-GATED ION CHANNEL
NICOTINIC RECEPTOR
PATCH CLAMP
MODULATION
topic LIGAND-GATED ION CHANNEL
NICOTINIC RECEPTOR
PATCH CLAMP
MODULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pentameric ligand-gated ion channels (pLGICs) are essential for translating neurotransmitter recognition into electrical signals in both vertebrates and invertebrates, contributing to fundamental processes such as movement, memory, cognition, and synaptic plasticity. These receptors are expressed not only in the nervous system but also in various non-neuronal cells, and are implicated in a wide spectrum of disorders, making them key pharmacological targets for clinically relevant drugs. In vertebrates, the pLGIC family includes cation-selective channels—nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors—as well as anion-selective channels such as glycine and GABAA_A receptors, whereas in invertebrates the repertoire is even more diverse. Remarkably, the free-living nematode Caenorhabditis elegans—a model for both human diseases and anthelmintic drug discovery—possesses one of the largest and most varied pLGIC families, making it an ideal system for investigating their function and therapeutic potential. Using a combination of experimental approaches, including high-resolution patch-clamp recordings primarily focused on nicotinic and serotonin receptors, we characterized their kinetic and functional properties and identified novel modulatory compounds, providing valuable insights into their potential as therapeutic targets. Extending this framework to C. elegans, we bridged molecular and organismal levels to uncover functional features of nematode pLGICs— some conserved and relevant to human diseases, others uniquely nematode-specific and emerging as anthelmintic targets. These findings highlight new molecular targets and lead compounds for the development of novel therapies. Our work offers insights into receptor function under both physiological and pathological conditions, paving the way for innovative therapeutic applications.
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XLVI Congreso Anual de la Sociedad de Farmacología de Chile
Valdivia
Chile
Sociedad de Farmacología de Chile
description Pentameric ligand-gated ion channels (pLGICs) are essential for translating neurotransmitter recognition into electrical signals in both vertebrates and invertebrates, contributing to fundamental processes such as movement, memory, cognition, and synaptic plasticity. These receptors are expressed not only in the nervous system but also in various non-neuronal cells, and are implicated in a wide spectrum of disorders, making them key pharmacological targets for clinically relevant drugs. In vertebrates, the pLGIC family includes cation-selective channels—nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors—as well as anion-selective channels such as glycine and GABAA_A receptors, whereas in invertebrates the repertoire is even more diverse. Remarkably, the free-living nematode Caenorhabditis elegans—a model for both human diseases and anthelmintic drug discovery—possesses one of the largest and most varied pLGIC families, making it an ideal system for investigating their function and therapeutic potential. Using a combination of experimental approaches, including high-resolution patch-clamp recordings primarily focused on nicotinic and serotonin receptors, we characterized their kinetic and functional properties and identified novel modulatory compounds, providing valuable insights into their potential as therapeutic targets. Extending this framework to C. elegans, we bridged molecular and organismal levels to uncover functional features of nematode pLGICs— some conserved and relevant to human diseases, others uniquely nematode-specific and emerging as anthelmintic targets. These findings highlight new molecular targets and lead compounds for the development of novel therapies. Our work offers insights into receptor function under both physiological and pathological conditions, paving the way for innovative therapeutic applications.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/289769
Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise; XLVI Congreso Anual de la Sociedad de Farmacología de Chile; Valdivia; Chile; 2025; 7-7
CONICET Digital
CONICET
url http://hdl.handle.net/11336/289769
identifier_str_mv Pentameric ligand-gated ion channels: Bridging molecular Insights and clinical promise; XLVI Congreso Anual de la Sociedad de Farmacología de Chile; Valdivia; Chile; 2025; 7-7
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://temasdesalud.cl/evento/xlvi-congreso-anual-de-la-sociedad-de-farmacologia-de-chile-2-al-5-de-diciembre-de-2025/
info:eu-repo/semantics/altIdentifier/url/https://www.sofarchi.cl/wp-content/uploads/Revista-Farmacologia-Vol1_2025.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Sociedad de Farmacología de Chile
publisher.none.fl_str_mv Sociedad de Farmacología de Chile
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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