WHF Roadmap on Single Pill Combination Therapies

Autores
Enrico G Ferro; Satheesh, Gautam; Castellano, José; Damasceno, Albertino; Erojikwe, Okeoma; Huffman, Mark; Irazola, Vilma; Joseph, Philip; Lanas, Fernando; Ogola, Elijah; Ordunez, Pedro; Perel, Pablo; Pineiro, Daniel; Uchmanowicz, Izabela; Vardeny, Orly; Webster, Ruth; Gamra, Habib; Gaziano, Thomas
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.
Fil: Enrico G Ferro. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Satheesh, Gautam. The George Institute For Global Health; India
Fil: Castellano, José. Spanish National Centre For Cardiovascular Research; España
Fil: Damasceno, Albertino. Eduardo Mondlane University; Mozambique
Fil: Erojikwe, Okeoma. No especifíca;
Fil: Huffman, Mark. Washington University in St. Louis; Estados Unidos
Fil: Irazola, Vilma. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Joseph, Philip. No especifíca;
Fil: Lanas, Fernando. Universidad de La Frontera; Chile
Fil: Ogola, Elijah. University Of Nairobi; Kenia
Fil: Ordunez, Pedro. No especifíca;
Fil: Perel, Pablo. No especifíca;
Fil: Pineiro, Daniel. No especifíca;
Fil: Uchmanowicz, Izabela. No especifíca;
Fil: Vardeny, Orly. No especifíca;
Fil: Webster, Ruth. No especifíca;
Fil: Gamra, Habib. No especifíca;
Fil: Gaziano, Thomas. No especifíca;
Materia
Cardiovascular disease
polypill
prevention
single pill combinations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/291161
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/291161
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling WHF Roadmap on Single Pill Combination TherapiesEnrico G FerroSatheesh, GautamCastellano, JoséDamasceno, AlbertinoErojikwe, OkeomaHuffman, MarkIrazola, VilmaJoseph, PhilipLanas, FernandoOgola, ElijahOrdunez, PedroPerel, PabloPineiro, DanielUchmanowicz, IzabelaVardeny, OrlyWebster, RuthGamra, HabibGaziano, ThomasCardiovascular diseasepolypillpreventionsingle pill combinationshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.Fil: Enrico G Ferro. Harvard University. Harvard School of Public Health; Estados UnidosFil: Satheesh, Gautam. The George Institute For Global Health; IndiaFil: Castellano, José. Spanish National Centre For Cardiovascular Research; EspañaFil: Damasceno, Albertino. Eduardo Mondlane University; MozambiqueFil: Erojikwe, Okeoma. No especifíca;Fil: Huffman, Mark. Washington University in St. Louis; Estados UnidosFil: Irazola, Vilma. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Joseph, Philip. No especifíca;Fil: Lanas, Fernando. Universidad de La Frontera; ChileFil: Ogola, Elijah. University Of Nairobi; KeniaFil: Ordunez, Pedro. No especifíca;Fil: Perel, Pablo. No especifíca;Fil: Pineiro, Daniel. No especifíca;Fil: Uchmanowicz, Izabela. No especifíca;Fil: Vardeny, Orly. No especifíca;Fil: Webster, Ruth. No especifíca;Fil: Gamra, Habib. No especifíca;Fil: Gaziano, Thomas. No especifíca;Ubiquity Press2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/291161Enrico G Ferro; Satheesh, Gautam; Castellano, José; Damasceno, Albertino; Erojikwe, Okeoma; et al.; WHF Roadmap on Single Pill Combination Therapies; Ubiquity Press; Global Heart; 20; 1; 8-2025; 1-152211-8179CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.5334/gh.1457info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:49:39Zoai:ri.conicet.gov.ar:11336/291161instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:49:39.637CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv WHF Roadmap on Single Pill Combination Therapies
title WHF Roadmap on Single Pill Combination Therapies
spellingShingle WHF Roadmap on Single Pill Combination Therapies
Enrico G Ferro
Cardiovascular disease
polypill
prevention
single pill combinations
title_short WHF Roadmap on Single Pill Combination Therapies
title_full WHF Roadmap on Single Pill Combination Therapies
title_fullStr WHF Roadmap on Single Pill Combination Therapies
title_full_unstemmed WHF Roadmap on Single Pill Combination Therapies
title_sort WHF Roadmap on Single Pill Combination Therapies
dc.creator.none.fl_str_mv Enrico G Ferro
Satheesh, Gautam
Castellano, José
Damasceno, Albertino
Erojikwe, Okeoma
Huffman, Mark
Irazola, Vilma
Joseph, Philip
Lanas, Fernando
Ogola, Elijah
Ordunez, Pedro
Perel, Pablo
Pineiro, Daniel
Uchmanowicz, Izabela
Vardeny, Orly
Webster, Ruth
Gamra, Habib
Gaziano, Thomas
author Enrico G Ferro
author_facet Enrico G Ferro
Satheesh, Gautam
Castellano, José
Damasceno, Albertino
Erojikwe, Okeoma
Huffman, Mark
Irazola, Vilma
Joseph, Philip
Lanas, Fernando
Ogola, Elijah
Ordunez, Pedro
Perel, Pablo
Pineiro, Daniel
Uchmanowicz, Izabela
Vardeny, Orly
Webster, Ruth
Gamra, Habib
Gaziano, Thomas
author_role author
author2 Satheesh, Gautam
Castellano, José
Damasceno, Albertino
Erojikwe, Okeoma
Huffman, Mark
Irazola, Vilma
Joseph, Philip
Lanas, Fernando
Ogola, Elijah
Ordunez, Pedro
Perel, Pablo
Pineiro, Daniel
Uchmanowicz, Izabela
Vardeny, Orly
Webster, Ruth
Gamra, Habib
Gaziano, Thomas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cardiovascular disease
polypill
prevention
single pill combinations
topic Cardiovascular disease
polypill
prevention
single pill combinations
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.
Fil: Enrico G Ferro. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Satheesh, Gautam. The George Institute For Global Health; India
Fil: Castellano, José. Spanish National Centre For Cardiovascular Research; España
Fil: Damasceno, Albertino. Eduardo Mondlane University; Mozambique
Fil: Erojikwe, Okeoma. No especifíca;
Fil: Huffman, Mark. Washington University in St. Louis; Estados Unidos
Fil: Irazola, Vilma. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Joseph, Philip. No especifíca;
Fil: Lanas, Fernando. Universidad de La Frontera; Chile
Fil: Ogola, Elijah. University Of Nairobi; Kenia
Fil: Ordunez, Pedro. No especifíca;
Fil: Perel, Pablo. No especifíca;
Fil: Pineiro, Daniel. No especifíca;
Fil: Uchmanowicz, Izabela. No especifíca;
Fil: Vardeny, Orly. No especifíca;
Fil: Webster, Ruth. No especifíca;
Fil: Gamra, Habib. No especifíca;
Fil: Gaziano, Thomas. No especifíca;
description Cardiovascular diseases (CVDs) are the leading global cause of mortality, with treatment adherence posing a major barrier to effective prevention and control. Single pill combinations (SPCs), also known as fixed-dose combinations, simplify treatment by combining multiple agents into one pill, improving adherence and reducing cardiovascular risk. This World Heart Federation Roadmap synthesizes the latest clinical evidence and identifies key barriers to SPC implementation, including limited manufacturing, affordability, regulatory complexity, and inconsistent guideline inclusion. Drawing on global expert input and health systems analysis, the Roadmap outlines practical, context-specific solutions to improve access, scale-up, and integration of SPCs into national strategies, especially in low- and middle-income countries. It serves as a tool for policymakers, clinicians, and advocates to drive progress in aligning cardiovascular prevention efforts with evidence-based, people-centred care.
publishDate 2025
dc.date.none.fl_str_mv 2025-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/291161
Enrico G Ferro; Satheesh, Gautam; Castellano, José; Damasceno, Albertino; Erojikwe, Okeoma; et al.; WHF Roadmap on Single Pill Combination Therapies; Ubiquity Press; Global Heart; 20; 1; 8-2025; 1-15
2211-8179
CONICET Digital
CONICET
url http://hdl.handle.net/11336/291161
identifier_str_mv Enrico G Ferro; Satheesh, Gautam; Castellano, José; Damasceno, Albertino; Erojikwe, Okeoma; et al.; WHF Roadmap on Single Pill Combination Therapies; Ubiquity Press; Global Heart; 20; 1; 8-2025; 1-15
2211-8179
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.5334/gh.1457
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Ubiquity Press
publisher.none.fl_str_mv Ubiquity Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874775850176479232
score 13.265058

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