Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation

Autores
Rodríguez, Juan Pablo; Casas, Javier; Balboa, María A.; Balsinde, Jesús
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Macrophages, crucial innate immune cells, defend against pathogens and resolvein ammation, maintaining tissue balance. They perform phagocytosis, presentantigens to T cells, and bond innate and adaptive immunity through variousactivation states. Classical activation is associated with Th1 responses andinterferon g production, while alternative activation, induced by interleukin 4, ischaracterized by increased endocytosis, reduced secretion of pro-in ammatorycytokines, and roles in immunoregulation and tissue remodeling. Although theserepresent opposite extremes observed in vitro, the remarkable plasticity ofmacrophages allows for a wide spectrum of activation phenotypes that arecomplex to characterize experimentally. While the application of omicstechniques has resulted in signi cant advances in the characterization ofmacrophage polarization, lipidomic studies have received lesser attention.Beyond their role as structural components and energy sources, lipids functionas signaling molecules that regulate macrophage activation and polarization,thereby shaping immune responses. This work reviews the interaction betweenlipid signaling and macrophage polarization, exploring how lipid metabolismin uences macrophage phenotype and function. These insights offer potentialtherapeutic strategies for immune-mediated diseases and in ammation-relateddisorders, including in ammaging.
Fil: Rodríguez, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Casas, Javier. Universidad de Valladolid; España
Fil: Balboa, María A.. Universidad de Valladolid; España
Fil: Balsinde, Jesús. Universidad de Valladolid; España
Materia
Macrophage phenotype
Lipid profiling
PLA2
Inflammaging
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/282814
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulationRodríguez, Juan PabloCasas, JavierBalboa, María A.Balsinde, JesúsMacrophage phenotypeLipid profilingPLA2Inflammaginghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Macrophages, crucial innate immune cells, defend against pathogens and resolvein ammation, maintaining tissue balance. They perform phagocytosis, presentantigens to T cells, and bond innate and adaptive immunity through variousactivation states. Classical activation is associated with Th1 responses andinterferon g production, while alternative activation, induced by interleukin 4, ischaracterized by increased endocytosis, reduced secretion of pro-in ammatorycytokines, and roles in immunoregulation and tissue remodeling. Although theserepresent opposite extremes observed in vitro, the remarkable plasticity ofmacrophages allows for a wide spectrum of activation phenotypes that arecomplex to characterize experimentally. While the application of omicstechniques has resulted in signi cant advances in the characterization ofmacrophage polarization, lipidomic studies have received lesser attention.Beyond their role as structural components and energy sources, lipids functionas signaling molecules that regulate macrophage activation and polarization,thereby shaping immune responses. This work reviews the interaction betweenlipid signaling and macrophage polarization, exploring how lipid metabolismin uences macrophage phenotype and function. These insights offer potentialtherapeutic strategies for immune-mediated diseases and in ammation-relateddisorders, including in ammaging.Fil: Rodríguez, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; ArgentinaFil: Casas, Javier. Universidad de Valladolid; EspañaFil: Balboa, María A.. Universidad de Valladolid; EspañaFil: Balsinde, Jesús. Universidad de Valladolid; EspañaFrontiers Media2025-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/282814Rodríguez, Juan Pablo; Casas, Javier; Balboa, María A.; Balsinde, Jesús; Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation; Frontiers Media; Frontiers in Immunology; 16; 2-2025; 1-211664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550500/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2025.1550500info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:37:40Zoai:ri.conicet.gov.ar:11336/282814instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:37:41.107CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
title Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
spellingShingle Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
Rodríguez, Juan Pablo
Macrophage phenotype
Lipid profiling
PLA2
Inflammaging
title_short Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
title_full Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
title_fullStr Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
title_full_unstemmed Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
title_sort Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation
dc.creator.none.fl_str_mv Rodríguez, Juan Pablo
Casas, Javier
Balboa, María A.
Balsinde, Jesús
author Rodríguez, Juan Pablo
author_facet Rodríguez, Juan Pablo
Casas, Javier
Balboa, María A.
Balsinde, Jesús
author_role author
author2 Casas, Javier
Balboa, María A.
Balsinde, Jesús
author2_role author
author
author
dc.subject.none.fl_str_mv Macrophage phenotype
Lipid profiling
PLA2
Inflammaging
topic Macrophage phenotype
Lipid profiling
PLA2
Inflammaging
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Macrophages, crucial innate immune cells, defend against pathogens and resolvein ammation, maintaining tissue balance. They perform phagocytosis, presentantigens to T cells, and bond innate and adaptive immunity through variousactivation states. Classical activation is associated with Th1 responses andinterferon g production, while alternative activation, induced by interleukin 4, ischaracterized by increased endocytosis, reduced secretion of pro-in ammatorycytokines, and roles in immunoregulation and tissue remodeling. Although theserepresent opposite extremes observed in vitro, the remarkable plasticity ofmacrophages allows for a wide spectrum of activation phenotypes that arecomplex to characterize experimentally. While the application of omicstechniques has resulted in signi cant advances in the characterization ofmacrophage polarization, lipidomic studies have received lesser attention.Beyond their role as structural components and energy sources, lipids functionas signaling molecules that regulate macrophage activation and polarization,thereby shaping immune responses. This work reviews the interaction betweenlipid signaling and macrophage polarization, exploring how lipid metabolismin uences macrophage phenotype and function. These insights offer potentialtherapeutic strategies for immune-mediated diseases and in ammation-relateddisorders, including in ammaging.
Fil: Rodríguez, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Casas, Javier. Universidad de Valladolid; España
Fil: Balboa, María A.. Universidad de Valladolid; España
Fil: Balsinde, Jesús. Universidad de Valladolid; España
description Macrophages, crucial innate immune cells, defend against pathogens and resolvein ammation, maintaining tissue balance. They perform phagocytosis, presentantigens to T cells, and bond innate and adaptive immunity through variousactivation states. Classical activation is associated with Th1 responses andinterferon g production, while alternative activation, induced by interleukin 4, ischaracterized by increased endocytosis, reduced secretion of pro-in ammatorycytokines, and roles in immunoregulation and tissue remodeling. Although theserepresent opposite extremes observed in vitro, the remarkable plasticity ofmacrophages allows for a wide spectrum of activation phenotypes that arecomplex to characterize experimentally. While the application of omicstechniques has resulted in signi cant advances in the characterization ofmacrophage polarization, lipidomic studies have received lesser attention.Beyond their role as structural components and energy sources, lipids functionas signaling molecules that regulate macrophage activation and polarization,thereby shaping immune responses. This work reviews the interaction betweenlipid signaling and macrophage polarization, exploring how lipid metabolismin uences macrophage phenotype and function. These insights offer potentialtherapeutic strategies for immune-mediated diseases and in ammation-relateddisorders, including in ammaging.
publishDate 2025
dc.date.none.fl_str_mv 2025-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/282814
Rodríguez, Juan Pablo; Casas, Javier; Balboa, María A.; Balsinde, Jesús; Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation; Frontiers Media; Frontiers in Immunology; 16; 2-2025; 1-21
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/282814
identifier_str_mv Rodríguez, Juan Pablo; Casas, Javier; Balboa, María A.; Balsinde, Jesús; Bioactive lipid signaling and lipidomics in macrophage polarization: Impact on inflammation and immune regulation; Frontiers Media; Frontiers in Immunology; 16; 2-2025; 1-21
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2025.1550500/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2025.1550500
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24418

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