Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries
- Autores
- Anjomshoaa, Ida; Briseño Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernando Adrián; Mereb, Juan C.; Leite, Aline L.; Barreta, Priscila A. T.; Silva, Thelma L.; Dizak, Piper; Ruff, Timothy; Patir, Asli; Koruyucu, Mine; Abbasoğlu, Zerrin; Casado, Priscila L.; Brown, Andrew; Zaky, Samer H.; Bayram, Merve; Küchler, Erika C.; Cooper, Margaret E.; Liu, Kai; Marazita, Mary L.; Tanboğa, İlknur; Granjeiro, José M.; Seymen, Figen; Castilla, Eduardo Enrique; Orioli, Iêda M.; Sfeir, Charles; Owyang, Hongjiao; Rabelo Buzalaf, Marilia Afonso; Vieira, Alexandre R.
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries experience. Interaction with genes involved in enamel formation was tested. The association between enamel microhardness at baseline, after creation of artificial caries lesion, and after exposure to fluoride and the genetic markers in AQP5 was tested. Finally, AQP5 expression in human whole saliva, after exposure to fluoride in a mammary gland cell line, which is known to express AQP5, and in Wistar rats was also verified. Nominal associations were found between caries experience and markers in the AQP5 locus. Since these associations suggested that AQP5 may be inhibited by levels of fluoride in the drinking water that cause fluorosis, we showed that fluoride levels above optimal levels change AQP5 expression in humans, cell lines, and rats. We have shown that AQP5 is involved in the pathogenesis of caries and likely interact with fluoride.
Fil: Anjomshoaa, Ida. University of Pittsburgh; Estados Unidos
Fil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados Unidos
Fil: Deeley, Kathleen. University of Pittsburgh; Estados Unidos
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Mereb, Juan C.. Provincia de Río Negro. Ministerio de Salud. Hospital de Área El Bolsón ; Argentina
Fil: Leite, Aline L.. Universidade de Sao Paulo; Brasil
Fil: Barreta, Priscila A. T.. Universidade de Sao Paulo; Brasil
Fil: Silva, Thelma L.. Universidade de Sao Paulo; Brasil
Fil: Dizak, Piper. University of Pittsburgh; Estados Unidos
Fil: Ruff, Timothy. University of Pittsburgh; Estados Unidos
Fil: Patir, Asli. İstanbul Medipol Üniversitesi; Turquía
Fil: Koruyucu, Mine. İstanbul Üniversitesi; Turquía
Fil: Abbasoğlu, Zerrin. Yeditepe Üniversitesi; Turquía
Fil: Casado, Priscila L.. Universidade Federal Fluminense; Brasil
Fil: Brown, Andrew. University of Pittsburgh; Estados Unidos
Fil: Zaky, Samer H.. University of Pittsburgh; Estados Unidos
Fil: Bayram, Merve. İstanbul Medipol Üniversitesi; Turquía
Fil: Küchler, Erika C.. University of Pittsburgh; Estados Unidos
Fil: Cooper, Margaret E.. University of Pittsburgh; Estados Unidos
Fil: Liu, Kai. University of Pittsburgh; Estados Unidos
Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos
Fil: Tanboğa, İlknur. Marmara Üniversitesi; Turquía
Fil: Granjeiro, José M.. Universidade Federal Fluminense; Brasil. Instituto Nacional de Metrologia, Qualidade e Tecnologia; Brasil
Fil: Seymen, Figen. İstanbul Üniversitesi; Turquía
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Fundación Oswaldo Cruz; Brasil
Fil: Orioli, Iêda M.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Sfeir, Charles. University of Pittsburgh; Estados Unidos
Fil: Owyang, Hongjiao. Marmara Üniversitesi; Turquía
Fil: Rabelo Buzalaf, Marilia Afonso. Universidade de Sao Paulo; Brasil
Fil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos - Materia
-
AQUAPORIN
CARIES
RISK
GENOME ASSOCIATION STUDY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/42295
Ver los metadatos del registro completo
| id |
CONICETDig_f2d28ddae1df1b591e0518a54066d609 |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/42295 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against CariesAnjomshoaa, IdaBriseño Ruiz, JessicaDeeley, KathleenPoletta, Fernando AdriánMereb, Juan C.Leite, Aline L.Barreta, Priscila A. T.Silva, Thelma L.Dizak, PiperRuff, TimothyPatir, AsliKoruyucu, MineAbbasoğlu, ZerrinCasado, Priscila L.Brown, AndrewZaky, Samer H.Bayram, MerveKüchler, Erika C.Cooper, Margaret E.Liu, KaiMarazita, Mary L.Tanboğa, İlknurGranjeiro, José M.Seymen, FigenCastilla, Eduardo EnriqueOrioli, Iêda M.Sfeir, CharlesOwyang, HongjiaoRabelo Buzalaf, Marilia AfonsoVieira, Alexandre R.AQUAPORINCARIESRISKGENOME ASSOCIATION STUDYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries experience. Interaction with genes involved in enamel formation was tested. The association between enamel microhardness at baseline, after creation of artificial caries lesion, and after exposure to fluoride and the genetic markers in AQP5 was tested. Finally, AQP5 expression in human whole saliva, after exposure to fluoride in a mammary gland cell line, which is known to express AQP5, and in Wistar rats was also verified. Nominal associations were found between caries experience and markers in the AQP5 locus. Since these associations suggested that AQP5 may be inhibited by levels of fluoride in the drinking water that cause fluorosis, we showed that fluoride levels above optimal levels change AQP5 expression in humans, cell lines, and rats. We have shown that AQP5 is involved in the pathogenesis of caries and likely interact with fluoride.Fil: Anjomshoaa, Ida. University of Pittsburgh; Estados UnidosFil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados UnidosFil: Deeley, Kathleen. University of Pittsburgh; Estados UnidosFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaFil: Mereb, Juan C.. Provincia de Río Negro. Ministerio de Salud. Hospital de Área El Bolsón ; ArgentinaFil: Leite, Aline L.. Universidade de Sao Paulo; BrasilFil: Barreta, Priscila A. T.. Universidade de Sao Paulo; BrasilFil: Silva, Thelma L.. Universidade de Sao Paulo; BrasilFil: Dizak, Piper. University of Pittsburgh; Estados UnidosFil: Ruff, Timothy. University of Pittsburgh; Estados UnidosFil: Patir, Asli. İstanbul Medipol Üniversitesi; TurquíaFil: Koruyucu, Mine. İstanbul Üniversitesi; TurquíaFil: Abbasoğlu, Zerrin. Yeditepe Üniversitesi; TurquíaFil: Casado, Priscila L.. Universidade Federal Fluminense; BrasilFil: Brown, Andrew. University of Pittsburgh; Estados UnidosFil: Zaky, Samer H.. University of Pittsburgh; Estados UnidosFil: Bayram, Merve. İstanbul Medipol Üniversitesi; TurquíaFil: Küchler, Erika C.. University of Pittsburgh; Estados UnidosFil: Cooper, Margaret E.. University of Pittsburgh; Estados UnidosFil: Liu, Kai. University of Pittsburgh; Estados UnidosFil: Marazita, Mary L.. University of Pittsburgh; Estados UnidosFil: Tanboğa, İlknur. Marmara Üniversitesi; TurquíaFil: Granjeiro, José M.. Universidade Federal Fluminense; Brasil. Instituto Nacional de Metrologia, Qualidade e Tecnologia; BrasilFil: Seymen, Figen. İstanbul Üniversitesi; TurquíaFil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Fundación Oswaldo Cruz; BrasilFil: Orioli, Iêda M.. Universidade Federal do Rio de Janeiro; BrasilFil: Sfeir, Charles. University of Pittsburgh; Estados UnidosFil: Owyang, Hongjiao. Marmara Üniversitesi; TurquíaFil: Rabelo Buzalaf, Marilia Afonso. Universidade de Sao Paulo; BrasilFil: Vieira, Alexandre R.. University of Pittsburgh; Estados UnidosPublic Library of Science2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42295Anjomshoaa, Ida; Briseño Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernando Adrián; Mereb, Juan C.; et al.; Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries; Public Library of Science; Plos One; 10; 12; 12-2015; 1-181932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0143068info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143068info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:43:48Zoai:ri.conicet.gov.ar:11336/42295instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:43:48.764CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| title |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| spellingShingle |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries Anjomshoaa, Ida AQUAPORIN CARIES RISK GENOME ASSOCIATION STUDY |
| title_short |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| title_full |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| title_fullStr |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| title_full_unstemmed |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| title_sort |
Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries |
| dc.creator.none.fl_str_mv |
Anjomshoaa, Ida Briseño Ruiz, Jessica Deeley, Kathleen Poletta, Fernando Adrián Mereb, Juan C. Leite, Aline L. Barreta, Priscila A. T. Silva, Thelma L. Dizak, Piper Ruff, Timothy Patir, Asli Koruyucu, Mine Abbasoğlu, Zerrin Casado, Priscila L. Brown, Andrew Zaky, Samer H. Bayram, Merve Küchler, Erika C. Cooper, Margaret E. Liu, Kai Marazita, Mary L. Tanboğa, İlknur Granjeiro, José M. Seymen, Figen Castilla, Eduardo Enrique Orioli, Iêda M. Sfeir, Charles Owyang, Hongjiao Rabelo Buzalaf, Marilia Afonso Vieira, Alexandre R. |
| author |
Anjomshoaa, Ida |
| author_facet |
Anjomshoaa, Ida Briseño Ruiz, Jessica Deeley, Kathleen Poletta, Fernando Adrián Mereb, Juan C. Leite, Aline L. Barreta, Priscila A. T. Silva, Thelma L. Dizak, Piper Ruff, Timothy Patir, Asli Koruyucu, Mine Abbasoğlu, Zerrin Casado, Priscila L. Brown, Andrew Zaky, Samer H. Bayram, Merve Küchler, Erika C. Cooper, Margaret E. Liu, Kai Marazita, Mary L. Tanboğa, İlknur Granjeiro, José M. Seymen, Figen Castilla, Eduardo Enrique Orioli, Iêda M. Sfeir, Charles Owyang, Hongjiao Rabelo Buzalaf, Marilia Afonso Vieira, Alexandre R. |
| author_role |
author |
| author2 |
Briseño Ruiz, Jessica Deeley, Kathleen Poletta, Fernando Adrián Mereb, Juan C. Leite, Aline L. Barreta, Priscila A. T. Silva, Thelma L. Dizak, Piper Ruff, Timothy Patir, Asli Koruyucu, Mine Abbasoğlu, Zerrin Casado, Priscila L. Brown, Andrew Zaky, Samer H. Bayram, Merve Küchler, Erika C. Cooper, Margaret E. Liu, Kai Marazita, Mary L. Tanboğa, İlknur Granjeiro, José M. Seymen, Figen Castilla, Eduardo Enrique Orioli, Iêda M. Sfeir, Charles Owyang, Hongjiao Rabelo Buzalaf, Marilia Afonso Vieira, Alexandre R. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
AQUAPORIN CARIES RISK GENOME ASSOCIATION STUDY |
| topic |
AQUAPORIN CARIES RISK GENOME ASSOCIATION STUDY |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries experience. Interaction with genes involved in enamel formation was tested. The association between enamel microhardness at baseline, after creation of artificial caries lesion, and after exposure to fluoride and the genetic markers in AQP5 was tested. Finally, AQP5 expression in human whole saliva, after exposure to fluoride in a mammary gland cell line, which is known to express AQP5, and in Wistar rats was also verified. Nominal associations were found between caries experience and markers in the AQP5 locus. Since these associations suggested that AQP5 may be inhibited by levels of fluoride in the drinking water that cause fluorosis, we showed that fluoride levels above optimal levels change AQP5 expression in humans, cell lines, and rats. We have shown that AQP5 is involved in the pathogenesis of caries and likely interact with fluoride. Fil: Anjomshoaa, Ida. University of Pittsburgh; Estados Unidos Fil: Briseño Ruiz, Jessica. University of Pittsburgh; Estados Unidos Fil: Deeley, Kathleen. University of Pittsburgh; Estados Unidos Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina Fil: Mereb, Juan C.. Provincia de Río Negro. Ministerio de Salud. Hospital de Área El Bolsón ; Argentina Fil: Leite, Aline L.. Universidade de Sao Paulo; Brasil Fil: Barreta, Priscila A. T.. Universidade de Sao Paulo; Brasil Fil: Silva, Thelma L.. Universidade de Sao Paulo; Brasil Fil: Dizak, Piper. University of Pittsburgh; Estados Unidos Fil: Ruff, Timothy. University of Pittsburgh; Estados Unidos Fil: Patir, Asli. İstanbul Medipol Üniversitesi; Turquía Fil: Koruyucu, Mine. İstanbul Üniversitesi; Turquía Fil: Abbasoğlu, Zerrin. Yeditepe Üniversitesi; Turquía Fil: Casado, Priscila L.. Universidade Federal Fluminense; Brasil Fil: Brown, Andrew. University of Pittsburgh; Estados Unidos Fil: Zaky, Samer H.. University of Pittsburgh; Estados Unidos Fil: Bayram, Merve. İstanbul Medipol Üniversitesi; Turquía Fil: Küchler, Erika C.. University of Pittsburgh; Estados Unidos Fil: Cooper, Margaret E.. University of Pittsburgh; Estados Unidos Fil: Liu, Kai. University of Pittsburgh; Estados Unidos Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos Fil: Tanboğa, İlknur. Marmara Üniversitesi; Turquía Fil: Granjeiro, José M.. Universidade Federal Fluminense; Brasil. Instituto Nacional de Metrologia, Qualidade e Tecnologia; Brasil Fil: Seymen, Figen. İstanbul Üniversitesi; Turquía Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Fundación Oswaldo Cruz; Brasil Fil: Orioli, Iêda M.. Universidade Federal do Rio de Janeiro; Brasil Fil: Sfeir, Charles. University of Pittsburgh; Estados Unidos Fil: Owyang, Hongjiao. Marmara Üniversitesi; Turquía Fil: Rabelo Buzalaf, Marilia Afonso. Universidade de Sao Paulo; Brasil Fil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos |
| description |
Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. DNA samples from 1,383 individuals from six groups were studied. Genotypes of eight single nucleotide polymorphisms covering the aquaporin locus were tested for association with caries experience. Interaction with genes involved in enamel formation was tested. The association between enamel microhardness at baseline, after creation of artificial caries lesion, and after exposure to fluoride and the genetic markers in AQP5 was tested. Finally, AQP5 expression in human whole saliva, after exposure to fluoride in a mammary gland cell line, which is known to express AQP5, and in Wistar rats was also verified. Nominal associations were found between caries experience and markers in the AQP5 locus. Since these associations suggested that AQP5 may be inhibited by levels of fluoride in the drinking water that cause fluorosis, we showed that fluoride levels above optimal levels change AQP5 expression in humans, cell lines, and rats. We have shown that AQP5 is involved in the pathogenesis of caries and likely interact with fluoride. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-12 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/42295 Anjomshoaa, Ida; Briseño Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernando Adrián; Mereb, Juan C.; et al.; Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries; Public Library of Science; Plos One; 10; 12; 12-2015; 1-18 1932-6203 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/42295 |
| identifier_str_mv |
Anjomshoaa, Ida; Briseño Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernando Adrián; Mereb, Juan C.; et al.; Aquaporin 5 Interacts with Fluoride and Possibly Protects Against Caries; Public Library of Science; Plos One; 10; 12; 12-2015; 1-18 1932-6203 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0143068 info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143068 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
| publisher.none.fl_str_mv |
Public Library of Science |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1874774560002277376 |
| score |
13.265058 |