Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa

Autores
Florin-Christensen, Mónica; Schnittger, Leonhard; Bastos, Reginaldo; Rathinasamy, Vignesh A.; Cooke, Brian M.; Alzan, Heba F.; Suarez, Carlos
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Apicomplexan parasites are responsible for important livestock diseases that affect the production of much needed protein resources, and those transmissible to humans pose a public health risk. Vaccines, recognized as a cost-effective and environmentally friendly method for the prevention of infectious diseases in livestock, can avert losses in food production and decrease the exposure of humans to zoonotic pathogens. This review focuses on the need for and advances in vaccine development against the apicomplexan parasites Theileria spp., Babesia spp., Toxoplasma gondii, Neospora caninum, Eimeria spp., Besnoitia spp., Sarcocystis spp., and Cryptosporidium parvum. Together, the effect of these parasites on the cattle industry worldwide causes an enormous burden, yet they remain poorly controlled and very few effective and practical vaccines against them are available. Vaccine development is hampered by our scarce and limited knowledge of the biology and mechanisms of pathogenesis of these microorganisms, and the absence of correlates of host immune protection. More studies focused on these aspects as well as on the identification of parasite vulnerabilities that can be exploited for vaccine design are needed. Novel “omics” and gene editing approaches in understanding complex parasite biology together with advances in vaccinology will facilitate the development of effective, sustainable, and practical vaccines against cattle diseases caused by apicomplexan parasites. Such vaccines will help prevent animal and human diseases and allow production of enough animal protein to feed the growing human population in the twenty-first century and beyond.
Instituto de Patobiología
Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Florin-Christensen, Monica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bastos, Reginaldo. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Rathinasamy, Vignesh A. James Cook University. Australian Institute of Tropical Health and Medicine; Australia
Fil: Cooke, Brian M. James Cook University. Australian Institute of Tropical Health and Medicine; Australia
Fil: Alzan, Heba F. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Alzan, Heba F. Washington State University. College of Veterinary Medicine. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Suarez, Carlos. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Suarez, Carlos. United States Department of Agricultural—Agricultural Research Service. Animal Disease Research Unit; Estados Unidos
Fuente
CABI Reviews 16 : 024 (2021)
Materia
Cattle
Vaccination
Animal Production
Theileria
Babesia
Toxoplasma
Eimeria
Sarcocystis
Cryptosporidium
Ganado Bovino
Vacunación
Producción Animal
Apicomplexan protozoa
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
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spelling Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoaFlorin-Christensen, MónicaSchnittger, LeonhardBastos, ReginaldoRathinasamy, Vignesh A.Cooke, Brian M.Alzan, Heba F.Suarez, CarlosCattleVaccinationAnimal ProductionTheileriaBabesiaToxoplasmaEimeriaSarcocystisCryptosporidiumGanado BovinoVacunaciónProducción AnimalApicomplexan protozoaApicomplexan parasites are responsible for important livestock diseases that affect the production of much needed protein resources, and those transmissible to humans pose a public health risk. Vaccines, recognized as a cost-effective and environmentally friendly method for the prevention of infectious diseases in livestock, can avert losses in food production and decrease the exposure of humans to zoonotic pathogens. This review focuses on the need for and advances in vaccine development against the apicomplexan parasites Theileria spp., Babesia spp., Toxoplasma gondii, Neospora caninum, Eimeria spp., Besnoitia spp., Sarcocystis spp., and Cryptosporidium parvum. Together, the effect of these parasites on the cattle industry worldwide causes an enormous burden, yet they remain poorly controlled and very few effective and practical vaccines against them are available. Vaccine development is hampered by our scarce and limited knowledge of the biology and mechanisms of pathogenesis of these microorganisms, and the absence of correlates of host immune protection. More studies focused on these aspects as well as on the identification of parasite vulnerabilities that can be exploited for vaccine design are needed. Novel “omics” and gene editing approaches in understanding complex parasite biology together with advances in vaccinology will facilitate the development of effective, sustainable, and practical vaccines against cattle diseases caused by apicomplexan parasites. Such vaccines will help prevent animal and human diseases and allow production of enough animal protein to feed the growing human population in the twenty-first century and beyond.Instituto de PatobiologíaFil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Florin-Christensen, Monica. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bastos, Reginaldo. Washington State University. Department of Veterinary Microbiology and Pathology; Estados UnidosFil: Rathinasamy, Vignesh A. James Cook University. Australian Institute of Tropical Health and Medicine; AustraliaFil: Cooke, Brian M. James Cook University. Australian Institute of Tropical Health and Medicine; AustraliaFil: Alzan, Heba F. Washington State University. Department of Veterinary Microbiology and Pathology; Estados UnidosFil: Alzan, Heba F. Washington State University. College of Veterinary Medicine. Department of Veterinary Microbiology and Pathology; Estados UnidosFil: Suarez, Carlos. Washington State University. Department of Veterinary Microbiology and Pathology; Estados UnidosFil: Suarez, Carlos. United States Department of Agricultural—Agricultural Research Service. Animal Disease Research Unit; Estados UnidosCAB International2026-06-08T10:13:31Z2026-06-08T10:13:31Z2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/26519https://www.cabidigitallibrary.org/doi/full/10.1079/PAVSNNR2021160241749-8848https://doi.org/10.1079/PAVSNNR202116024CABI Reviews 16 : 024 (2021)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud públicainfo:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y lainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-09-24T11:43:18Zoai:localhost:20.500.12123/26519instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-09-24 11:43:19.078INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
title Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
spellingShingle Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
Florin-Christensen, Mónica
Cattle
Vaccination
Animal Production
Theileria
Babesia
Toxoplasma
Eimeria
Sarcocystis
Cryptosporidium
Ganado Bovino
Vacunación
Producción Animal
Apicomplexan protozoa
title_short Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
title_full Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
title_fullStr Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
title_full_unstemmed Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
title_sort Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa
dc.creator.none.fl_str_mv Florin-Christensen, Mónica
Schnittger, Leonhard
Bastos, Reginaldo
Rathinasamy, Vignesh A.
Cooke, Brian M.
Alzan, Heba F.
Suarez, Carlos
author Florin-Christensen, Mónica
author_facet Florin-Christensen, Mónica
Schnittger, Leonhard
Bastos, Reginaldo
Rathinasamy, Vignesh A.
Cooke, Brian M.
Alzan, Heba F.
Suarez, Carlos
author_role author
author2 Schnittger, Leonhard
Bastos, Reginaldo
Rathinasamy, Vignesh A.
Cooke, Brian M.
Alzan, Heba F.
Suarez, Carlos
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cattle
Vaccination
Animal Production
Theileria
Babesia
Toxoplasma
Eimeria
Sarcocystis
Cryptosporidium
Ganado Bovino
Vacunación
Producción Animal
Apicomplexan protozoa
topic Cattle
Vaccination
Animal Production
Theileria
Babesia
Toxoplasma
Eimeria
Sarcocystis
Cryptosporidium
Ganado Bovino
Vacunación
Producción Animal
Apicomplexan protozoa
dc.description.none.fl_txt_mv Apicomplexan parasites are responsible for important livestock diseases that affect the production of much needed protein resources, and those transmissible to humans pose a public health risk. Vaccines, recognized as a cost-effective and environmentally friendly method for the prevention of infectious diseases in livestock, can avert losses in food production and decrease the exposure of humans to zoonotic pathogens. This review focuses on the need for and advances in vaccine development against the apicomplexan parasites Theileria spp., Babesia spp., Toxoplasma gondii, Neospora caninum, Eimeria spp., Besnoitia spp., Sarcocystis spp., and Cryptosporidium parvum. Together, the effect of these parasites on the cattle industry worldwide causes an enormous burden, yet they remain poorly controlled and very few effective and practical vaccines against them are available. Vaccine development is hampered by our scarce and limited knowledge of the biology and mechanisms of pathogenesis of these microorganisms, and the absence of correlates of host immune protection. More studies focused on these aspects as well as on the identification of parasite vulnerabilities that can be exploited for vaccine design are needed. Novel “omics” and gene editing approaches in understanding complex parasite biology together with advances in vaccinology will facilitate the development of effective, sustainable, and practical vaccines against cattle diseases caused by apicomplexan parasites. Such vaccines will help prevent animal and human diseases and allow production of enough animal protein to feed the growing human population in the twenty-first century and beyond.
Instituto de Patobiología
Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Florin-Christensen, Monica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bastos, Reginaldo. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Rathinasamy, Vignesh A. James Cook University. Australian Institute of Tropical Health and Medicine; Australia
Fil: Cooke, Brian M. James Cook University. Australian Institute of Tropical Health and Medicine; Australia
Fil: Alzan, Heba F. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Alzan, Heba F. Washington State University. College of Veterinary Medicine. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Suarez, Carlos. Washington State University. Department of Veterinary Microbiology and Pathology; Estados Unidos
Fil: Suarez, Carlos. United States Department of Agricultural—Agricultural Research Service. Animal Disease Research Unit; Estados Unidos
description Apicomplexan parasites are responsible for important livestock diseases that affect the production of much needed protein resources, and those transmissible to humans pose a public health risk. Vaccines, recognized as a cost-effective and environmentally friendly method for the prevention of infectious diseases in livestock, can avert losses in food production and decrease the exposure of humans to zoonotic pathogens. This review focuses on the need for and advances in vaccine development against the apicomplexan parasites Theileria spp., Babesia spp., Toxoplasma gondii, Neospora caninum, Eimeria spp., Besnoitia spp., Sarcocystis spp., and Cryptosporidium parvum. Together, the effect of these parasites on the cattle industry worldwide causes an enormous burden, yet they remain poorly controlled and very few effective and practical vaccines against them are available. Vaccine development is hampered by our scarce and limited knowledge of the biology and mechanisms of pathogenesis of these microorganisms, and the absence of correlates of host immune protection. More studies focused on these aspects as well as on the identification of parasite vulnerabilities that can be exploited for vaccine design are needed. Novel “omics” and gene editing approaches in understanding complex parasite biology together with advances in vaccinology will facilitate the development of effective, sustainable, and practical vaccines against cattle diseases caused by apicomplexan parasites. Such vaccines will help prevent animal and human diseases and allow production of enough animal protein to feed the growing human population in the twenty-first century and beyond.
publishDate 2021
dc.date.none.fl_str_mv 2021
2026-06-08T10:13:31Z
2026-06-08T10:13:31Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/26519
https://www.cabidigitallibrary.org/doi/full/10.1079/PAVSNNR202116024
1749-8848
https://doi.org/10.1079/PAVSNNR202116024
url http://hdl.handle.net/20.500.12123/26519
https://www.cabidigitallibrary.org/doi/full/10.1079/PAVSNNR202116024
https://doi.org/10.1079/PAVSNNR202116024
identifier_str_mv 1749-8848
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública
info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv CAB International
publisher.none.fl_str_mv CAB International
dc.source.none.fl_str_mv CABI Reviews 16 : 024 (2021)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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