Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat

Autores
Goszczynski, Daniel Estanislao; Papaleo Mazzucco, Juliana; Ripoli, María Verónica; Villarreal, Edgardo Leopoldo; Rogberg Muñoz, Andres; Mezzadra, Carlos Alberto; Melucci, Lilia Magdalena; Giovambattista, Guillermo
Año de publicación
2014
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a va riety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unre lated animals from different cattle breeds were re-sequenced and 21 SNPs were detected over approximately 2600 bp, five of these SNPs were novel. Three SNPs were selected, on the basis of evolutionary conservation, to perform validation and association studies in a crossbred cattle popula tion. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p b 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p b 0.01), may be helpful to improve the quality of meat and improve health.
EEA Balcarce
Fil: Goszczynski, Daniel Estanislao. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Goszczynski, Daniel Estanislao. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Ripoli, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Ripoli, María Verónica. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Villarreal, Edgardo Leopoldo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Rogberg Muñoz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Rogberg Muñoz, Andres. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Mezzadra, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Melucci, Lilia Magdalena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Giovambattista, Guillermo. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fuente
Meta Gene 2 : 746-760 (december 2014)
Materia
Variación Genética
Ganado de Carne
Contenido de Lípidos
Genetic Variation
Beef Cattle
Lipid Content
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/26942
Acceder
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oai_identifier_str oai:localhost:20.500.12123/26942
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network_name_str INTA Digital (INTA)
spelling Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meatGoszczynski, Daniel EstanislaoPapaleo Mazzucco, JulianaRipoli, María VerónicaVillarreal, Edgardo LeopoldoRogberg Muñoz, AndresMezzadra, Carlos AlbertoMelucci, Lilia MagdalenaGiovambattista, GuillermoVariación GenéticaGanado de CarneContenido de LípidosGenetic VariationBeef CattleLipid ContentLIPE is an intracellular neutral lipase, which is capable of hydrolyzing a va riety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unre lated animals from different cattle breeds were re-sequenced and 21 SNPs were detected over approximately 2600 bp, five of these SNPs were novel. Three SNPs were selected, on the basis of evolutionary conservation, to perform validation and association studies in a crossbred cattle popula tion. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p b 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p b 0.01), may be helpful to improve the quality of meat and improve health.EEA BalcarceFil: Goszczynski, Daniel Estanislao. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Goszczynski, Daniel Estanislao. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Ripoli, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Ripoli, María Verónica. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Villarreal, Edgardo Leopoldo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Rogberg Muñoz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Rogberg Muñoz, Andres. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Mezzadra, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Melucci, Lilia Magdalena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; ArgentinaFil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); ArgentinaFil: Giovambattista, Guillermo. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); ArgentinaElsevier2026-07-06T19:59:30Z2026-07-06T19:59:30Z2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/26942https://www.sciencedirect.com/science/article/pii/S22145400140005652214-5400https://doi.org/10.1016/j.mgene.2014.09.001Meta Gene 2 : 746-760 (december 2014)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaspainfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-09-24T11:43:27Zoai:localhost:20.500.12123/26942instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-09-24 11:43:28.015INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
title Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
spellingShingle Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
Goszczynski, Daniel Estanislao
Variación Genética
Ganado de Carne
Contenido de Lípidos
Genetic Variation
Beef Cattle
Lipid Content
title_short Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
title_full Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
title_fullStr Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
title_full_unstemmed Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
title_sort Characterization of the bovine gene LIPE and possible influence on fatty acid composition of meat
dc.creator.none.fl_str_mv Goszczynski, Daniel Estanislao
Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villarreal, Edgardo Leopoldo
Rogberg Muñoz, Andres
Mezzadra, Carlos Alberto
Melucci, Lilia Magdalena
Giovambattista, Guillermo
author Goszczynski, Daniel Estanislao
author_facet Goszczynski, Daniel Estanislao
Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villarreal, Edgardo Leopoldo
Rogberg Muñoz, Andres
Mezzadra, Carlos Alberto
Melucci, Lilia Magdalena
Giovambattista, Guillermo
author_role author
author2 Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villarreal, Edgardo Leopoldo
Rogberg Muñoz, Andres
Mezzadra, Carlos Alberto
Melucci, Lilia Magdalena
Giovambattista, Guillermo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Variación Genética
Ganado de Carne
Contenido de Lípidos
Genetic Variation
Beef Cattle
Lipid Content
topic Variación Genética
Ganado de Carne
Contenido de Lípidos
Genetic Variation
Beef Cattle
Lipid Content
dc.description.none.fl_txt_mv LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a va riety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unre lated animals from different cattle breeds were re-sequenced and 21 SNPs were detected over approximately 2600 bp, five of these SNPs were novel. Three SNPs were selected, on the basis of evolutionary conservation, to perform validation and association studies in a crossbred cattle popula tion. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p b 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p b 0.01), may be helpful to improve the quality of meat and improve health.
EEA Balcarce
Fil: Goszczynski, Daniel Estanislao. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Goszczynski, Daniel Estanislao. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Papaleo Mazzucco, Juliana. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Ripoli, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Ripoli, María Verónica. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Villarreal, Edgardo Leopoldo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Rogberg Muñoz, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Rogberg Muñoz, Andres. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Mezzadra, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Melucci, Lilia Magdalena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentina
Fil: Giovambattista, Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Genética Veterinaria (IGEVET); Argentina
Fil: Giovambattista, Guillermo. Universidad Nacional de La Plata (UNLP). Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria (IGEVET); Argentina
description LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a va riety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of this gene with the fatty acid composition of meat in a cattle population. Forty-three unre lated animals from different cattle breeds were re-sequenced and 21 SNPs were detected over approximately 2600 bp, five of these SNPs were novel. Three SNPs were selected, on the basis of evolutionary conservation, to perform validation and association studies in a crossbred cattle popula tion. Our results may suggest a possible association of SNP1 with contents of oleic acid and total monounsaturated fatty acids (p b 0.01), and SNP2 and SNP3 with Heneicosylic acid content (p b 0.01), may be helpful to improve the quality of meat and improve health.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
2026-07-06T19:59:30Z
2026-07-06T19:59:30Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/26942
https://www.sciencedirect.com/science/article/pii/S2214540014000565
2214-5400
https://doi.org/10.1016/j.mgene.2014.09.001
url http://hdl.handle.net/20.500.12123/26942
https://www.sciencedirect.com/science/article/pii/S2214540014000565
https://doi.org/10.1016/j.mgene.2014.09.001
identifier_str_mv 2214-5400
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Meta Gene 2 : 746-760 (december 2014)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.754232

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