Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses

Autores
Franco, María Del Rocío; Truchet, Daniela María; Okada, Elena; Menone, Mirta Luján; Medici, Sandra Karina; Pérez, Débora Jesabel
Año de publicación
2026
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Animal feeding operation effluents are major sources of veterinary antibiotics in freshwaters. Enrofloxacin (ENRO) is an emerging contaminant of increasing environmental concern. Phytoremediation using wetland macrophytes represents a sustainable and cost-effective mitigation strategy. In this study, a biotransformation kinetic model for ENRO conversion into ciprofloxacin (CIPRO) was systematically established for the first time in Typha latifolia, and the influence of its zwitterionic speciation on uptake, bioaccumulation and translocation was elucidated. Plants were hydroponically exposed to environmentally relevant concentrations (0, 10, and 100 μg/L) for 35 days, including exposure and depuration phases, to evaluate phytotoxicity, removal efficiency, toxicokinetic, and biotransformation. ENRO induced a transient hormetic stimulation of root elongation and increased photosynthetic pigment contents, without detectable morpho-physiological or biochemical toxicity effects. Removal efficiency reached ∼90%, following first-order kinetics ( = 0.32 d−1 and 0.44 d‐1 at 10 and 100 μg/L, respectively). Uptake and elimination kinetics were significant in both roots and leaves, with roots as the dominant accumulation compartment with steady-state bioaccumulation factors = 238.88 ± 25.83 L/kg and 13,082.97 ± 1541.29 L/kg, whereas leaf accumulation was markedly lower (= 2.01 ± 0.69 to 168.51 ± 27.11 L/kg). At the experimental pH (5.5), ENRO occurred mainly as zwitterionic and cationic species. Electrostatic attraction to negatively charged functional groups at the root surface likely enhanced outer-layer retention, restricted symplastic diffusion, and limited shoot translocation, mechanistically explaining the preferential root accumulation and slow upward mobility observed. Biotransformation to CIPRO occurred primarily in roots, and kinetic modeling confirmed significant transformation dynamics in leaves, supporting both in situ formation and translocation processes. Overall, T. latifolia exhibited high tolerance and strong phytoremediation capacity for ENRO. This study provides a quantitative and mechanistic framework for the toxicokinetics of ENRO, including uptake, accumulation, elimination, and biotransformation, in T. latifolia, supporting its application in mitigating veterinary antibiotic contamination.
EEA Balcarce
Fil: Franco, María del Rocío. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
Fil: Franco, María del Rocío. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Truchet, Daniela María. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Okada, Elena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Menone, Mirta Luján. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Medici, Sandra Karina. Fares Taie Instituto de Análisis; Argentina
Fil: Medici, Sandra Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina
Fil: Pérez, Débora Jesabel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
Fil: Pérez, Débora Jesabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Pérez, Débora Jesabel. Universidad de la Fraternidad de Agrupaciones Santo Tomás de Aquino. Facultad de Ingeniería; Argentina
Fuente
Science of The Total Environment 1029 : 181763 (May 2026)
Materia
Antibióticos
Contaminación
Antibiotics
Contamination
Bioaccumulation
Phytoremediation
Typha
Bioacumulación
Fitodecontaminación
Fitorremediación
Enrofloxacina
Enrofloxacin
Typha latifolia
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/26862
Acceder
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spelling Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responsesFranco, María Del RocíoTruchet, Daniela MaríaOkada, ElenaMenone, Mirta LujánMedici, Sandra KarinaPérez, Débora JesabelAntibióticosContaminaciónAntibioticsContaminationBioaccumulationPhytoremediationTyphaBioacumulaciónFitodecontaminaciónFitorremediaciónEnrofloxacinaEnrofloxacinTypha latifoliaAnimal feeding operation effluents are major sources of veterinary antibiotics in freshwaters. Enrofloxacin (ENRO) is an emerging contaminant of increasing environmental concern. Phytoremediation using wetland macrophytes represents a sustainable and cost-effective mitigation strategy. In this study, a biotransformation kinetic model for ENRO conversion into ciprofloxacin (CIPRO) was systematically established for the first time in Typha latifolia, and the influence of its zwitterionic speciation on uptake, bioaccumulation and translocation was elucidated. Plants were hydroponically exposed to environmentally relevant concentrations (0, 10, and 100 μg/L) for 35 days, including exposure and depuration phases, to evaluate phytotoxicity, removal efficiency, toxicokinetic, and biotransformation. ENRO induced a transient hormetic stimulation of root elongation and increased photosynthetic pigment contents, without detectable morpho-physiological or biochemical toxicity effects. Removal efficiency reached ∼90%, following first-order kinetics ( = 0.32 d−1 and 0.44 d‐1 at 10 and 100 μg/L, respectively). Uptake and elimination kinetics were significant in both roots and leaves, with roots as the dominant accumulation compartment with steady-state bioaccumulation factors = 238.88 ± 25.83 L/kg and 13,082.97 ± 1541.29 L/kg, whereas leaf accumulation was markedly lower (= 2.01 ± 0.69 to 168.51 ± 27.11 L/kg). At the experimental pH (5.5), ENRO occurred mainly as zwitterionic and cationic species. Electrostatic attraction to negatively charged functional groups at the root surface likely enhanced outer-layer retention, restricted symplastic diffusion, and limited shoot translocation, mechanistically explaining the preferential root accumulation and slow upward mobility observed. Biotransformation to CIPRO occurred primarily in roots, and kinetic modeling confirmed significant transformation dynamics in leaves, supporting both in situ formation and translocation processes. Overall, T. latifolia exhibited high tolerance and strong phytoremediation capacity for ENRO. This study provides a quantitative and mechanistic framework for the toxicokinetics of ENRO, including uptake, accumulation, elimination, and biotransformation, in T. latifolia, supporting its application in mitigating veterinary antibiotic contamination.EEA BalcarceFil: Franco, María del Rocío. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; ArgentinaFil: Franco, María del Rocío. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; ArgentinaFil: Truchet, Daniela María. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Okada, Elena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; ArgentinaFil: Menone, Mirta Luján. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Medici, Sandra Karina. Fares Taie Instituto de Análisis; ArgentinaFil: Medici, Sandra Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones en Producción, Sanidad y Ambiente; ArgentinaFil: Pérez, Débora Jesabel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; ArgentinaFil: Pérez, Débora Jesabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; ArgentinaFil: Pérez, Débora Jesabel. Universidad de la Fraternidad de Agrupaciones Santo Tomás de Aquino. Facultad de Ingeniería; ArgentinaElsevier2026-07-01T10:04:02Z2026-07-01T10:04:02Z2026-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/26862https://www.sciencedirect.com/science/article/abs/pii/S00489697260042741879-1026 (Online)0048-9697 (Print)https://doi.org/10.1016/j.scitotenv.2026.181763Science of The Total Environment 1029 : 181763 (May 2026)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaspainfo:eu-repograntAgreement/INTA/2023-PD-L03-I094, Gestión ambiental de los agroquímicos: manejo, mitigación y remediacióninfo:eu-repograntAgreement/INTA/2023-PE-L04-I030, Abordaje integral de procesos de valorización territorial y economía circular en el área de influencia del CERBASinfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-09-24T11:43:24Zoai:localhost:20.500.12123/26862instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-09-24 11:43:25.505INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
title Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
spellingShingle Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
Franco, María Del Rocío
Antibióticos
Contaminación
Antibiotics
Contamination
Bioaccumulation
Phytoremediation
Typha
Bioacumulación
Fitodecontaminación
Fitorremediación
Enrofloxacina
Enrofloxacin
Typha latifolia
title_short Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
title_full Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
title_fullStr Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
title_full_unstemmed Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
title_sort Comprehensive evaluation of enrofloxacin removal and toxicokinetic dynamics in Typha latifolia L.: Uptake, bioaccumulation, elimination, biotransformation, and plant responses
dc.creator.none.fl_str_mv Franco, María Del Rocío
Truchet, Daniela María
Okada, Elena
Menone, Mirta Luján
Medici, Sandra Karina
Pérez, Débora Jesabel
author Franco, María Del Rocío
author_facet Franco, María Del Rocío
Truchet, Daniela María
Okada, Elena
Menone, Mirta Luján
Medici, Sandra Karina
Pérez, Débora Jesabel
author_role author
author2 Truchet, Daniela María
Okada, Elena
Menone, Mirta Luján
Medici, Sandra Karina
Pérez, Débora Jesabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antibióticos
Contaminación
Antibiotics
Contamination
Bioaccumulation
Phytoremediation
Typha
Bioacumulación
Fitodecontaminación
Fitorremediación
Enrofloxacina
Enrofloxacin
Typha latifolia
topic Antibióticos
Contaminación
Antibiotics
Contamination
Bioaccumulation
Phytoremediation
Typha
Bioacumulación
Fitodecontaminación
Fitorremediación
Enrofloxacina
Enrofloxacin
Typha latifolia
dc.description.none.fl_txt_mv Animal feeding operation effluents are major sources of veterinary antibiotics in freshwaters. Enrofloxacin (ENRO) is an emerging contaminant of increasing environmental concern. Phytoremediation using wetland macrophytes represents a sustainable and cost-effective mitigation strategy. In this study, a biotransformation kinetic model for ENRO conversion into ciprofloxacin (CIPRO) was systematically established for the first time in Typha latifolia, and the influence of its zwitterionic speciation on uptake, bioaccumulation and translocation was elucidated. Plants were hydroponically exposed to environmentally relevant concentrations (0, 10, and 100 μg/L) for 35 days, including exposure and depuration phases, to evaluate phytotoxicity, removal efficiency, toxicokinetic, and biotransformation. ENRO induced a transient hormetic stimulation of root elongation and increased photosynthetic pigment contents, without detectable morpho-physiological or biochemical toxicity effects. Removal efficiency reached ∼90%, following first-order kinetics ( = 0.32 d−1 and 0.44 d‐1 at 10 and 100 μg/L, respectively). Uptake and elimination kinetics were significant in both roots and leaves, with roots as the dominant accumulation compartment with steady-state bioaccumulation factors = 238.88 ± 25.83 L/kg and 13,082.97 ± 1541.29 L/kg, whereas leaf accumulation was markedly lower (= 2.01 ± 0.69 to 168.51 ± 27.11 L/kg). At the experimental pH (5.5), ENRO occurred mainly as zwitterionic and cationic species. Electrostatic attraction to negatively charged functional groups at the root surface likely enhanced outer-layer retention, restricted symplastic diffusion, and limited shoot translocation, mechanistically explaining the preferential root accumulation and slow upward mobility observed. Biotransformation to CIPRO occurred primarily in roots, and kinetic modeling confirmed significant transformation dynamics in leaves, supporting both in situ formation and translocation processes. Overall, T. latifolia exhibited high tolerance and strong phytoremediation capacity for ENRO. This study provides a quantitative and mechanistic framework for the toxicokinetics of ENRO, including uptake, accumulation, elimination, and biotransformation, in T. latifolia, supporting its application in mitigating veterinary antibiotic contamination.
EEA Balcarce
Fil: Franco, María del Rocío. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
Fil: Franco, María del Rocío. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Truchet, Daniela María. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Okada, Elena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Menone, Mirta Luján. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Marinas y Costeras; Argentina
Fil: Medici, Sandra Karina. Fares Taie Instituto de Análisis; Argentina
Fil: Medici, Sandra Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones en Producción, Sanidad y Ambiente; Argentina
Fil: Pérez, Débora Jesabel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Agrarias; Argentina
Fil: Pérez, Débora Jesabel. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Pérez, Débora Jesabel. Universidad de la Fraternidad de Agrupaciones Santo Tomás de Aquino. Facultad de Ingeniería; Argentina
description Animal feeding operation effluents are major sources of veterinary antibiotics in freshwaters. Enrofloxacin (ENRO) is an emerging contaminant of increasing environmental concern. Phytoremediation using wetland macrophytes represents a sustainable and cost-effective mitigation strategy. In this study, a biotransformation kinetic model for ENRO conversion into ciprofloxacin (CIPRO) was systematically established for the first time in Typha latifolia, and the influence of its zwitterionic speciation on uptake, bioaccumulation and translocation was elucidated. Plants were hydroponically exposed to environmentally relevant concentrations (0, 10, and 100 μg/L) for 35 days, including exposure and depuration phases, to evaluate phytotoxicity, removal efficiency, toxicokinetic, and biotransformation. ENRO induced a transient hormetic stimulation of root elongation and increased photosynthetic pigment contents, without detectable morpho-physiological or biochemical toxicity effects. Removal efficiency reached ∼90%, following first-order kinetics ( = 0.32 d−1 and 0.44 d‐1 at 10 and 100 μg/L, respectively). Uptake and elimination kinetics were significant in both roots and leaves, with roots as the dominant accumulation compartment with steady-state bioaccumulation factors = 238.88 ± 25.83 L/kg and 13,082.97 ± 1541.29 L/kg, whereas leaf accumulation was markedly lower (= 2.01 ± 0.69 to 168.51 ± 27.11 L/kg). At the experimental pH (5.5), ENRO occurred mainly as zwitterionic and cationic species. Electrostatic attraction to negatively charged functional groups at the root surface likely enhanced outer-layer retention, restricted symplastic diffusion, and limited shoot translocation, mechanistically explaining the preferential root accumulation and slow upward mobility observed. Biotransformation to CIPRO occurred primarily in roots, and kinetic modeling confirmed significant transformation dynamics in leaves, supporting both in situ formation and translocation processes. Overall, T. latifolia exhibited high tolerance and strong phytoremediation capacity for ENRO. This study provides a quantitative and mechanistic framework for the toxicokinetics of ENRO, including uptake, accumulation, elimination, and biotransformation, in T. latifolia, supporting its application in mitigating veterinary antibiotic contamination.
publishDate 2026
dc.date.none.fl_str_mv 2026-07-01T10:04:02Z
2026-07-01T10:04:02Z
2026-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/26862
https://www.sciencedirect.com/science/article/abs/pii/S0048969726004274
1879-1026 (Online)
0048-9697 (Print)
https://doi.org/10.1016/j.scitotenv.2026.181763
url http://hdl.handle.net/20.500.12123/26862
https://www.sciencedirect.com/science/article/abs/pii/S0048969726004274
https://doi.org/10.1016/j.scitotenv.2026.181763
identifier_str_mv 1879-1026 (Online)
0048-9697 (Print)
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2023-PD-L03-I094, Gestión ambiental de los agroquímicos: manejo, mitigación y remediación
info:eu-repograntAgreement/INTA/2023-PE-L04-I030, Abordaje integral de procesos de valorización territorial y economía circular en el área de influencia del CERBAS
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Science of The Total Environment 1029 : 181763 (May 2026)
reponame:INTA Digital (INTA)
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reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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