Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b

Autores
Tomás, Gonzalo; Techera, Claudia; Marandino, Ana; Olivera, Valeria Soledad; Williman, Joaquín; Panzera, Yanina; Pérez, Rubén; Vagnozzi, Ariel Eduardo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The infectious bursal disease virus (IBDV) is a significant pathogen affecting the poultry industry worldwide. Its epidemiological history has been marked by the emergence of strains with different antigenic, pathogenic, and genetic features, some of which have shown notable spread potential. The A2dB1b genotype, also known as novel variant, has become widespread and gained increased relevance in IBDV epidemiology. This genotype was described in China in the 2010s and rapidly spread in Asia and Africa. The present study describes the circulation of the A2dB1b genotype in Argentina. Applying a next-generation sequencing approach, we obtained the complete coding sequence of 18 Argentine viruses. The high level of genomic homogeneity observed amongst these viruses, their monophyletic clustering in both partial and complete segments A and B derived phylogenies, and their close relatedness to some Chinese strains suggest that a unique transcontinental spread event from China to Argentina occurred recently. The apparent success of the A2dB1b genotype spreading throughout Asia, Africa, and South America may partially be due to specific amino acid characteristics. Novel residues in the hypervariable region of VP2 may help A2dB1b IBDVs evade the protection elicited by the applied commercial vaccines. Our findings underscore the importance of continuous characterization of field samples and evaluation of the control measures currently applied to fight against this specific IBDV genotype.
Instituto de Virología
Fil: Tomás, Gonzalo. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Techera, Claudia. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Marandino, Ana. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Williman, Joaquín. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Panzera, Yanina. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Pérez, Rubén. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Vagnozzi, Ariel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fuente
Avian Pathology 53 (5) : 430-438. (October 2024)
Materia
Genómica
Virus Bursitis Infecciosa
Genotipos
Aves de Corral
Argentina
China
Genomics
Infectious Bursal Disease Virus
Genotypes
Poultry
Transcontinental Spread
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/27689
Acceder
id INTADig_efc6460a9ed702b45486a07460821e18
oai_identifier_str oai:localhost:20.500.12123/27689
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1bTomás, GonzaloTechera, ClaudiaMarandino, AnaOlivera, Valeria SoledadWilliman, JoaquínPanzera, YaninaPérez, RubénVagnozzi, Ariel EduardoGenómicaVirus Bursitis InfecciosaGenotiposAves de CorralArgentinaChinaGenomicsInfectious Bursal Disease VirusGenotypesPoultryTranscontinental SpreadThe infectious bursal disease virus (IBDV) is a significant pathogen affecting the poultry industry worldwide. Its epidemiological history has been marked by the emergence of strains with different antigenic, pathogenic, and genetic features, some of which have shown notable spread potential. The A2dB1b genotype, also known as novel variant, has become widespread and gained increased relevance in IBDV epidemiology. This genotype was described in China in the 2010s and rapidly spread in Asia and Africa. The present study describes the circulation of the A2dB1b genotype in Argentina. Applying a next-generation sequencing approach, we obtained the complete coding sequence of 18 Argentine viruses. The high level of genomic homogeneity observed amongst these viruses, their monophyletic clustering in both partial and complete segments A and B derived phylogenies, and their close relatedness to some Chinese strains suggest that a unique transcontinental spread event from China to Argentina occurred recently. The apparent success of the A2dB1b genotype spreading throughout Asia, Africa, and South America may partially be due to specific amino acid characteristics. Novel residues in the hypervariable region of VP2 may help A2dB1b IBDVs evade the protection elicited by the applied commercial vaccines. Our findings underscore the importance of continuous characterization of field samples and evaluation of the control measures currently applied to fight against this specific IBDV genotype.Instituto de VirologíaFil: Tomás, Gonzalo. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Techera, Claudia. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Marandino, Ana. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaFil: Williman, Joaquín. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Panzera, Yanina. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Pérez, Rubén. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; UruguayFil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; ArgentinaFil: Vagnozzi, Ariel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); ArgentinaTaylor and Francis2026-09-08T13:18:54Z2026-09-08T13:18:54Z2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/27689https://www.tandfonline.com/doi/full/10.1080/03079457.2024.23559180307-9457 (impreso)1465-3338 (online)https://doi.org/10.1080/03079457.2024.2355918Avian Pathology 53 (5) : 430-438. (October 2024)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología AgropecuariaengArgentina .......... (nation) (World, South America)7006477China .......... (nation) (World, Asia)1000111info:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-09-24T11:43:47Zoai:localhost:20.500.12123/27689instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-09-24 11:43:48.542INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
title Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
spellingShingle Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
Tomás, Gonzalo
Genómica
Virus Bursitis Infecciosa
Genotipos
Aves de Corral
Argentina
China
Genomics
Infectious Bursal Disease Virus
Genotypes
Poultry
Transcontinental Spread
title_short Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
title_full Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
title_fullStr Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
title_full_unstemmed Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
title_sort Genomic characterization of infectious bursal disease virus in Argentina provides evidence of the recent transcontinental spread of Chinese genotype A2dB1b
dc.creator.none.fl_str_mv Tomás, Gonzalo
Techera, Claudia
Marandino, Ana
Olivera, Valeria Soledad
Williman, Joaquín
Panzera, Yanina
Pérez, Rubén
Vagnozzi, Ariel Eduardo
author Tomás, Gonzalo
author_facet Tomás, Gonzalo
Techera, Claudia
Marandino, Ana
Olivera, Valeria Soledad
Williman, Joaquín
Panzera, Yanina
Pérez, Rubén
Vagnozzi, Ariel Eduardo
author_role author
author2 Techera, Claudia
Marandino, Ana
Olivera, Valeria Soledad
Williman, Joaquín
Panzera, Yanina
Pérez, Rubén
Vagnozzi, Ariel Eduardo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genómica
Virus Bursitis Infecciosa
Genotipos
Aves de Corral
Argentina
China
Genomics
Infectious Bursal Disease Virus
Genotypes
Poultry
Transcontinental Spread
topic Genómica
Virus Bursitis Infecciosa
Genotipos
Aves de Corral
Argentina
China
Genomics
Infectious Bursal Disease Virus
Genotypes
Poultry
Transcontinental Spread
dc.description.none.fl_txt_mv The infectious bursal disease virus (IBDV) is a significant pathogen affecting the poultry industry worldwide. Its epidemiological history has been marked by the emergence of strains with different antigenic, pathogenic, and genetic features, some of which have shown notable spread potential. The A2dB1b genotype, also known as novel variant, has become widespread and gained increased relevance in IBDV epidemiology. This genotype was described in China in the 2010s and rapidly spread in Asia and Africa. The present study describes the circulation of the A2dB1b genotype in Argentina. Applying a next-generation sequencing approach, we obtained the complete coding sequence of 18 Argentine viruses. The high level of genomic homogeneity observed amongst these viruses, their monophyletic clustering in both partial and complete segments A and B derived phylogenies, and their close relatedness to some Chinese strains suggest that a unique transcontinental spread event from China to Argentina occurred recently. The apparent success of the A2dB1b genotype spreading throughout Asia, Africa, and South America may partially be due to specific amino acid characteristics. Novel residues in the hypervariable region of VP2 may help A2dB1b IBDVs evade the protection elicited by the applied commercial vaccines. Our findings underscore the importance of continuous characterization of field samples and evaluation of the control measures currently applied to fight against this specific IBDV genotype.
Instituto de Virología
Fil: Tomás, Gonzalo. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Techera, Claudia. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Marandino, Ana. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Olivera, Valeria Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Olivera, Valeria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
Fil: Williman, Joaquín. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Panzera, Yanina. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Pérez, Rubén. Universidad de la República. Instituto de Biología. Sección Genética Evolutiva; Uruguay
Fil: Vagnozzi, Ariel Eduardo. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Virología; Argentina
Fil: Vagnozzi, Ariel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina
description The infectious bursal disease virus (IBDV) is a significant pathogen affecting the poultry industry worldwide. Its epidemiological history has been marked by the emergence of strains with different antigenic, pathogenic, and genetic features, some of which have shown notable spread potential. The A2dB1b genotype, also known as novel variant, has become widespread and gained increased relevance in IBDV epidemiology. This genotype was described in China in the 2010s and rapidly spread in Asia and Africa. The present study describes the circulation of the A2dB1b genotype in Argentina. Applying a next-generation sequencing approach, we obtained the complete coding sequence of 18 Argentine viruses. The high level of genomic homogeneity observed amongst these viruses, their monophyletic clustering in both partial and complete segments A and B derived phylogenies, and their close relatedness to some Chinese strains suggest that a unique transcontinental spread event from China to Argentina occurred recently. The apparent success of the A2dB1b genotype spreading throughout Asia, Africa, and South America may partially be due to specific amino acid characteristics. Novel residues in the hypervariable region of VP2 may help A2dB1b IBDVs evade the protection elicited by the applied commercial vaccines. Our findings underscore the importance of continuous characterization of field samples and evaluation of the control measures currently applied to fight against this specific IBDV genotype.
publishDate 2024
dc.date.none.fl_str_mv 2024-10
2026-09-08T13:18:54Z
2026-09-08T13:18:54Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/27689
https://www.tandfonline.com/doi/full/10.1080/03079457.2024.2355918
0307-9457 (impreso)
1465-3338 (online)
https://doi.org/10.1080/03079457.2024.2355918
url http://hdl.handle.net/20.500.12123/27689
https://www.tandfonline.com/doi/full/10.1080/03079457.2024.2355918
https://doi.org/10.1080/03079457.2024.2355918
identifier_str_mv 0307-9457 (impreso)
1465-3338 (online)
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv Argentina .......... (nation) (World, South America)
7006477
China .......... (nation) (World, Asia)
1000111
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv Avian Pathology 53 (5) : 430-438. (October 2024)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1877227357645832192
score 12.754232

Publicaciones similares