KETO/LP-SBA-15 Composite as a drug release system.

Autores
Cussa , Jorgelina; Juárez , Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata , Oscar Alfredo; Anunziata , Oscar Alfredo; Juárez , Juliana María
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Prados, Antonela. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Materia
Drug Delivery Systems
LP-SBA-15
Ketorolac Tromethamine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/13892
Acceder
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oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/13892
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling KETO/LP-SBA-15 Composite as a drug release system.Cussa , JorgelinaJuárez , Juliana MaríaPrados, AntonelaGómez Costa, Marcos BrunoAnunziata , Oscar AlfredoAnunziata , Oscar AlfredoJuárez , Juliana MaríaDrug Delivery SystemsLP-SBA-15Ketorolac TromethamineControlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Prados, Antonela. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Universidad Tecnológica Nacional Regional Córdoba.2025-10-03T20:27:24Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfXXVIII International Materials Research Congress.https://hdl.handle.net/20.500.12272/13892enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Cussa, Jorgelina; Juárez, Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.https://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:44:48Zoai:ria.utn.edu.ar:20.500.12272/13892instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:44:49.179Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv KETO/LP-SBA-15 Composite as a drug release system.
title KETO/LP-SBA-15 Composite as a drug release system.
spellingShingle KETO/LP-SBA-15 Composite as a drug release system.
Cussa , Jorgelina
Drug Delivery Systems
LP-SBA-15
Ketorolac Tromethamine
title_short KETO/LP-SBA-15 Composite as a drug release system.
title_full KETO/LP-SBA-15 Composite as a drug release system.
title_fullStr KETO/LP-SBA-15 Composite as a drug release system.
title_full_unstemmed KETO/LP-SBA-15 Composite as a drug release system.
title_sort KETO/LP-SBA-15 Composite as a drug release system.
dc.creator.none.fl_str_mv Cussa , Jorgelina
Juárez , Juliana María
Prados, Antonela
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
Anunziata , Oscar Alfredo
Juárez , Juliana María
author Cussa , Jorgelina
author_facet Cussa , Jorgelina
Juárez , Juliana María
Prados, Antonela
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author_role author
author2 Juárez , Juliana María
Prados, Antonela
Gómez Costa, Marcos Bruno
Anunziata , Oscar Alfredo
author2_role author
author
author
author
dc.subject.none.fl_str_mv Drug Delivery Systems
LP-SBA-15
Ketorolac Tromethamine
topic Drug Delivery Systems
LP-SBA-15
Ketorolac Tromethamine
dc.description.none.fl_txt_mv Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Prados, Antonela. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
description Controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and below the toxicity threshold, improving therapeutic efficacy and reducing toxicity. SBA-15 with larger pore sizes material (LP-SBA-15) is a new promising host for drug delivery systems due to high biocompatibility, in vivo biodegradability and low toxicity. Large pore mesoporous silica supports has been applied in studies of ketorolac tromethamine (KETO) adsorption and release. KETO/LP-SBA-15 composite was synthesized. The material synthesis and loading of KETO into LP-SBA-15 pores were successful. We obtained promising results for controlled drug release using the novel LP-SBA-15 material. The ability of KETO/LP-SBA-15 release was measured. The concentration of KETO in HCl solution or buffer in a specific time was determined by UV-Vis. First-order, Higuchi and Ritger-Peppas (or Korsmeyer-Peppas) models were used to fit experimental release data. Figure 1 show the fitting results, where Qt/Q? is the release fraction per unit mass in time t, k represents release rate in all models and n is a measure of desorption intensity in Ritger-Peppas regression. In this work, we have shown a promising drug storage material for the effective encapsulation and controlled release of KETO, achieving the required therapeutic efficacy. KETO was adsorbed into LP-SBA-15 channel surface without affecting the chemical structure or composition of KETO. The study also demonstrates the storage capacity and release properties of LP-SBA-15 containing KETO. The release of KETO contained in LP-SBA-15 can offer significant improve in controlled drug release and enhance a good analgesia effect.
publishDate 2017
dc.date.none.fl_str_mv 2017
2025-10-03T20:27:24Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv XXVIII International Materials Research Congress.
https://hdl.handle.net/20.500.12272/13892
identifier_str_mv XXVIII International Materials Research Congress.
url https://hdl.handle.net/20.500.12272/13892
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cussa, Jorgelina; Juárez, Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Cussa, Jorgelina; Juárez, Juliana María; Prados, Antonela; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo.
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidad Tecnológica Nacional Regional Córdoba.
publisher.none.fl_str_mv Universidad Tecnológica Nacional Regional Córdoba.
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
_version_ 1877230887843659776
score 13.24418

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