Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery

Autores
Cuello, Natalia; Elías, Verónica; Mendieta, Silvia; Longhi, María; Oliva, Marcos Iván; Crivello, Mónica; Eimer, Griselda Alejandra
Año de publicación
2016
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Synthesis of MCM-41 having magnetic elements embedded inside has been researched in order to develop very interesting drug-delivery systems. In this work, MCM-41 nanostructured materials modified with iron were synthesized using the direct synthesis method (DI) and a hydrothermal treatment (HT) was applied [1]. Due to that silanol groups can form hydrogen bridge bonds with the carboxyl and carbonyl groups of indomethacin (IN), the silanol groups density on the support was analyzed by IR spectroscopy. Then, the drug was incorporated into both iron modified samples and into the pure MCM-41 and their release profiles were evaluated "in vitro" using simulated body fluid as medium. All modified materials have faster profiles than the pure silica matrix. This could be due to the presence of nanospecies of oxides inside channels that might increase the steric diffusion resistance. Thus, the drug could diffuse through the channels of the modified material with less freedom that through those of MCM-41. However, the sample modified with iron by this method with HT have a behavior similar to that of MCM-41 possibly due to the refiner effect of HT on the nanospecies size. In addition, materials with HT have an increased availability of silanol groups capable to interact with the indomethacin. This would explain their high drug adsorption capacity and the slow drug release rate. Then, this solid have good properties of adsorption and release, similar to that of the parent pure MCM-41 and simultaneously their modification with iron nanospecies leads to materials with superparamagnetic behavior.
Fil: Fil. Cuello, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Elías, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Mendieta, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Longhi, María. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Oliva, Marcos Iván. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación. Instituto de Física Enrique Gaviola; Argentina.
Fil: Crivello, Mónica. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Eimer, Griselda Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Materia
Hydrothermal treatment
MCM-41
Drug release
Indomethacin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
2022-05-26T14:47:37Z
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/6460
Acceder
id RIAUTN_81f161bc168604ca9bce23dc9ff66a24
oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/6460
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug deliveryCuello, NataliaElías, VerónicaMendieta, SilviaLonghi, MaríaOliva, Marcos IvánCrivello, MónicaEimer, Griselda AlejandraHydrothermal treatmentMCM-41Drug releaseIndomethacinSynthesis of MCM-41 having magnetic elements embedded inside has been researched in order to develop very interesting drug-delivery systems. In this work, MCM-41 nanostructured materials modified with iron were synthesized using the direct synthesis method (DI) and a hydrothermal treatment (HT) was applied [1]. Due to that silanol groups can form hydrogen bridge bonds with the carboxyl and carbonyl groups of indomethacin (IN), the silanol groups density on the support was analyzed by IR spectroscopy. Then, the drug was incorporated into both iron modified samples and into the pure MCM-41 and their release profiles were evaluated "in vitro" using simulated body fluid as medium. All modified materials have faster profiles than the pure silica matrix. This could be due to the presence of nanospecies of oxides inside channels that might increase the steric diffusion resistance. Thus, the drug could diffuse through the channels of the modified material with less freedom that through those of MCM-41. However, the sample modified with iron by this method with HT have a behavior similar to that of MCM-41 possibly due to the refiner effect of HT on the nanospecies size. In addition, materials with HT have an increased availability of silanol groups capable to interact with the indomethacin. This would explain their high drug adsorption capacity and the slow drug release rate. Then, this solid have good properties of adsorption and release, similar to that of the parent pure MCM-41 and simultaneously their modification with iron nanospecies leads to materials with superparamagnetic behavior.Fil: Fil. Cuello, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Elías, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Mendieta, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Longhi, María. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Oliva, Marcos Iván. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación. Instituto de Física Enrique Gaviola; Argentina.Fil: Crivello, Mónica. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.Fil: Eimer, Griselda Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.2022-05-26T14:47:37Z2022-05-26T14:47:37Z2016info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciapdfapplication/pdf4ta Reunión Internacional de Ciencias Farmacéuticashttp://hdl.handle.net/20.500.12272/6460engenginfo:eu-repo/semantics/openAccess2022-05-26T14:47:37Zhttp://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 InternacionalEimer, Griselda AlejandraNo comercial. Sólo de uso académico.reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:45:37Zoai:ria.utn.edu.ar:20.500.12272/6460instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:45:38.298Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
spellingShingle Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
Cuello, Natalia
Hydrothermal treatment
MCM-41
Drug release
Indomethacin
title_short Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_full Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_fullStr Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_full_unstemmed Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_sort Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
dc.creator.none.fl_str_mv Cuello, Natalia
Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
author Cuello, Natalia
author_facet Cuello, Natalia
Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
author_role author
author2 Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Hydrothermal treatment
MCM-41
Drug release
Indomethacin
topic Hydrothermal treatment
MCM-41
Drug release
Indomethacin
dc.description.none.fl_txt_mv Synthesis of MCM-41 having magnetic elements embedded inside has been researched in order to develop very interesting drug-delivery systems. In this work, MCM-41 nanostructured materials modified with iron were synthesized using the direct synthesis method (DI) and a hydrothermal treatment (HT) was applied [1]. Due to that silanol groups can form hydrogen bridge bonds with the carboxyl and carbonyl groups of indomethacin (IN), the silanol groups density on the support was analyzed by IR spectroscopy. Then, the drug was incorporated into both iron modified samples and into the pure MCM-41 and their release profiles were evaluated "in vitro" using simulated body fluid as medium. All modified materials have faster profiles than the pure silica matrix. This could be due to the presence of nanospecies of oxides inside channels that might increase the steric diffusion resistance. Thus, the drug could diffuse through the channels of the modified material with less freedom that through those of MCM-41. However, the sample modified with iron by this method with HT have a behavior similar to that of MCM-41 possibly due to the refiner effect of HT on the nanospecies size. In addition, materials with HT have an increased availability of silanol groups capable to interact with the indomethacin. This would explain their high drug adsorption capacity and the slow drug release rate. Then, this solid have good properties of adsorption and release, similar to that of the parent pure MCM-41 and simultaneously their modification with iron nanospecies leads to materials with superparamagnetic behavior.
Fil: Fil. Cuello, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Elías, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Mendieta, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Longhi, María. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Oliva, Marcos Iván. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía, Física y Computación. Instituto de Física Enrique Gaviola; Argentina.
Fil: Crivello, Mónica. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
Fil: Eimer, Griselda Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
description Synthesis of MCM-41 having magnetic elements embedded inside has been researched in order to develop very interesting drug-delivery systems. In this work, MCM-41 nanostructured materials modified with iron were synthesized using the direct synthesis method (DI) and a hydrothermal treatment (HT) was applied [1]. Due to that silanol groups can form hydrogen bridge bonds with the carboxyl and carbonyl groups of indomethacin (IN), the silanol groups density on the support was analyzed by IR spectroscopy. Then, the drug was incorporated into both iron modified samples and into the pure MCM-41 and their release profiles were evaluated "in vitro" using simulated body fluid as medium. All modified materials have faster profiles than the pure silica matrix. This could be due to the presence of nanospecies of oxides inside channels that might increase the steric diffusion resistance. Thus, the drug could diffuse through the channels of the modified material with less freedom that through those of MCM-41. However, the sample modified with iron by this method with HT have a behavior similar to that of MCM-41 possibly due to the refiner effect of HT on the nanospecies size. In addition, materials with HT have an increased availability of silanol groups capable to interact with the indomethacin. This would explain their high drug adsorption capacity and the slow drug release rate. Then, this solid have good properties of adsorption and release, similar to that of the parent pure MCM-41 and simultaneously their modification with iron nanospecies leads to materials with superparamagnetic behavior.
publishDate 2016
dc.date.none.fl_str_mv 2016
2022-05-26T14:47:37Z
2022-05-26T14:47:37Z
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv 4ta Reunión Internacional de Ciencias Farmacéuticas
http://hdl.handle.net/20.500.12272/6460
identifier_str_mv 4ta Reunión Internacional de Ciencias Farmacéuticas
url http://hdl.handle.net/20.500.12272/6460
dc.language.none.fl_str_mv eng
eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
2022-05-26T14:47:37Z
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Eimer, Griselda Alejandra
No comercial. Sólo de uso académico.
eu_rights_str_mv openAccess
rights_invalid_str_mv 2022-05-26T14:47:37Z
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Eimer, Griselda Alejandra
No comercial. Sólo de uso académico.
dc.format.none.fl_str_mv pdf
application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 13.265058

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