Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties

Autores
Mendieta, Silvia; Oliva, Marcos; Pérez, Celso; Herrero, Eduardo; Heredia, Angélica; Crivello, Mónica
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Layered double hydroxides (LDH), also known as hydrotalcite like compounds or anionic clay, have technological importance in catalysis, optics, medical science and nanocomposite material engineering. Moreover, LDH are biocompatible materials, and may act as stable host matrices for storage and delivery of various intercalated bioactive molecules and drugs [1]. One important feature is that the labile bioactive substances intercalated into LDH could effectively be protected against rapid degradation by light, temperature, oxygen, alkali metals, etc. Indomethacin is a member of the NSAID. It is used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc., however, are well known side effects including gastrointestinal disturbance. The drug is described as poorly soluble and highly permeable (class II) drug. The MgAl-Indo samples have been prepared following direct synthesis by coprecipitation from Mg and Al chlorides; was added over a suspension with indomethacin [2]. The synthesis was prepared at different pH (8, 9 and 10) ± 0.2; the pH was maintained constant by continuous adding of 0.1 M NaOH. The coprecipitation was carried out at 35 °C under nitrogen atmosphere to avoid the incorporation of CO2. The resulting suspension was stirred for 20 h at 60 ºC under nitrogen atmosphere. The samples were characterized by X-ray powder diffraction, FT-IR spectra, Scanning electron microscopy, Thermogravimetric analyses and Differential scanning calorimetry analyses. Drug content was determined by UV absorption spectrophotometer Jasco 7800 at λ=320 nm. Successful intercalation of indomethacin into the LDH host is demonstrated by the XRD diagrams of the nano hybrids. On the other hand, the drug was absorbed on the surface of the LDH synthesized at pH 8 and 9. At pH = 10 showed higher order crystalline structure of LDH. The drug suffers a change of structure due to the heat treatments performed during the synthesis confirmed by FT-IR. The nanoclay confers more thermal stability to the drug observed by DSC; the decomposition temperature is enhanced about 100°C. The maximum incorporation was obtained with LDH synthesized at pH=8. The present results imply that the nano hybrids particles can be potentially used as a novel drug storage and delivery.
Fil: Mendieta, Silvia. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Oliva, Marcos. Universidad Nacional de Córdoba; Argentina.
Fil: Pérez, Celso. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Herrero, Eduardo. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Heredia, Angélica. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Crivello, Mónica. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Peer Reviewed
Materia
LDH-AINES drugs
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/13566
Acceder
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oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/13566
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability propertiesMendieta, SilviaOliva, MarcosPérez, CelsoHerrero, EduardoHeredia, AngélicaCrivello, MónicaLDH-AINES drugsLayered double hydroxides (LDH), also known as hydrotalcite like compounds or anionic clay, have technological importance in catalysis, optics, medical science and nanocomposite material engineering. Moreover, LDH are biocompatible materials, and may act as stable host matrices for storage and delivery of various intercalated bioactive molecules and drugs [1]. One important feature is that the labile bioactive substances intercalated into LDH could effectively be protected against rapid degradation by light, temperature, oxygen, alkali metals, etc. Indomethacin is a member of the NSAID. It is used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc., however, are well known side effects including gastrointestinal disturbance. The drug is described as poorly soluble and highly permeable (class II) drug. The MgAl-Indo samples have been prepared following direct synthesis by coprecipitation from Mg and Al chlorides; was added over a suspension with indomethacin [2]. The synthesis was prepared at different pH (8, 9 and 10) ± 0.2; the pH was maintained constant by continuous adding of 0.1 M NaOH. The coprecipitation was carried out at 35 °C under nitrogen atmosphere to avoid the incorporation of CO2. The resulting suspension was stirred for 20 h at 60 ºC under nitrogen atmosphere. The samples were characterized by X-ray powder diffraction, FT-IR spectra, Scanning electron microscopy, Thermogravimetric analyses and Differential scanning calorimetry analyses. Drug content was determined by UV absorption spectrophotometer Jasco 7800 at λ=320 nm. Successful intercalation of indomethacin into the LDH host is demonstrated by the XRD diagrams of the nano hybrids. On the other hand, the drug was absorbed on the surface of the LDH synthesized at pH 8 and 9. At pH = 10 showed higher order crystalline structure of LDH. The drug suffers a change of structure due to the heat treatments performed during the synthesis confirmed by FT-IR. The nanoclay confers more thermal stability to the drug observed by DSC; the decomposition temperature is enhanced about 100°C. The maximum incorporation was obtained with LDH synthesized at pH=8. The present results imply that the nano hybrids particles can be potentially used as a novel drug storage and delivery.Fil: Mendieta, Silvia. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Oliva, Marcos. Universidad Nacional de Córdoba; Argentina.Fil: Pérez, Celso. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Herrero, Eduardo. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Heredia, Angélica. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Fil: Crivello, Mónica. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.Peer Reviewed5th Czech-Italian-Spanish Conference on Molecular Sieves and Catalysis2025-07-30T19:29:45Z2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfhttps://hdl.handle.net/20.500.12272/13566enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-10-01T11:57:19Zoai:ria.utn.edu.ar:20.500.12272/13566instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-10-01 11:57:20.588Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
title Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
spellingShingle Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
Mendieta, Silvia
LDH-AINES drugs
title_short Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
title_full Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
title_fullStr Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
title_full_unstemmed Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
title_sort Nanohibrids of LDH-AINES drugs: synthesis, characterization and stability properties
dc.creator.none.fl_str_mv Mendieta, Silvia
Oliva, Marcos
Pérez, Celso
Herrero, Eduardo
Heredia, Angélica
Crivello, Mónica
author Mendieta, Silvia
author_facet Mendieta, Silvia
Oliva, Marcos
Pérez, Celso
Herrero, Eduardo
Heredia, Angélica
Crivello, Mónica
author_role author
author2 Oliva, Marcos
Pérez, Celso
Herrero, Eduardo
Heredia, Angélica
Crivello, Mónica
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv LDH-AINES drugs
topic LDH-AINES drugs
dc.description.none.fl_txt_mv Layered double hydroxides (LDH), also known as hydrotalcite like compounds or anionic clay, have technological importance in catalysis, optics, medical science and nanocomposite material engineering. Moreover, LDH are biocompatible materials, and may act as stable host matrices for storage and delivery of various intercalated bioactive molecules and drugs [1]. One important feature is that the labile bioactive substances intercalated into LDH could effectively be protected against rapid degradation by light, temperature, oxygen, alkali metals, etc. Indomethacin is a member of the NSAID. It is used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc., however, are well known side effects including gastrointestinal disturbance. The drug is described as poorly soluble and highly permeable (class II) drug. The MgAl-Indo samples have been prepared following direct synthesis by coprecipitation from Mg and Al chlorides; was added over a suspension with indomethacin [2]. The synthesis was prepared at different pH (8, 9 and 10) ± 0.2; the pH was maintained constant by continuous adding of 0.1 M NaOH. The coprecipitation was carried out at 35 °C under nitrogen atmosphere to avoid the incorporation of CO2. The resulting suspension was stirred for 20 h at 60 ºC under nitrogen atmosphere. The samples were characterized by X-ray powder diffraction, FT-IR spectra, Scanning electron microscopy, Thermogravimetric analyses and Differential scanning calorimetry analyses. Drug content was determined by UV absorption spectrophotometer Jasco 7800 at λ=320 nm. Successful intercalation of indomethacin into the LDH host is demonstrated by the XRD diagrams of the nano hybrids. On the other hand, the drug was absorbed on the surface of the LDH synthesized at pH 8 and 9. At pH = 10 showed higher order crystalline structure of LDH. The drug suffers a change of structure due to the heat treatments performed during the synthesis confirmed by FT-IR. The nanoclay confers more thermal stability to the drug observed by DSC; the decomposition temperature is enhanced about 100°C. The maximum incorporation was obtained with LDH synthesized at pH=8. The present results imply that the nano hybrids particles can be potentially used as a novel drug storage and delivery.
Fil: Mendieta, Silvia. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Oliva, Marcos. Universidad Nacional de Córdoba; Argentina.
Fil: Pérez, Celso. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Herrero, Eduardo. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Heredia, Angélica. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Fil: Crivello, Mónica. Universidad tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina.
Peer Reviewed
description Layered double hydroxides (LDH), also known as hydrotalcite like compounds or anionic clay, have technological importance in catalysis, optics, medical science and nanocomposite material engineering. Moreover, LDH are biocompatible materials, and may act as stable host matrices for storage and delivery of various intercalated bioactive molecules and drugs [1]. One important feature is that the labile bioactive substances intercalated into LDH could effectively be protected against rapid degradation by light, temperature, oxygen, alkali metals, etc. Indomethacin is a member of the NSAID. It is used to reduce pain involved in osteoarthritis, rheumatoid arthritis, bursitis, gout, etc., however, are well known side effects including gastrointestinal disturbance. The drug is described as poorly soluble and highly permeable (class II) drug. The MgAl-Indo samples have been prepared following direct synthesis by coprecipitation from Mg and Al chlorides; was added over a suspension with indomethacin [2]. The synthesis was prepared at different pH (8, 9 and 10) ± 0.2; the pH was maintained constant by continuous adding of 0.1 M NaOH. The coprecipitation was carried out at 35 °C under nitrogen atmosphere to avoid the incorporation of CO2. The resulting suspension was stirred for 20 h at 60 ºC under nitrogen atmosphere. The samples were characterized by X-ray powder diffraction, FT-IR spectra, Scanning electron microscopy, Thermogravimetric analyses and Differential scanning calorimetry analyses. Drug content was determined by UV absorption spectrophotometer Jasco 7800 at λ=320 nm. Successful intercalation of indomethacin into the LDH host is demonstrated by the XRD diagrams of the nano hybrids. On the other hand, the drug was absorbed on the surface of the LDH synthesized at pH 8 and 9. At pH = 10 showed higher order crystalline structure of LDH. The drug suffers a change of structure due to the heat treatments performed during the synthesis confirmed by FT-IR. The nanoclay confers more thermal stability to the drug observed by DSC; the decomposition temperature is enhanced about 100°C. The maximum incorporation was obtained with LDH synthesized at pH=8. The present results imply that the nano hybrids particles can be potentially used as a novel drug storage and delivery.
publishDate 2013
dc.date.none.fl_str_mv 2013
2025-07-30T19:29:45Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12272/13566
url https://hdl.handle.net/20.500.12272/13566
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv 5th Czech-Italian-Spanish Conference on Molecular Sieves and Catalysis
publisher.none.fl_str_mv 5th Czech-Italian-Spanish Conference on Molecular Sieves and Catalysis
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 12.854657

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