Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fract...

Autores
Aryana, Arash; Irastorza, Ramiro M.; Berjano, Enrique; Cohen, Richard J.; Kraus, Jeffrey; Haghighi‐Mood, Ali; Reddy, Vivek Y.; d'Avila, André
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: During radiofrequency ablation (RFA) using conventional RFA catheters (RFC), ~90% of the energy dissipates into the bloodstream/surrounding tissue. We hypothesized that a novel insulated‐tip ablation catheter (SMT) capable of blocking the radiofrequency path may focus most of the energy into the targeted tissue while utilizing reduced power and irrigation. Methods: This study evaluated the outcomes of RFA using SMT versus an RFC in silico, ex vivo, and in vivo. Radiofrequency applications were delivered over porcine myocardium (ex vivo) and porcine thigh muscle preparations superfused with heparinized blood (in vivo). Altogether, 274 radiofrequency applications were delivered using SMT (4–15 W, 2 or 20 ml/min) and 74 applications using RFC (30 W, 30 ml/min). Results: RFA using SMT proved capable of directing 66.8% of the radiofrequency energy into the targeted tissue. Accordingly, low power–low irrigation RFA using SMT (8–12 W, 2 ml/min) yielded lesion sizes comparable with RFC, whereas high power–high irrigation (15 W, 20 ml/min) RFA with SMT yielded lesions larger than RFC (p < .05). Although SMT was associated with greater impedance drops ex vivo and in vivo, ablation using RFC was associated with increased charring/steam pop/ tissue cavitation (p < .05). Lastly, lesions created with SMT were more homogeneous than RFC (p < .001). Conclusion: Low power–low irrigation (8–12 W, 2 ml/min) RFA using the novel SMT ablation catheter can create more uniform, but comparable‐sized lesions as RFC with reduced charring/steam pop/tissue cavitation. High power–high irrigation (15 W, 20 ml/min) RFA with SMT yields lesions larger than RFC.
Fil: Aryana, Arash. Mercy General Hospital. Dignity Health Heart and Vascular Institute; Estados Unidos.
Fil: Irastorza, Ramiro M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina.
Fil: Irastorza, Ramiro M. Universidad Nacional Arturo Jauretche. Instituto de Ingeniería y Agronomía; Argentina.
Fil: Berjano, Enrique. Universitat Politècnica de València. Department of Electronic Engineering. BioMIT; España.
Fil: Cohen, Richard J. Massachusetts Institute of Technology. Institute for Medical Engineering and Science; Estados Unidos.
Fil: Kraus, Jeffrey. Sirona Medical Technologies; Estados Unidos.
Fil: Haghighi‐Mood, Ali. Sirona Medical Technologies; Estados Unidos.
Fil: Reddy, Vivek Y. Mount Sinai School of Medicine. Helmsley Cardiac Arrhythmia Service; Estados Unidos.
Fil: d'Avila, André. Beth Israel Deaconess Medical Center; Estados Unidos.
Materia
Catheter ablation
Power
Radiofrequency
SMT
Steam pop
Nivel de accesibilidad
acceso abierto
Condiciones de uso
info:ar-repo/semantics/accesoabierto
Repositorio
Repositorio Institucional Digital de Acceso Abierto
Institución
Universidad Nacional Arturo Jauretche
OAI Identificador
oai:rid.unaj.edu.ar:123456789/3645
Acceder
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oai_identifier_str oai:rid.unaj.edu.ar:123456789/3645
network_acronym_str RIDUNAJ
repository_id_str
network_name_str Repositorio Institucional Digital de Acceso Abierto
spelling Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigationAryana, ArashIrastorza, Ramiro M.Berjano, EnriqueCohen, Richard J.Kraus, JeffreyHaghighi‐Mood, AliReddy, Vivek Y.d&apos;Avila, AndréCatheter ablationPowerRadiofrequencySMTSteam popIntroduction: During radiofrequency ablation (RFA) using conventional RFA catheters (RFC), ~90% of the energy dissipates into the bloodstream/surrounding tissue. We hypothesized that a novel insulated‐tip ablation catheter (SMT) capable of blocking the radiofrequency path may focus most of the energy into the targeted tissue while utilizing reduced power and irrigation. Methods: This study evaluated the outcomes of RFA using SMT versus an RFC in silico, ex vivo, and in vivo. Radiofrequency applications were delivered over porcine myocardium (ex vivo) and porcine thigh muscle preparations superfused with heparinized blood (in vivo). Altogether, 274 radiofrequency applications were delivered using SMT (4–15 W, 2 or 20 ml/min) and 74 applications using RFC (30 W, 30 ml/min). Results: RFA using SMT proved capable of directing 66.8% of the radiofrequency energy into the targeted tissue. Accordingly, low power–low irrigation RFA using SMT (8–12 W, 2 ml/min) yielded lesion sizes comparable with RFC, whereas high power–high irrigation (15 W, 20 ml/min) RFA with SMT yielded lesions larger than RFC (p &lt; .05). Although SMT was associated with greater impedance drops ex vivo and in vivo, ablation using RFC was associated with increased charring/steam pop/ tissue cavitation (p &lt; .05). Lastly, lesions created with SMT were more homogeneous than RFC (p &lt; .001). Conclusion: Low power–low irrigation (8–12 W, 2 ml/min) RFA using the novel SMT ablation catheter can create more uniform, but comparable‐sized lesions as RFC with reduced charring/steam pop/tissue cavitation. High power–high irrigation (15 W, 20 ml/min) RFA with SMT yields lesions larger than RFC.Fil: Aryana, Arash. Mercy General Hospital. Dignity Health Heart and Vascular Institute; Estados Unidos.Fil: Irastorza, Ramiro M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina.Fil: Irastorza, Ramiro M. Universidad Nacional Arturo Jauretche. Instituto de Ingeniería y Agronomía; Argentina.Fil: Berjano, Enrique. Universitat Politècnica de València. Department of Electronic Engineering. BioMIT; España.Fil: Cohen, Richard J. Massachusetts Institute of Technology. Institute for Medical Engineering and Science; Estados Unidos.Fil: Kraus, Jeffrey. Sirona Medical Technologies; Estados Unidos.Fil: Haghighi‐Mood, Ali. Sirona Medical Technologies; Estados Unidos.Fil: Reddy, Vivek Y. Mount Sinai School of Medicine. Helmsley Cardiac Arrhythmia Service; Estados Unidos.Fil: d&apos;Avila, André. Beth Israel Deaconess Medical Center; Estados Unidos.2022-03-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://rid.unaj.edu.ar/handle/123456789/3645engJournal of Cardiovascular Electrophysiology, 33(6)info:eu-repo/semantics/altIdentifier/eissn/1540-8167info:eu-repo/semantics/altIdentifier/url/doi.org/10.1111/jce.15461info:eu-repo/semantics/openAccessinfo:ar-repo/semantics/accesoabiertohttps://creativecommons.org/licenses/by-nc/4.0/reponame:Repositorio Institucional Digital de Acceso Abiertoinstname:Universidad Nacional Arturo Jauretche2026-09-24T13:53:51Zoai:rid.unaj.edu.ar:123456789/3645instacron:UNAJInstitucionalhttps://rid.unaj.edu.ar/homeUniversidad públicahttps://www.unaj.edu.ar/https://rid.unaj.edu.ar/server/oai/snrdrepositorio@unaj.edu.arArgentinaopendoar:2026-09-24 13:53:51.948Repositorio Institucional Digital de Acceso Abierto - Universidad Nacional Arturo Jauretchefalse
dc.title.none.fl_str_mv Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
title Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
spellingShingle Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
Aryana, Arash
Catheter ablation
Power
Radiofrequency
SMT
Steam pop
title_short Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
title_full Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
title_fullStr Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
title_full_unstemmed Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
title_sort Radiofrequency ablation using a novel insulated‐tip ablation catheter can create uniform lesions comparable in size to conventional irrigated ablation catheters while using a fraction of the energy and irrigation
dc.creator.none.fl_str_mv Aryana, Arash
Irastorza, Ramiro M.
Berjano, Enrique
Cohen, Richard J.
Kraus, Jeffrey
Haghighi‐Mood, Ali
Reddy, Vivek Y.
d&apos;Avila, André
author Aryana, Arash
author_facet Aryana, Arash
Irastorza, Ramiro M.
Berjano, Enrique
Cohen, Richard J.
Kraus, Jeffrey
Haghighi‐Mood, Ali
Reddy, Vivek Y.
d&apos;Avila, André
author_role author
author2 Irastorza, Ramiro M.
Berjano, Enrique
Cohen, Richard J.
Kraus, Jeffrey
Haghighi‐Mood, Ali
Reddy, Vivek Y.
d&apos;Avila, André
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Catheter ablation
Power
Radiofrequency
SMT
Steam pop
topic Catheter ablation
Power
Radiofrequency
SMT
Steam pop
dc.description.none.fl_txt_mv Introduction: During radiofrequency ablation (RFA) using conventional RFA catheters (RFC), ~90% of the energy dissipates into the bloodstream/surrounding tissue. We hypothesized that a novel insulated‐tip ablation catheter (SMT) capable of blocking the radiofrequency path may focus most of the energy into the targeted tissue while utilizing reduced power and irrigation. Methods: This study evaluated the outcomes of RFA using SMT versus an RFC in silico, ex vivo, and in vivo. Radiofrequency applications were delivered over porcine myocardium (ex vivo) and porcine thigh muscle preparations superfused with heparinized blood (in vivo). Altogether, 274 radiofrequency applications were delivered using SMT (4–15 W, 2 or 20 ml/min) and 74 applications using RFC (30 W, 30 ml/min). Results: RFA using SMT proved capable of directing 66.8% of the radiofrequency energy into the targeted tissue. Accordingly, low power–low irrigation RFA using SMT (8–12 W, 2 ml/min) yielded lesion sizes comparable with RFC, whereas high power–high irrigation (15 W, 20 ml/min) RFA with SMT yielded lesions larger than RFC (p &lt; .05). Although SMT was associated with greater impedance drops ex vivo and in vivo, ablation using RFC was associated with increased charring/steam pop/ tissue cavitation (p &lt; .05). Lastly, lesions created with SMT were more homogeneous than RFC (p &lt; .001). Conclusion: Low power–low irrigation (8–12 W, 2 ml/min) RFA using the novel SMT ablation catheter can create more uniform, but comparable‐sized lesions as RFC with reduced charring/steam pop/tissue cavitation. High power–high irrigation (15 W, 20 ml/min) RFA with SMT yields lesions larger than RFC.
Fil: Aryana, Arash. Mercy General Hospital. Dignity Health Heart and Vascular Institute; Estados Unidos.
Fil: Irastorza, Ramiro M. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Física de Líquidos y Sistemas Biológicos; Argentina.
Fil: Irastorza, Ramiro M. Universidad Nacional Arturo Jauretche. Instituto de Ingeniería y Agronomía; Argentina.
Fil: Berjano, Enrique. Universitat Politècnica de València. Department of Electronic Engineering. BioMIT; España.
Fil: Cohen, Richard J. Massachusetts Institute of Technology. Institute for Medical Engineering and Science; Estados Unidos.
Fil: Kraus, Jeffrey. Sirona Medical Technologies; Estados Unidos.
Fil: Haghighi‐Mood, Ali. Sirona Medical Technologies; Estados Unidos.
Fil: Reddy, Vivek Y. Mount Sinai School of Medicine. Helmsley Cardiac Arrhythmia Service; Estados Unidos.
Fil: d&apos;Avila, André. Beth Israel Deaconess Medical Center; Estados Unidos.
description Introduction: During radiofrequency ablation (RFA) using conventional RFA catheters (RFC), ~90% of the energy dissipates into the bloodstream/surrounding tissue. We hypothesized that a novel insulated‐tip ablation catheter (SMT) capable of blocking the radiofrequency path may focus most of the energy into the targeted tissue while utilizing reduced power and irrigation. Methods: This study evaluated the outcomes of RFA using SMT versus an RFC in silico, ex vivo, and in vivo. Radiofrequency applications were delivered over porcine myocardium (ex vivo) and porcine thigh muscle preparations superfused with heparinized blood (in vivo). Altogether, 274 radiofrequency applications were delivered using SMT (4–15 W, 2 or 20 ml/min) and 74 applications using RFC (30 W, 30 ml/min). Results: RFA using SMT proved capable of directing 66.8% of the radiofrequency energy into the targeted tissue. Accordingly, low power–low irrigation RFA using SMT (8–12 W, 2 ml/min) yielded lesion sizes comparable with RFC, whereas high power–high irrigation (15 W, 20 ml/min) RFA with SMT yielded lesions larger than RFC (p &lt; .05). Although SMT was associated with greater impedance drops ex vivo and in vivo, ablation using RFC was associated with increased charring/steam pop/ tissue cavitation (p &lt; .05). Lastly, lesions created with SMT were more homogeneous than RFC (p &lt; .001). Conclusion: Low power–low irrigation (8–12 W, 2 ml/min) RFA using the novel SMT ablation catheter can create more uniform, but comparable‐sized lesions as RFC with reduced charring/steam pop/tissue cavitation. High power–high irrigation (15 W, 20 ml/min) RFA with SMT yields lesions larger than RFC.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://rid.unaj.edu.ar/handle/123456789/3645
url https://rid.unaj.edu.ar/handle/123456789/3645
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Cardiovascular Electrophysiology, 33(6)
info:eu-repo/semantics/altIdentifier/eissn/1540-8167
info:eu-repo/semantics/altIdentifier/url/doi.org/10.1111/jce.15461
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
info:ar-repo/semantics/accesoabierto
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv info:ar-repo/semantics/accesoabierto
https://creativecommons.org/licenses/by-nc/4.0/
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Digital de Acceso Abierto
instname:Universidad Nacional Arturo Jauretche
reponame_str Repositorio Institucional Digital de Acceso Abierto
collection Repositorio Institucional Digital de Acceso Abierto
instname_str Universidad Nacional Arturo Jauretche
repository.name.fl_str_mv Repositorio Institucional Digital de Acceso Abierto - Universidad Nacional Arturo Jauretche
repository.mail.fl_str_mv repositorio@unaj.edu.ar
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score 12.733355

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