Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study
- Autores
- Speisky, Daniela; Nicoud, Melisa Beatriz; Iotti, Alejandro; Formoso, Karina; Lauretta, Paolo; García de Dávila, María Teresa; Medina, Vanina A.
- Año de publicación
- 2026
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fil: Speisky, Daniela. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina
Fil: Nicoud, Melisa B. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Iotti, Alejandro. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina
Fil: Formoso, Karina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: Lauretta, Paolo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argentina
Fil: García de Dávila, María Teresa. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina
Fil: Medina, Vanina A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argentina
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide, with a mortality rate almost equal to its incidence, highlighting the urgent need for novel biomarkers and therapeutic targets. This pilot study aims to investigate the potential value of histamine H3 receptor (H3R) as a prognostic biomarker for this lethal disease. We analyzed the H3R expression in PDAC using the RNA sequencing data set from The Cancer Genome Atlas (Pan-Cancer Atlas). In addition, H3R protein levels were evaluated by immunohistochemistry in 27 PDAC samples and compared with adjacent preneoplastic pancreatic tissue of the same patient, and with 10 non-related healthy pancreatic tissues. This preliminary study shows that the H3R is barely expressed in healthy tissue. Interestingly, H3R was detected in 96% of PDAC samples, and its expression in tumoral tissue was significantly higher when compared with its expression in preneoplastic tissue, and it was associated with a better prognosis in terms of overall survival. Present findings suggest that H3R may serve as a potential prognostic biomarker in PDAC. Future research aimed at elucidating the role of H3R in PDAC biology and its prognostic value in larger patient cohorts is warranted - Fuente
- The Journal of Histochemistry and Cytochemistry, vol. 74, n. 2
- Materia
-
ADENOCARCINOMA DUCTAL PANCREATICO
RECEPTORES DE HISTAMINA
INMUNOHISTOQUIMICA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Pontificia Universidad Católica Argentina
- OAI Identificador
- oai:ucacris:123456789/21981
Ver los metadatos del registro completo
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Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot studySpeisky, DanielaNicoud, Melisa BeatrizIotti, AlejandroFormoso, KarinaLauretta, PaoloGarcía de Dávila, María TeresaMedina, Vanina A.ADENOCARCINOMA DUCTAL PANCREATICORECEPTORES DE HISTAMINAINMUNOHISTOQUIMICAFil: Speisky, Daniela. Hospital Británico de Buenos Aires. Departamento de Patología; ArgentinaFil: Nicoud, Melisa B. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Iotti, Alejandro. Hospital Británico de Buenos Aires. Departamento de Patología; ArgentinaFil: Formoso, Karina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: Lauretta, Paolo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; ArgentinaFil: García de Dávila, María Teresa. Hospital Británico de Buenos Aires. Departamento de Patología; ArgentinaFil: Medina, Vanina A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; ArgentinaPancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide, with a mortality rate almost equal to its incidence, highlighting the urgent need for novel biomarkers and therapeutic targets. This pilot study aims to investigate the potential value of histamine H3 receptor (H3R) as a prognostic biomarker for this lethal disease. We analyzed the H3R expression in PDAC using the RNA sequencing data set from The Cancer Genome Atlas (Pan-Cancer Atlas). In addition, H3R protein levels were evaluated by immunohistochemistry in 27 PDAC samples and compared with adjacent preneoplastic pancreatic tissue of the same patient, and with 10 non-related healthy pancreatic tissues. This preliminary study shows that the H3R is barely expressed in healthy tissue. Interestingly, H3R was detected in 96% of PDAC samples, and its expression in tumoral tissue was significantly higher when compared with its expression in preneoplastic tissue, and it was associated with a better prognosis in terms of overall survival. Present findings suggest that H3R may serve as a potential prognostic biomarker in PDAC. Future research aimed at elucidating the role of H3R in PDAC biology and its prognostic value in larger patient cohorts is warrantedSAGE Publications2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/219811551-504410.1369/00221554251410292The Journal of Histochemistry and Cytochemistry, vol. 74, n. 2reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2026-09-28T11:10:44Zoai:ucacris:123456789/21981instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852026-09-28 11:10:45.455Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse |
| dc.title.none.fl_str_mv |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| title |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| spellingShingle |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study Speisky, Daniela ADENOCARCINOMA DUCTAL PANCREATICO RECEPTORES DE HISTAMINA INMUNOHISTOQUIMICA |
| title_short |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| title_full |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| title_fullStr |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| title_full_unstemmed |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| title_sort |
Differential expression of histamine H3 receptor in healthy, preneoplastic, and tumoral pancreatic tissue: a pilot study |
| dc.creator.none.fl_str_mv |
Speisky, Daniela Nicoud, Melisa Beatriz Iotti, Alejandro Formoso, Karina Lauretta, Paolo García de Dávila, María Teresa Medina, Vanina A. |
| author |
Speisky, Daniela |
| author_facet |
Speisky, Daniela Nicoud, Melisa Beatriz Iotti, Alejandro Formoso, Karina Lauretta, Paolo García de Dávila, María Teresa Medina, Vanina A. |
| author_role |
author |
| author2 |
Nicoud, Melisa Beatriz Iotti, Alejandro Formoso, Karina Lauretta, Paolo García de Dávila, María Teresa Medina, Vanina A. |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
ADENOCARCINOMA DUCTAL PANCREATICO RECEPTORES DE HISTAMINA INMUNOHISTOQUIMICA |
| topic |
ADENOCARCINOMA DUCTAL PANCREATICO RECEPTORES DE HISTAMINA INMUNOHISTOQUIMICA |
| dc.description.none.fl_txt_mv |
Fil: Speisky, Daniela. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina Fil: Nicoud, Melisa B. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Iotti, Alejandro. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina Fil: Formoso, Karina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina Fil: Lauretta, Paolo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argentina Fil: García de Dávila, María Teresa. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina Fil: Medina, Vanina A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argentina Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide, with a mortality rate almost equal to its incidence, highlighting the urgent need for novel biomarkers and therapeutic targets. This pilot study aims to investigate the potential value of histamine H3 receptor (H3R) as a prognostic biomarker for this lethal disease. We analyzed the H3R expression in PDAC using the RNA sequencing data set from The Cancer Genome Atlas (Pan-Cancer Atlas). In addition, H3R protein levels were evaluated by immunohistochemistry in 27 PDAC samples and compared with adjacent preneoplastic pancreatic tissue of the same patient, and with 10 non-related healthy pancreatic tissues. This preliminary study shows that the H3R is barely expressed in healthy tissue. Interestingly, H3R was detected in 96% of PDAC samples, and its expression in tumoral tissue was significantly higher when compared with its expression in preneoplastic tissue, and it was associated with a better prognosis in terms of overall survival. Present findings suggest that H3R may serve as a potential prognostic biomarker in PDAC. Future research aimed at elucidating the role of H3R in PDAC biology and its prognostic value in larger patient cohorts is warranted |
| description |
Fil: Speisky, Daniela. Hospital Británico de Buenos Aires. Departamento de Patología; Argentina |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
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https://repositorio.uca.edu.ar/handle/123456789/21981 1551-5044 10.1369/00221554251410292 |
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https://repositorio.uca.edu.ar/handle/123456789/21981 |
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1551-5044 10.1369/00221554251410292 |
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eng |
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eng |
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application/pdf |
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SAGE Publications |
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SAGE Publications |
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The Journal of Histochemistry and Cytochemistry, vol. 74, n. 2 reponame:Repositorio Institucional (UCA) instname:Pontificia Universidad Católica Argentina |
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Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina |
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claudia_fernandez@uca.edu.ar |
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