Guidelines for diet-induced models of cardiometabolic syndrome

Autores
Sveeggen, Timothy M.; Bagher, Pooneh; Toba, Hiroe; Lindsey, Merry L.; Ritchie, Rebecca H.; Miksztowicz, Verónica J.; González, Germán E.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Sveeggen, Timothy M. University of Nebraska Medical Center; Estados Unidos
Fil: Bagher, Pooneh. University of Nebraska Medical Center; Estados Unidos
Fil: Toba, Hiroe. Kyoto Pharmaceutical University; Japón
Fil: Lindsey, Merry L. Nashville VA Medical Center; Estados Unidos
Fil: Ritchie, Rebecca H. Monash University; Australia
Fil: Miksztowicz, Verónica J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: González, Germán E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Patología Cardiovascular Experimental e Hipertensión Arterial; Argentina
Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension, that collectively increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. A lack of reporting standards and variability in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility assessment and translational impact evaluation. We provide standardized guidelines for the consideration, preparation, and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared with genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key components include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. In addition, we outline husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is essential for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.
Fuente
American Journal of Physiology-Heart and Circulatory Physiology, vol. 329, n. 4
Materia
SINDROME CARDIOMETABOLICO
FISIOPATOLOGÍA CARDIOVASCULAR
SINDROME METABOLICO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/22028
Acceder
id RIUCA_8092ed0c311cbfb3c28835ecf5404313
oai_identifier_str oai:ucacris:123456789/22028
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Guidelines for diet-induced models of cardiometabolic syndromeSveeggen, Timothy M.Bagher, PoonehToba, HiroeLindsey, Merry L.Ritchie, Rebecca H.Miksztowicz, Verónica J.González, Germán E.SINDROME CARDIOMETABOLICOFISIOPATOLOGÍA CARDIOVASCULARSINDROME METABOLICOFil: Sveeggen, Timothy M. University of Nebraska Medical Center; Estados UnidosFil: Bagher, Pooneh. University of Nebraska Medical Center; Estados UnidosFil: Toba, Hiroe. Kyoto Pharmaceutical University; JapónFil: Lindsey, Merry L. Nashville VA Medical Center; Estados UnidosFil: Ritchie, Rebecca H. Monash University; AustraliaFil: Miksztowicz, Verónica J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; ArgentinaFil: González, Germán E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Patología Cardiovascular Experimental e Hipertensión Arterial; ArgentinaCardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension, that collectively increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. A lack of reporting standards and variability in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility assessment and translational impact evaluation. We provide standardized guidelines for the consideration, preparation, and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared with genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key components include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. In addition, we outline husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is essential for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.American Physiological Society2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/220281522-153910.1152/ajpheart.00359.2025American Journal of Physiology-Heart and Circulatory Physiology, vol. 329, n. 4reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2026-10-01T12:03:37Zoai:ucacris:123456789/22028instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852026-10-01 12:03:37.949Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Guidelines for diet-induced models of cardiometabolic syndrome
title Guidelines for diet-induced models of cardiometabolic syndrome
spellingShingle Guidelines for diet-induced models of cardiometabolic syndrome
Sveeggen, Timothy M.
SINDROME CARDIOMETABOLICO
FISIOPATOLOGÍA CARDIOVASCULAR
SINDROME METABOLICO
title_short Guidelines for diet-induced models of cardiometabolic syndrome
title_full Guidelines for diet-induced models of cardiometabolic syndrome
title_fullStr Guidelines for diet-induced models of cardiometabolic syndrome
title_full_unstemmed Guidelines for diet-induced models of cardiometabolic syndrome
title_sort Guidelines for diet-induced models of cardiometabolic syndrome
dc.creator.none.fl_str_mv Sveeggen, Timothy M.
Bagher, Pooneh
Toba, Hiroe
Lindsey, Merry L.
Ritchie, Rebecca H.
Miksztowicz, Verónica J.
González, Germán E.
author Sveeggen, Timothy M.
author_facet Sveeggen, Timothy M.
Bagher, Pooneh
Toba, Hiroe
Lindsey, Merry L.
Ritchie, Rebecca H.
Miksztowicz, Verónica J.
González, Germán E.
author_role author
author2 Bagher, Pooneh
Toba, Hiroe
Lindsey, Merry L.
Ritchie, Rebecca H.
Miksztowicz, Verónica J.
González, Germán E.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv SINDROME CARDIOMETABOLICO
FISIOPATOLOGÍA CARDIOVASCULAR
SINDROME METABOLICO
topic SINDROME CARDIOMETABOLICO
FISIOPATOLOGÍA CARDIOVASCULAR
SINDROME METABOLICO
dc.description.none.fl_txt_mv Fil: Sveeggen, Timothy M. University of Nebraska Medical Center; Estados Unidos
Fil: Bagher, Pooneh. University of Nebraska Medical Center; Estados Unidos
Fil: Toba, Hiroe. Kyoto Pharmaceutical University; Japón
Fil: Lindsey, Merry L. Nashville VA Medical Center; Estados Unidos
Fil: Ritchie, Rebecca H. Monash University; Australia
Fil: Miksztowicz, Verónica J. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina
Fil: González, Germán E. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Patología Cardiovascular Experimental e Hipertensión Arterial; Argentina
Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension, that collectively increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. A lack of reporting standards and variability in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility assessment and translational impact evaluation. We provide standardized guidelines for the consideration, preparation, and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared with genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key components include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. In addition, we outline husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is essential for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.
description Fil: Sveeggen, Timothy M. University of Nebraska Medical Center; Estados Unidos
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/22028
1522-1539
10.1152/ajpheart.00359.2025
url https://repositorio.uca.edu.ar/handle/123456789/22028
identifier_str_mv 1522-1539
10.1152/ajpheart.00359.2025
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv American Journal of Physiology-Heart and Circulatory Physiology, vol. 329, n. 4
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
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score 12.854657

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