Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity

Autores
Guzman, Carla Florencia; Ramirez, Dario; Gomez Mejiba, Sandra Esther
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A chronic positive energy balance, as observed in obesity, leads to an increase in circulating free fatty acids (FFAs), which can activate inflammatory signaling in M1 macrophages. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that controls the expression of several genes involved in the cellular response to redox changes, xenobiotic detoxification, and adipogenesis. The signaling pathway that leads to the migration of Nrf2 to the cell nucleus is well known, but its role in regulating the adipogenesis process remains controversial. Activation of the Nrf2 signaling pathway leads to increased expression of critical enzymes involved in FFA esterification, such as triglycerides, the safest way to store FFAs. This paper reviews recent information on the role of Nrf2 in the differentiation of preadipocytes into adipocytes, which helps explain controversial information. Adipocytes specialize in storing FFAs as triglycerides and act as endocrine cells. However, in obesity, its functions are dysregulated along with the macrophage-induced inflammation of adipose tissue. Adipose tissue inflammation is the main cause of low-grade systemic inflammation observed in obese patients and the main link between adipose tissue inflammation and obesity-associated insulin resistance. Therefore, a deeper understanding of the role of Nrf2 in the process of adipogenesis is essential for the development of new agonists to prevent metabolic abnormalities associated with obesity.
Fil: Guzman, Carla Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia
ADIPOGENESIS
NRF2
INFLAMMATION
METABOLIC RISK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/290287
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with ObesityGuzman, Carla FlorenciaRamirez, DarioGomez Mejiba, Sandra EstherADIPOGENESISNRF2INFLAMMATIONMETABOLIC RISKhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A chronic positive energy balance, as observed in obesity, leads to an increase in circulating free fatty acids (FFAs), which can activate inflammatory signaling in M1 macrophages. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that controls the expression of several genes involved in the cellular response to redox changes, xenobiotic detoxification, and adipogenesis. The signaling pathway that leads to the migration of Nrf2 to the cell nucleus is well known, but its role in regulating the adipogenesis process remains controversial. Activation of the Nrf2 signaling pathway leads to increased expression of critical enzymes involved in FFA esterification, such as triglycerides, the safest way to store FFAs. This paper reviews recent information on the role of Nrf2 in the differentiation of preadipocytes into adipocytes, which helps explain controversial information. Adipocytes specialize in storing FFAs as triglycerides and act as endocrine cells. However, in obesity, its functions are dysregulated along with the macrophage-induced inflammation of adipose tissue. Adipose tissue inflammation is the main cause of low-grade systemic inflammation observed in obese patients and the main link between adipose tissue inflammation and obesity-associated insulin resistance. Therefore, a deeper understanding of the role of Nrf2 in the process of adipogenesis is essential for the development of new agonists to prevent metabolic abnormalities associated with obesity.Fil: Guzman, Carla Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaMDPI2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/290287Guzman, Carla Florencia; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity; MDPI; Preprints; 5-2025; 1-192310-287XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.preprints.org/manuscript/202505.1688/v1info:eu-repo/semantics/altIdentifier/doi/10.20944/preprints202505.1688.v1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:31:01Zoai:ri.conicet.gov.ar:11336/290287instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:31:01.482CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
title Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
spellingShingle Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
Guzman, Carla Florencia
ADIPOGENESIS
NRF2
INFLAMMATION
METABOLIC RISK
title_short Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
title_full Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
title_fullStr Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
title_full_unstemmed Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
title_sort Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
dc.creator.none.fl_str_mv Guzman, Carla Florencia
Ramirez, Dario
Gomez Mejiba, Sandra Esther
author Guzman, Carla Florencia
author_facet Guzman, Carla Florencia
Ramirez, Dario
Gomez Mejiba, Sandra Esther
author_role author
author2 Ramirez, Dario
Gomez Mejiba, Sandra Esther
author2_role author
author
dc.subject.none.fl_str_mv ADIPOGENESIS
NRF2
INFLAMMATION
METABOLIC RISK
topic ADIPOGENESIS
NRF2
INFLAMMATION
METABOLIC RISK
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A chronic positive energy balance, as observed in obesity, leads to an increase in circulating free fatty acids (FFAs), which can activate inflammatory signaling in M1 macrophages. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that controls the expression of several genes involved in the cellular response to redox changes, xenobiotic detoxification, and adipogenesis. The signaling pathway that leads to the migration of Nrf2 to the cell nucleus is well known, but its role in regulating the adipogenesis process remains controversial. Activation of the Nrf2 signaling pathway leads to increased expression of critical enzymes involved in FFA esterification, such as triglycerides, the safest way to store FFAs. This paper reviews recent information on the role of Nrf2 in the differentiation of preadipocytes into adipocytes, which helps explain controversial information. Adipocytes specialize in storing FFAs as triglycerides and act as endocrine cells. However, in obesity, its functions are dysregulated along with the macrophage-induced inflammation of adipose tissue. Adipose tissue inflammation is the main cause of low-grade systemic inflammation observed in obese patients and the main link between adipose tissue inflammation and obesity-associated insulin resistance. Therefore, a deeper understanding of the role of Nrf2 in the process of adipogenesis is essential for the development of new agonists to prevent metabolic abnormalities associated with obesity.
Fil: Guzman, Carla Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Gomez Mejiba, Sandra Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description A chronic positive energy balance, as observed in obesity, leads to an increase in circulating free fatty acids (FFAs), which can activate inflammatory signaling in M1 macrophages. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that controls the expression of several genes involved in the cellular response to redox changes, xenobiotic detoxification, and adipogenesis. The signaling pathway that leads to the migration of Nrf2 to the cell nucleus is well known, but its role in regulating the adipogenesis process remains controversial. Activation of the Nrf2 signaling pathway leads to increased expression of critical enzymes involved in FFA esterification, such as triglycerides, the safest way to store FFAs. This paper reviews recent information on the role of Nrf2 in the differentiation of preadipocytes into adipocytes, which helps explain controversial information. Adipocytes specialize in storing FFAs as triglycerides and act as endocrine cells. However, in obesity, its functions are dysregulated along with the macrophage-induced inflammation of adipose tissue. Adipose tissue inflammation is the main cause of low-grade systemic inflammation observed in obese patients and the main link between adipose tissue inflammation and obesity-associated insulin resistance. Therefore, a deeper understanding of the role of Nrf2 in the process of adipogenesis is essential for the development of new agonists to prevent metabolic abnormalities associated with obesity.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/290287
Guzman, Carla Florencia; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity; MDPI; Preprints; 5-2025; 1-19
2310-287X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/290287
identifier_str_mv Guzman, Carla Florencia; Ramirez, Dario; Gomez Mejiba, Sandra Esther; Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity; MDPI; Preprints; 5-2025; 1-19
2310-287X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.preprints.org/manuscript/202505.1688/v1
info:eu-repo/semantics/altIdentifier/doi/10.20944/preprints202505.1688.v1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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