Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina

Autores
Panei, Carlos Javier; Suzuki, K.; Echeverria, Maria Gabriela; Serena, Maria Soledad; Metz, German Ernesto; Gonzalez, Ester Teresa
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
Fil: Panei, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Suzuki, K.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Serena, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Gonzalez, Ester Teresa. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Materia
HOLANDO-ARGENTINO
MHC
MODELLING
PCR-RFLP
SOUTH AMERICA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79543
Acceder
id CONICETDig_2e6a3bec55f5062b84549f686ee04e17
oai_identifier_str oai:ri.conicet.gov.ar:11336/79543
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in ArgentinaPanei, Carlos JavierSuzuki, K.Echeverria, Maria GabrielaSerena, Maria SoledadMetz, German ErnestoGonzalez, Ester TeresaHOLANDO-ARGENTINOMHCMODELLINGPCR-RFLPSOUTH AMERICAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.Fil: Panei, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Suzuki, K.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaFil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaFil: Serena, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaFil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaFil: Gonzalez, Ester Teresa. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; ArgentinaAcademic Journals2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79543Panei, Carlos Javier; Suzuki, K.; Echeverria, Maria Gabriela; Serena, Maria Soledad; Metz, German Ernesto; et al.; Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina; Academic Journals; International Journal of Dairy Science; 4; 3; 12-2009; 123-1281811-97431811-9751CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3923/ijds.2009.123.128info:eu-repo/semantics/altIdentifier/url/https://scialert.net/abstract/?doi=ijds.2009.123.128info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:57:13Zoai:ri.conicet.gov.ar:11336/79543instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:57:14.066CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
spellingShingle Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
Panei, Carlos Javier
HOLANDO-ARGENTINO
MHC
MODELLING
PCR-RFLP
SOUTH AMERICA
title_short Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_full Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_fullStr Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_full_unstemmed Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_sort Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
dc.creator.none.fl_str_mv Panei, Carlos Javier
Suzuki, K.
Echeverria, Maria Gabriela
Serena, Maria Soledad
Metz, German Ernesto
Gonzalez, Ester Teresa
author Panei, Carlos Javier
author_facet Panei, Carlos Javier
Suzuki, K.
Echeverria, Maria Gabriela
Serena, Maria Soledad
Metz, German Ernesto
Gonzalez, Ester Teresa
author_role author
author2 Suzuki, K.
Echeverria, Maria Gabriela
Serena, Maria Soledad
Metz, German Ernesto
Gonzalez, Ester Teresa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HOLANDO-ARGENTINO
MHC
MODELLING
PCR-RFLP
SOUTH AMERICA
topic HOLANDO-ARGENTINO
MHC
MODELLING
PCR-RFLP
SOUTH AMERICA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
Fil: Panei, Carlos Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Suzuki, K.. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Echeverria, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Serena, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Metz, German Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
Fil: Gonzalez, Ester Teresa. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Microbiología. Cátedra de Virología; Argentina
description The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79543
Panei, Carlos Javier; Suzuki, K.; Echeverria, Maria Gabriela; Serena, Maria Soledad; Metz, German Ernesto; et al.; Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina; Academic Journals; International Journal of Dairy Science; 4; 3; 12-2009; 123-128
1811-9743
1811-9751
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79543
identifier_str_mv Panei, Carlos Javier; Suzuki, K.; Echeverria, Maria Gabriela; Serena, Maria Soledad; Metz, German Ernesto; et al.; Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina; Academic Journals; International Journal of Dairy Science; 4; 3; 12-2009; 123-128
1811-9743
1811-9751
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3923/ijds.2009.123.128
info:eu-repo/semantics/altIdentifier/url/https://scialert.net/abstract/?doi=ijds.2009.123.128
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Journals
publisher.none.fl_str_mv Academic Journals
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.265058

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