Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina

Autores
Panei, Carlos Javier; Suzuki, Kuniaki; Echeverría, María Gabriela; Serena, María Soledad; Metz, Germán Ernesto; González, Ester Teresa
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
Facultad de Ciencias Veterinarias
Instituto de Genética Veterinaria
Materia
Ciencias Veterinarias
Holando-Argentino
MHC
Modelling
PCR-RFLP
South America
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/82781
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/82781
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in ArgentinaPanei, Carlos JavierSuzuki, KuniakiEcheverría, María GabrielaSerena, María SoledadMetz, Germán ErnestoGonzález, Ester TeresaCiencias VeterinariasHolando-ArgentinoMHCModellingPCR-RFLPSouth AmericaThe objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.Facultad de Ciencias VeterinariasInstituto de Genética Veterinaria2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf123-128http://sedici.unlp.edu.ar/handle/10915/82781enginfo:eu-repo/semantics/altIdentifier/issn/1811-9743info:eu-repo/semantics/altIdentifier/doi/10.3923/ijds.2009.123.128info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2026-06-23T10:38:06Zoai:sedici.unlp.edu.ar:10915/82781Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292026-06-23 10:38:07.073SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
spellingShingle Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
Panei, Carlos Javier
Ciencias Veterinarias
Holando-Argentino
MHC
Modelling
PCR-RFLP
South America
title_short Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_full Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_fullStr Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_full_unstemmed Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
title_sort Association of BoLA-DRB3.2 alleles with resistance and susceptibility to persistent lymphocytosis in BLV infected cattle in Argentina
dc.creator.none.fl_str_mv Panei, Carlos Javier
Suzuki, Kuniaki
Echeverría, María Gabriela
Serena, María Soledad
Metz, Germán Ernesto
González, Ester Teresa
author Panei, Carlos Javier
author_facet Panei, Carlos Javier
Suzuki, Kuniaki
Echeverría, María Gabriela
Serena, María Soledad
Metz, Germán Ernesto
González, Ester Teresa
author_role author
author2 Suzuki, Kuniaki
Echeverría, María Gabriela
Serena, María Soledad
Metz, Germán Ernesto
González, Ester Teresa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Holando-Argentino
MHC
Modelling
PCR-RFLP
South America
topic Ciencias Veterinarias
Holando-Argentino
MHC
Modelling
PCR-RFLP
South America
dc.description.none.fl_txt_mv The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
Facultad de Ciencias Veterinarias
Instituto de Genética Veterinaria
description The objective of this preliminary study was to describe alleles of bovine major histocompatibility complex class II BoLA-DRB3.2 gene associated with resistance and susceptibility to Persistent Lymphocytosis (PL) in Bovine leukaemia virus (BLV) infected cattle, to set a direction for the future studies. A total of 81 dairy cattle in Argentina were investigated for the distribution of BoLA-DRB3.2 alleles. The study cattle were categorized into 3 groups as follows: Category PL+ (BLV seropositive with PL); Category PL- (BLV seropositive without PL) and Category BLV- (BLV seronegative). The alleles were identified by polymerase chain reaction with subsequent analysis of restriction fragment length polymorphism. The association between the BoLA-DRB3.2 alleles and the PL+ and PL- categories was determined as the odds ratio. Some alleles BoLA-DRB3.2 mediating (1) resistance and (2) susceptibility to PL were observed, respectively. A stochastic model including Shannon's diversity index calculation was run based on Markov-Chain Monte Carlo simulation method. The Shannon's diversity indices in each of the cattle categories indicated that the richness of gene diversity decreased as leading to a clinical stage of BLV. This relates to the existence of alleles mediating resistance and susceptibility to PL. The stochastic prediction with inclusion of uncertainty is important which can serve as a future study beacon.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/82781
url http://sedici.unlp.edu.ar/handle/10915/82781
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1811-9743
info:eu-repo/semantics/altIdentifier/doi/10.3923/ijds.2009.123.128
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
123-128
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.265058

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