Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma

Autores
Blanco, Nicolás Olegario; Frattini, Natalia María; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Among the reasons of childhood mortality, cancer is the leading cause ofdeath [1,2]. Of all paediatric cancers diagnosed, soft tissue sarcomas account for7%, of which approximately 50% are rhabdomyosarcoma (RMS), with anincidence of 4.71 per million children and adolescents under 20 years of age [3,4].RMS can occur anywhere in the body, originating from mesenchymal cellsdestined to differentiate into skeletal muscle cells [5-7]. Treatment includessurgical resection, chemotherapy and radiotherapy, combined or not, dependingon the location and tumour size, and the presence of metastases, in the lattercase clinical outcomes are unsatisfactory [8]. Currently, the need for newtreatments is emphasized, aimed at minimizing the long-term impact of therapyand improving patient life quality. In this context, the ability to induce celldifferentiation of tumoral cells is particularly valuable, as it can provide analternative approach to combat the uncontrolled growth and malignant behaviorof undifferentiated cancer cells.
Fil: Blanco, Nicolás Olegario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Frattini, Natalia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Pronsato, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Milanesi, Lorena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Vasconsuelo, Andrea Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Materia
INDOLE
C2C12
RHABDOMYOSARCOMA
DIFFERENTIATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/288190
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against RhabdomyosarcomaBlanco, Nicolás OlegarioFrattini, Natalia MaríaPronsato, LucíaMilanesi, Lorena MagdalenaVasconsuelo, Andrea AnahiINDOLEC2C12RHABDOMYOSARCOMADIFFERENTIATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Among the reasons of childhood mortality, cancer is the leading cause ofdeath [1,2]. Of all paediatric cancers diagnosed, soft tissue sarcomas account for7%, of which approximately 50% are rhabdomyosarcoma (RMS), with anincidence of 4.71 per million children and adolescents under 20 years of age [3,4].RMS can occur anywhere in the body, originating from mesenchymal cellsdestined to differentiate into skeletal muscle cells [5-7]. Treatment includessurgical resection, chemotherapy and radiotherapy, combined or not, dependingon the location and tumour size, and the presence of metastases, in the lattercase clinical outcomes are unsatisfactory [8]. Currently, the need for newtreatments is emphasized, aimed at minimizing the long-term impact of therapyand improving patient life quality. In this context, the ability to induce celldifferentiation of tumoral cells is particularly valuable, as it can provide analternative approach to combat the uncontrolled growth and malignant behaviorof undifferentiated cancer cells.Fil: Blanco, Nicolás Olegario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Frattini, Natalia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Pronsato, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Milanesi, Lorena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Vasconsuelo, Andrea Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaScientific Archives2025-03-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/288190Blanco, Nicolás Olegario; Frattini, Natalia María; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi; Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma; Scientific Archives; Archives of Cancer Biology and Therapy; 3; 1; 11-3-2025; 1-42692-8302CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scientificarchives.com/journal/Archives-of-Cancer-Biology-and-Therapy-articlesinfo:eu-repo/semantics/altIdentifier/doi/10.33696/cancerbiology.3.027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T14:30:30Zoai:ri.conicet.gov.ar:11336/288190instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 14:30:30.911CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
title Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
spellingShingle Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
Blanco, Nicolás Olegario
INDOLE
C2C12
RHABDOMYOSARCOMA
DIFFERENTIATION
title_short Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
title_full Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
title_fullStr Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
title_full_unstemmed Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
title_sort Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
dc.creator.none.fl_str_mv Blanco, Nicolás Olegario
Frattini, Natalia María
Pronsato, Lucía
Milanesi, Lorena Magdalena
Vasconsuelo, Andrea Anahi
author Blanco, Nicolás Olegario
author_facet Blanco, Nicolás Olegario
Frattini, Natalia María
Pronsato, Lucía
Milanesi, Lorena Magdalena
Vasconsuelo, Andrea Anahi
author_role author
author2 Frattini, Natalia María
Pronsato, Lucía
Milanesi, Lorena Magdalena
Vasconsuelo, Andrea Anahi
author2_role author
author
author
author
dc.subject.none.fl_str_mv INDOLE
C2C12
RHABDOMYOSARCOMA
DIFFERENTIATION
topic INDOLE
C2C12
RHABDOMYOSARCOMA
DIFFERENTIATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Among the reasons of childhood mortality, cancer is the leading cause ofdeath [1,2]. Of all paediatric cancers diagnosed, soft tissue sarcomas account for7%, of which approximately 50% are rhabdomyosarcoma (RMS), with anincidence of 4.71 per million children and adolescents under 20 years of age [3,4].RMS can occur anywhere in the body, originating from mesenchymal cellsdestined to differentiate into skeletal muscle cells [5-7]. Treatment includessurgical resection, chemotherapy and radiotherapy, combined or not, dependingon the location and tumour size, and the presence of metastases, in the lattercase clinical outcomes are unsatisfactory [8]. Currently, the need for newtreatments is emphasized, aimed at minimizing the long-term impact of therapyand improving patient life quality. In this context, the ability to induce celldifferentiation of tumoral cells is particularly valuable, as it can provide analternative approach to combat the uncontrolled growth and malignant behaviorof undifferentiated cancer cells.
Fil: Blanco, Nicolás Olegario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Frattini, Natalia María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Pronsato, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Milanesi, Lorena Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Vasconsuelo, Andrea Anahi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
description Among the reasons of childhood mortality, cancer is the leading cause ofdeath [1,2]. Of all paediatric cancers diagnosed, soft tissue sarcomas account for7%, of which approximately 50% are rhabdomyosarcoma (RMS), with anincidence of 4.71 per million children and adolescents under 20 years of age [3,4].RMS can occur anywhere in the body, originating from mesenchymal cellsdestined to differentiate into skeletal muscle cells [5-7]. Treatment includessurgical resection, chemotherapy and radiotherapy, combined or not, dependingon the location and tumour size, and the presence of metastases, in the lattercase clinical outcomes are unsatisfactory [8]. Currently, the need for newtreatments is emphasized, aimed at minimizing the long-term impact of therapyand improving patient life quality. In this context, the ability to induce celldifferentiation of tumoral cells is particularly valuable, as it can provide analternative approach to combat the uncontrolled growth and malignant behaviorof undifferentiated cancer cells.
publishDate 2025
dc.date.none.fl_str_mv 2025-03-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/288190
Blanco, Nicolás Olegario; Frattini, Natalia María; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi; Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma; Scientific Archives; Archives of Cancer Biology and Therapy; 3; 1; 11-3-2025; 1-4
2692-8302
CONICET Digital
CONICET
url http://hdl.handle.net/11336/288190
identifier_str_mv Blanco, Nicolás Olegario; Frattini, Natalia María; Pronsato, Lucía; Milanesi, Lorena Magdalena; Vasconsuelo, Andrea Anahi; Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma; Scientific Archives; Archives of Cancer Biology and Therapy; 3; 1; 11-3-2025; 1-4
2692-8302
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.scientificarchives.com/journal/Archives-of-Cancer-Biology-and-Therapy-articles
info:eu-repo/semantics/altIdentifier/doi/10.33696/cancerbiology.3.027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific Archives
publisher.none.fl_str_mv Scientific Archives
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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