Calcitriol implications on human rhabdomyosarcoma: An unexplored field

Autores
Buitrago, Claudia Graciela; Irazoqui, Ana Paula
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work is an extension of our published article in 2022 (https://doi.org/10.1016/j.jsbmb.2022.106146), where we further discuss any recentupdates in this research and analyse the issues addressed in the focal article.Calcitriol, the active form of vitamin D3, is also acknowledged as 1α, 25-dihydroxy vitamin D3. This steroid hormone is known for its role incalcium homeostasis and bone metabolism. Recent studies suggest that calcitriol also exerts anti-cancer effects in various malignancies. Wepreviously reported (in 2022) that treatment with this steroid hormone triggers apoptosis in RD cells, a known rhabdomyosarcoma (RMS)cell line. RMS is a common soft tissue sarcoma that develops malignant tumor derived from skeletal muscle cells, predominantly affectingchildren. However, high risk RMS treatment has not been improved over the last three decades, indicating that it is important to elucidatethe molecular mechanisms underlying this disease. There is no updated information about the influence of calcitriol in RMS that couldcomplement and extend our previously published article. However, we recognize the potential of this steroid hormone as a future therapeuticagent in managing this challenging cancer.
Fil: Buitrago, Claudia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Irazoqui, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Materia
RHABDOMYOSARCOMA
VITAMIN D3
UNEXPLORED FIELD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/262167
Acceder
id CONICETDig_b027fb704e7ae1c7e0acff3ec2388f03
oai_identifier_str oai:ri.conicet.gov.ar:11336/262167
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Calcitriol implications on human rhabdomyosarcoma: An unexplored fieldBuitrago, Claudia GracielaIrazoqui, Ana PaulaRHABDOMYOSARCOMAVITAMIN D3UNEXPLORED FIELDhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This work is an extension of our published article in 2022 (https://doi.org/10.1016/j.jsbmb.2022.106146), where we further discuss any recentupdates in this research and analyse the issues addressed in the focal article.Calcitriol, the active form of vitamin D3, is also acknowledged as 1α, 25-dihydroxy vitamin D3. This steroid hormone is known for its role incalcium homeostasis and bone metabolism. Recent studies suggest that calcitriol also exerts anti-cancer effects in various malignancies. Wepreviously reported (in 2022) that treatment with this steroid hormone triggers apoptosis in RD cells, a known rhabdomyosarcoma (RMS)cell line. RMS is a common soft tissue sarcoma that develops malignant tumor derived from skeletal muscle cells, predominantly affectingchildren. However, high risk RMS treatment has not been improved over the last three decades, indicating that it is important to elucidatethe molecular mechanisms underlying this disease. There is no updated information about the influence of calcitriol in RMS that couldcomplement and extend our previously published article. However, we recognize the potential of this steroid hormone as a future therapeuticagent in managing this challenging cancer.Fil: Buitrago, Claudia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; ArgentinaFil: Irazoqui, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaScientific Archives2025-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/262167Buitrago, Claudia Graciela; Irazoqui, Ana Paula; Calcitriol implications on human rhabdomyosarcoma: An unexplored field; Scientific Archives; Journal of Cellular Signaling; 6; 1; 2-2025; 9-122692-0638CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scientificarchives.com/article/calcitriol-implications-on-human-rhabdomyosarcoma-an-unexplored-fieldinfo:eu-repo/semantics/altIdentifier/doi/10.33696/Signaling.6.128info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-08-25T15:53:12Zoai:ri.conicet.gov.ar:11336/262167instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-08-25 15:53:12.789CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Calcitriol implications on human rhabdomyosarcoma: An unexplored field
title Calcitriol implications on human rhabdomyosarcoma: An unexplored field
spellingShingle Calcitriol implications on human rhabdomyosarcoma: An unexplored field
Buitrago, Claudia Graciela
RHABDOMYOSARCOMA
VITAMIN D3
UNEXPLORED FIELD
title_short Calcitriol implications on human rhabdomyosarcoma: An unexplored field
title_full Calcitriol implications on human rhabdomyosarcoma: An unexplored field
title_fullStr Calcitriol implications on human rhabdomyosarcoma: An unexplored field
title_full_unstemmed Calcitriol implications on human rhabdomyosarcoma: An unexplored field
title_sort Calcitriol implications on human rhabdomyosarcoma: An unexplored field
dc.creator.none.fl_str_mv Buitrago, Claudia Graciela
Irazoqui, Ana Paula
author Buitrago, Claudia Graciela
author_facet Buitrago, Claudia Graciela
Irazoqui, Ana Paula
author_role author
author2 Irazoqui, Ana Paula
author2_role author
dc.subject.none.fl_str_mv RHABDOMYOSARCOMA
VITAMIN D3
UNEXPLORED FIELD
topic RHABDOMYOSARCOMA
VITAMIN D3
UNEXPLORED FIELD
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This work is an extension of our published article in 2022 (https://doi.org/10.1016/j.jsbmb.2022.106146), where we further discuss any recentupdates in this research and analyse the issues addressed in the focal article.Calcitriol, the active form of vitamin D3, is also acknowledged as 1α, 25-dihydroxy vitamin D3. This steroid hormone is known for its role incalcium homeostasis and bone metabolism. Recent studies suggest that calcitriol also exerts anti-cancer effects in various malignancies. Wepreviously reported (in 2022) that treatment with this steroid hormone triggers apoptosis in RD cells, a known rhabdomyosarcoma (RMS)cell line. RMS is a common soft tissue sarcoma that develops malignant tumor derived from skeletal muscle cells, predominantly affectingchildren. However, high risk RMS treatment has not been improved over the last three decades, indicating that it is important to elucidatethe molecular mechanisms underlying this disease. There is no updated information about the influence of calcitriol in RMS that couldcomplement and extend our previously published article. However, we recognize the potential of this steroid hormone as a future therapeuticagent in managing this challenging cancer.
Fil: Buitrago, Claudia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
Fil: Irazoqui, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
description This work is an extension of our published article in 2022 (https://doi.org/10.1016/j.jsbmb.2022.106146), where we further discuss any recentupdates in this research and analyse the issues addressed in the focal article.Calcitriol, the active form of vitamin D3, is also acknowledged as 1α, 25-dihydroxy vitamin D3. This steroid hormone is known for its role incalcium homeostasis and bone metabolism. Recent studies suggest that calcitriol also exerts anti-cancer effects in various malignancies. Wepreviously reported (in 2022) that treatment with this steroid hormone triggers apoptosis in RD cells, a known rhabdomyosarcoma (RMS)cell line. RMS is a common soft tissue sarcoma that develops malignant tumor derived from skeletal muscle cells, predominantly affectingchildren. However, high risk RMS treatment has not been improved over the last three decades, indicating that it is important to elucidatethe molecular mechanisms underlying this disease. There is no updated information about the influence of calcitriol in RMS that couldcomplement and extend our previously published article. However, we recognize the potential of this steroid hormone as a future therapeuticagent in managing this challenging cancer.
publishDate 2025
dc.date.none.fl_str_mv 2025-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/262167
Buitrago, Claudia Graciela; Irazoqui, Ana Paula; Calcitriol implications on human rhabdomyosarcoma: An unexplored field; Scientific Archives; Journal of Cellular Signaling; 6; 1; 2-2025; 9-12
2692-0638
CONICET Digital
CONICET
url http://hdl.handle.net/11336/262167
identifier_str_mv Buitrago, Claudia Graciela; Irazoqui, Ana Paula; Calcitriol implications on human rhabdomyosarcoma: An unexplored field; Scientific Archives; Journal of Cellular Signaling; 6; 1; 2-2025; 9-12
2692-0638
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.scientificarchives.com/article/calcitriol-implications-on-human-rhabdomyosarcoma-an-unexplored-field
info:eu-repo/semantics/altIdentifier/doi/10.33696/Signaling.6.128
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific Archives
publisher.none.fl_str_mv Scientific Archives
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1874775925355184128
score 13.265058

Publicaciones similares