Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues

Autores
Rosales Hurtado, Juan José; Nieto Farías, María Victoria; Burucúa, Mercedes María; Marin, Maia Solange; Perez, Sandra
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to analyze whether an antiviral IFN-λ3 response is mounted after infection with bovine alphaherpesviruses (BoHV-1 and BoHV-5) in vitro, in neuronal-type cells, and in neural tissues from experimentally-infected calves. This study demonstrated that there is a strong IFN-λ3 response early after BoHV-1infection of undifferentiated neuroblastoma cells. During acute BoHV-1 and BoHV-5 infection of calves, low levels of IFN-λ3 expression were detected in the brain, which would favor virus spread within this tissue. Striking differences in the transcriptional levels of IFN-λ3 were observed in trigeminal gan glion, particularly in BoHV-1-acutely- and latently-infected calves. During reactivation, IFN-λ3 expression was down-regulated, which may be a requirement for virus replication and spread. Overall, different patterns of IFN- λ3 expression were detected during BoHV-1 and BoHV-5 infection, particularly during latency.
EEA Balcarce
Fil: Rosales Hurtado, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Rosales Hurtado, Juan José. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Nieto Farías, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Nieto Farías, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Burucúa, Mercedes María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); Argentina
Fil: Burucúa, Mercedes María. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); Argentina
Fil: Marin, Maia Solange. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); Argentina
Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Perez, Sandra. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fuente
Veterinary Immunology and Immunopathology 245 : 110391 (march 2022)
Materia
Enfermedad de los Animales
Herpes Virus Bovino
Respuesta Inmunológica
Animal Diseases
Bovine Herpesvirus
Immune Response
Alfaherpesvirus bovino
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/26943
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oai_identifier_str oai:localhost:20.500.12123/26943
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissuesRosales Hurtado, Juan JoséNieto Farías, María VictoriaBurucúa, Mercedes MaríaMarin, Maia SolangePerez, SandraEnfermedad de los AnimalesHerpes Virus BovinoRespuesta InmunológicaAnimal DiseasesBovine HerpesvirusImmune ResponseAlfaherpesvirus bovinoType III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to analyze whether an antiviral IFN-λ3 response is mounted after infection with bovine alphaherpesviruses (BoHV-1 and BoHV-5) in vitro, in neuronal-type cells, and in neural tissues from experimentally-infected calves. This study demonstrated that there is a strong IFN-λ3 response early after BoHV-1infection of undifferentiated neuroblastoma cells. During acute BoHV-1 and BoHV-5 infection of calves, low levels of IFN-λ3 expression were detected in the brain, which would favor virus spread within this tissue. Striking differences in the transcriptional levels of IFN-λ3 were observed in trigeminal gan glion, particularly in BoHV-1-acutely- and latently-infected calves. During reactivation, IFN-λ3 expression was down-regulated, which may be a requirement for virus replication and spread. Overall, different patterns of IFN- λ3 expression were detected during BoHV-1 and BoHV-5 infection, particularly during latency.EEA BalcarceFil: Rosales Hurtado, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Rosales Hurtado, Juan José. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Nieto Farías, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Nieto Farías, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Burucúa, Mercedes María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); ArgentinaFil: Burucúa, Mercedes María. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); ArgentinaFil: Marin, Maia Solange. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); ArgentinaFil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; ArgentinaFil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaFil: Perez, Sandra. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); ArgentinaElsevier2026-07-06T20:35:05Z2026-07-06T20:35:05Z2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/26943https://www.sciencedirect.com/science/article/abs/pii/S01652427220001130165-2427https://doi.org/10.1016/j.vetimm.2022.110391Veterinary Immunology and Immunopathology 245 : 110391 (march 2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2026-09-24T11:43:27Zoai:localhost:20.500.12123/26943instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2026-09-24 11:43:28.031INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
title Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
spellingShingle Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
Rosales Hurtado, Juan José
Enfermedad de los Animales
Herpes Virus Bovino
Respuesta Inmunológica
Animal Diseases
Bovine Herpesvirus
Immune Response
Alfaherpesvirus bovino
title_short Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
title_full Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
title_fullStr Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
title_full_unstemmed Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
title_sort Infection by bovine alphaherpesvirus types 1 and 5 induces IFN-λ3 expression in neuronal-type cells and bovine neural tissues
dc.creator.none.fl_str_mv Rosales Hurtado, Juan José
Nieto Farías, María Victoria
Burucúa, Mercedes María
Marin, Maia Solange
Perez, Sandra
author Rosales Hurtado, Juan José
author_facet Rosales Hurtado, Juan José
Nieto Farías, María Victoria
Burucúa, Mercedes María
Marin, Maia Solange
Perez, Sandra
author_role author
author2 Nieto Farías, María Victoria
Burucúa, Mercedes María
Marin, Maia Solange
Perez, Sandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv Enfermedad de los Animales
Herpes Virus Bovino
Respuesta Inmunológica
Animal Diseases
Bovine Herpesvirus
Immune Response
Alfaherpesvirus bovino
topic Enfermedad de los Animales
Herpes Virus Bovino
Respuesta Inmunológica
Animal Diseases
Bovine Herpesvirus
Immune Response
Alfaherpesvirus bovino
dc.description.none.fl_txt_mv Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to analyze whether an antiviral IFN-λ3 response is mounted after infection with bovine alphaherpesviruses (BoHV-1 and BoHV-5) in vitro, in neuronal-type cells, and in neural tissues from experimentally-infected calves. This study demonstrated that there is a strong IFN-λ3 response early after BoHV-1infection of undifferentiated neuroblastoma cells. During acute BoHV-1 and BoHV-5 infection of calves, low levels of IFN-λ3 expression were detected in the brain, which would favor virus spread within this tissue. Striking differences in the transcriptional levels of IFN-λ3 were observed in trigeminal gan glion, particularly in BoHV-1-acutely- and latently-infected calves. During reactivation, IFN-λ3 expression was down-regulated, which may be a requirement for virus replication and spread. Overall, different patterns of IFN- λ3 expression were detected during BoHV-1 and BoHV-5 infection, particularly during latency.
EEA Balcarce
Fil: Rosales Hurtado, Juan José. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Rosales Hurtado, Juan José. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Nieto Farías, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Nieto Farías, María Victoria. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Burucúa, Mercedes María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); Argentina
Fil: Burucúa, Mercedes María. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); Argentina
Fil: Marin, Maia Solange. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible (IPADS); Argentina
Fil: Marin, Maia Solange. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Instituto de Innovación para la Producción Agropecuaria y el Desarrollo Sostenible; Argentina
Fil: Perez, Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
Fil: Perez, Sandra. Universidad Nacional del Centro de la Provincia de Buenos Aires (UNICEN). Centro de Investigación Veterinaria de Tandil (CIVETAN); Argentina
description Type III interferons (IFNs) are components of the innate immunity, with IFN lambda- (λ)3 having the most potent bioactivity in humans. IFN-λ has a predominant role in epithelial cells. However, antiviral function in certain infections of the central nervous system has also been demonstrated. IFN-λ3 expression in neural tissues of cattle has not been investigated. Thus, the aim of this study was to analyze whether an antiviral IFN-λ3 response is mounted after infection with bovine alphaherpesviruses (BoHV-1 and BoHV-5) in vitro, in neuronal-type cells, and in neural tissues from experimentally-infected calves. This study demonstrated that there is a strong IFN-λ3 response early after BoHV-1infection of undifferentiated neuroblastoma cells. During acute BoHV-1 and BoHV-5 infection of calves, low levels of IFN-λ3 expression were detected in the brain, which would favor virus spread within this tissue. Striking differences in the transcriptional levels of IFN-λ3 were observed in trigeminal gan glion, particularly in BoHV-1-acutely- and latently-infected calves. During reactivation, IFN-λ3 expression was down-regulated, which may be a requirement for virus replication and spread. Overall, different patterns of IFN- λ3 expression were detected during BoHV-1 and BoHV-5 infection, particularly during latency.
publishDate 2022
dc.date.none.fl_str_mv 2022-03
2026-07-06T20:35:05Z
2026-07-06T20:35:05Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/26943
https://www.sciencedirect.com/science/article/abs/pii/S0165242722000113
0165-2427
https://doi.org/10.1016/j.vetimm.2022.110391
url http://hdl.handle.net/20.500.12123/26943
https://www.sciencedirect.com/science/article/abs/pii/S0165242722000113
https://doi.org/10.1016/j.vetimm.2022.110391
identifier_str_mv 0165-2427
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Veterinary Immunology and Immunopathology 245 : 110391 (march 2022)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.754232

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