Comprehensive model of electromigrative transport in microfluidic paper based analytical devices

Autores
Schaumburg, Federico; Kler, Pablo A.; Berli, Claudio L. A.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
A complete mathematical model for electromigration in paper-based analytical devices is derived, based on differential equations describing the motion of fluids by pressure sources and EOF, the transport of charged chemical species and the electric potential distribution. The porous medium created by the cellulose fibers is considered like a network of tortuous capillaries and represented by macroscopic parameters following an effective medium approach. The equations are obtained starting from their open-channel counterparts, applying scaling laws and, where necessary, including additional terms. With this approach, effective parameters are derived, describing diffusion, mobility and conductivity for porous media. While the foundations of these phenomena can be found in previous reports, here, all the contributions are analyzed systematically and provided in a comprehensive way. Moreover, a novel electrophoretically driven dispersive transport mechanism in porous materials is proposed. Results of the numerical implementation of the mathematical model are compared with experimental data, showing good agreement and supporting the validity of the proposed model. Finally, the model succeeds in simulating a challenging case of free-flow electrophoresis in paper, involving capillary flow and electrophoretic transport developed in a 2D geometry.
Fil: Schaumburg, Federico. CONICET-UNL. Instituto de Desarrollo Tecnológico para la Industria Química (INTEC); Argentina.
Fil: Berli, Claudio L. A. CONICET-UNL. Instituto de Desarrollo Tecnológico para la Industria Química (INTEC); Argentina.
Fil: Kler, Pablo A. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Departamento de Ingeniería en Sistemas de Información; Argentina.
Fil: Kler, Pablo A. CONICET-UNL. Centro de Investigación en Métodos Computacionales (CIMEC); Argentina.
Peer Reviewed
Fuente
Electrophoresis, 41: 598-606 (2020)
Materia
Electroosmotic flow
Electrophoresis
Mathematical modelling
Paper based microfluidics
Transport phenomena
Nivel de accesibilidad
acceso abierto
Condiciones de uso
2024-03-27T21:31:16Z
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/10240
Acceder
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network_acronym_str RIAUTN
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network_name_str Repositorio Institucional Abierto (UTN)
spelling Comprehensive model of electromigrative transport in microfluidic paper based analytical devicesSchaumburg, FedericoKler, Pablo A.Berli, Claudio L. A.Electroosmotic flowElectrophoresisMathematical modellingPaper based microfluidicsTransport phenomenaA complete mathematical model for electromigration in paper-based analytical devices is derived, based on differential equations describing the motion of fluids by pressure sources and EOF, the transport of charged chemical species and the electric potential distribution. The porous medium created by the cellulose fibers is considered like a network of tortuous capillaries and represented by macroscopic parameters following an effective medium approach. The equations are obtained starting from their open-channel counterparts, applying scaling laws and, where necessary, including additional terms. With this approach, effective parameters are derived, describing diffusion, mobility and conductivity for porous media. While the foundations of these phenomena can be found in previous reports, here, all the contributions are analyzed systematically and provided in a comprehensive way. Moreover, a novel electrophoretically driven dispersive transport mechanism in porous materials is proposed. Results of the numerical implementation of the mathematical model are compared with experimental data, showing good agreement and supporting the validity of the proposed model. Finally, the model succeeds in simulating a challenging case of free-flow electrophoresis in paper, involving capillary flow and electrophoretic transport developed in a 2D geometry.Fil: Schaumburg, Federico. CONICET-UNL. Instituto de Desarrollo Tecnológico para la Industria Química (INTEC); Argentina.Fil: Berli, Claudio L. A. CONICET-UNL. Instituto de Desarrollo Tecnológico para la Industria Química (INTEC); Argentina.Fil: Kler, Pablo A. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Departamento de Ingeniería en Sistemas de Información; Argentina.Fil: Kler, Pablo A. CONICET-UNL. Centro de Investigación en Métodos Computacionales (CIMEC); Argentina.Peer Reviewed2024-03-27T21:31:16Z2024-03-27T21:31:16Z2020-01-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfSchaumburg, F., Kler, P.A. and Berli, C.L.A. (2020), Comprehensive model of electromigrative transport in microfluidic paper based analytical devices. ELECTROPHORESIS, 41: 598-606http://hdl.handle.net/20.500.12272/1024010.1002/elps.201900353Electrophoresis, 41: 598-606 (2020)reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica NacionalengASUTIFE0005525TC - Prototipos numéricos de alto desempeño computacional para flujo y transporte multifásico en aplicaciones ingenierilesinfo:eu-repo/semantics/openAccess2024-03-27T21:31:16Zhttp://creativecommons.org/licenses/by/4.0/Atribución 4.0 InternacionalLos autoresCreativeCommons2026-09-24T12:46:18Zoai:ria.utn.edu.ar:20.500.12272/10240instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:46:19.995Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
title Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
spellingShingle Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
Schaumburg, Federico
Electroosmotic flow
Electrophoresis
Mathematical modelling
Paper based microfluidics
Transport phenomena
title_short Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
title_full Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
title_fullStr Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
title_full_unstemmed Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
title_sort Comprehensive model of electromigrative transport in microfluidic paper based analytical devices
dc.creator.none.fl_str_mv Schaumburg, Federico
Kler, Pablo A.
Berli, Claudio L. A.
author Schaumburg, Federico
author_facet Schaumburg, Federico
Kler, Pablo A.
Berli, Claudio L. A.
author_role author
author2 Kler, Pablo A.
Berli, Claudio L. A.
author2_role author
author
dc.subject.none.fl_str_mv Electroosmotic flow
Electrophoresis
Mathematical modelling
Paper based microfluidics
Transport phenomena
topic Electroosmotic flow
Electrophoresis
Mathematical modelling
Paper based microfluidics
Transport phenomena
dc.description.none.fl_txt_mv A complete mathematical model for electromigration in paper-based analytical devices is derived, based on differential equations describing the motion of fluids by pressure sources and EOF, the transport of charged chemical species and the electric potential distribution. The porous medium created by the cellulose fibers is considered like a network of tortuous capillaries and represented by macroscopic parameters following an effective medium approach. The equations are obtained starting from their open-channel counterparts, applying scaling laws and, where necessary, including additional terms. With this approach, effective parameters are derived, describing diffusion, mobility and conductivity for porous media. While the foundations of these phenomena can be found in previous reports, here, all the contributions are analyzed systematically and provided in a comprehensive way. Moreover, a novel electrophoretically driven dispersive transport mechanism in porous materials is proposed. Results of the numerical implementation of the mathematical model are compared with experimental data, showing good agreement and supporting the validity of the proposed model. Finally, the model succeeds in simulating a challenging case of free-flow electrophoresis in paper, involving capillary flow and electrophoretic transport developed in a 2D geometry.
Fil: Schaumburg, Federico. CONICET-UNL. Instituto de Desarrollo Tecnológico para la Industria Química (INTEC); Argentina.
Fil: Berli, Claudio L. A. CONICET-UNL. Instituto de Desarrollo Tecnológico para la Industria Química (INTEC); Argentina.
Fil: Kler, Pablo A. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Departamento de Ingeniería en Sistemas de Información; Argentina.
Fil: Kler, Pablo A. CONICET-UNL. Centro de Investigación en Métodos Computacionales (CIMEC); Argentina.
Peer Reviewed
description A complete mathematical model for electromigration in paper-based analytical devices is derived, based on differential equations describing the motion of fluids by pressure sources and EOF, the transport of charged chemical species and the electric potential distribution. The porous medium created by the cellulose fibers is considered like a network of tortuous capillaries and represented by macroscopic parameters following an effective medium approach. The equations are obtained starting from their open-channel counterparts, applying scaling laws and, where necessary, including additional terms. With this approach, effective parameters are derived, describing diffusion, mobility and conductivity for porous media. While the foundations of these phenomena can be found in previous reports, here, all the contributions are analyzed systematically and provided in a comprehensive way. Moreover, a novel electrophoretically driven dispersive transport mechanism in porous materials is proposed. Results of the numerical implementation of the mathematical model are compared with experimental data, showing good agreement and supporting the validity of the proposed model. Finally, the model succeeds in simulating a challenging case of free-flow electrophoresis in paper, involving capillary flow and electrophoretic transport developed in a 2D geometry.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-06
2024-03-27T21:31:16Z
2024-03-27T21:31:16Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv Schaumburg, F., Kler, P.A. and Berli, C.L.A. (2020), Comprehensive model of electromigrative transport in microfluidic paper based analytical devices. ELECTROPHORESIS, 41: 598-606
http://hdl.handle.net/20.500.12272/10240
10.1002/elps.201900353
identifier_str_mv Schaumburg, F., Kler, P.A. and Berli, C.L.A. (2020), Comprehensive model of electromigrative transport in microfluidic paper based analytical devices. ELECTROPHORESIS, 41: 598-606
10.1002/elps.201900353
url http://hdl.handle.net/20.500.12272/10240
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv ASUTIFE0005525TC - Prototipos numéricos de alto desempeño computacional para flujo y transporte multifásico en aplicaciones ingenieriles
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
2024-03-27T21:31:16Z
http://creativecommons.org/licenses/by/4.0/
Atribución 4.0 Internacional
Los autores
CreativeCommons
eu_rights_str_mv openAccess
rights_invalid_str_mv 2024-03-27T21:31:16Z
http://creativecommons.org/licenses/by/4.0/
Atribución 4.0 Internacional
Los autores
CreativeCommons
dc.format.none.fl_str_mv pdf
application/pdf
dc.source.none.fl_str_mv Electrophoresis, 41: 598-606 (2020)
reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
_version_ 1877230919544209408
score 13.24418

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