Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)

Autores
Juárez, Juliana María; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanotransporters have received a great deal of research attention because of their promising opportunities in drug delivery [1-5]. Attempting to minimize the secondary adverse events of anticancer drugs and enhance the therapeutic rate, various nanotransporters have been devised, including dendrimers [6, 7], liposomes [8, 9], inorganic nanoparticles, and polymeric nanoparticles [10-13]. Chlorambucil (CLB), is a substance classified as a human carcinogen [14], it is used as a chemotherapy drug administered for treating some types of cancer. It is mainly used to treat chronic lymphocytic leukemia, low-grade nonHodgkin's lymphoma, Hodgkin's lymphoma and ovarian cancer. Chemically, it is 4-[4-bis(2-chloroethyl) amino phenyl butyric acid. MCFs (mesostructured siliceous cellular foams), that can be derived after the inclusion of a bulking medium in the synthesis procedure of SBA-15 [4], are composed of spherically uniform cells 15-50 nm diameter [15], exhibit high surface areas and porosities, and have adjustable pore size distributions [15, 16]. The open large pore system gives MCF unique advantages as catalyst support and separation media for processes involving large molecules. In addition to their specific physicochemical properties, they possess high biocompatibility and low adverse effects, which with their biodegradability, making them attractive for controlled drug release applications.
Fil: Juárez, Juliana María.Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.
Peer Reviewed
Materia
Drug release system
Chlorambucil
Nivel de accesibilidad
acceso abierto
Condiciones de uso
2024-04-11T18:14:00Z
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/10460
Acceder
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network_name_str Repositorio Institucional Abierto (UTN)
spelling Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)Juárez, Juliana MaríaAnunziata, Oscar AlfredoGómez Costa, Marcos BrunoDrug release systemChlorambucilNanotransporters have received a great deal of research attention because of their promising opportunities in drug delivery [1-5]. Attempting to minimize the secondary adverse events of anticancer drugs and enhance the therapeutic rate, various nanotransporters have been devised, including dendrimers [6, 7], liposomes [8, 9], inorganic nanoparticles, and polymeric nanoparticles [10-13]. Chlorambucil (CLB), is a substance classified as a human carcinogen [14], it is used as a chemotherapy drug administered for treating some types of cancer. It is mainly used to treat chronic lymphocytic leukemia, low-grade nonHodgkin's lymphoma, Hodgkin's lymphoma and ovarian cancer. Chemically, it is 4-[4-bis(2-chloroethyl) amino phenyl butyric acid. MCFs (mesostructured siliceous cellular foams), that can be derived after the inclusion of a bulking medium in the synthesis procedure of SBA-15 [4], are composed of spherically uniform cells 15-50 nm diameter [15], exhibit high surface areas and porosities, and have adjustable pore size distributions [15, 16]. The open large pore system gives MCF unique advantages as catalyst support and separation media for processes involving large molecules. In addition to their specific physicochemical properties, they possess high biocompatibility and low adverse effects, which with their biodegradability, making them attractive for controlled drug release applications.Fil: Juárez, Juliana María.Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.Peer Reviewed2024-04-11T18:14:00Z2024-04-11T18:14:00Z2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdf20Th International Zeolite Conference;2022.http://hdl.handle.net/20.500.12272/10460-enginfo:eu-repo/semantics/openAccess2024-04-11T18:14:00Zhttp://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 InternacionalJuárez, Juliana María; Anunziata, Oscar Alfredo; Gómez Costa, Marcos BrunoNo comercial. Sólo de uso académico.reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:43:59Zoai:ria.utn.edu.ar:20.500.12272/10460instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:43:59.466Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
title Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
spellingShingle Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
Juárez, Juliana María
Drug release system
Chlorambucil
title_short Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
title_full Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
title_fullStr Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
title_full_unstemmed Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
title_sort Drug release system: Chlorambucil loaded in mesoporous cellular foam (MCF)
dc.creator.none.fl_str_mv Juárez, Juliana María
Anunziata, Oscar Alfredo
Gómez Costa, Marcos Bruno
author Juárez, Juliana María
author_facet Juárez, Juliana María
Anunziata, Oscar Alfredo
Gómez Costa, Marcos Bruno
author_role author
author2 Anunziata, Oscar Alfredo
Gómez Costa, Marcos Bruno
author2_role author
author
dc.subject.none.fl_str_mv Drug release system
Chlorambucil
topic Drug release system
Chlorambucil
dc.description.none.fl_txt_mv Nanotransporters have received a great deal of research attention because of their promising opportunities in drug delivery [1-5]. Attempting to minimize the secondary adverse events of anticancer drugs and enhance the therapeutic rate, various nanotransporters have been devised, including dendrimers [6, 7], liposomes [8, 9], inorganic nanoparticles, and polymeric nanoparticles [10-13]. Chlorambucil (CLB), is a substance classified as a human carcinogen [14], it is used as a chemotherapy drug administered for treating some types of cancer. It is mainly used to treat chronic lymphocytic leukemia, low-grade nonHodgkin's lymphoma, Hodgkin's lymphoma and ovarian cancer. Chemically, it is 4-[4-bis(2-chloroethyl) amino phenyl butyric acid. MCFs (mesostructured siliceous cellular foams), that can be derived after the inclusion of a bulking medium in the synthesis procedure of SBA-15 [4], are composed of spherically uniform cells 15-50 nm diameter [15], exhibit high surface areas and porosities, and have adjustable pore size distributions [15, 16]. The open large pore system gives MCF unique advantages as catalyst support and separation media for processes involving large molecules. In addition to their specific physicochemical properties, they possess high biocompatibility and low adverse effects, which with their biodegradability, making them attractive for controlled drug release applications.
Fil: Juárez, Juliana María.Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología (NANOTEC); Argentina.
Peer Reviewed
description Nanotransporters have received a great deal of research attention because of their promising opportunities in drug delivery [1-5]. Attempting to minimize the secondary adverse events of anticancer drugs and enhance the therapeutic rate, various nanotransporters have been devised, including dendrimers [6, 7], liposomes [8, 9], inorganic nanoparticles, and polymeric nanoparticles [10-13]. Chlorambucil (CLB), is a substance classified as a human carcinogen [14], it is used as a chemotherapy drug administered for treating some types of cancer. It is mainly used to treat chronic lymphocytic leukemia, low-grade nonHodgkin's lymphoma, Hodgkin's lymphoma and ovarian cancer. Chemically, it is 4-[4-bis(2-chloroethyl) amino phenyl butyric acid. MCFs (mesostructured siliceous cellular foams), that can be derived after the inclusion of a bulking medium in the synthesis procedure of SBA-15 [4], are composed of spherically uniform cells 15-50 nm diameter [15], exhibit high surface areas and porosities, and have adjustable pore size distributions [15, 16]. The open large pore system gives MCF unique advantages as catalyst support and separation media for processes involving large molecules. In addition to their specific physicochemical properties, they possess high biocompatibility and low adverse effects, which with their biodegradability, making them attractive for controlled drug release applications.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024-04-11T18:14:00Z
2024-04-11T18:14:00Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 20Th International Zeolite Conference;2022.
http://hdl.handle.net/20.500.12272/10460
-
identifier_str_mv 20Th International Zeolite Conference;2022.
-
url http://hdl.handle.net/20.500.12272/10460
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
2024-04-11T18:14:00Z
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Juárez, Juliana María; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
No comercial. Sólo de uso académico.
eu_rights_str_mv openAccess
rights_invalid_str_mv 2024-04-11T18:14:00Z
http://creativecommons.org/licenses/by-nc-nd/4.0/
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Juárez, Juliana María; Anunziata, Oscar Alfredo; Gómez Costa, Marcos Bruno
No comercial. Sólo de uso académico.
dc.format.none.fl_str_mv pdf
application/pdf
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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