Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system

Autores
Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanoscale controlled drug delivery systems allowed for essential progress in pharmaceuticals, represent the change in medicine in the 21st century. Usually, controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and under the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured cellular foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, biodegradability and low toxicity. In this work, Ketorolac-Tromethamine/MCF material was synthesized. The material synthesis and loading of ketorolac-tromethamine (KETO) into MCF pores were successful. We obtain auspicious results for drugs controlled release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times, thereby maintaining the drug concentration within the range of therapeutic efficacy, which makes it highly applicable for the treatment of diseases that need a rapid response.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
Materia
MCF
Ketorolac-Tromethamine
Drug release system
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/14648
Acceder
id RIAUTN_589607035a08c9234f69f6afc6362819
oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/14648
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release systemCussa, JorgelinaJuárez, Juliana MaríaGómez Costa, Marcos BrunoAnunziata, Oscar AlfredoMCFKetorolac-TromethamineDrug release systemNanoscale controlled drug delivery systems allowed for essential progress in pharmaceuticals, represent the change in medicine in the 21st century. Usually, controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and under the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured cellular foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, biodegradability and low toxicity. In this work, Ketorolac-Tromethamine/MCF material was synthesized. The material synthesis and loading of ketorolac-tromethamine (KETO) into MCF pores were successful. We obtain auspicious results for drugs controlled release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times, thereby maintaining the drug concentration within the range of therapeutic efficacy, which makes it highly applicable for the treatment of diseases that need a rapid response.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.Peer ReviewedSBCat2026-03-05T14:15:15Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdf19º Congresso Brasileiro de Catálise e IX Congresso Mercosul de Catálisehttps://hdl.handle.net/20.500.12272/14648enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Oscar Alfredo Anunziata2017reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:44:30Zoai:ria.utn.edu.ar:20.500.12272/14648instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:44:30.44Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
title Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
spellingShingle Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
Cussa, Jorgelina
MCF
Ketorolac-Tromethamine
Drug release system
title_short Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
title_full Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
title_fullStr Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
title_full_unstemmed Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
title_sort Use of mesostructured cellular foams (MCF) as host in ketorolac tromethamine release system
dc.creator.none.fl_str_mv Cussa, Jorgelina
Juárez, Juliana María
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfredo
author Cussa, Jorgelina
author_facet Cussa, Jorgelina
Juárez, Juliana María
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfredo
author_role author
author2 Juárez, Juliana María
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv MCF
Ketorolac-Tromethamine
Drug release system
topic MCF
Ketorolac-Tromethamine
Drug release system
dc.description.none.fl_txt_mv Nanoscale controlled drug delivery systems allowed for essential progress in pharmaceuticals, represent the change in medicine in the 21st century. Usually, controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and under the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured cellular foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, biodegradability and low toxicity. In this work, Ketorolac-Tromethamine/MCF material was synthesized. The material synthesis and loading of ketorolac-tromethamine (KETO) into MCF pores were successful. We obtain auspicious results for drugs controlled release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times, thereby maintaining the drug concentration within the range of therapeutic efficacy, which makes it highly applicable for the treatment of diseases that need a rapid response.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
description Nanoscale controlled drug delivery systems allowed for essential progress in pharmaceuticals, represent the change in medicine in the 21st century. Usually, controlled drug delivery systems can maintain the concentration of drugs in the exact sites of the body within the optimum range and under the toxicity threshold, improving therapeutic efficacy and reducing toxicity. Mesostructured cellular foam (MCF) material is a new promising host for drug delivery systems due to high biocompatibility, biodegradability and low toxicity. In this work, Ketorolac-Tromethamine/MCF material was synthesized. The material synthesis and loading of ketorolac-tromethamine (KETO) into MCF pores were successful. We obtain auspicious results for drugs controlled release using the novel MCF material. The application of these materials in KETO release is innovative, achieving an initial high release rate and then maintaining a constant rate at high times, thereby maintaining the drug concentration within the range of therapeutic efficacy, which makes it highly applicable for the treatment of diseases that need a rapid response.
publishDate 2017
dc.date.none.fl_str_mv 2017
2026-03-05T14:15:15Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 19º Congresso Brasileiro de Catálise e IX Congresso Mercosul de Catálise
https://hdl.handle.net/20.500.12272/14648
identifier_str_mv 19º Congresso Brasileiro de Catálise e IX Congresso Mercosul de Catálise
url https://hdl.handle.net/20.500.12272/14648
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Oscar Alfredo Anunziata
2017
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Oscar Alfredo Anunziata
2017
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv SBCat
publisher.none.fl_str_mv SBCat
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
_version_ 1877230882156183552
score 13.24418

Publicaciones similares