Nanostructured SBA-15 host applied in ketorolac tromethamine release system

Autores
Cussa, Jorgelina; Juárez, Juliana María; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfreco
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption andrelease. The SBA 15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA 15 silica nanochan- nels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/ SBA-15 were characterized by X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0–2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten® ) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA 15 provides significant improvement in the controlled release of ketor- olac tromethamine.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Fil: Gomez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
Materia
mesoporous silica SBA-15
ketorolac tromethamine
reléase system
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Attribution-NonCommercial-NoDerivatives 4.0 International
Repositorio
Repositorio Institucional Abierto (UTN)
Institución
Universidad Tecnológica Nacional
OAI Identificador
oai:ria.utn.edu.ar:20.500.12272/12332
Acceder
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oai_identifier_str oai:ria.utn.edu.ar:20.500.12272/12332
network_acronym_str RIAUTN
repository_id_str a
network_name_str Repositorio Institucional Abierto (UTN)
spelling Nanostructured SBA-15 host applied in ketorolac tromethamine release systemCussa, JorgelinaJuárez, Juliana MaríaGómez Costa, Marcos BrunoAnunziata, Oscar Alfrecomesoporous silica SBA-15ketorolac tromethaminereléase systemThe ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption andrelease. The SBA 15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA 15 silica nanochan- nels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/ SBA-15 were characterized by X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0–2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten® ) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA 15 provides significant improvement in the controlled release of ketor- olac tromethamine.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.Fil: Gomez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.Peer ReviewedSpringer Science+Business Media2025-03-07T21:25:23Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articulopdfapplication/pdfhttp://hdl.handle.net/20.500.12272/12332DOI 10.1007/s10856-017-5925-4enginfo:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Jorgelina CussaCC BY-NC-ND (Autoría-No comercial-No derivadas)reponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2026-09-24T12:46:05Zoai:ria.utn.edu.ar:20.500.12272/12332instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2026-09-24 12:46:07.346Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse
dc.title.none.fl_str_mv Nanostructured SBA-15 host applied in ketorolac tromethamine release system
title Nanostructured SBA-15 host applied in ketorolac tromethamine release system
spellingShingle Nanostructured SBA-15 host applied in ketorolac tromethamine release system
Cussa, Jorgelina
mesoporous silica SBA-15
ketorolac tromethamine
reléase system
title_short Nanostructured SBA-15 host applied in ketorolac tromethamine release system
title_full Nanostructured SBA-15 host applied in ketorolac tromethamine release system
title_fullStr Nanostructured SBA-15 host applied in ketorolac tromethamine release system
title_full_unstemmed Nanostructured SBA-15 host applied in ketorolac tromethamine release system
title_sort Nanostructured SBA-15 host applied in ketorolac tromethamine release system
dc.creator.none.fl_str_mv Cussa, Jorgelina
Juárez, Juliana María
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfreco
author Cussa, Jorgelina
author_facet Cussa, Jorgelina
Juárez, Juliana María
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfreco
author_role author
author2 Juárez, Juliana María
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfreco
author2_role author
author
author
dc.subject.none.fl_str_mv mesoporous silica SBA-15
ketorolac tromethamine
reléase system
topic mesoporous silica SBA-15
ketorolac tromethamine
reléase system
dc.description.none.fl_txt_mv The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption andrelease. The SBA 15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA 15 silica nanochan- nels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/ SBA-15 were characterized by X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0–2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten® ) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA 15 provides significant improvement in the controlled release of ketor- olac tromethamine.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Fil: Juárez, Juliana María. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Fil: Gomez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina.
Peer Reviewed
description The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption andrelease. The SBA 15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA 15 silica nanochan- nels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/ SBA-15 were characterized by X-ray diffraction, thermo gravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies. Drug release was evaluated by soaking the loaded silica mesoporous material into a solution of HCl (0.1 N) at initial time (0–2 h) and buffer pH 7 at high times at 37 °C under continuous stirring. Oral commercial Keto tablets (Dolten® ) and Keto solution (Keto power) were study for the contrast. Release studies were performed in order to evaluate the required therapeutic efficacy. SBA 15 provides significant improvement in the controlled release of ketor- olac tromethamine.
publishDate 2017
dc.date.none.fl_str_mv 2017
2025-03-07T21:25:23Z
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12272/12332
DOI 10.1007/s10856-017-5925-4
url http://hdl.handle.net/20.500.12272/12332
identifier_str_mv DOI 10.1007/s10856-017-5925-4
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Jorgelina Cussa
CC BY-NC-ND (Autoría-No comercial-No derivadas)
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Jorgelina Cussa
CC BY-NC-ND (Autoría-No comercial-No derivadas)
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Science+Business Media
publisher.none.fl_str_mv Springer Science+Business Media
dc.source.none.fl_str_mv reponame:Repositorio Institucional Abierto (UTN)
instname:Universidad Tecnológica Nacional
reponame_str Repositorio Institucional Abierto (UTN)
collection Repositorio Institucional Abierto (UTN)
instname_str Universidad Tecnológica Nacional
repository.name.fl_str_mv Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional
repository.mail.fl_str_mv gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar
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score 13.24418

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